Genular: Defining Cellular Identity and Function

Details for: Actb

Gene ID: 11461

Symbol: Actb

Ensembl ID: ENSMUSG00000029580

Description: actin, beta

Associated with

Adherens junctions interactions
(R-MMU-418990)
Axon guidance
(R-MMU-422475)
B-wich complex positively regulates rrna expression
(R-MMU-5250924)
Cell-cell communication
(R-MMU-1500931)
Cell-cell junction organization
(R-MMU-421270)
Cell-extracellular matrix interactions
(R-MMU-446353)
Cell junction organization
(R-MMU-446728)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Deubiquitination
(R-MMU-5688426)
Developmental biology
(R-MMU-1266738)
Dna damage recognition in gg-ner
(R-MMU-5696394)
Dna repair
(R-MMU-73894)
Eph-ephrin signaling
(R-MMU-2682334)
Ephb-mediated forward signaling
(R-MMU-3928662)
Epigenetic regulation of gene expression
(R-MMU-212165)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
Formation of annular gap junctions
(R-MMU-196025)
Gap junction degradation
(R-MMU-190873)
Gap junction trafficking
(R-MMU-190828)
Gap junction trafficking and regulation
(R-MMU-157858)
Gene expression (transcription)
(R-MMU-74160)
Global genome nucleotide excision repair (gg-ner)
(R-MMU-5696399)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interaction between l1 and ankyrins
(R-MMU-445095)
L1cam interactions
(R-MMU-373760)
Map2k and mapk activation
(R-MMU-5674135)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Nervous system development
(R-MMU-9675108)
Nucleotide excision repair
(R-MMU-5696398)
Positive epigenetic regulation of rrna expression
(R-MMU-5250913)
Post-translational protein modification
(R-MMU-597592)
Raf/map kinase cascade
(R-MMU-5673001)
Recycling pathway of l1
(R-MMU-437239)
Regulation of actin dynamics for phagocytic cup formation
(R-MMU-2029482)
Rhof gtpase cycle
(R-MMU-9035034)
Rho gtpase cycle
(R-MMU-9012999)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Rho gtpases activate iqgaps
(R-MMU-5626467)
Rho gtpases activate wasps and waves
(R-MMU-5663213)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Uch proteinases
(R-MMU-5689603)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vesicle-mediated transport
(R-MMU-5653656)
Adherens junction assembly
(GO:0034333)
Apical protein localization
(GO:0045176)
Atp binding
(GO:0005524)
Axonogenesis
(GO:0007409)
Cell motility
(GO:0048870)
Cellular response to cytochalasin b
(GO:0072749)
Cellular response to electrical stimulus
(GO:0071257)
Chromatin
(GO:0000785)
Chromatin remodeling
(GO:0006338)
Establishment or maintenance of cell polarity
(GO:0007163)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Kinesin binding
(GO:0019894)
Kinetochore
(GO:0000776)
Morphogenesis of a polarized epithelium
(GO:0001738)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of cyclin-dependent protein kinase activity
(GO:1904030)
Negative regulation of protein binding
(GO:0032091)
Nitric-oxide synthase binding
(GO:0050998)
Nucleosome
(GO:0000786)
Nucleotide binding
(GO:0000166)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of double-strand break repair
(GO:2000781)
Positive regulation of double-strand break repair via homologous recombination
(GO:1905168)
Positive regulation of myoblast differentiation
(GO:0045663)
Positive regulation of stem cell population maintenance
(GO:1902459)
Positive regulation of t cell differentiation
(GO:0045582)
Postsynaptic actin cytoskeleton organization
(GO:0098974)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein localization to adherens junction
(GO:0071896)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell cycle
(GO:0051726)
Regulation of double-strand break repair
(GO:2000779)
Regulation of g0 to g1 transition
(GO:0070316)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of mitotic metaphase/anaphase transition
(GO:0030071)
Regulation of norepinephrine uptake
(GO:0051621)
Regulation of nucleotide-excision repair
(GO:2000819)
Regulation of protein localization to plasma membrane
(GO:1903076)
Regulation of synaptic vesicle endocytosis
(GO:1900242)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of transepithelial transport
(GO:0150111)
Regulation of transmembrane transporter activity
(GO:0022898)
Structural constituent of postsynaptic actin cytoskeleton
(GO:0098973)
Tat protein binding
(GO:0030957)

