CHUK | ENSG00000213341 | NCBI 1147

Details for: CHUK

Gene ID: 1147

Symbol: CHUK

Ensembl ID: ENSG00000213341

Description: component of inhibitor of nuclear factor kappa B kinase complex

Associated with

Activation of nf-kappab in b cells
(R-HSA-1169091)
Adaptive immune system
(R-HSA-1280218)
Akt phosphorylates targets in the cytosol
(R-HSA-198323)
Antigen processing-cross presentation
(R-HSA-1236975)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Cytokine signaling in immune system
(R-HSA-1280215)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Death receptor signaling
(R-HSA-73887)
Dectin-1 mediated noncanonical nf-kb signaling
(R-HSA-5607761)
Disease
(R-HSA-1643685)
Diseases associated with the tlr signaling cascade
(R-HSA-5602358)
Diseases of immune system
(R-HSA-5260271)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Er-phagosome pathway
(R-HSA-1236974)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Ikba variant leads to eda-id
(R-HSA-5603029)
Ikbkb deficiency causes scid
(R-HSA-5602636)
Ikbkg deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (eda-id) (via tlr)
(R-HSA-5603027)
Ikk complex recruitment mediated by rip1
(R-HSA-937041)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon signaling
(R-HSA-913531)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irak1 recruits ikk complex
(R-HSA-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-HSA-975144)
Map3k8 (tpl2)-dependent mapk1/3 activation
(R-HSA-5684264)
Map kinase activation
(R-HSA-450294)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Nf-kb activation through fadd/rip-1 pathway mediated by caspase-8 and -10
(R-HSA-933543)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Pkr-mediated signaling
(R-HSA-9833482)
Regulation of nf-kappa b signaling
(R-HSA-9758274)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Rip-mediated nfkb activation via zbp1
(R-HSA-1810476)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by interleukins
(R-HSA-449147)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signal transduction
(R-HSA-162582)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Tcr signaling
(R-HSA-202403)
Ticam1, rip1-mediated ikk complex recruitment
(R-HSA-168927)
Tnfr1-induced nf-kappa-b signaling pathway
(R-HSA-5357956)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Tnf signaling
(R-HSA-75893)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6 mediated nf-kb activation
(R-HSA-933542)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Zbp1(dai) mediated induction of type i ifns
(R-HSA-1606322)
Atp binding
(GO:0005524)
Canonical nf-kappab signal transduction
(GO:0007249)
I-kappab phosphorylation
(GO:0007252)
Ikappab kinase activity
(GO:0008384)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Scaffold protein binding
(GO:0097110)
Skeletal muscle contraction
(GO:0003009)
Transferrin receptor binding
(GO:1990459)

Other Information

Proteins

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Genular Protein ID: 3505593183

Symbol: IKKA_HUMAN

Name: Inhibitor of nuclear factor kappa-B kinase subunit alpha

UniProtKB Accession Codes:

O15111 O14666 Q13132 Q5W0I4 Q92467

Database IDs:

Citations:

PubMed ID: 9244310

Title: Identification and characterization of an IkappaB kinase.

PubMed ID: 9244310

DOI: 10.1016/s0092-8674(00)80344-x

PubMed ID: 9252186

Title: A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.

PubMed ID: 9252186

DOI: 10.1038/41493

PubMed ID: 9346484

Title: IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.

PubMed ID: 9346484

DOI: 10.1126/science.278.5339.860

PubMed ID: 9813230

Title: IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes.

PubMed ID: 9813230

DOI: 10.1016/s0378-1119(98)00462-4

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 8777433

Title: CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain.

PubMed ID: 8777433

PubMed ID: 17116858

Title: Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.

PubMed ID: 17116858

DOI: 10.1073/pnas.0608995103

PubMed ID: 9751059

Title: IKAP is a scaffold protein of the IkappaB kinase complex.

PubMed ID: 9751059

DOI: 10.1038/26254

PubMed ID: 9520446

Title: NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.

