Details for: ADCY8
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 4.4147
Cell Significance Index: 3.1600 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 3.3751
Cell Significance Index: 47.2000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.1924
Cell Significance Index: 786.3700 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.6930
Cell Significance Index: 28.9400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.3982
Cell Significance Index: 967.0400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.3737
Cell Significance Index: 39.2000 - Cell Name: chandelier cell (CL4023083)
Fold Change: 0.9276
Cell Significance Index: 7.4900 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.8451
Cell Significance Index: 10.9600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.7822
Cell Significance Index: 18.7600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7081
Cell Significance Index: 142.0500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5852
Cell Significance Index: 35.9700 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.5261
Cell Significance Index: 6.5600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1419
Cell Significance Index: 267.2000 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: 0.1284
Cell Significance Index: 1.6200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.0485
Cell Significance Index: 1.0300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0340
Cell Significance Index: 21.5800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0003
Cell Significance Index: -0.0100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0122
Cell Significance Index: -16.6000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0146
Cell Significance Index: -26.9600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0162
Cell Significance Index: -24.8800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0311
Cell Significance Index: -0.4500 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0382
Cell Significance Index: -0.6600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0399
Cell Significance Index: -24.9400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0436
Cell Significance Index: -32.2600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0447
Cell Significance Index: -33.8400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0455
Cell Significance Index: -33.3400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0492
Cell Significance Index: -22.3500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0566
Cell Significance Index: -31.9200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0576
Cell Significance Index: -3.8800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0665
Cell Significance Index: -1.1400 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.0775
Cell Significance Index: -0.6400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0959
Cell Significance Index: -27.6000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1469
Cell Significance Index: -29.1600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1573
Cell Significance Index: -33.1300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1614
Cell Significance Index: -4.5100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1798
Cell Significance Index: -32.4200 - Cell Name: neural cell (CL0002319)
Fold Change: -0.1817
Cell Significance Index: -2.1200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1886
Cell Significance Index: -32.2000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1964
Cell Significance Index: -28.5500 - Cell Name: neuron (CL0000540)
Fold Change: -0.2511
Cell Significance Index: -2.3800 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.2599
Cell Significance Index: -3.2800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.2644
Cell Significance Index: -32.5200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2774
Cell Significance Index: -5.5700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2869
Cell Significance Index: -29.8700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3055
Cell Significance Index: -35.6000 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.3132
