ADCY8 | ENSG00000155897 | NCBI 114

Details for: ADCY8

Gene ID: 114

Symbol: ADCY8

Ensembl ID: ENSG00000155897

Description: adenylate cyclase 8

Associated with

Activation of gabab receptors
(R-HSA-991365)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adenylate cyclase activating pathway
(R-HSA-170660)
Adenylate cyclase inhibitory pathway
(R-HSA-170670)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Cam pathway
(R-HSA-111997)
Creb1 phosphorylation through the activation of adenylate cyclase
(R-HSA-442720)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gper1 signaling
(R-HSA-9634597)
Hedgehog 'off' state
(R-HSA-5610787)
Infectious disease
(R-HSA-5663205)
Integration of energy metabolism
(R-HSA-163685)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Pka-mediated phosphorylation of creb
(R-HSA-111931)
Pka activation
(R-HSA-163615)
Pka activation in glucagon signalling
(R-HSA-164378)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Activation of protein kinase a activity
(GO:0034199)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase activity
(GO:0004016)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Basolateral plasma membrane
(GO:0016323)
Calcium- and calmodulin-responsive adenylate cyclase activity
(GO:0008294)
Calmodulin binding
(GO:0005516)
Camp biosynthetic process
(GO:0006171)
Caveola
(GO:0005901)
Cellular response to calcium ion
(GO:0071277)
Cellular response to forskolin
(GO:1904322)
Cellular response to glucagon stimulus
(GO:0071377)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to morphine
(GO:0071315)
Clathrin-coated pit
(GO:0005905)
Clathrin-coated vesicle membrane
(GO:0030665)
Dendrite
(GO:0030425)
Glucose homeostasis
(GO:0042593)
Glucose mediated signaling pathway
(GO:0010255)
G protein-coupled opioid receptor signaling pathway
(GO:0038003)
Intracellular signal transduction
(GO:0035556)
Learning or memory
(GO:0007611)
Locomotory behavior
(GO:0007626)
Long-term memory
(GO:0007616)
Membrane
(GO:0016020)
Memory
(GO:0007613)
Metal ion binding
(GO:0046872)
Neuroinflammatory response
(GO:0150076)
Neuronal cell body membrane
(GO:0032809)
Plasma membrane
(GO:0005886)
Plasma membrane raft
(GO:0044853)
Positive regulation of creb transcription factor activity
(GO:0032793)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of long-term synaptic depression
(GO:1900454)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of synaptic plasticity
(GO:0031915)
Postsynaptic density
(GO:0014069)
Presynaptic membrane
(GO:0042734)
Protein complex oligomerization
(GO:0051259)
Protein dimerization activity
(GO:0046983)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein homooligomerization
(GO:0051260)
Protein phosphatase 2a binding
(GO:0051721)
Regulation of cellular response to stress
(GO:0080135)
Regulation of cytosolic calcium ion concentration
(GO:0051480)
Regulation of insulin secretion
(GO:0050796)
Signal transduction
(GO:0007165)

Other Information

Proteins

ATP pyrophosphate-lyase 8
Q4F7X0_HUMAN

Genular Protein ID: 3797197339

Symbol: ADCY8_HUMAN

Name: ATP pyrophosphate-lyase 8

UniProtKB Accession Codes:

P40145

Database IDs:

Citations:

PubMed ID: 8076676

Title: Molecular cloning of the human type VIII adenylyl cyclase.

PubMed ID: 8076676

DOI: 10.1016/0014-5793(94)00836-1

PubMed ID: 1715695

Title: Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain.

PubMed ID: 1715695

DOI: 10.1016/0006-291x(91)91392-p

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 25403481

Title: Multilevel control of glucose homeostasis by adenylyl cyclase 8.

PubMed ID: 25403481

DOI: 10.1007/s00125-014-3445-z

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 1251
Mass: 140122
Checksum: ABF25C40493E07C3
Sequence:

