Details for: CHRND
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 3.7848
Cell Significance Index: -0.9600 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.9463
Cell Significance Index: 33.2700 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.8342
Cell Significance Index: 13.4600 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.6636
Cell Significance Index: 5.6400 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.5921
Cell Significance Index: 8.1200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.5639
Cell Significance Index: 13.7600 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.4789
Cell Significance Index: 6.9800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.3339
Cell Significance Index: 3.6300 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.2278
Cell Significance Index: 3.6900 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.1935
Cell Significance Index: 2.4500 - Cell Name: muscle cell (CL0000187)
Fold Change: 0.1516
Cell Significance Index: 1.4500 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.1475
Cell Significance Index: 1.1400 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.1336
Cell Significance Index: 1.9400 - Cell Name: muscle precursor cell (CL0000680)
Fold Change: 0.1010
Cell Significance Index: 0.6900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0996
Cell Significance Index: 3.4600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0852
Cell Significance Index: 2.1900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0658
Cell Significance Index: 1.4400 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.0632
Cell Significance Index: 0.6600 - Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
Fold Change: 0.0504
Cell Significance Index: 0.5200 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.0476
Cell Significance Index: 0.5800 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.0468
Cell Significance Index: 0.1100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0343
Cell Significance Index: 6.8100 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0276
Cell Significance Index: 0.6900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0207
Cell Significance Index: 0.5500 - Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.0153
Cell Significance Index: 0.2000 - Cell Name: slow muscle cell (CL0000189)
Fold Change: 0.0134
Cell Significance Index: 0.2000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0084
Cell Significance Index: 0.2300 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.0044
Cell Significance Index: 0.0400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0007
Cell Significance Index: 1.1300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0006
Cell Significance Index: 1.1200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0004
Cell Significance Index: 0.0900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0003
Cell Significance Index: 0.6500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0002
Cell Significance Index: 0.2100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0001
Cell Significance Index: 0.0200 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0004
Cell Significance Index: -0.1500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0007
Cell Significance Index: -0.4600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0008
Cell Significance Index: -0.6200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0009
Cell Significance Index: -0.0500 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0010
Cell Significance Index: -0.5400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0014
Cell Significance Index: -0.0200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0015
Cell Significance Index: -0.7000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0015
Cell Significance Index: -0.8300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0016
Cell Significance Index: -0.2300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0016
Cell Significance Index: -0.4700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0017
Cell Significance Index: -0.2900 - Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.0038
Cell Significance Index: -0.0200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0041
Cell Significance Index: -0.8600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0041
Cell Significance Index: -0.1100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0047
Cell Significance Index: -0.1000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0053
Cell Significance Index: -0.6100 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0057
Cell Significance Index: -0.0600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0058
Cell Significance Index: -0.8000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0064
Cell Significance Index: -0.7900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0082
Cell Significance Index: -0.8600 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0085
Cell Significance Index: -0.1400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0093
Cell Significance Index: -0.6300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0099
Cell Significance Index: -0.6100 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: -0.0109
Cell Significance Index: -0.1400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0112
Cell Significance Index: -0.8600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0118
Cell Significance Index: -0.7300 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0131
Cell Significance Index: -0.1700 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: -0.0135
Cell Significance Index: -0.1900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0135
Cell Significance Index: -0.7100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0150
Cell Significance Index: -0.6100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0151
Cell Significance Index: -0.7600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0159
Cell Significance Index: -0.4000 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0161
Cell Significance Index: -0.5100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0162
Cell Significance Index: -0.7600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0170
Cell Significance Index: -0.7500 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: -0.0171
Cell Significance Index: -0.1800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0171
Cell Significance Index: -0.6000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0172
Cell Significance Index: -0.6500 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0196
Cell Significance Index: -0.5000 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0215
Cell Significance Index: -0.4200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0220
Cell Significance Index: -0.7200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0226
Cell Significance Index: -0.7200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0248
Cell Significance Index: -0.7300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0248
Cell Significance Index: -0.5200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0257
Cell Significance Index: -0.4300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0258
Cell Significance Index: -0.6900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0274
Cell Significance Index: -0.5500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0279
Cell Significance Index: -0.8000 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0291
Cell Significance Index: -0.7300 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0303
Cell Significance Index: -0.6000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0307
Cell Significance Index: -0.8900 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0310
Cell Significance Index: -0.6700 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0311
Cell Significance Index: -0.2100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0312
Cell Significance Index: -0.4600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0312
Cell Significance Index: -0.5300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0328
Cell Significance Index: -0.6800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0334
Cell Significance Index: -0.8000 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0335
Cell Significance Index: -0.4400 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0336
Cell Significance Index: -0.5700 - Cell Name: macroglial cell (CL0000126)
Fold Change: -0.0337
Cell Significance Index: -0.3900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0343
Cell Significance Index: -0.6700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0348
Cell Significance Index: -0.8700 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0351
Cell Significance Index: -0.3400 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0354
Cell Significance Index: -0.6100 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0355
Cell Significance Index: -0.8600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 293335746
Symbol: ACHD_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2564429
Title: A muscle acetylcholine receptor is expressed in the human cerebellar medulloblastoma cell line TE671.
