CHRNB2 | ENSG00000160716 | NCBI 1141

Details for: CHRNB2

Gene ID: 1141

Symbol: CHRNB2

Ensembl ID: ENSG00000160716

Description: cholinergic receptor nicotinic beta 2 subunit

Associated with

Acetylcholine binding and downstream events
(R-HSA-181431)
Highly calcium permeable nicotinic acetylcholine receptors
(R-HSA-629597)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
(R-HSA-629594)
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
(R-HSA-629587)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Postsynaptic nicotinic acetylcholine receptors
(R-HSA-622327)
Presynaptic nicotinic acetylcholine receptors
(R-HSA-622323)
Transmission across chemical synapses
(R-HSA-112315)
Acetylcholine-gated channel complex
(GO:0005892)
Acetylcholine-gated monoatomic cation-selective channel activity
(GO:0022848)
Acetylcholine binding
(GO:0042166)
Acetylcholine receptor activity
(GO:0015464)
Acetylcholine receptor signaling pathway
(GO:0095500)
Associative learning
(GO:0008306)
B cell activation
(GO:0042113)
Behavioral response to nicotine
(GO:0035095)
Calcium ion transport
(GO:0006816)
Central nervous system projection neuron axonogenesis
(GO:0021952)
Chemical synaptic transmission
(GO:0007268)
Cholinergic synapse
(GO:0098981)
Cognition
(GO:0050890)
Excitatory postsynaptic potential
(GO:0060079)
External side of plasma membrane
(GO:0009897)
Heterocyclic compound binding
(GO:1901363)
Lateral geniculate nucleus development
(GO:0021771)
Learning
(GO:0007612)
Ligand-gated monoatomic ion channel activity
(GO:0015276)
Locomotory behavior
(GO:0007626)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Memory
(GO:0007613)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Negative regulation of action potential
(GO:0045759)
Nervous system process
(GO:0050877)
Neuron projection
(GO:0043005)
Optic nerve morphogenesis
(GO:0021631)
Plasma membrane
(GO:0005886)
Plasma membrane raft
(GO:0044853)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of dopamine secretion
(GO:0033603)
Postsynaptic specialization membrane
(GO:0099634)
Presynaptic membrane
(GO:0042734)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Quaternary ammonium group binding
(GO:0050997)
Regulation of circadian sleep/wake cycle, rem sleep
(GO:0042320)
Regulation of dendrite morphogenesis
(GO:0048814)
Regulation of dopamine metabolic process
(GO:0042053)
Regulation of dopamine secretion
(GO:0014059)
Regulation of synapse assembly
(GO:0051963)
Regulation of synaptic transmission, dopaminergic
(GO:0032225)
Response to acetylcholine
(GO:1905144)
Response to cocaine
(GO:0042220)
Response to ethanol
(GO:0045471)
Response to hypoxia
(GO:0001666)
Response to nicotine
(GO:0035094)
Sensory perception of pain
(GO:0019233)
Sensory perception of sound
(GO:0007605)
Signal transduction
(GO:0007165)
Smooth muscle contraction
(GO:0006939)
Social behavior
(GO:0035176)
Synapse
(GO:0045202)
Synaptic transmission, cholinergic
(GO:0007271)
Synaptic transmission involved in micturition
(GO:0060084)
Vestibulocochlear nerve development
(GO:0021562)
Visual learning
(GO:0008542)
Visual perception
(GO:0007601)

Other Information

Proteins

Neuronal acetylcholine receptor subunit beta-2

Genular Protein ID: 1091050914

Symbol: ACHB2_HUMAN

Name: Neuronal acetylcholine receptor subunit beta-2

UniProtKB Accession Codes:

P17787 Q9UEH9

Database IDs:

Citations:

PubMed ID: 2377478

Title: Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene.

PubMed ID: 2377478

DOI: 10.1093/nar/18.14.4272

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 9009220

Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

PubMed ID: 9009220

DOI: 10.1016/s0014-5793(96)01383-x

PubMed ID: 9921897

Title: The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3).

PubMed ID: 9921897

DOI: 10.1007/s004390050885

PubMed ID: 10441742

Title: Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes.

PubMed ID: 10441742

DOI: 10.1007/s003359901111

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15609996

Title: Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.

PubMed ID: 15609996

DOI: 10.1021/bi048918g

PubMed ID: 16120769

Title: RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.

PubMed ID: 16120769

DOI: 10.1124/mol.105.017459

PubMed ID: 27344019

Title: Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

PubMed ID: 27344019

DOI: 10.1111/jnc.13718

PubMed ID: 27493220

Title: Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound alpha2 homopentamer.

PubMed ID: 27493220

DOI: 10.1073/pnas.1602619113

PubMed ID: 20441771

Title: NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit.

PubMed ID: 20441771

DOI: 10.1016/j.bbamem.2010.04.014

PubMed ID: 22361591

Title: NMR structures of the transmembrane domains of the alpha4beta2 nAChR.

PubMed ID: 22361591

DOI: 10.1016/j.bbamem.2012.02.008

PubMed ID: 11062464

Title: The nicotinic receptor beta-2 subunit is mutant in nocturnal frontal lobe epilepsy.

PubMed ID: 11062464

DOI: 10.1038/81566

PubMed ID: 11104662

Title: CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy.

PubMed ID: 11104662

DOI: 10.1086/316946

PubMed ID: 11906688

Title: Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2).

PubMed ID: 11906688

DOI: 10.1080/14622200110098419

Sequence Information:

Length: 502
Mass: 57019
Checksum: 7EEDEF6ADFDC9F23
Sequence:

MARRCGPVAL LLGFGLLRLC SGVWGTDTEE RLVEHLLDPS RYNKLIRPAT NGSELVTVQL 
MVSLAQLISV HEREQIMTTN VWLTQEWEDY RLTWKPEEFD NMKKVRLPSK HIWLPDVVLY 
NNADGMYEVS FYSNAVVSYD GSIFWLPPAI YKSACKIEVK HFPFDQQNCT MKFRSWTYDR 
TEIDLVLKSE VASLDDFTPS GEWDIVALPG RRNENPDDST YVDITYDFII RRKPLFYTIN 
LIIPCVLITS LAILVFYLPS DCGEKMTLCI SVLLALTVFL LLISKIVPPT SLDVPLVGKY 
LMFTMVLVTF SIVTSVCVLN VHHRSPTTHT MAPWVKVVFL EKLPALLFMQ QPRHHCARQR 
LRLRRRQRER EGAGALFFRE APGADSCTCF VNRASVQGLA GAFGAEPAPV AGPGRSGEPC 
GCGLREAVDG VRFIADHMRS EDDDQSVSED WKYVAMVIDR LFLWIFVFVC VFGTIGMFLQ 
PLFQNYTTTT FLHSDHSAPS SK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CHRNB2

Associated with

Other Information

Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene. PubMed ID: 2377478

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. PubMed ID: 8906617

Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. PubMed ID: 9009220

The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3). PubMed ID: 9921897

Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes. PubMed ID: 10441742

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. PubMed ID: 15609996

RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells. PubMed ID: 16120769

Functional interaction between Lypd6 and nicotinic acetylcholine receptors. PubMed ID: 27344019

Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound alpha2 homopentamer. PubMed ID: 27493220

NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit. PubMed ID: 20441771

NMR structures of the transmembrane domains of the alpha4beta2 nAChR. PubMed ID: 22361591

The nicotinic receptor beta-2 subunit is mutant in nocturnal frontal lobe epilepsy. PubMed ID: 11062464

CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy. PubMed ID: 11104662

Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2). PubMed ID: 11906688