Details for: CHRNG

Gene ID: 1146

Symbol: CHRNG

Ensembl ID: ENSG00000196811

Description: cholinergic receptor nicotinic gamma subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6024
    Cell Significance Index: 12.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.3244
    Cell Significance Index: -0.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2269
    Cell Significance Index: 45.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1726
    Cell Significance Index: 3.5800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.1290
    Cell Significance Index: 1.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1104
    Cell Significance Index: 3.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1030
    Cell Significance Index: 1.4800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0918
    Cell Significance Index: 1.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0566
    Cell Significance Index: 1.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0366
    Cell Significance Index: 0.5400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0340
    Cell Significance Index: 0.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0321
    Cell Significance Index: 1.8000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.0265
    Cell Significance Index: 0.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0262
    Cell Significance Index: 18.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0257
    Cell Significance Index: 0.3500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0201
    Cell Significance Index: 0.3000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0186
    Cell Significance Index: 0.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0176
    Cell Significance Index: 0.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0115
    Cell Significance Index: 2.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0102
    Cell Significance Index: 0.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0088
    Cell Significance Index: 1.0200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0076
    Cell Significance Index: 0.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0061
    Cell Significance Index: 0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0034
    Cell Significance Index: 5.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0025
    Cell Significance Index: 3.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0022
    Cell Significance Index: 0.4000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0022
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0019
    Cell Significance Index: 3.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0018
    Cell Significance Index: 0.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0016
    Cell Significance Index: 0.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0017
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0023
    Cell Significance Index: -0.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0025
    Cell Significance Index: -1.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0030
    Cell Significance Index: -1.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0031
    Cell Significance Index: -0.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0039
    Cell Significance Index: -1.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0059
    Cell Significance Index: -0.2600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0061
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0065
    Cell Significance Index: -1.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0078
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0090
    Cell Significance Index: -1.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0109
    Cell Significance Index: -1.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0112
    Cell Significance Index: -1.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0154
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0160
    Cell Significance Index: -1.8300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0174
    Cell Significance Index: -0.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0192
    Cell Significance Index: -0.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0206
    Cell Significance Index: -0.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0211
    Cell Significance Index: -1.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0212
    Cell Significance Index: -1.3000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0230
    Cell Significance Index: -0.3100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0232
    Cell Significance Index: -0.3000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0234
    Cell Significance Index: -0.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0264
    Cell Significance Index: -0.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0266
    Cell Significance Index: -1.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0287
    Cell Significance Index: -1.0100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0321
    Cell Significance Index: -0.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0326
    Cell Significance Index: -2.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0331
    Cell Significance Index: -1.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0345
    Cell Significance Index: -1.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0349
    Cell Significance Index: -1.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0364
    Cell Significance Index: -0.9900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0375
    Cell Significance Index: -0.4800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0379
    Cell Significance Index: -0.5200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0384
    Cell Significance Index: -0.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0390
    Cell Significance Index: -0.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0409
    Cell Significance Index: -1.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0422
    Cell Significance Index: -1.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0430
    Cell Significance Index: -0.9000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0445
    Cell Significance Index: -0.6700
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0468
    Cell Significance Index: -0.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0494
    Cell Significance Index: -1.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0504
    Cell Significance Index: -1.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0509
    Cell Significance Index: -1.0800
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0512
    Cell Significance Index: -0.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0529
    Cell Significance Index: -1.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0551
    Cell Significance Index: -1.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0554
    Cell Significance Index: -1.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0572
    Cell Significance Index: -1.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0579
    Cell Significance Index: -1.1300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0589
    Cell Significance Index: -1.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0602
    Cell Significance Index: -0.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0603
    Cell Significance Index: -1.2100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0604
    Cell Significance Index: -0.7100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0628
    Cell Significance Index: -0.7400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0630
    Cell Significance Index: -1.0100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0635
    Cell Significance Index: -0.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0652
    Cell Significance Index: -1.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0659
    Cell Significance Index: -1.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0663
    Cell Significance Index: -1.3100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0666
    Cell Significance Index: -0.8400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0668
    Cell Significance Index: -0.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0670
    Cell Significance Index: -1.9200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0683
    Cell Significance Index: -1.7000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0700
    Cell Significance Index: -1.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit composition:** The CHRNG gene encodes the gamma subunit of the nAChR, which is a heteropentameric receptor composed of two alpha, one beta, and one gamma subunits. 2. **Expression:** CHRNG is widely expressed in various tissues, including the nervous system, muscle, and epithelial cells. 3. **Function:** The gamma subunit is crucial for the proper functioning of the nAChR, facilitating the receptor's ability to bind acetylcholine and transmit signals across synapses. 4. **Disease association:** Dysregulation of the CHRNG gene has been implicated in several neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. **Pathways and Functions:** The CHRNG gene is involved in several key pathways, including: 1. **Acetylcholine-gated channel complex:** The nAChR, containing the CHRNG subunit, forms a complex with other subunits that facilitates the binding of acetylcholine and the transmission of signals across synapses. 2. **Acetylcholine binding and downstream events:** The CHRNG subunit plays a crucial role in the binding of acetylcholine to the nAChR, which triggers a series of downstream events that ultimately lead to neurotransmission. 3. **Signal transduction:** The nAChR, containing the CHRNG subunit, is involved in various signal transduction pathways, including those involved in muscle contraction, neurotransmission, and synaptic plasticity. 4. **Neurotransmitter receptors and postsynaptic signal transmission:** The CHRNG subunit is essential for the proper functioning of nAChR, which is involved in the transmission of signals across synapses. **Clinical Significance:** Dysregulation of the CHRNG gene has been implicated in several neurological and psychiatric disorders, including: 1. **Alzheimer's disease:** The CHRNG gene has been shown to be downregulated in Alzheimer's disease, suggesting a potential role in the disease's pathogenesis. 2. **Parkinson's disease:** The CHRNG gene has been shown to be upregulated in Parkinson's disease, suggesting a potential role in the disease's pathogenesis. 3. **Schizophrenia:** The CHRNG gene has been shown to be associated with schizophrenia, suggesting a potential role in the disease's pathogenesis. 4. **Muscle disorders:** The CHRNG gene has been shown to be involved in various muscle disorders, including myasthenia gravis and muscular dystrophy. In conclusion, the CHRNG gene plays a critical role in the cholinergic system, and its dysregulation has been implicated in several neurological and psychiatric disorders. Further research is needed to fully understand the role of the CHRNG gene in these disorders and to develop effective therapeutic strategies.

