Genular: Defining Cellular Identity and Function

Details for: Chrna1

Gene ID: 11435

Symbol: Chrna1

Ensembl ID: ENSMUSG00000027107

Description: cholinergic receptor nicotinic alpha 1 subunit

Associated with

Acetylcholine binding and downstream events
(R-MMU-181431)
Highly calcium permeable nicotinic acetylcholine receptors
(R-MMU-629597)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
(R-MMU-629594)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Postsynaptic nicotinic acetylcholine receptors
(R-MMU-622327)
Presynaptic nicotinic acetylcholine receptors
(R-MMU-622323)
Transmission across chemical synapses
(R-MMU-112315)
Acetylcholine-gated channel complex
(GO:0005892)
Acetylcholine-gated monoatomic cation-selective channel activity
(GO:0022848)
Acetylcholine binding
(GO:0042166)
Acetylcholine receptor activity
(GO:0015464)
Acetylcholine receptor signaling pathway
(GO:0095500)
Cell surface
(GO:0009986)
Excitatory extracellular ligand-gated monoatomic ion channel activity
(GO:0005231)
Extracellular ligand-gated monoatomic ion channel activity
(GO:0005230)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Monoatomic cation transport
(GO:0006812)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Muscle cell cellular homeostasis
(GO:0046716)
Musculoskeletal movement
(GO:0050881)
Nervous system process
(GO:0050877)
Neuromuscular junction
(GO:0031594)
Neuromuscular junction development
(GO:0007528)
Neuromuscular process
(GO:0050905)
Neuromuscular synaptic transmission
(GO:0007274)
Neuronal action potential
(GO:0019228)
Neuron cellular homeostasis
(GO:0070050)
Neuron projection
(GO:0043005)
Plasma membrane
(GO:0005886)
Postsynaptic membrane
(GO:0045211)
Postsynaptic specialization membrane
(GO:0099634)
Protein binding
(GO:0005515)
Regulation of membrane potential
(GO:0042391)
Response to nicotine
(GO:0035094)
Skeletal muscle contraction
(GO:0003009)
Skeletal muscle tissue growth
(GO:0048630)
Synapse
(GO:0045202)
Synaptic transmission, cholinergic
(GO:0007271)
Transmembrane signaling receptor activity
(GO:0004888)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Other Information

Proteins

Acetylcholine receptor subunit alpha

Genular Protein ID: 788416037

Symbol: ACHA_MOUSE

Name: Acetylcholine receptor subunit alpha

UniProtKB Accession Codes:

P04756

Database IDs:

Citations:

PubMed ID: 3755237

Title: Nucleotide sequence of the mouse muscle nicotinic acetylcholine receptor alpha subunit.

PubMed ID: 3755237

DOI: 10.1093/nar/14.12.5111

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 2993547

Title: Isolation of a clone coding for the alpha-subunit of a mouse acetylcholine receptor.

PubMed ID: 2993547

DOI: 10.1523/jneurosci.05-09-02545.1985

PubMed ID: 17643119

Title: Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution.

PubMed ID: 17643119

DOI: 10.1038/nn1942

Sequence Information:

Length: 457
Mass: 51939
Checksum: 5CB606D144F29436
Sequence:

MELSTVLLLL GLCSAGLVLG SEHETRLVAK LFEDYSSVVR PVEDHREIVQ VTVGLQLIQL 
INVDEVNQIV TTNVRLKQQW VDYNLKWNPD DYGGVKKIHI PSEKIWRPDV VLYNNADGDF 
AIVKFTKVLL DYTGHITWTP PAIFKSYCEI IVTHFPFDEQ NCSMKLGTWT YDGSVVAINP 
ESDQPDLSNF MESGEWVIKE ARGWKHWVFY SCCPTTPYLD ITYHFVMQRL PLYFIVNVII 
PCLLFSFLTS LVFYLPTDSG EKMTLSISVL LSLTVFLLVI VELIPSTSSA VPLIGKYMLF 
TMVFVIASII ITVIVINTHH RSPSTHIMPE WVRKVFIDTI PNIMFFSTMK RPSRDKQEKR 
IFTEDIDISD ISGKPGPPPM GFHSPLIKHP EVKSAIEGVK YIAETMKSDQ ESNNAAEEWK 
YVAMVMDHIL LGVFMLVCLI GTLAVFAGRL IELHQQG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chrna1

Associated with

Other Information

Nucleotide sequence of the mouse muscle nicotinic acetylcholine receptor alpha subunit. PubMed ID: 3755237

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Isolation of a clone coding for the alpha-subunit of a mouse acetylcholine receptor. PubMed ID: 2993547

Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution. PubMed ID: 17643119

Database document:

PubMed ID: 3755237

PubMed ID: 16141072

PubMed ID: 2993547

PubMed ID: 17643119