Details for: CHRNB2

Gene ID: 1141

Symbol: CHRNB2

Ensembl ID: ENSG00000160716

Description: cholinergic receptor nicotinic beta 2 subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.6515
    Cell Significance Index: 223.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3508
    Cell Significance Index: 257.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6586
    Cell Significance Index: 14.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6498
    Cell Significance Index: 64.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5713
    Cell Significance Index: 515.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5449
    Cell Significance Index: 11.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4212
    Cell Significance Index: 26.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3913
    Cell Significance Index: 42.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3473
    Cell Significance Index: 56.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3256
    Cell Significance Index: 19.5500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2737
    Cell Significance Index: 2.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1997
    Cell Significance Index: 13.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1969
    Cell Significance Index: 39.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1622
    Cell Significance Index: 4.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1273
    Cell Significance Index: 45.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0693
    Cell Significance Index: 47.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0692
    Cell Significance Index: 3.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0546
    Cell Significance Index: 3.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0520
    Cell Significance Index: 1.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0288
    Cell Significance Index: 0.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0164
    Cell Significance Index: 1.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0113
    Cell Significance Index: 4.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0064
    Cell Significance Index: 0.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0014
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0035
    Cell Significance Index: -0.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -5.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0065
    Cell Significance Index: -3.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0097
    Cell Significance Index: -6.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0098
    Cell Significance Index: -2.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0103
    Cell Significance Index: -5.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0109
    Cell Significance Index: -6.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0147
    Cell Significance Index: -6.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0148
    Cell Significance Index: -0.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0181
    Cell Significance Index: -0.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0225
    Cell Significance Index: -0.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0233
    Cell Significance Index: -4.6200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0276
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0278
    Cell Significance Index: -5.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0343
    Cell Significance Index: -6.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0351
    Cell Significance Index: -6.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0398
    Cell Significance Index: -0.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0417
    Cell Significance Index: -5.7200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0422
    Cell Significance Index: -0.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0444
    Cell Significance Index: -0.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0450
    Cell Significance Index: -5.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0475
    Cell Significance Index: -6.9000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0491
    Cell Significance Index: -0.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0524
    Cell Significance Index: -6.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0525
    Cell Significance Index: -6.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0565
    Cell Significance Index: -1.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0568
    Cell Significance Index: -4.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0591
    Cell Significance Index: -6.1500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0678
    Cell Significance Index: -0.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0687
    Cell Significance Index: -7.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0707
    Cell Significance Index: -1.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0752
    Cell Significance Index: -5.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0773
    Cell Significance Index: -5.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0794
    Cell Significance Index: -3.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0804
    Cell Significance Index: -1.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0841
    Cell Significance Index: -4.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0864
    Cell Significance Index: -1.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0870
    Cell Significance Index: -2.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0877
    Cell Significance Index: -2.8700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0889
    Cell Significance Index: -1.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1085
    Cell Significance Index: -3.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1168
    Cell Significance Index: -6.0700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1177
    Cell Significance Index: -1.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1185
    Cell Significance Index: -2.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1246
    Cell Significance Index: -6.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1352
    Cell Significance Index: -6.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1375
    Cell Significance Index: -3.4300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1425
    Cell Significance Index: -1.9000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1429
    Cell Significance Index: -1.9600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1503
    Cell Significance Index: -3.8300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1612
    Cell Significance Index: -2.0900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1615
    Cell Significance Index: -3.3700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1634
    Cell Significance Index: -2.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1694
    Cell Significance Index: -6.2200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1716
    Cell Significance Index: -1.8700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1761
    Cell Significance Index: -2.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1762
    Cell Significance Index: -4.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1804
    Cell Significance Index: -4.9100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1861
    Cell Significance Index: -2.3200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1915
    Cell Significance Index: -3.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1981
    Cell Significance Index: -5.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1982
    Cell Significance Index: -4.8400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1990
    Cell Significance Index: -4.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2013
    Cell Significance Index: -5.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2043
    Cell Significance Index: -7.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2128
    Cell Significance Index: -4.4600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2149
    Cell Significance Index: -2.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2153
    Cell Significance Index: -5.7700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2186
    Cell Significance Index: -4.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2187
    Cell Significance Index: -5.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit composition:** The CHRNB2 gene encodes for the beta 2 subunit of the nicotinic cholinergic receptor, which is composed of multiple subunits. 2. **Expression pattern:** The gene is significantly expressed in various cell types, including those found in the nervous system, immune system, and epithelial tissues. 3. **Function:** The beta 2 subunit is involved in the transmission of signals in the nervous system, including cognitive function, learning, memory, and synaptic transmission. 4. **Regulation:** The gene is regulated by various factors, including ligands, hormones, and other signaling molecules. **Pathways and Functions:** 1. **Acetylcholine-gated channel complex:** The CHRNB2 gene is involved in the formation of the acetylcholine-gated channel complex, which is a transmembrane protein complex that plays a crucial role in the transmission of signals in the nervous system. 2. **Acetylcholine binding:** The beta 2 subunit is involved in the binding of acetylcholine, a neurotransmitter that plays a critical role in cognitive function and synaptic transmission. 3. **Calcium ion transport:** The CHRNB2 gene is involved in the transport of calcium ions across cell membranes, which is essential for various physiological processes, including synaptic transmission and muscle contraction. 4. **Neurotransmitter receptors and postsynaptic signal transmission:** The beta 2 subunit is involved in the transmission of signals from neurotransmitters to postsynaptic neurons, which is critical for cognitive function, learning, and memory. **Clinical Significance:** 1. **Neurological disorders:** Mutations in the CHRNB2 gene have been associated with various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cognitive function:** The beta 2 subunit plays a critical role in cognitive function, including attention, memory, and learning. 3. **Neurodevelopmental disorders:** The CHRNB2 gene is involved in neurodevelopmental disorders, including autism spectrum disorder and attention deficit hyperactivity disorder (ADHD). 4. **Cancer:** The beta 2 subunit has been implicated in the development and progression of various cancers, including lung, breast, and colon cancer. In conclusion, the CHRNB2 gene plays a critical role in the transmission of signals in the nervous system, and its dysregulation has been implicated in various neurological and neurodevelopmental disorders. Further research is needed to fully understand the mechanisms by which the CHRNB2 gene regulates cognitive function and synaptic transmission, and to explore its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 1091050914

