Genular: Defining Cellular Identity and Function

Details for: Chrna7

Gene ID: 11441

Symbol: Chrna7

Ensembl ID: ENSMUSG00000030525

Description: cholinergic receptor, nicotinic, alpha polypeptide 7

Associated with

Acetylcholine binding and downstream events
(R-MMU-181431)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
(R-MMU-629594)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Postsynaptic nicotinic acetylcholine receptors
(R-MMU-622327)
Transmission across chemical synapses
(R-MMU-112315)
Acetylcholine-gated channel complex
(GO:0005892)
Acetylcholine-gated monoatomic cation-selective channel activity
(GO:0022848)
Acetylcholine binding
(GO:0042166)
Acetylcholine receptor activity
(GO:0015464)
Acetylcholine receptor signaling pathway
(GO:0095500)
Adenylate cyclase binding
(GO:0008179)
Amyloid-beta binding
(GO:0001540)
Associative learning
(GO:0008306)
Atpase binding
(GO:0051117)
B cell activation
(GO:0042113)
Behavioral response to ethanol
(GO:0048149)
Behavioral response to nicotine
(GO:0035095)
Calcium ion transport
(GO:0006816)
Chemical synaptic transmission
(GO:0007268)
Chloride channel regulator activity
(GO:0017081)
Dendrite arborization
(GO:0140059)
Dendritic spine organization
(GO:0097061)
Endocytosis
(GO:0006897)
Establishment of localization in cell
(GO:0051649)
External side of plasma membrane
(GO:0009897)
Extracellular ligand-gated monoatomic ion channel activity
(GO:0005230)
Flagellated sperm motility
(GO:0030317)
Generation of ovulation cycle rhythm
(GO:0060112)
Interleukin-1 beta production
(GO:0032611)
Interleukin-6 production
(GO:0032635)
Learning or memory
(GO:0007611)
Memory
(GO:0007613)
Modulation of chemical synaptic transmission
(GO:0050804)
Modulation of excitatory postsynaptic potential
(GO:0098815)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of interleukin-1 beta production
(GO:0032691)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nervous system process
(GO:0050877)
Neuronal action potential
(GO:0019228)
Ovulation cycle
(GO:0042698)
Plasma membrane
(GO:0005886)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of coa-transferase activity
(GO:1905920)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
(GO:0001988)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of protein phosphorylation
(GO:0001934)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Regulation of amyloid fibril formation
(GO:1905906)
Regulation of inflammatory response
(GO:0050727)
Regulation of membrane potential
(GO:0042391)
Regulation of norepinephrine secretion
(GO:0014061)
Regulation of response to drug
(GO:2001023)
Regulation of synapse structural plasticity
(GO:0051823)
Regulation of synaptic transmission, dopaminergic
(GO:0032225)
Response to acetylcholine
(GO:1905144)
Response to amyloid-beta
(GO:1904645)
Response to cold
(GO:0009409)
Response to ethanol
(GO:0045471)
Response to food
(GO:0032094)
Response to nicotine
(GO:0035094)
Scaffold protein binding
(GO:0097110)
Sensory processing
(GO:0050893)
Synapse organization
(GO:0050808)
Synaptic transmission, cholinergic
(GO:0007271)
T cell activation
(GO:0042110)
Toxic substance binding
(GO:0015643)
Transmembrane signaling receptor activity
(GO:0004888)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)
Tumor necrosis factor production
(GO:0032640)

Other Information

Proteins

Neuronal acetylcholine receptor subunit alpha-7
Q8CC01_MOUSE

Genular Protein ID: 2910389334

Symbol: ACHA7_MOUSE

Name: Neuronal acetylcholine receptor subunit alpha-7

UniProtKB Accession Codes:

P49582

Database IDs:

Citations:

PubMed ID: 7601470

Title: Cloning and mapping of the mouse alpha 7-neuronal nicotinic acetylcholine receptor.

PubMed ID: 7601470

DOI: 10.1016/0888-7543(95)80228-e

PubMed ID: 32783947

Title: NACHO Engages N-Glycosylation ER Chaperone Pathways for alpha7 Nicotinic Receptor Assembly.

PubMed ID: 32783947

DOI: 10.1016/j.celrep.2020.108025

Sequence Information:

Length: 502
Mass: 56632
Checksum: C9312E5226D120E3
Sequence:

MCGRRGGIWL ALAAALLHVS LQGEFQRRLY KELVKNYNPL ERPVANDSQP LTVYFSLSLL 
QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN MSEYPGVKNV RFPDGQIWKP DILLYNSADE 
RFDATFHTNV LVNASGHCQY LPPGIFKSSC YIDVRWFPFD VQQCKLKFGS WSYGGWSLDL 
QMQEADISSY IPNGEWDLMG IPGKRNEKFY ECCKEPYPDV TYTVTMRRRT LYYGLNLLIP 
CVLISALALL VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST 
MIIVGLSVVV TVIVLRYHHH DPDGGKMPKW TRIILLNWCA WFLRMKRPGE DKVRPACQHK 
PRRCSLASVE LSAGAGPPTS NGNLLYIGFR GLEGMHCAPT PDSGVVCGRL ACSPTHDEHL 
MHGTHPSDGD PDLAKILEEV RYIANRFRCQ DESEVICSEW KFAACVVDRL CLMAFSVFTI 
ICTIGILMSA PNFVEAVSKD FA

Genular Protein ID: 809251456

Symbol: Q8CC01_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CC01

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 145
Mass: 17031
Checksum: 79E0F3657FC496FB
Sequence:

MCGRRGGIWL ALAAALLHVS LQGEFQRRLY KELVKNYNPL ERPVANDSQP LTVYFSLSLL 
QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN MSEYPGVKNV RFPDGQIWKP DILLYNRSSE 
PSRMAVHVSP FWMHLRIVCY ALLFT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chrna7

Associated with

Other Information

Cloning and mapping of the mouse alpha 7-neuronal nicotinic acetylcholine receptor. PubMed ID: 7601470

NACHO Engages N-Glycosylation ER Chaperone Pathways for alpha7 Nicotinic Receptor Assembly. PubMed ID: 32783947

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073