Genular: Defining Cellular Identity and Function

Details for: Chrna4

Gene ID: 11438

Symbol: Chrna4

Ensembl ID: ENSMUSG00000027577

Description: cholinergic receptor, nicotinic, alpha polypeptide 4

Associated with

Acetylcholine binding and downstream events
(R-MMU-181431)
Highly calcium permeable nicotinic acetylcholine receptors
(R-MMU-629597)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
(R-MMU-629594)
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
(R-MMU-629587)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Postsynaptic nicotinic acetylcholine receptors
(R-MMU-622327)
Presynaptic nicotinic acetylcholine receptors
(R-MMU-622323)
Transmission across chemical synapses
(R-MMU-112315)
Acetylcholine-gated channel complex
(GO:0005892)
Acetylcholine-gated monoatomic cation-selective channel activity
(GO:0022848)
Acetylcholine binding
(GO:0042166)
Acetylcholine receptor activity
(GO:0015464)
Acetylcholine receptor signaling pathway
(GO:0095500)
B cell activation
(GO:0042113)
Behavioral response to nicotine
(GO:0035095)
Calcium ion transport
(GO:0006816)
Cholinergic synapse
(GO:0098981)
Cognition
(GO:0050890)
Dendrite
(GO:0030425)
Dna repair
(GO:0006281)
Dopaminergic synapse
(GO:0098691)
Exploration behavior
(GO:0035640)
External side of plasma membrane
(GO:0009897)
Extracellular ligand-gated monoatomic ion channel activity
(GO:0005230)
Heterocyclic compound binding
(GO:1901363)
Inhibitory postsynaptic potential
(GO:0060080)
Locomotory behavior
(GO:0007626)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Nervous system process
(GO:0050877)
Neuronal action potential
(GO:0019228)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Plasma membrane
(GO:0005886)
Postsynaptic membrane
(GO:0045211)
Postsynaptic specialization membrane
(GO:0099634)
Presynaptic membrane
(GO:0042734)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Quaternary ammonium group binding
(GO:0050997)
Regulation of dopamine secretion
(GO:0014059)
Regulation of membrane potential
(GO:0042391)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Response to acetylcholine
(GO:1905144)
Response to hypoxia
(GO:0001666)
Response to nicotine
(GO:0035094)
Response to oxidative stress
(GO:0006979)
Sensory perception of pain
(GO:0019233)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)
Synaptic transmission, cholinergic
(GO:0007271)
Transmembrane signaling receptor activity
(GO:0004888)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Other Information

Proteins

Neuronal acetylcholine receptor subunit alpha-4

Genular Protein ID: 879360524

Symbol: ACHA4_MOUSE

Name: Neuronal acetylcholine receptor subunit alpha-4

UniProtKB Accession Codes:

O70174 Q8BHE9 Q8VI10 Q9ET51

Database IDs:

Citations:

PubMed ID: 11434511

Title: Long sleep and short sleep mice differ in nicotine-stimulated 86Rb+ efflux and alpha4 nicotinic receptor subunit cDNA sequence.

PubMed ID: 11434511

DOI: 10.1097/00008571-200106000-00008

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9749753

Title: Promoter analysis of the neuronal nicotinic acetylcholine receptor alpha4 gene: methylation and expression of the transgene.

PubMed ID: 9749753

DOI: 10.1046/j.1460-9568.1998.00235.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 629
Mass: 70305
Checksum: 261455B6ED50B41C
Sequence:

MEIGGSGAPP PLLLLPLLLL LGTGLLPASS HIETRAHAEE RLLKRLFSGY NKWSRPVANI 
SDVVLVRFGL SIAQLIDVDE KNQMMTTNVW VKQEWHDYKL RWDPGDYENV TSIRIPSELI 
WRPDIVLYNN ADGDFAVTHL TKAHLFYDGR VQWTPPAIYK SSCSIDVTFF PFDQQNCTMK 
FGSWTYDKAK IDLVSMHSRV DQLDFWESGE WVIVDAVGTY NTRKYECCAE IYPDITYAFI 
IRRLPLFYTI NLIIPCLLIS CLTVLVFYLP SECGEKVTLC ISVLLSLTVF LLLITEIIPS 
TSLVIPLIGE YLLFTMIFVT LSIVITVFVL NVHHRSPRTH TMPAWVRRVF LDIVPRLLFM 
KRPSVVKDNC RRLIESMHKM ANAPRFWPEP ESEPGILGDI CNQGLSPAPT FCNRMDTAVE 
TQPTCRSPSH KVPDLKTSEV EKASPCPSPG SCHPPNSSGA PVLIKARSLS VQHVPSSQEA 
AEGSIRCRSR SIQYCVSQDG AASLTESKPT GSPASLKTRP SQLPVSDQTS PCKCTCKEPS 
PVSPITVLKA GGTKAPPQHL PLSPALTRAV EGVQYIADHL KAEDTDFSVK EDWKYVAMVI 
DRIFLWMFII VCLLGTVGLF LPPWLAGMI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chrna4

Associated with

Other Information

Long sleep and short sleep mice differ in nicotine-stimulated 86Rb+ efflux and alpha4 nicotinic receptor subunit cDNA sequence. PubMed ID: 11434511

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334