Details for: CHRNB3

Gene ID: 1142

Symbol: CHRNB3

Ensembl ID: ENSG00000147432

Description: cholinergic receptor nicotinic beta 3 subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 9.24
    Marker Score: 5119
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.7
    Marker Score: 2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.58
    Marker Score: 30271
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.33
    Marker Score: 4596
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.22
    Marker Score: 1171
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.79
    Marker Score: 748
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.63
    Marker Score: 16787
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.59
    Marker Score: 665
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170130
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.33
    Marker Score: 364
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.2
    Marker Score: 1340
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.06
    Marker Score: 2010
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16577
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.93
    Marker Score: 7136
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.93
    Marker Score: 417
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.93
    Marker Score: 6179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.92
    Marker Score: 606
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.9
    Marker Score: 1010
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1801
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.88
    Marker Score: 1096
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.78
    Marker Score: 1623.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.62
    Marker Score: 5367
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 373.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.62
    Marker Score: 357
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.59
    Marker Score: 948
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.57
    Marker Score: 282
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.48
    Marker Score: 147
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 203
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.42
    Marker Score: 566
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.42
    Marker Score: 1191
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.41
    Marker Score: 15474
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.4
    Marker Score: 377
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.38
    Marker Score: 175
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.33
    Marker Score: 66
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 139
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.27
    Marker Score: 59
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.27
    Marker Score: 157
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 96
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.25
    Marker Score: 102
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.24
    Marker Score: 230
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 215
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.24
    Marker Score: 124.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.24
    Marker Score: 60
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.21
    Marker Score: 875
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.21
    Marker Score: 66
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.19
    Marker Score: 67
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.19
    Marker Score: 217.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.18
    Marker Score: 159
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.18
    Marker Score: 125
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.18
    Marker Score: 2404
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.18
    Marker Score: 217
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.18
    Marker Score: 230
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.17
    Marker Score: 65
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.17
    Marker Score: 58
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.17
    Marker Score: 83
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 52
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.16
    Marker Score: 55
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.16
    Marker Score: 194
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.16
    Marker Score: 103
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 57
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.15
    Marker Score: 596
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.15
    Marker Score: 55
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.15
    Marker Score: 423
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.15
    Marker Score: 253
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 141
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.14
    Marker Score: 50
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.14
    Marker Score: 45
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.14
    Marker Score: 155
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.14
    Marker Score: 106
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.13
    Marker Score: 54
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.13
    Marker Score: 53
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.13
    Marker Score: 255
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.12
    Marker Score: 65
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.12
    Marker Score: 293
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.12
    Marker Score: 368
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.12
    Marker Score: 81

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics**: - The protein is a transmembrane protein that is expressed in the plasma membrane. - It is a member of the nicotinic acetylcholine receptor family of proteins. - It is a ligand-gated channel that is sensitive to acetylcholine. - It is expressed in high levels in the central nervous system, where it is involved in regulating synaptic transmission. **Pathways and functions**: - The CHRNB3 gene is involved in the regulation of synaptic transmission by nicotinic acetylcholine. - It is a key component of the excitatory postsynaptic potential, which is a wave of action potentials that is generated by acetylcholine receptors on the postsynaptic membrane. - The receptor is also involved in the regulation of neuronal excitability and synaptic plasticity. **Clinical significance**: - Mutations in the CHRNB3 gene have been linked to a number of neurological disorders, including Alzheimer's disease, schizophrenia, and depression. - These disorders are characterized by abnormalities in synaptic transmission, which can be caused by mutations in a variety of genes that are involved in the nicotinic acetylcholine receptor complex. - Therefore, the CHRNB3 gene is an important target for the development of new treatments for these disorders.

Genular Protein ID: 4255645983

Symbol: ACHB3_HUMAN

Name: Neuronal acetylcholine receptor subunit beta-3

UniProtKB Accession Codes:

Q05901 Q15827

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 12 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 9009220

Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

PubMed ID: 9009220

DOI: 10.1016/s0014-5793(96)01383-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7690916

Title: Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit.

PubMed ID: 7690916

DOI: 10.1016/0304-3940(93)90691-d

Sequence Information:

  • Length: 458
  • Mass: 52729
  • Checksum: D6E919E53CBD21F8
  • Sequence:
    • MLPDFMLVLI VLGIPSSATT GFNSIAENED ALLRHLFQGY QKWVRPVLHS NDTIKVYFGL 
KISQLVDVDE KNQLMTTNVW LKQEWTDHKL RWNPDDYGGI HSIKVPSESL WLPDIVLFEN 
ADGRFEGSLM TKVIVKSNGT VVWTPPASYK SSCTMDVTFF PFDRQNCSMK FGSWTYDGTM 
VDLILINENV DRKDFFDNGE WEILNAKGMK GNRRDGVYSY PFITYSFVLR RLPLFYTLFL 
IIPCLGLSFL TVLVFYLPSD EGEKLSLSTS VLVSLTVFLL VIEEIIPSSS KVIPLIGEYL 
LFIMIFVTLS IIVTVFVINV HHRSSSTYHP MAPWVKRLFL QKLPKLLCMK DHVDRYSSPE 
KEESQPVVKG KVLEKKKQKQ LSDGEKVLVA FLEKAADSIR YISRHVKKEH FISQVVQDWK 
FVAQVLDRIF LWLFLIVSVT GSVLIFTPAL KMWLHSYH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.