Cell Significance Index: -3.8900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3150
Cell Significance Index: -36.0900 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.3331
Cell Significance Index: -6.9500 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3336
Cell Significance Index: -8.3200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.3430
Cell Significance Index: -35.0400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3921
Cell Significance Index: -30.0900 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.4035
Cell Significance Index: -4.8300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4228
Cell Significance Index: -9.1400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4270
Cell Significance Index: -13.6000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4281
Cell Significance Index: -24.0200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4496
Cell Significance Index: -14.7200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4859
Cell Significance Index: -25.5100 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.5076
Cell Significance Index: -5.8100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5552
Cell Significance Index: -19.4500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5900
Cell Significance Index: -27.5100 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -0.5908
Cell Significance Index: -5.1100 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.6636
Cell Significance Index: -5.2800 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.6708
Cell Significance Index: -8.6800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.7034
Cell Significance Index: -33.0600 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.7209
Cell Significance Index: -7.5100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7314
Cell Significance Index: -32.3500 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.7679
Cell Significance Index: -10.5300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7826
Cell Significance Index: -28.7300 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.8123
Cell Significance Index: -19.6800 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.8389
Cell Significance Index: -9.1400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8546
Cell Significance Index: -32.3600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.9036
Cell Significance Index: -31.7500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9512
Cell Significance Index: -24.4500 - Cell Name: granule cell (CL0000120)
Fold Change: -0.9548
Cell Significance Index: -10.8700 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -1.0344
Cell Significance Index: -20.3600 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -1.0399
Cell Significance Index: -25.9400 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -1.0535
Cell Significance Index: -33.3200 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -1.0621
Cell Significance Index: -21.1800 - Cell Name: secretory cell (CL0000151)
Fold Change: -1.0844
Cell Significance Index: -7.5200 - Cell Name: erythrocyte (CL0000232)
Fold Change: -1.0978
Cell Significance Index: -27.9700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.1009
Cell Significance Index: -31.7200 - Cell Name: preadipocyte (CL0002334)
Fold Change: -1.1626
Cell Significance Index: -22.6900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1740
Cell Significance Index: -34.5800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.1934
Cell Significance Index: -34.2100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -1.2475
Cell Significance Index: -33.3100 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -1.2478
Cell Significance Index: -11.2800 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.2595
Cell Significance Index: -30.7300 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -1.2635
Cell Significance Index: -25.7100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -1.2663
Cell Significance Index: -33.3000 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -1.2678
Cell Significance Index: -16.9000 - Cell Name: peg cell (CL4033014)
Fold Change: -1.2795
Cell Significance Index: -29.5600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -1.3064