Symbol: ACHB2_HUMAN

Name: Neuronal acetylcholine receptor subunit beta-2

UniProtKB Accession Codes:

P17787 Q9UEH9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 8 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 19 DrugCentral 1 EMBL 11 EMDB 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 56 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2377478

Title: Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene.

PubMed ID: 2377478

DOI: 10.1093/nar/18.14.4272

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 9009220

Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

PubMed ID: 9009220

DOI: 10.1016/s0014-5793(96)01383-x

PubMed ID: 9921897

Title: The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3).

PubMed ID: 9921897

DOI: 10.1007/s004390050885

PubMed ID: 10441742

Title: Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes.

PubMed ID: 10441742

DOI: 10.1007/s003359901111

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15609996

Title: Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.

PubMed ID: 15609996

DOI: 10.1021/bi048918g

PubMed ID: 16120769

Title: RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.

PubMed ID: 16120769

DOI: 10.1124/mol.105.017459

PubMed ID: 27344019

Title: Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

PubMed ID: 27344019

DOI: 10.1111/jnc.13718

PubMed ID: 27493220

Title: Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound alpha2 homopentamer.

PubMed ID: 27493220

DOI: 10.1073/pnas.1602619113

PubMed ID: 20441771

Title: NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit.

PubMed ID: 20441771

DOI: 10.1016/j.bbamem.2010.04.014

PubMed ID: 22361591

Title: NMR structures of the transmembrane domains of the alpha4beta2 nAChR.

PubMed ID: 22361591

DOI: 10.1016/j.bbamem.2012.02.008

PubMed ID: 11062464

Title: The nicotinic receptor beta-2 subunit is mutant in nocturnal frontal lobe epilepsy.

PubMed ID: 11062464

DOI: 10.1038/81566

PubMed ID: 11104662

Title: CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy.

PubMed ID: 11104662

DOI: 10.1086/316946

PubMed ID: 11906688

Title: Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2).

PubMed ID: 11906688

DOI: 10.1080/14622200110098419

Sequence Information:

  • Length: 502
  • Mass: 57019
  • Checksum: 7EEDEF6ADFDC9F23
  • Sequence:
    • MARRCGPVAL LLGFGLLRLC SGVWGTDTEE RLVEHLLDPS RYNKLIRPAT NGSELVTVQL 
MVSLAQLISV HEREQIMTTN VWLTQEWEDY RLTWKPEEFD NMKKVRLPSK HIWLPDVVLY 
NNADGMYEVS FYSNAVVSYD GSIFWLPPAI YKSACKIEVK HFPFDQQNCT MKFRSWTYDR 
TEIDLVLKSE VASLDDFTPS GEWDIVALPG RRNENPDDST YVDITYDFII RRKPLFYTIN 
LIIPCVLITS LAILVFYLPS DCGEKMTLCI SVLLALTVFL LLISKIVPPT SLDVPLVGKY 
LMFTMVLVTF SIVTSVCVLN VHHRSPTTHT MAPWVKVVFL EKLPALLFMQ QPRHHCARQR 
LRLRRRQRER EGAGALFFRE APGADSCTCF VNRASVQGLA GAFGAEPAPV AGPGRSGEPC 
GCGLREAVDG VRFIADHMRS EDDDQSVSED WKYVAMVIDR LFLWIFVFVC VFGTIGMFLQ 
PLFQNYTTTT FLHSDHSAPS SK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.