Genular: Defining Cellular Identity and Function

Details for: Ache

Gene ID: 11423

Symbol: Ache

Ensembl ID: ENSMUSG00000023328

Description: acetylcholinesterase

Associated with

Acetylcholine binding
(GO:0042166)
Acetylcholine catabolic process
(GO:0006581)
Acetylcholine metabolic process
(GO:0008291)
Acetylcholine receptor signaling pathway
(GO:0095500)
Acetylcholinesterase activity
(GO:0003990)
Axon
(GO:0030424)
Basement membrane
(GO:0005604)
Carboxylic ester hydrolase activity
(GO:0052689)
Cell adhesion
(GO:0007155)
Cell surface
(GO:0009986)
Choline binding
(GO:0033265)
Choline metabolic process
(GO:0019695)
Cholinesterase activity
(GO:0004104)
Collagen binding
(GO:0005518)
Dendrite
(GO:0030425)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Laminin binding
(GO:0043236)
Membrane
(GO:0016020)
Neuromuscular junction
(GO:0031594)
Neuronal cell body
(GO:0043025)
Nuclear envelope
(GO:0005635)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of axonogenesis
(GO:0050772)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Postsynaptic membrane
(GO:0045211)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein self-association
(GO:0043621)
Receptor internalization
(GO:0031623)
Regulation of receptor recycling
(GO:0001919)
Response to insulin
(GO:0032868)
Retina development in camera-type eye
(GO:0060041)
Serine hydrolase activity
(GO:0017171)
Side of membrane
(GO:0098552)
Synapse
(GO:0045202)
Synapse assembly
(GO:0007416)
Synaptic cleft
(GO:0043083)

Other Information

Proteins

Acetylcholinesterase

Genular Protein ID: 4223630667

Symbol: ACES_MOUSE

Name: Acetylcholinesterase

UniProtKB Accession Codes:

P21836

Database IDs:

Citations:

PubMed ID: 2400605

Title: Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species.

PubMed ID: 2400605

DOI: 10.1016/0896-6273(90)90168-f

PubMed ID: 11239002

Title: Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.

PubMed ID: 11239002

DOI: 10.1093/nar/29.6.1352

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11804574

Title: PRiMA: the membrane anchor of acetylcholinesterase in the brain.

PubMed ID: 11804574

DOI: 10.1016/s0896-6273(01)00584-0

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 8521480

Title: Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex.

PubMed ID: 8521480

DOI: 10.1016/0092-8674(95)90128-0

PubMed ID: 9915834

Title: Crystal structure of mouse acetylcholinesterase. A peripheral site-occluding loop in a tetrameric assembly.

PubMed ID: 9915834

DOI: 10.1074/jbc.274.5.2963

PubMed ID: 12505979

Title: Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site.

PubMed ID: 12505979

DOI: 10.1093/emboj/cdg005

Sequence Information:

Length: 614
Mass: 68169
Checksum: 66E2512463C21172
Sequence:

MRPPWYPLHT PSLAFPLLFL LLSLLGGGAR AEGREDPQLL VRVRGGQLRG IRLKAPGGPV 
SAFLGIPFAE PPVGSRRFMP PEPKRPWSGV LDATTFQNVC YQYVDTLYPG FEGTEMWNPN 
RELSEDCLYL NVWTPYPRPA SPTPVLIWIY GGGFYSGAAS LDVYDGRFLA QVEGAVLVSM 
NYRVGTFGFL ALPGSREAPG NVGLLDQRLA LQWVQENIAA FGGDPMSVTL FGESAGAASV 
GMHILSLPSR SLFHRAVLQS GTPNGPWATV SAGEARRRAT LLARLVGCPP GGAGGNDTEL 
IACLRTRPAQ DLVDHEWHVL PQESIFRFSF VPVVDGDFLS DTPEALINTG DFQDLQVLVG 
VVKDEGSYFL VYGVPGFSKD NESLISRAQF LAGVRIGVPQ ASDLAAEAVV LHYTDWLHPE 
DPTHLRDAMS AVVGDHNVVC PVAQLAGRLA AQGARVYAYI FEHRASTLTW PLWMGVPHGY 
EIEFIFGLPL DPSLNYTTEE RIFAQRLMKY WTNFARTGDP NDPRDSKSPQ WPPYTTAAQQ 
YVSLNLKPLE VRRGLRAQTC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN 
QFDHYSKQER CSDL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ache

Associated with

Other Information

Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species. PubMed ID: 2400605

Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. PubMed ID: 11239002

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PRiMA: the membrane anchor of acetylcholinesterase in the brain. PubMed ID: 11804574

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex. PubMed ID: 8521480

Crystal structure of mouse acetylcholinesterase. A peripheral site-occluding loop in a tetrameric assembly. PubMed ID: 9915834

Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site. PubMed ID: 12505979