Details for: CHRNB4

Gene ID: 1143

Symbol: CHRNB4

Ensembl ID: ENSG00000117971

Description: cholinergic receptor nicotinic beta 4 subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 7.1420
    Cell Significance Index: 100.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.1560
    Cell Significance Index: -2.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0247
    Cell Significance Index: 22.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7255
    Cell Significance Index: 19.4400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.7093
    Cell Significance Index: 7.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6106
    Cell Significance Index: 13.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5053
    Cell Significance Index: 12.2400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.4459
    Cell Significance Index: 11.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3145
    Cell Significance Index: 5.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2701
    Cell Significance Index: 16.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2410
    Cell Significance Index: 14.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2308
    Cell Significance Index: 43.9200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.2188
    Cell Significance Index: 1.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2151
    Cell Significance Index: 12.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1324
    Cell Significance Index: 3.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1152
    Cell Significance Index: 5.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1120
    Cell Significance Index: 12.1800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0867
    Cell Significance Index: 0.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0806
    Cell Significance Index: 1.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0747
    Cell Significance Index: 4.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0726
    Cell Significance Index: 0.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0583
    Cell Significance Index: 11.5600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0436
    Cell Significance Index: 0.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0377
    Cell Significance Index: 2.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0368
    Cell Significance Index: 25.4200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0365
    Cell Significance Index: 0.5300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0262
    Cell Significance Index: 0.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0217
    Cell Significance Index: 0.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0182
    Cell Significance Index: 0.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0166
    Cell Significance Index: 3.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0162
    Cell Significance Index: 14.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0127
    Cell Significance Index: 2.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0121
    Cell Significance Index: 0.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0095
    Cell Significance Index: 1.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0091
    Cell Significance Index: 1.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0062
    Cell Significance Index: 0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0057
    Cell Significance Index: 3.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0049
    Cell Significance Index: 1.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0038
    Cell Significance Index: 7.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0013
    Cell Significance Index: 2.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0006
    Cell Significance Index: 0.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0016
    Cell Significance Index: -0.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0028
    Cell Significance Index: -0.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0030
    Cell Significance Index: -1.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0039
    Cell Significance Index: -2.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0041
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0048
    Cell Significance Index: -0.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0048
    Cell Significance Index: -2.6000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0049
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0051
    Cell Significance Index: -3.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0079
    Cell Significance Index: -0.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0101
    Cell Significance Index: -0.2200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0111
    Cell Significance Index: -0.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0112
    Cell Significance Index: -1.1100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0147
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0147
    Cell Significance Index: -3.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0184
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0186
    Cell Significance Index: -1.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0188
    Cell Significance Index: -0.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0192
    Cell Significance Index: -2.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0242
    Cell Significance Index: -2.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0256
    Cell Significance Index: -2.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0266
    Cell Significance Index: -2.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0272
    Cell Significance Index: -0.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0285
    Cell Significance Index: -0.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0296
    Cell Significance Index: -3.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0297
    Cell Significance Index: -0.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0304
    Cell Significance Index: -1.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0325
    Cell Significance Index: -0.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0352
    Cell Significance Index: -2.7000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0397
    Cell Significance Index: -0.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0417
    Cell Significance Index: -1.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0490
    Cell Significance Index: -2.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0514
    Cell Significance Index: -2.7000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0523
    Cell Significance Index: -0.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0526
    Cell Significance Index: -1.1000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0553
    Cell Significance Index: -0.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0556
    Cell Significance Index: -2.6200
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0592
    Cell Significance Index: -0.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0602
    Cell Significance Index: -2.2100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0642
    Cell Significance Index: -1.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0676
    Cell Significance Index: -1.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0692
    Cell Significance Index: -2.4300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0694
    Cell Significance Index: -0.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0722
    Cell Significance Index: -2.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0770
    Cell Significance Index: -2.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0778
    Cell Significance Index: -2.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0783
    Cell Significance Index: -2.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0788
    Cell Significance Index: -2.5100
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.0801
    Cell Significance Index: -0.5800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0811
    Cell Significance Index: -1.9800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0817
    Cell Significance Index: -1.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0826
    Cell Significance Index: -2.2100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0909
    Cell Significance Index: -2.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Subunit composition**: The CHRNB4 gene encodes the beta-4 subunit of the nicotinic acetylcholine receptor (nAChR), which is composed of five subunits (alpha, beta, gamma, delta, and epsilon). 2. **Ion channel activity**: The nAChR, including the CHRNB4 subunit, is a ligand-gated ion channel complex that allows the flow of ions across the cell membrane. 3. **High calcium permeability**: The nAChR, including the CHRNB4 subunit, has high calcium permeability, which is important for various cellular processes, including neurotransmission and immune response. 4. **Expression in multiple tissues**: The CHRNB4 gene is highly expressed in multiple tissues, including the kidney, photoreceptor cells, colon, cardiac endothelial cells, and neural cells. 5. **Regulation of neurotransmitter secretion**: The nAChR, including the CHRNB4 subunit, plays a role in regulating neurotransmitter secretion, particularly in the nervous system. **Pathways and Functions** 1. **Acetylcholine-gated channel complex**: The nAChR, including the CHRNB4 subunit, is a ligand-gated ion channel complex that is activated by acetylcholine, a neurotransmitter released by motor neurons. 2. **Acetylcholine-gated monoatomic cation-selective channel activity**: The nAChR, including the CHRNB4 subunit, allows the flow of monoatomic ions (such as sodium and calcium) across the cell membrane. 3. **Acetylcholine binding and downstream events**: The nAChR, including the CHRNB4 subunit, is activated by acetylcholine binding to the receptor, leading to downstream signaling events, including changes in membrane potential and neurotransmitter release. 4. **Behavioral response to nicotine**: The nAChR, including the CHRNB4 subunit, plays a role in regulating behavioral responses to nicotine, a stimulant that activates the nAChR. 5. **Immune system**: The nAChR, including the CHRNB4 subunit, is involved in regulating immune responses, particularly in the innate immune system. **Clinical Significance** 1. **Neurological disorders**: Alterations in the CHRNB4 gene have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: The nAChR, including the CHRNB4 subunit, has been implicated in cancer, particularly in the regulation of tumor cell growth and metastasis. 3. **Neuromuscular disorders**: The nAChR, including the CHRNB4 subunit, plays a role in regulating muscle contraction and relaxation, and alterations in the CHRNB4 gene have been implicated in neuromuscular disorders, such as myasthenia gravis. 4. **Infectious diseases**: The nAChR, including the CHRNB4 subunit, is involved in regulating immune responses to infectious diseases, particularly in the innate immune system. In conclusion, the CHRNB4 gene encodes the beta-4 subunit of the nicotinic acetylcholine receptor, which plays a crucial role in various physiological processes, including neurotransmission, immune response, and smooth muscle contraction. The nAChR, including the CHRNB4 subunit, is involved in various signaling pathways, including those involved in synaptic transmission, immune response, and smooth muscle contraction. Alterations in the CHRNB4 gene have been implicated in various diseases, including neurological disorders, cancer, and neuromuscular disorders. Further research is needed to fully understand the role of the CHRNB4 gene in human health and disease.