Genular Protein ID: 3487293272

Symbol: ACHG_HUMAN

Name: N/A

UniProtKB Accession Codes:

P07510 B3KWM8 Q14DU4 Q53RG2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 2 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3967651

Title: Cloning and sequence analysis of human genomic DNA encoding gamma subunit precursor of muscle acetylcholine receptor.

PubMed ID: 3967651

DOI: 10.1111/j.1432-1033.1985.tb08614.x

PubMed ID: 7688301

Title: Primary structure of the human muscle acetylcholine receptor. cDNA cloning of the gamma and epsilon subunits.

PubMed ID: 7688301

DOI: 10.1111/j.1432-1033.1993.tb18027.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16826520

Title: Escobar syndrome is a prenatal myasthenia caused by disruption of the acetylcholine receptor fetal gamma subunit.

PubMed ID: 16826520

DOI: 10.1086/506257

PubMed ID: 16826531

Title: Mutations in the embryonal subunit of the acetylcholine receptor (CHRNG) cause lethal and Escobar variants of multiple pterygium syndrome.

PubMed ID: 16826531

DOI: 10.1086/506256

Sequence Information:

  • Length: 517
  • Mass: 57883
  • Checksum: 7C78F533D4997D7A
  • Sequence:
    • MHGGQGPLLL LLLLAVCLGA QGRNQEERLL ADLMQNYDPN LRPAERDSDV VNVSLKLTLT 
NLISLNEREE ALTTNVWIEM QWCDYRLRWD PRDYEGLWVL RVPSTMVWRP DIVLENNVDG 
VFEVALYCNV LVSPDGCIYW LPPAIFRSAC SISVTYFPFD WQNCSLIFQS QTYSTNEIDL 
QLSQEDGQTI EWIFIDPEAF TENGEWAIQH RPAKMLLDPA APAQEAGHQK VVFYLLIQRK 
PLFYVINIIA PCVLISSVAI LIHFLPAKAG GQKCTVAINV LLAQTVFLFL VAKKVPETSQ 
AVPLISKYLT FLLVVTILIV VNAVVVLNVS LRSPHTHSMA RGVRKVFLRL LPQLLRMHVR 
PLAPAAVQDT QSRLQNGSSG WSITTGEEVA LCLPRSELLF QQWQRQGLVA AALEKLEKGP 
ELGLSQFCGS LKQAAPAIQA CVEACNLIAC ARHQQSHFDN GNEEWFLVGR VLDRVCFLAM 
LSLFICGTAG IFLMAHYNRV PALPFPGDPR PYLPSPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.