Details for: CHRNB3

Gene ID: 1142

Symbol: CHRNB3

Ensembl ID: ENSG00000147432

Description: cholinergic receptor nicotinic beta 3 subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.6332
    Cell Significance Index: 62.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.5410
    Cell Significance Index: 75.6900
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 3.1901
    Cell Significance Index: 26.1200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.5029
    Cell Significance Index: 15.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1869
    Cell Significance Index: 820.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8203
    Cell Significance Index: 19.8700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6349
    Cell Significance Index: 7.8800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.5803
    Cell Significance Index: 4.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5666
    Cell Significance Index: -1.2400
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.4311
    Cell Significance Index: 3.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.4053
    Cell Significance Index: 10.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3097
    Cell Significance Index: 4.4400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2594
    Cell Significance Index: 3.4600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2446
    Cell Significance Index: 3.0500
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1142
    Cell Significance Index: 1.2600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0961
    Cell Significance Index: 0.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0891
    Cell Significance Index: 31.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0782
    Cell Significance Index: 0.8100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0642
    Cell Significance Index: 0.8100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0535
    Cell Significance Index: 0.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0517
    Cell Significance Index: 0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0310
    Cell Significance Index: 6.2200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0307
    Cell Significance Index: 0.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0294
    Cell Significance Index: 54.1600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0240
    Cell Significance Index: 0.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0105
    Cell Significance Index: 16.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0040
    Cell Significance Index: 5.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0011
    Cell Significance Index: 0.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0020
    Cell Significance Index: -0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0020
    Cell Significance Index: -0.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0028
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0037
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0064
    Cell Significance Index: -0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0079
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0087
    Cell Significance Index: -5.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0112
    Cell Significance Index: -0.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0138
    Cell Significance Index: -2.0000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0153
    Cell Significance Index: -0.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0165
    Cell Significance Index: -0.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0182
    Cell Significance Index: -1.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0187
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0192
    Cell Significance Index: -2.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0244
    Cell Significance Index: -4.3900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0245
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0263
    Cell Significance Index: -5.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0358
    Cell Significance Index: -3.7300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0369
    Cell Significance Index: -0.3500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0376
    Cell Significance Index: -0.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0387
    Cell Significance Index: -2.9700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0394
    Cell Significance Index: -0.5400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0416
    Cell Significance Index: -0.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0422
    Cell Significance Index: -5.1900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0425
    Cell Significance Index: -0.5500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0472
    Cell Significance Index: -0.7700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0489
    Cell Significance Index: -0.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0517
    Cell Significance Index: -1.0100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0559
    Cell Significance Index: -1.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0599
    Cell Significance Index: -4.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0615
    Cell Significance Index: -1.5800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0680
    Cell Significance Index: -1.6600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0686
    Cell Significance Index: -0.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0688
    Cell Significance Index: -2.4100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0716
    Cell Significance Index: -0.6800
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0721
    Cell Significance Index: -0.6900
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0742
    Cell Significance Index: -0.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0788
    Cell Significance Index: -2.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0804
    Cell Significance Index: -2.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0832
    Cell Significance Index: -3.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0879
    Cell Significance Index: -1.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0892
    Cell Significance Index: -4.1900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0919
    Cell Significance Index: -1.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0947
    Cell Significance Index: -2.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0957
    Cell Significance Index: -1.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0961
    Cell Significance Index: -2.7700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1001
    Cell Significance Index: -1.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1006
    Cell Significance Index: -3.8100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1040
    Cell Significance Index: -1.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1091
    Cell Significance Index: -1.6100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1118
    Cell Significance Index: -1.4900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1132
    Cell Significance Index: -1.6500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1132
    Cell Significance Index: -1.4800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1141
    Cell Significance Index: -1.5400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1154
    Cell Significance Index: -1.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1169
    Cell Significance Index: -2.4300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1187
    Cell Significance Index: -2.9600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1201
    Cell Significance Index: -1.6200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1203
    Cell Significance Index: -2.6000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1203
    Cell Significance Index: -1.8000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1205
    Cell Significance Index: -1.5200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1223
    Cell Significance Index: -1.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1258
    Cell Significance Index: -3.3700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1306
    Cell Significance Index: -1.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1323
    Cell Significance Index: -2.6200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1335
    Cell Significance Index: -1.5700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1356
    Cell Significance Index: -2.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit structure:** The CHRNB3 subunit is one of the five subunits that comprise the nAChR complex. The other subunits are alpha, beta, epsilon, delta, and gamma. 2. **Ligand binding:** The CHRNB3 subunit plays a key role in the binding of acetylcholine (ACh) and other agonists to the nAChR complex. 3. **Channel activity:** The CHRNB3 subunit contributes to the opening and closing of the ion channel, regulating the flow of ions across the cell membrane. 4. **Signaling pathways:** The CHRNB3 subunit is involved in the activation of downstream signaling pathways, including the activation of protein kinase C and the regulation of gene expression. **Pathways and Functions:** 1. **Acetylcholine-gated channel complex:** The CHRNB3 subunit is a critical component of the nAChR complex, which is activated by the binding of ACh to the receptor. 2. **Acetylcholine-gated monoatomic cation-selective channel activity:** The CHRNB3 subunit contributes to the opening of the ion channel, allowing the flow of ions across the cell membrane. 3. **Acetylcholine binding:** The CHRNB3 subunit is involved in the binding of ACh to the nAChR complex, regulating the receptor's activity. 4. **Acetylcholine receptor signaling pathway:** The CHRNB3 subunit is part of the signaling pathway that follows the activation of the nAChR complex by ACh. 5. **Dopaminergic synapse:** The CHRNB3 subunit is also expressed in dopaminergic neurons, suggesting a role in the regulation of dopamine release and transmission. **Clinical Significance:** 1. **Neurological disorders:** Alterations in the CHRNB3 gene have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** The CHRNB3 subunit has been identified as a potential target for cancer therapy, as it is overexpressed in certain types of cancer, including lung and breast cancer. 3. **Neuropsychiatric disorders:** The CHRNB3 subunit has been linked to neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD) and schizophrenia. 4. **Neurodegenerative diseases:** The CHRNB3 subunit is also involved in the regulation of neurodegenerative diseases, including Huntington's disease and prion disease. In conclusion, the CHRNB3 gene plays a critical role in the regulation of nicotinic acetylcholine receptor activity, which is essential for the transmission of signals across synapses. Alterations in the CHRNB3 gene have been implicated in various neurological and neuropsychiatric disorders, highlighting its importance as a potential therapeutic target.

