Details for: ADCY8

Gene ID: 114

Symbol: ADCY8

Ensembl ID: ENSG00000155897

Description: adenylate cyclase 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.91
    Marker Score: 3830
  • Cell Name: interneuron (CL0000099)
    Fold Change: 3.87
    Marker Score: 1769
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.91
    Marker Score: 2524
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.85
    Marker Score: 6546
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.8
    Marker Score: 7981
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.66
    Marker Score: 3672
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.59
    Marker Score: 51576
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.57
    Marker Score: 10657
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.42
    Marker Score: 51652
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.35
    Marker Score: 986
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.31
    Marker Score: 6630.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.29
    Marker Score: 84305
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.2
    Marker Score: 1159
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.99
    Marker Score: 3765
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.95
    Marker Score: 7532
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.79
    Marker Score: 489
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.78
    Marker Score: 1171
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.77
    Marker Score: 7395
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.74
    Marker Score: 13151
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.72
    Marker Score: 3562
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.52
    Marker Score: 57703
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.46
    Marker Score: 1804
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2240
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.43
    Marker Score: 12257
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.42
    Marker Score: 21250
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.38
    Marker Score: 2799
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.37
    Marker Score: 573
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.29
    Marker Score: 2173
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.19
    Marker Score: 4856
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.16
    Marker Score: 6242
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17571
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7446
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.12
    Marker Score: 2637
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.1
    Marker Score: 8425
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.09
    Marker Score: 654
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.08
    Marker Score: 11181
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.06
    Marker Score: 4911
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.03
    Marker Score: 327.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71794
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48016
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1
    Marker Score: 4165
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.98
    Marker Score: 554
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.97
    Marker Score: 640
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.95
    Marker Score: 1059
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.84
    Marker Score: 7970
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.81
    Marker Score: 2727
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.81
    Marker Score: 1005
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.79
    Marker Score: 378
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1174
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.67
    Marker Score: 2809
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.67
    Marker Score: 318
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.65
    Marker Score: 376
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 502
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.63
    Marker Score: 242
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.58
    Marker Score: 634
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 179
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.54
    Marker Score: 983
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.52
    Marker Score: 2718
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5
    Marker Score: 147
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.47
    Marker Score: 148
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 206
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.45
    Marker Score: 166
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.45
    Marker Score: 27499
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 113
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.42
    Marker Score: 244
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.4
    Marker Score: 968
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.39
    Marker Score: 173
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.35
    Marker Score: 197
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.34
    Marker Score: 120
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.34
    Marker Score: 103
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.33
    Marker Score: 198
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 291
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.3
    Marker Score: 86
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.3
    Marker Score: 122
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.3
    Marker Score: 109
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3
    Marker Score: 606.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.28
    Marker Score: 263
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.27
    Marker Score: 255.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.27
    Marker Score: 268
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.27
    Marker Score: 78
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.26
    Marker Score: 74
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.26
    Marker Score: 53
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.25
    Marker Score: 148
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.25
    Marker Score: 55
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.24
    Marker Score: 2435
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.24
    Marker Score: 60
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.22
    Marker Score: 655
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.22
    Marker Score: 249
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.21
    Marker Score: 60

