Details for: Adipoq

Gene ID: 11450

Symbol: Adipoq

Ensembl ID: ENSMUSG00000022878

Description: adiponectin, C1Q and collagen domain containing

Associated with

  • Ampk inhibits chrebp transcriptional activation activity
    (R-MMU-163680)
  • Integration of energy metabolism
    (R-MMU-163685)
  • Metabolism
    (R-MMU-1430728)
  • Brown fat cell differentiation
    (GO:0050873)
  • Cell surface
    (GO:0009986)
  • Cellular response to camp
    (GO:0071320)
  • Cellular response to epinephrine stimulus
    (GO:0071872)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Collagen trimer
    (GO:0005581)
  • Detection of oxidative stress
    (GO:0070994)
  • Endoplasmic reticulum
    (GO:0005783)
  • Extracellular matrix structural constituent
    (GO:0005201)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fatty acid beta-oxidation
    (GO:0006635)
  • Fatty acid oxidation
    (GO:0019395)
  • Gene expression
    (GO:0010467)
  • Glucose homeostasis
    (GO:0042593)
  • Glucose metabolic process
    (GO:0006006)
  • Hormone activity
    (GO:0005179)
  • Identical protein binding
    (GO:0042802)
  • Low-density lipoprotein particle clearance
    (GO:0034383)
  • Negative regulation of blood pressure
    (GO:0045776)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cold-induced thermogenesis
    (GO:0120163)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of dna biosynthetic process
    (GO:2000279)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of fat cell differentiation
    (GO:0045599)
  • Negative regulation of gluconeogenesis
    (GO:0045721)
  • Negative regulation of granulocyte differentiation
    (GO:0030853)
  • Negative regulation of heterotypic cell-cell adhesion
    (GO:0034115)
  • Negative regulation of hormone secretion
    (GO:0046888)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of intracellular protein transport
    (GO:0090317)
  • Negative regulation of low-density lipoprotein receptor activity
    (GO:1905598)
  • Negative regulation of macrophage derived foam cell differentiation
    (GO:0010745)
  • Negative regulation of macrophage differentiation
    (GO:0045650)
  • Negative regulation of map kinase activity
    (GO:0043407)
  • Negative regulation of metanephric mesenchymal cell migration
    (GO:2000590)
  • Negative regulation of phagocytosis
    (GO:0050765)
  • Negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
    (GO:2000584)
  • Negative regulation of platelet-derived growth factor receptor signaling pathway
    (GO:0010642)
  • Negative regulation of protein autophosphorylation
    (GO:0031953)
  • Negative regulation of receptor binding
    (GO:1900121)
  • Negative regulation of synaptic transmission
    (GO:0050805)
  • Negative regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010804)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of vascular associated smooth muscle cell migration
    (GO:1904753)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Positive regulation of camp-dependent protein kinase activity
    (GO:2000481)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cholesterol efflux
    (GO:0010875)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of fatty acid metabolic process
    (GO:0045923)
  • Positive regulation of glucose import
    (GO:0046326)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of lipid transporter activity
    (GO:0110113)
  • Positive regulation of metanephric podocyte development
    (GO:2000478)
  • Positive regulation of monocyte chemotactic protein-1 production
    (GO:0071639)
  • Positive regulation of myeloid cell apoptotic process
    (GO:0033034)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of protein kinase a signaling
    (GO:0010739)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of renal albumin absorption
    (GO:2000534)
  • Positive regulation of signal transduction
    (GO:0009967)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein localization to plasma membrane
    (GO:0072659)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Regulation of glucose metabolic process
    (GO:0010906)
  • Response to bacterium
    (GO:0009617)
  • Response to glucose
    (GO:0009749)
  • Response to tumor necrosis factor
    (GO:0034612)
  • Sialic acid binding
    (GO:0033691)
  • Signaling receptor binding
    (GO:0005102)

Other Information

Genular Protein ID: 3620209890

Symbol: ADIPO_MOUSE

Name: Adiponectin

UniProtKB Accession Codes:

Q60994 Q62400 Q6GTX4 Q9DC68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CORUM 1 CPTAC 3 DIP 1 DNASU 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 83 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 7592907

Title: A novel serum protein similar to C1q, produced exclusively in adipocytes.

PubMed ID: 7592907

DOI: 10.1074/jbc.270.45.26746

PubMed ID: 8631877

Title: AdipoQ is a novel adipose-specific gene dysregulated in obesity.

PubMed ID: 8631877

DOI: 10.1074/jbc.271.18.10697

PubMed ID: 11162643

Title: Chromosomal localization, expression pattern, and promoter analysis of the mouse gene encoding adipocyte-specific secretory protein Acrp30.

PubMed ID: 11162643

DOI: 10.1006/bbrc.2001.4217

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11912203

Title: Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity.

PubMed ID: 11912203

DOI: 10.1074/jbc.m200601200

PubMed ID: 11382781

Title: Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q.

PubMed ID: 11382781

DOI: 10.1074/jbc.m104148200

PubMed ID: 11479627

Title: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.

PubMed ID: 11479627

DOI: 10.1038/90984

PubMed ID: 11479628

Title: The adipocyte-secreted protein Acrp30 enhances hepatic insulin action.

PubMed ID: 11479628

DOI: 10.1038/90992

PubMed ID: 12840063

Title: The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice.

PubMed ID: 12840063

DOI: 10.1172/jci17797

PubMed ID: 15760892

Title: Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes.

PubMed ID: 15760892

DOI: 10.1074/jbc.m414231200

PubMed ID: 15734737

Title: Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner.

PubMed ID: 15734737

DOI: 10.1074/jbc.m501149200

PubMed ID: 16621799

Title: Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex.

PubMed ID: 16621799

DOI: 10.1074/jbc.m513907200

PubMed ID: 18787108

Title: Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin.

PubMed ID: 18787108

DOI: 10.1096/fj.08-114991

PubMed ID: 19592500

Title: Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin.

PubMed ID: 19592500

DOI: 10.1074/jbc.m109.019257

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19855092

Title: Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation.

PubMed ID: 19855092

DOI: 10.1210/me.2009-0133

PubMed ID: 23209641

Title: The activities of lysyl hydroxylase 3 (LH3) regulate the amount and oligomerization status of adiponectin.

PubMed ID: 23209641

DOI: 10.1371/journal.pone.0050045

PubMed ID: 9512423

Title: The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor.

PubMed ID: 9512423

DOI: 10.1016/s0960-9822(98)70133-2

Sequence Information:

  • Length: 247
  • Mass: 26809
  • Checksum: 0ECC687D9A8E8123
  • Sequence:
    • MLLLQALLFL LILPSHAEDD VTTTEELAPA LVPPPKGTCA GWMAGIPGHP GHNGTPGRDG 
RDGTPGEKGE KGDAGLLGPK GETGDVGMTG AEGPRGFPGT PGRKGEPGEA AYVYRSAFSV 
GLETRVTVPN VPIRFTKIFY NQQNHYDGST GKFYCNIPGL YYFSYHITVY MKDVKVSLFK 
KDKAVLFTYD QYQEKNVDQA SGSVLLHLEV GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF 
LLYHDTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.