Details for: CHRNG

Gene ID: 1146

Symbol: CHRNG

Ensembl ID: ENSG00000196811

Description: cholinergic receptor nicotinic gamma subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.22
    Marker Score: 2238
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4822
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 506
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.97
    Marker Score: 2829
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1349
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 464
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.52
    Marker Score: 494
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.48
    Marker Score: 185
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.44
    Marker Score: 6824
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.44
    Marker Score: 902
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.41
    Marker Score: 455
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.4
    Marker Score: 233
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.35
    Marker Score: 433
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.32
    Marker Score: 506
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.31
    Marker Score: 631
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.3
    Marker Score: 950
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.29
    Marker Score: 168
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.28
    Marker Score: 215
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.27
    Marker Score: 2248
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.26
    Marker Score: 746
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.25
    Marker Score: 480
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.22
    Marker Score: 70
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.21
    Marker Score: 142.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.17
    Marker Score: 91
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.14
    Marker Score: 429
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.13
    Marker Score: 308
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 119
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 89
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.09
    Marker Score: 228
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.09
    Marker Score: 66
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 56
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.08
    Marker Score: 131
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.08
    Marker Score: 455
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.07
    Marker Score: 944.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 125
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.07
    Marker Score: 81
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.06
    Marker Score: 87
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.05
    Marker Score: 22.5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 157
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.05
    Marker Score: 135
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 106
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.04
    Marker Score: 57
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.04
    Marker Score: 114
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 13

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Other Information

**Key characteristics:** * The CHRNG gene is located on chromosome 17q23.1. * It is a large gene encoding a protein of approximately 1300 amino acids. * The gene product is a single polypeptide chain. * It is a member of the acetylcholine receptor family. **Pathways and functions:** * The CHRNG gene is involved in a variety of cellular processes, including: * Muscle contraction * Nervous system process * Postsynaptic signal transmission * It is expressed in a wide range of cells, including blood vessel endothelial cells, colon goblet cells, intestinal stem cells, and cerebral cortex neurons. * Activation of nAChRs by acetylcholine induces the closure of nicotinic acetylcholine receptors on the plasma membrane, leading to changes in intracellular signaling pathways. * These changes can influence muscle contraction, neuronal signaling, and other cellular processes. **Clinical significance:** * Mutations in the CHRNG gene have been linked to several neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. * nAChRs are a major target for therapeutic interventions in these diseases, which could potentially modulate neuronal signaling pathways involved in disease pathogenesis. **Additional notes:** * The CHRNG gene is also involved in the regulation of gastric acid secretion and intestinal epithelial cell migration. * It is a highly conserved gene, with a similar gene found in mammals, birds, and reptiles. * The expression of the CHRNG gene is upregulated in several brain diseases, including Alzheimer's disease and Parkinson's disease.

Genular Protein ID: 3487293272

Symbol: ACHG_HUMAN

Name: Acetylcholine receptor subunit gamma

UniProtKB Accession Codes:

P07510 B3KWM8 Q14DU4 Q53RG2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3967651

Title: Cloning and sequence analysis of human genomic DNA encoding gamma subunit precursor of muscle acetylcholine receptor.

PubMed ID: 3967651

DOI: 10.1111/j.1432-1033.1985.tb08614.x

PubMed ID: 7688301

Title: Primary structure of the human muscle acetylcholine receptor. cDNA cloning of the gamma and epsilon subunits.

PubMed ID: 7688301

DOI: 10.1111/j.1432-1033.1993.tb18027.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16826520

Title: Escobar syndrome is a prenatal myasthenia caused by disruption of the acetylcholine receptor fetal gamma subunit.

PubMed ID: 16826520

DOI: 10.1086/506257

PubMed ID: 16826531

Title: Mutations in the embryonal subunit of the acetylcholine receptor (CHRNG) cause lethal and Escobar variants of multiple pterygium syndrome.

PubMed ID: 16826531

DOI: 10.1086/506256

Sequence Information:

  • Length: 517
  • Mass: 57883
  • Checksum: 7C78F533D4997D7A
  • Sequence:
    • MHGGQGPLLL LLLLAVCLGA QGRNQEERLL ADLMQNYDPN LRPAERDSDV VNVSLKLTLT 
NLISLNEREE ALTTNVWIEM QWCDYRLRWD PRDYEGLWVL RVPSTMVWRP DIVLENNVDG 
VFEVALYCNV LVSPDGCIYW LPPAIFRSAC SISVTYFPFD WQNCSLIFQS QTYSTNEIDL 
QLSQEDGQTI EWIFIDPEAF TENGEWAIQH RPAKMLLDPA APAQEAGHQK VVFYLLIQRK 
PLFYVINIIA PCVLISSVAI LIHFLPAKAG GQKCTVAINV LLAQTVFLFL VAKKVPETSQ 
AVPLISKYLT FLLVVTILIV VNAVVVLNVS LRSPHTHSMA RGVRKVFLRL LPQLLRMHVR 
PLAPAAVQDT QSRLQNGSSG WSITTGEEVA LCLPRSELLF QQWQRQGLVA AALEKLEKGP 
ELGLSQFCGS LKQAAPAIQA CVEACNLIAC ARHQQSHFDN GNEEWFLVGR VLDRVCFLAM 
LSLFICGTAG IFLMAHYNRV PALPFPGDPR PYLPSPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.