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Other Information

**Key characteristics:** * The ADCY8 gene is located on chromosome 19q21.1. * It encodes a protein that is 1100 amino acids long. * The protein is a transmembrane protein that is expressed in the plasma membrane. * It is a homodimeric protein, meaning it consists of two identical subunits that are held together by a disulfide bond. * The protein is a chaperone protein, which means that it helps to fold and maintain the structure of other proteins. **Pathways and functions:** * ADCY8 is a key regulator of aquaporin-mediated transport. Aquaporins are proteins that allow water and small molecules to pass through their lipid bilayer. ADCY8 is expressed in cells that are involved in maintaining water homeostasis, such as erythrocytes, renal cells, and brain cells. * It is also involved in the regulation of the Gpcr downstream signaling pathway, the hedgehog 'off' state, and infectious disease. * ADCY8 is a regulator of insulin secretion. It is expressed in pancreatic beta cells, which produce insulin. Insulin helps to regulate blood sugar levels by allowing glucose to enter cells. ADCY8 inhibits insulin secretion, which can lead to hyperglycemia. **Clinical significance:** Mutations in the ADCY8 gene have been linked to several human diseases, including diabetes, hypertension, and heart failure. These diseases are characterized by abnormal water and electrolyte balance, which can be caused by defects in aquaporins or other proteins that are regulated by ADCY8. **Additional information:** * ADCY8 is a highly conserved protein, with similar genes found in organisms from yeast to humans. * The protein is a member of the ADP-ribosylation factor (ARF) family of proteins. * ADCY8 is a potential therapeutic target for diseases characterized by abnormal water and electrolyte balance.

Genular Protein ID: 3797197339

Symbol: ADCY8_HUMAN

Name: ATP pyrophosphate-lyase 8

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8076676

Title: Molecular cloning of the human type VIII adenylyl cyclase.

PubMed ID: 8076676

DOI: 10.1016/0014-5793(94)00836-1

PubMed ID: 1715695

Title: Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain.

PubMed ID: 1715695

DOI: 10.1016/0006-291x(91)91392-p

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 25403481

Title: Multilevel control of glucose homeostasis by adenylyl cyclase 8.

PubMed ID: 25403481

DOI: 10.1007/s00125-014-3445-z

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1251
  • Mass: 140122
  • Checksum: ABF25C40493E07C3
  • Sequence:
  • MELSDVRCLT GSEELYTIHP TPPAGDGRSA SRPQRLLWQT AVRHITEQRF IHGHRGGSGS 
    GSGGSGKASD PAGGGPNHHA PQLSGDSALP LYSLGPGERA HSTCGTKVFP ERSGSGSASG 
    SGGGGDLGFL HLDCAPSNSD FFLNGGYSYR GVIFPTLRNS FKSRDLERLY QRYFLGQRRK 
    SEVVMNVLDV LTKLTLLVLH LSLASAPMDP LKGILLGFFT GIEVVICALV VVRKDTTSHT 
    YLQYSGVVTW VAMTTQILAA GLGYGLLGDG IGYVLFTLFA TYSMLPLPLT WAILAGLGTS 
    LLQVILQVVI PRLAVISINQ VVAQAVLFMC MNTAGIFISY LSDRAQRQAF LETRRCVEAR 
    LRLETENQRQ ERLVLSVLPR FVVLEMINDM TNVEDEHLQH QFHRIYIHRY ENVSILFADV 
    KGFTNLSTTL SAQELVRMLN ELFARFDRLA HEHHCLRIKI LGDCYYCVSG LPEPRQDHAH 
    CCVEMGLSMI KTIRYVRSRT KHDVDMRIGI HSGSVLCGVL GLRKWQFDVW SWDVDIANKL 
    ESGGIPGRIH ISKATLDCLN GDYNVEEGHG KERNEFLRKH NIETYLIKQP EDSLLSLPED 
    IVKESVSSSD RRNSGATFTE GSWSPELPFD NIVGKQNTLA ALTRNSINLL PNHLAQALHV 
    QSGPEEINKR IEHTIDLRSG DKLRREHIKP FSLMFKDSSL EHKYSQMRDE VFKSNLVCAF 
    IVLLFITAIQ SLLPSSRVMP MTIQFSILIM LHSALVLITT AEDYKCLPLI LRKTCCWINE 
    TYLARNVIIF ASILINFLGA ILNILWCDFD KSIPLKNLTF NSSAVFTDIC SYPEYFVFTG 
    VLAMVTCAVF LRLNSVLKLA VLLIMIAIYA LLTETVYAGL FLRYDNLNHS GEDFLGTKEV 
    SLLLMAMFLL AVFYHGQQLE YTARLDFLWR VQAKEEINEM KELREHNENM LRNILPSHVA 
    RHFLEKDRDN EELYSQSYDA VGVMFASIPG FADFYSQTEM NNQGVECLRL LNEIIADFDE 
    LLGEDRFQDI EKIKTIGSTY MAVSGLSPEK QQCEDKWGHL CALADFSLAL TESIQEINKH 
    SFNNFELRIG ISHGSVVAGV IGAKKPQYDI WGKTVNLASR MDSTGVSGRI QVPEETYLIL 
    KDQGFAFDYR GEIYVKGISE QEGKIKTYFL LGRVQPNPFI LPPRRLPGQY SLAAVVLGLV 
    QSLNRQRQKQ LLNENNNTGI IKGHYNRRTL LSPSGTEPGA QAEGTDKSDL P

