CHRNB4 | ENSG00000117971 | NCBI 1143

Details for: CHRNB4

Gene ID: 1143

Symbol: CHRNB4

Ensembl ID: ENSG00000117971

Description: cholinergic receptor nicotinic beta 4 subunit

Associated with

Acetylcholine binding and downstream events
(R-HSA-181431)
Highly calcium permeable nicotinic acetylcholine receptors
(R-HSA-629597)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
(R-HSA-629594)
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
(R-HSA-629587)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Neutrophil degranulation
(R-HSA-6798695)
Postsynaptic nicotinic acetylcholine receptors
(R-HSA-622327)
Presynaptic nicotinic acetylcholine receptors
(R-HSA-622323)
Transmission across chemical synapses
(R-HSA-112315)
Acetylcholine-gated channel complex
(GO:0005892)
Acetylcholine-gated monoatomic cation-selective channel activity
(GO:0022848)
Acetylcholine receptor activity
(GO:0015464)
Acetylcholine receptor signaling pathway
(GO:0095500)
Behavioral response to nicotine
(GO:0035095)
Chemical synaptic transmission
(GO:0007268)
Cholinergic synapse
(GO:0098981)
Excitatory postsynaptic potential
(GO:0060079)
Ligand-gated monoatomic ion channel activity
(GO:0015276)
Locomotory behavior
(GO:0007626)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Nervous system process
(GO:0050877)
Neuronal action potential
(GO:0019228)
Neuron projection
(GO:0043005)
Plasma membrane
(GO:0005886)
Positive regulation of transmission of nerve impulse
(GO:0051971)
Postsynaptic membrane
(GO:0045211)
Protein binding
(GO:0005515)
Regulation of neurotransmitter secretion
(GO:0046928)
Regulation of smooth muscle contraction
(GO:0006940)
Signal transduction
(GO:0007165)
Smooth muscle contraction
(GO:0006939)
Specific granule membrane
(GO:0035579)
Synapse
(GO:0045202)
Synaptic transmission, cholinergic
(GO:0007271)
Synaptic transmission involved in micturition
(GO:0060084)
Tertiary granule membrane
(GO:0070821)

Other Information

Proteins

Neuronal acetylcholine receptor subunit beta-4

Genular Protein ID: 1989280699

Symbol: ACHB4_HUMAN

Name: Neuronal acetylcholine receptor subunit beta-4

UniProtKB Accession Codes:

P30926 A4FTX5 E9PHE8 Q16607 Q4VBA5 Q8WXC8 Q9BQR4

Database IDs:

Citations:

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 9203638

Title: 'Orphan' alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor.

PubMed ID: 9203638

DOI: 10.1124/mol.51.2.320

PubMed ID: 9009220

Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

PubMed ID: 9009220

DOI: 10.1016/s0014-5793(96)01383-x

PubMed ID: 11450844

Title: Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4.

PubMed ID: 11450844

DOI: 10.1007/pl00010921

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11742001

Title: Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes.

PubMed ID: 11742001

DOI: 10.1074/jbc.m110454200

PubMed ID: 1330682

Title: Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines.

PubMed ID: 1330682

DOI: 10.1016/0014-5793(92)81411-e

PubMed ID: 15609996

Title: Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.

PubMed ID: 15609996

DOI: 10.1021/bi048918g

PubMed ID: 16120769

Title: RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.

PubMed ID: 16120769

DOI: 10.1124/mol.105.017459

PubMed ID: 27344019

Title: Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

PubMed ID: 27344019

DOI: 10.1111/jnc.13718

Sequence Information:

Length: 498
Mass: 56380
Checksum: 0D48AB203F3FD03E
Sequence:

MRRAPSLVLF FLVALCGRGN CRVANAEEKL MDDLLNKTRY NNLIRPATSS SQLISIKLQL 
SLAQLISVNE REQIMTTNVW LKQEWTDYRL TWNSSRYEGV NILRIPAKRI WLPDIVLYNN 
ADGTYEVSVY TNLIVRSNGS VLWLPPAIYK SACKIEVKYF PFDQQNCTLK FRSWTYDHTE 
IDMVLMTPTA SMDDFTPSGE WDIVALPGRR TVNPQDPSYV DVTYDFIIKR KPLFYTINLI 
IPCVLTTLLA ILVFYLPSDC GEKMTLCISV LLALTFFLLL ISKIVPPTSL DVPLIGKYLM 
FTMVLVTFSI VTSVCVLNVH HRSPSTHTMA PWVKRCFLHK LPTFLFMKRP GPDSSPARAF 
PPSKSCVTKP EATATSTSPS NFYGNSMYFV NPASAASKSP AGSTPVAIPR DFWLRSSGRF 
RQDVQEALEG VSFIAQHMKN DDEDQSVVED WKYVAMVVDR LFLWVFMFVC VLGTVGLFLP 
PLFQTHAASE GPYAAQRD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CHRNB4

Associated with

Other Information

Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. PubMed ID: 8906617

'Orphan' alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor. PubMed ID: 9203638

Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. PubMed ID: 9009220

Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4. PubMed ID: 11450844

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes. PubMed ID: 11742001

Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines. PubMed ID: 1330682

Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. PubMed ID: 15609996

RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells. PubMed ID: 16120769

Functional interaction between Lypd6 and nicotinic acetylcholine receptors. PubMed ID: 27344019