Other Information

Proteins

Actin, cytoplasmic 1

Genular Protein ID: 2192485768

Symbol: ACTB_MOUSE

Name: Actin, cytoplasmic 1

UniProtKB Accession Codes:

P60710 P02570 P70514 P99021 Q11211 Q3TI89 Q3TVP6 Q64316 Q6ZWM3

Database IDs:

Citations:

PubMed ID: 3754329

Title: Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA.

PubMed ID: 3754329

DOI: 10.1093/nar/14.6.2829

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 213279

Title: Actin amino-acid sequences. Comparison of actins from calf thymus, bovine brain, and SV40-transformed mouse 3T3 cells with rabbit skeletal muscle actin.

PubMed ID: 213279

DOI: 10.1111/j.1432-1033.1978.tb12624.x

PubMed ID: 3084797

Title: Comparison of three actin-coding sequences in the mouse; evolutionary relationships between the actin genes of warm-blooded vertebrates.

PubMed ID: 3084797

DOI: 10.1007/bf02100994

PubMed ID: 12522145

Title: Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.

PubMed ID: 12522145

DOI: 10.1074/jbc.m212632200

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 21128978

Title: Identification and characterization of a novel Rab GTPase-activating protein in spermatids.

PubMed ID: 21128978

DOI: 10.1111/j.1365-2605.2010.01126.x

PubMed ID: 21969592

Title: Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition.

PubMed ID: 21969592

DOI: 10.1073/pnas.1103318108

PubMed ID: 23911929

Title: MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.

PubMed ID: 23911929

DOI: 10.1016/j.molcel.2013.06.019

PubMed ID: 23558171

Title: Nuclear actin network assembly by formins regulates the SRF coactivator MAL.

PubMed ID: 23558171

DOI: 10.1126/science.1235038

PubMed ID: 25759381

Title: Nuclear F-actin formation and reorganization upon cell spreading.

PubMed ID: 25759381

DOI: 10.1074/jbc.m114.627166

PubMed ID: 30659401

Title: Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis.

PubMed ID: 30659401

DOI: 10.1007/s10735-019-09813-3

PubMed ID: 30626964

Title: SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

PubMed ID: 30626964

DOI: 10.1038/s41586-018-0821-8

PubMed ID: 31605441

Title: Identification and classification of epithelial cells in nephron segments by actin cytoskeleton patterns.

PubMed ID: 31605441

DOI: 10.1111/febs.15088

Sequence Information:

Length: 375
Mass: 41737
Checksum: 6AFD05CA94E360E2
Sequence:

MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS 
KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT 
QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL 
AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY 
ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS 
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ 
EYDESGPSIV HRKCF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Actb

Associated with

Other Information

Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA. PubMed ID: 3754329

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Actin amino-acid sequences. Comparison of actins from calf thymus, bovine brain, and SV40-transformed mouse 3T3 cells with rabbit skeletal muscle actin. PubMed ID: 213279

Comparison of three actin-coding sequences in the mouse; evolutionary relationships between the actin genes of warm-blooded vertebrates. PubMed ID: 3084797

Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. PubMed ID: 12522145

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. PubMed ID: 16139798

Identification and characterization of a novel Rab GTPase-activating protein in spermatids. PubMed ID: 21128978

Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition. PubMed ID: 21969592

MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. PubMed ID: 23911929

Nuclear actin network assembly by formins regulates the SRF coactivator MAL. PubMed ID: 23558171

Nuclear F-actin formation and reorganization upon cell spreading. PubMed ID: 25759381

Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis. PubMed ID: 30659401

SETD3 is an actin histidine methyltransferase that prevents primary dystocia. PubMed ID: 30626964

Identification and classification of epithelial cells in nephron segments by actin cytoskeleton patterns. PubMed ID: 31605441