MELSDVRCLT GSEELYTIHP TPPAGDGRSA SRPQRLLWQT AVRHITEQRF IHGHRGGSGS 
GSGGSGKASD PAGGGPNHHA PQLSGDSALP LYSLGPGERA HSTCGTKVFP ERSGSGSASG 
SGGGGDLGFL HLDCAPSNSD FFLNGGYSYR GVIFPTLRNS FKSRDLERLY QRYFLGQRRK 
SEVVMNVLDV LTKLTLLVLH LSLASAPMDP LKGILLGFFT GIEVVICALV VVRKDTTSHT 
YLQYSGVVTW VAMTTQILAA GLGYGLLGDG IGYVLFTLFA TYSMLPLPLT WAILAGLGTS 
LLQVILQVVI PRLAVISINQ VVAQAVLFMC MNTAGIFISY LSDRAQRQAF LETRRCVEAR 
LRLETENQRQ ERLVLSVLPR FVVLEMINDM TNVEDEHLQH QFHRIYIHRY ENVSILFADV 
KGFTNLSTTL SAQELVRMLN ELFARFDRLA HEHHCLRIKI LGDCYYCVSG LPEPRQDHAH 
CCVEMGLSMI KTIRYVRSRT KHDVDMRIGI HSGSVLCGVL GLRKWQFDVW SWDVDIANKL 
ESGGIPGRIH ISKATLDCLN GDYNVEEGHG KERNEFLRKH NIETYLIKQP EDSLLSLPED 
IVKESVSSSD RRNSGATFTE GSWSPELPFD NIVGKQNTLA ALTRNSINLL PNHLAQALHV 
QSGPEEINKR IEHTIDLRSG DKLRREHIKP FSLMFKDSSL EHKYSQMRDE VFKSNLVCAF 
IVLLFITAIQ SLLPSSRVMP MTIQFSILIM LHSALVLITT AEDYKCLPLI LRKTCCWINE 
TYLARNVIIF ASILINFLGA ILNILWCDFD KSIPLKNLTF NSSAVFTDIC SYPEYFVFTG 
VLAMVTCAVF LRLNSVLKLA VLLIMIAIYA LLTETVYAGL FLRYDNLNHS GEDFLGTKEV 
SLLLMAMFLL AVFYHGQQLE YTARLDFLWR VQAKEEINEM KELREHNENM LRNILPSHVA 
RHFLEKDRDN EELYSQSYDA VGVMFASIPG FADFYSQTEM NNQGVECLRL LNEIIADFDE 
LLGEDRFQDI EKIKTIGSTY MAVSGLSPEK QQCEDKWGHL CALADFSLAL TESIQEINKH 
SFNNFELRIG ISHGSVVAGV IGAKKPQYDI WGKTVNLASR MDSTGVSGRI QVPEETYLIL 
KDQGFAFDYR GEIYVKGISE QEGKIKTYFL LGRVQPNPFI LPPRRLPGQY SLAAVVLGLV 
QSLNRQRQKQ LLNENNNTGI IKGHYNRRTL LSPSGTEPGA QAEGTDKSDL P

Genular Protein ID: 1286591004

Symbol: Q4F7X0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4F7X0

Database IDs:

Sequence Information:

Length: 1120
Mass: 124842
Checksum: 618E235C2AB002C2
Sequence:

MELSDVRCLT GSEELYTIHP TPPAGDGRSA SRPQRLLWQT AVRHITEQRF IHGHRGGSGS 
GSGGSGKASD PAGGGPNHHA PQLSGDSALP LYSLGPGERA HSTCGTKVFP ERSGSGSASG 
SGGGGDLGFL HLDCAPSNSD FFLNGGYSYR GVIFPTLRNS FKSRDLERLY QRYFLGQRRK 
SEVVMNVLDV LTKLTLLVLH LSLASAPMDP LKGILLGFFT GIEVVICALV VVRKDTTSHT 
YLQYSGVVTW VAMTTQILAA GLGYGLLGDG IGYVLFTLFA TYGMLPLPLT WAILAGLGTS 
LLQVILQVVI PRLAVISINR VVAQAVLFMC MNTAGIFISY LSDRAQRQAF LETRRCVEAR 
LRLETENQRQ ERLVLSVLPR FVVLEMINDM TNVEDGHLQH QFHRIYIHRY ENVSILFADV 
KGFTNLSATL SAQELVRMLN ELFARFDRLV HEHHCLRIKI LGDCYYCVSG LPEPRQDHAH 
CCVEMGLSMI KTIRYVRSRT KHDVDMRIGI HSGSVLCGVL GLRKWQFDVW SWDVDIANKL 
ESGGIPGRIH ISEATLDCLN GDYNVEEGHG KERNEFLGKH NIETYLIKQP EDSLLSLPED 
IVKESVSSSD RRNSGATFTE GSWSPELPFD NIVGKQNTLA ALTRNSINLL PNHLAQALHV 
QSGPEEINKR IEHTIDLRSG DKLRREHIKP FSLMFKDSSL EHKYFVFTGV LAMVTCAVFL 
RLNSVLKLAV LLIMIAIYAP LTETVYAGLF LRYDNLNHSG EDFLGTKEVS LLLMAMFLLA 
VFYHGQQLEY TARLDFLWRV QAKEEINEMK ELREHNENML RNILPSHVAR HFLEKDQDNE 
ELYSQSYDAV GVMFASIPGF ADFYSQTEMN NQGVECLRLL NEIIADFDEL LGEDRFQDIE 
KIKTIGSTYM AVSGPSPEKQ QCEDKWGHLC ALADFSLALT ESIQEINKHS FNNFELRIGI 
SHGSVVAGVI GAKKPQYDIW GKTVNLASRM DSTGVSGRIQ VPEETYLILK DQGFAFDYRG 
EIYVKGISEQ EGKIKTYFLL GRVQPNPFIL PPRILPGQYS LAAVVLGLVQ SLNRQGQKQL 
LNENNNTGII KGHYNRRTLL SPSGTEPGAQ AEGTDKSDLP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADCY8

Associated with

Other Information

Molecular cloning of the human type VIII adenylyl cyclase. PubMed ID: 8076676

Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain. PubMed ID: 1715695

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648