PubMed ID: 2564429
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15609996
Title: Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.
PubMed ID: 15609996
DOI: 10.1021/bi048918g
PubMed ID: 16916845
Title: CHRND mutation causes a congenital myasthenic syndrome by impairing co-clustering of the acetylcholine receptor with rapsyn.
PubMed ID: 16916845
DOI: 10.1093/brain/awl188
PubMed ID: 18398509
Title: Congenital myasthenia-related AChR delta subunit mutation interferes with intersubunit communication essential for channel gating.
PubMed ID: 18398509
DOI: 10.1172/jci34527
PubMed ID: 27375219
Title: Mutations causing slow-channel myasthenia reveal that a valine ring in the channel pore of muscle AChR is optimized for stabilizing channel gating.
PubMed ID: 27375219
DOI: 10.1002/humu.23043
PubMed ID: 8872460
Title: New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome.
PubMed ID: 8872460
DOI: 10.1093/hmg/5.9.1217
PubMed ID: 11782989
Title: Novel delta subunit mutation in slow-channel syndrome causes severe weakness by novel mechanisms.
PubMed ID: 11782989
DOI: 10.1002/ana.10077
PubMed ID: 11435464
Title: Acetylcholine receptor delta subunit mutations underlie a fast-channel myasthenic syndrome and arthrogryposis multiplex congenita.
PubMed ID: 11435464
DOI: 10.1172/jci12935
PubMed ID: 12499478
Title: Congenital myasthenic syndrome caused by low-expressor fast-channel AChR delta subunit mutation.
PubMed ID: 12499478
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 18252226
Title: Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders.
PubMed ID: 18252226
Sequence Information:
- Length: 517
- Mass: 58895
- Checksum: 195CEF69358758BD
- Sequence:
MEGPVLTLGL LAALAVCGSW GLNEEERLIR HLFQEKGYNK ELRPVAHKEE SVDVALALTL SNLISLKEVE ETLTTNVWIE HGWTDNRLKW NAEEFGNISV LRLPPDMVWL PEIVLENNND GSFQISYSCN VLVYHYGFVY WLPPAIFRSS CPISVTYFPF DWQNCSLKFS SLKYTAKEIT LSLKQDAKEN RTYPVEWIII DPEGFTENGE WEIVHRPARV NVDPRAPLDS PSRQDITFYL IIRRKPLFYI INILVPCVLI SFMVNLVFYL PADSGEKTSV AISVLLAQSV FLLLISKRLP ATSMAIPLIG KFLLFGMVLV TMVVVICVIV LNIHFRTPST HVLSEGVKKL FLETLPELLH MSRPAEDGPS PGALVRRSSS LGYISKAEEY FLLKSRSDLM FEKQSERHGL ARRLTTARRP PASSEQAQQE LFNELKPAVD GANFIVNHMR DQNNYNEEKD SWNRVARTVD RLCLFVVTPV MVVGTAWIFL QGVYNQPPPQ PFPGDPYSYN VQDKRFI
Genular Protein ID: 4099709599
Symbol: B4E3W4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 323
- Mass: 35465
- Checksum: 6573DD93F5FB7D9D
- Sequence:
MLKNLETSVS CASPRTWCGS QRLCWRTTMT APSRSPTPAT CLSTTTASCT GCHLPSSAPP APSLSPISPS TGRTAPSSSG GEKTSVAISV LLAQSVFLLL ISKRLPATSM AIPLIGKFLL FGMVLVTMVV VICVIVLNIH FRTPSTHVLS EGVKKLFLET LPELLHMSRP AEDGPSPGAL VRRSSSLGYI SKAEEYFLLK SRSDLMFEKQ SERHGLARRL TTARRPPASS EQAQQELFNE LKPAVDGANF IVNHMRDQNN YNEEKDSWNR VARTVDRLCL FVVTPVMVVG TAWIFLQGVY NQPPPQPFPG DPYSYNVQDK RFI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.