Cell Significance Index: -32.6300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.3325
Cell Significance Index: -35.7100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.3499
Cell Significance Index: -28.2600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -1.4038
Cell Significance Index: -38.2100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.4304
Cell Significance Index: -30.5800 - Cell Name: macroglial cell (CL0000126)
Fold Change: -1.4855
Cell Significance Index: -17.2000 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -1.4895
Cell Significance Index: -19.4400 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -1.5102
Cell Significance Index: -24.4600 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -1.5166
Cell Significance Index: -31.6300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3797197339
Symbol: ADCY8_HUMAN
Name: ATP pyrophosphate-lyase 8
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8076676
Title: Molecular cloning of the human type VIII adenylyl cyclase.
PubMed ID: 8076676
PubMed ID: 1715695
Title: Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain.
PubMed ID: 1715695
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 25403481
Title: Multilevel control of glucose homeostasis by adenylyl cyclase 8.
PubMed ID: 25403481
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 1251
- Mass: 140122
- Checksum: ABF25C40493E07C3
- Sequence:
MELSDVRCLT GSEELYTIHP TPPAGDGRSA SRPQRLLWQT AVRHITEQRF IHGHRGGSGS GSGGSGKASD PAGGGPNHHA PQLSGDSALP LYSLGPGERA HSTCGTKVFP ERSGSGSASG SGGGGDLGFL HLDCAPSNSD FFLNGGYSYR GVIFPTLRNS FKSRDLERLY QRYFLGQRRK SEVVMNVLDV LTKLTLLVLH LSLASAPMDP LKGILLGFFT GIEVVICALV VVRKDTTSHT YLQYSGVVTW VAMTTQILAA GLGYGLLGDG IGYVLFTLFA TYSMLPLPLT WAILAGLGTS LLQVILQVVI PRLAVISINQ VVAQAVLFMC MNTAGIFISY LSDRAQRQAF LETRRCVEAR LRLETENQRQ ERLVLSVLPR FVVLEMINDM TNVEDEHLQH QFHRIYIHRY ENVSILFADV KGFTNLSTTL SAQELVRMLN ELFARFDRLA HEHHCLRIKI LGDCYYCVSG LPEPRQDHAH CCVEMGLSMI KTIRYVRSRT KHDVDMRIGI HSGSVLCGVL GLRKWQFDVW SWDVDIANKL ESGGIPGRIH ISKATLDCLN GDYNVEEGHG KERNEFLRKH NIETYLIKQP EDSLLSLPED IVKESVSSSD RRNSGATFTE GSWSPELPFD NIVGKQNTLA ALTRNSINLL PNHLAQALHV QSGPEEINKR IEHTIDLRSG DKLRREHIKP FSLMFKDSSL EHKYSQMRDE VFKSNLVCAF IVLLFITAIQ SLLPSSRVMP MTIQFSILIM LHSALVLITT AEDYKCLPLI LRKTCCWINE TYLARNVIIF ASILINFLGA ILNILWCDFD KSIPLKNLTF NSSAVFTDIC SYPEYFVFTG VLAMVTCAVF LRLNSVLKLA VLLIMIAIYA LLTETVYAGL FLRYDNLNHS GEDFLGTKEV SLLLMAMFLL AVFYHGQQLE YTARLDFLWR VQAKEEINEM KELREHNENM LRNILPSHVA RHFLEKDRDN EELYSQSYDA VGVMFASIPG FADFYSQTEM NNQGVECLRL LNEIIADFDE LLGEDRFQDI EKIKTIGSTY MAVSGLSPEK QQCEDKWGHL CALADFSLAL TESIQEINKH SFNNFELRIG ISHGSVVAGV IGAKKPQYDI WGKTVNLASR MDSTGVSGRI QVPEETYLIL KDQGFAFDYR GEIYVKGISE QEGKIKTYFL LGRVQPNPFI LPPRRLPGQY SLAAVVLGLV QSLNRQRQKQ LLNENNNTGI IKGHYNRRTL LSPSGTEPGA QAEGTDKSDL P
Genular Protein ID: 1286591004
Symbol: Q4F7X0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1120
- Mass: 124842
- Checksum: 618E235C2AB002C2
- Sequence:
MELSDVRCLT GSEELYTIHP TPPAGDGRSA SRPQRLLWQT AVRHITEQRF IHGHRGGSGS GSGGSGKASD PAGGGPNHHA PQLSGDSALP LYSLGPGERA HSTCGTKVFP ERSGSGSASG SGGGGDLGFL HLDCAPSNSD FFLNGGYSYR GVIFPTLRNS FKSRDLERLY QRYFLGQRRK SEVVMNVLDV LTKLTLLVLH LSLASAPMDP LKGILLGFFT GIEVVICALV VVRKDTTSHT YLQYSGVVTW VAMTTQILAA GLGYGLLGDG IGYVLFTLFA TYGMLPLPLT WAILAGLGTS LLQVILQVVI PRLAVISINR VVAQAVLFMC MNTAGIFISY LSDRAQRQAF LETRRCVEAR LRLETENQRQ ERLVLSVLPR FVVLEMINDM TNVEDGHLQH QFHRIYIHRY ENVSILFADV KGFTNLSATL SAQELVRMLN ELFARFDRLV HEHHCLRIKI LGDCYYCVSG LPEPRQDHAH CCVEMGLSMI KTIRYVRSRT KHDVDMRIGI HSGSVLCGVL GLRKWQFDVW SWDVDIANKL ESGGIPGRIH ISEATLDCLN GDYNVEEGHG KERNEFLGKH NIETYLIKQP EDSLLSLPED IVKESVSSSD RRNSGATFTE GSWSPELPFD NIVGKQNTLA ALTRNSINLL PNHLAQALHV QSGPEEINKR IEHTIDLRSG DKLRREHIKP FSLMFKDSSL EHKYFVFTGV LAMVTCAVFL RLNSVLKLAV LLIMIAIYAP LTETVYAGLF LRYDNLNHSG EDFLGTKEVS LLLMAMFLLA VFYHGQQLEY TARLDFLWRV QAKEEINEMK ELREHNENML RNILPSHVAR HFLEKDQDNE ELYSQSYDAV GVMFASIPGF ADFYSQTEMN NQGVECLRLL NEIIADFDEL LGEDRFQDIE KIKTIGSTYM AVSGPSPEKQ QCEDKWGHLC ALADFSLALT ESIQEINKHS FNNFELRIGI SHGSVVAGVI GAKKPQYDIW GKTVNLASRM DSTGVSGRIQ VPEETYLILK DQGFAFDYRG EIYVKGISEQ EGKIKTYFLL GRVQPNPFIL PPRILPGQYS LAAVVLGLVQ SLNRQGQKQL LNENNNTGII KGHYNRRTLL SPSGTEPGAQ AEGTDKSDLP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.