PubMed ID: 9520446

DOI: 10.1073/pnas.95.7.3792

PubMed ID: 10485710

Title: NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase.

PubMed ID: 10485710

DOI: 10.1038/43466

PubMed ID: 10195894

Title: Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.

PubMed ID: 10195894

DOI: 10.1126/science.284.5412.309

PubMed ID: 9819420

Title: Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.

PubMed ID: 9819420

DOI: 10.1128/mcb.18.12.7336

PubMed ID: 10712233

Title: The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection.

PubMed ID: 10712233

DOI: 10.1152/ajpcell.2000.278.3.c451

PubMed ID: 11971985

Title: Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.

PubMed ID: 11971985

DOI: 10.1128/mcb.22.10.3549-3561.2002

PubMed ID: 12612076

Title: Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.

PubMed ID: 12612076

DOI: 10.1128/mcb.23.6.2029-2041.2003

PubMed ID: 12789342

Title: Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.

PubMed ID: 12789342

DOI: 10.1038/nature01576

PubMed ID: 15084260

Title: IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.

PubMed ID: 15084260

DOI: 10.1016/s0092-8674(04)00302-2

PubMed ID: 15456791

Title: PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.

PubMed ID: 15456791

DOI: 10.1074/jbc.m406741200

PubMed ID: 15173580

Title: beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.

PubMed ID: 15173580

DOI: 10.1073/pnas.0402851101

PubMed ID: 16177806

Title: Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.

PubMed ID: 16177806

DOI: 10.1038/nature04193

PubMed ID: 17540171

Title: Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.

PubMed ID: 17540171

DOI: 10.1016/j.cell.2007.03.056

PubMed ID: 17434128

Title: Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.

PubMed ID: 17434128

DOI: 10.1016/j.molcel.2007.02.019

PubMed ID: 18626576

Title: The IkappaB kinase complex: master regulator of NF-kappaB signaling.

PubMed ID: 18626576

DOI: 10.1007/s12026-008-8025-1

PubMed ID: 19088076

Title: SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression.

PubMed ID: 19088076

DOI: 10.1074/jbc.m805055200

PubMed ID: 19150425

Title: PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.

PubMed ID: 19150425

DOI: 10.1016/j.molcel.2008.11.023

PubMed ID: 20434986

Title: NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.

PubMed ID: 20434986

DOI: 10.1016/j.cell.2010.03.040

PubMed ID: 20855622

Title: The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}.

PubMed ID: 20855622

DOI: 10.1073/pnas.1007765107

PubMed ID: 20961246

Title: Mutant CHUK and severe fetal encasement malformation.

PubMed ID: 20961246

DOI: 10.1056/nejmoa0911698

PubMed ID: 20501937

Title: Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.

PubMed ID: 20501937

DOI: 10.1126/scisignal.2000778

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21765415

Title: The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1.

PubMed ID: 21765415

DOI: 10.1038/ni.2066

PubMed ID: 23091055

Title: The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-kappaB signaling.

PubMed ID: 23091055

DOI: 10.1074/jbc.m112.399923

PubMed ID: 23776175

Title: SASH1 is a scaffold molecule in endothelial TLR4 signaling.

PubMed ID: 23776175

DOI: 10.4049/jimmunol.1200583

PubMed ID: 26334375

Title: IFIT5 positively regulates NF-kappaB signaling through synergizing the recruitment of IkappaB kinase (IKK) to TGF-beta-activated kinase 1 (TAK1).

PubMed ID: 26334375

DOI: 10.1016/j.cellsig.2015.08.018

PubMed ID: 27426725

Title: LRRC14 attenuates Toll-like receptor-mediated NF-kappa-B signaling through disruption of IKK complex.

PubMed ID: 27426725

DOI: 10.1016/j.yexcr.2016.07.011

PubMed ID: 30341167

Title: DDX3 directly facilitates IKKalpha activation and regulates downstream signalling pathways.

PubMed ID: 30341167

DOI: 10.1042/bcj20180163

PubMed ID: 30217973

Title: HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKalpha.