Genular Protein ID: 1286591004

Symbol: Q4F7X0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1120
  • Mass: 124842
  • Checksum: 618E235C2AB002C2
  • Sequence:
  • MELSDVRCLT GSEELYTIHP TPPAGDGRSA SRPQRLLWQT AVRHITEQRF IHGHRGGSGS 
    GSGGSGKASD PAGGGPNHHA PQLSGDSALP LYSLGPGERA HSTCGTKVFP ERSGSGSASG 
    SGGGGDLGFL HLDCAPSNSD FFLNGGYSYR GVIFPTLRNS FKSRDLERLY QRYFLGQRRK 
    SEVVMNVLDV LTKLTLLVLH LSLASAPMDP LKGILLGFFT GIEVVICALV VVRKDTTSHT 
    YLQYSGVVTW VAMTTQILAA GLGYGLLGDG IGYVLFTLFA TYGMLPLPLT WAILAGLGTS 
    LLQVILQVVI PRLAVISINR VVAQAVLFMC MNTAGIFISY LSDRAQRQAF LETRRCVEAR 
    LRLETENQRQ ERLVLSVLPR FVVLEMINDM TNVEDGHLQH QFHRIYIHRY ENVSILFADV 
    KGFTNLSATL SAQELVRMLN ELFARFDRLV HEHHCLRIKI LGDCYYCVSG LPEPRQDHAH 
    CCVEMGLSMI KTIRYVRSRT KHDVDMRIGI HSGSVLCGVL GLRKWQFDVW SWDVDIANKL 
    ESGGIPGRIH ISEATLDCLN GDYNVEEGHG KERNEFLGKH NIETYLIKQP EDSLLSLPED 
    IVKESVSSSD RRNSGATFTE GSWSPELPFD NIVGKQNTLA ALTRNSINLL PNHLAQALHV 
    QSGPEEINKR IEHTIDLRSG DKLRREHIKP FSLMFKDSSL EHKYFVFTGV LAMVTCAVFL 
    RLNSVLKLAV LLIMIAIYAP LTETVYAGLF LRYDNLNHSG EDFLGTKEVS LLLMAMFLLA 
    VFYHGQQLEY TARLDFLWRV QAKEEINEMK ELREHNENML RNILPSHVAR HFLEKDQDNE 
    ELYSQSYDAV GVMFASIPGF ADFYSQTEMN NQGVECLRLL NEIIADFDEL LGEDRFQDIE 
    KIKTIGSTYM AVSGPSPEKQ QCEDKWGHLC ALADFSLALT ESIQEINKHS FNNFELRIGI 
    SHGSVVAGVI GAKKPQYDIW GKTVNLASRM DSTGVSGRIQ VPEETYLILK DQGFAFDYRG 
    EIYVKGISEQ EGKIKTYFLL GRVQPNPFIL PPRILPGQYS LAAVVLGLVQ SLNRQGQKQL 
    LNENNNTGII KGHYNRRTLL SPSGTEPGAQ AEGTDKSDLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.