Genular Protein ID: 4255645983

Symbol: ACHB3_HUMAN

Name: Neuronal acetylcholine receptor subunit beta-3

UniProtKB Accession Codes:

Q05901 Q15827

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 12 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 9009220

Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

PubMed ID: 9009220

DOI: 10.1016/s0014-5793(96)01383-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7690916

Title: Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit.

PubMed ID: 7690916

DOI: 10.1016/0304-3940(93)90691-d

Sequence Information:

  • Length: 458
  • Mass: 52729
  • Checksum: D6E919E53CBD21F8
  • Sequence:
    • MLPDFMLVLI VLGIPSSATT GFNSIAENED ALLRHLFQGY QKWVRPVLHS NDTIKVYFGL 
KISQLVDVDE KNQLMTTNVW LKQEWTDHKL RWNPDDYGGI HSIKVPSESL WLPDIVLFEN 
ADGRFEGSLM TKVIVKSNGT VVWTPPASYK SSCTMDVTFF PFDRQNCSMK FGSWTYDGTM 
VDLILINENV DRKDFFDNGE WEILNAKGMK GNRRDGVYSY PFITYSFVLR RLPLFYTLFL 
IIPCLGLSFL TVLVFYLPSD EGEKLSLSTS VLVSLTVFLL VIEEIIPSSS KVIPLIGEYL 
LFIMIFVTLS IIVTVFVINV HHRSSSTYHP MAPWVKRLFL QKLPKLLCMK DHVDRYSSPE 
KEESQPVVKG KVLEKKKQKQ LSDGEKVLVA FLEKAADSIR YISRHVKKEH FISQVVQDWK 
FVAQVLDRIF LWLFLIVSVT GSVLIFTPAL KMWLHSYH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.