Genular Protein ID: 1989280699

Symbol: ACHB4_HUMAN

Name: Neuronal acetylcholine receptor subunit beta-4

UniProtKB Accession Codes:

P30926 A4FTX5 E9PHE8 Q16607 Q4VBA5 Q8WXC8 Q9BQR4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 7 ComplexPortal 5 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EMBL 22 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 4 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8906617

Title: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PubMed ID: 8906617

DOI: 10.1007/bf02736842

PubMed ID: 9203638

Title: 'Orphan' alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor.

PubMed ID: 9203638

DOI: 10.1124/mol.51.2.320

PubMed ID: 9009220

Title: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.

PubMed ID: 9009220

DOI: 10.1016/s0014-5793(96)01383-x

PubMed ID: 11450844

Title: Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4.

PubMed ID: 11450844

DOI: 10.1007/pl00010921

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11742001

Title: Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes.

PubMed ID: 11742001

DOI: 10.1074/jbc.m110454200

PubMed ID: 1330682

Title: Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines.

PubMed ID: 1330682

DOI: 10.1016/0014-5793(92)81411-e

PubMed ID: 15609996

Title: Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.

PubMed ID: 15609996

DOI: 10.1021/bi048918g

PubMed ID: 16120769

Title: RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.

PubMed ID: 16120769

DOI: 10.1124/mol.105.017459

PubMed ID: 27344019

Title: Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

PubMed ID: 27344019

DOI: 10.1111/jnc.13718

Sequence Information:

  • Length: 498
  • Mass: 56380
  • Checksum: 0D48AB203F3FD03E
  • Sequence:
    • MRRAPSLVLF FLVALCGRGN CRVANAEEKL MDDLLNKTRY NNLIRPATSS SQLISIKLQL 
SLAQLISVNE REQIMTTNVW LKQEWTDYRL TWNSSRYEGV NILRIPAKRI WLPDIVLYNN 
ADGTYEVSVY TNLIVRSNGS VLWLPPAIYK SACKIEVKYF PFDQQNCTLK FRSWTYDHTE 
IDMVLMTPTA SMDDFTPSGE WDIVALPGRR TVNPQDPSYV DVTYDFIIKR KPLFYTINLI 
IPCVLTTLLA ILVFYLPSDC GEKMTLCISV LLALTFFLLL ISKIVPPTSL DVPLIGKYLM 
FTMVLVTFSI VTSVCVLNVH HRSPSTHTMA PWVKRCFLHK LPTFLFMKRP GPDSSPARAF 
PPSKSCVTKP EATATSTSPS NFYGNSMYFV NPASAASKSP AGSTPVAIPR DFWLRSSGRF 
RQDVQEALEG VSFIAQHMKN DDEDQSVVED WKYVAMVVDR LFLWVFMFVC VLGTVGLFLP 
PLFQTHAASE GPYAAQRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.