PubMed ID: 30217973

DOI: 10.1038/s41467-018-05722-3

PubMed ID: 32935379

Title: Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.

PubMed ID: 32935379

DOI: 10.15252/embj.2020105139

PubMed ID: 35952808

Title: TRIM56 positively regulates TNFalpha-induced NF-kappaB signaling by enhancing the ubiquitination of TAK1.

PubMed ID: 35952808

DOI: 10.1016/j.ijbiomac.2022.08.019

PubMed ID: 25691407

Title: Expanding the genetic and phenotypic spectrum of popliteal pterygium disorders.

PubMed ID: 25691407

DOI: 10.1002/ajmg.a.36896

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18462684

Title: Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.

PubMed ID: 18462684

DOI: 10.1016/j.str.2008.02.012

Sequence Information:

Length: 745
Mass: 84640
Checksum: 4EA55C6FFC66FA16
Sequence:

MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDLK IAIKSCRLEL STKNRERWCH 
EIQIMKKLNH ANVVKACDVP EELNILIHDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ 
ILSLLSDIGS GIRYLHENKI IHRDLKPENI VLQDVGGKII HKIIDLGYAK DVDQGSLCTS 
FVGTLQYLAP ELFENKPYTA TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK 
CIFACEEMSG EVRFSSHLPQ PNSLCSLVVE PMENWLQLML NWDPQQRGGP VDLTLKQPRC 
FVLMDHILNL KIVHILNMTS AKIISFLLPP DESLHSLQSR IERETGINTG SQELLSETGI 
SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS RSLSDCVNYI VQDSKIQLPI 
IQLRKVWAEA VHYVSGLKED YSRLFQGQRA AMLSLLRYNA NLTKMKNTLI SASQQLKAKL 
EFFHKSIQLD LERYSEQMTY GISSEKMLKA WKEMEEKAIH YAEVGVIGYL EDQIMSLHAE 
IMELQKSPYG RRQGDLMESL EQRAIDLYKQ LKHRPSDHSY SDSTEMVKII VHTVQSQDRV 
LKELFGHLSK LLGCKQKIID LLPKVEVALS NIKEADNTVM FMQGKRQKEI WHLLKIACTQ 
SSARSLVGSS LEGAVTPQTS AWLPPTSAEH DHSLSCVVTP QDGETSAQMI EENLNCLGHL 
STIIHEANEE QGNSMMNLDW SWLTE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CHUK

Associated with

Other Information

Identification and characterization of an IkappaB kinase. PubMed ID: 9244310

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. PubMed ID: 9252186

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. PubMed ID: 9346484

IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. PubMed ID: 9813230

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain. PubMed ID: 8777433

Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling. PubMed ID: 17116858

IKAP is a scaffold protein of the IkappaB kinase complex. PubMed ID: 9751059

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. PubMed ID: 9520446

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. PubMed ID: 10485710

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. PubMed ID: 10195894

Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. PubMed ID: 9819420

The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection. PubMed ID: 10712233

Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase. PubMed ID: 11971985

Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation. PubMed ID: 12612076

Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. PubMed ID: 12789342

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. PubMed ID: 15084260

PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages. PubMed ID: 15456791

beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. PubMed ID: 15173580

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. PubMed ID: 16177806

Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity. PubMed ID: 17540171

Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. PubMed ID: 17434128

The IkappaB kinase complex: master regulator of NF-kappaB signaling. PubMed ID: 18626576

SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression. PubMed ID: 19088076

PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. PubMed ID: 19150425

NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. PubMed ID: 20434986

The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}. PubMed ID: 20855622

Mutant CHUK and severe fetal encasement malformation. PubMed ID: 20961246

Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. PubMed ID: 20501937

Initial characterization of the human central proteome. PubMed ID: 21269460

The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1. PubMed ID: 21765415

The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-kappaB signaling. PubMed ID: 23091055

SASH1 is a scaffold molecule in endothelial TLR4 signaling. PubMed ID: 23776175

IFIT5 positively regulates NF-kappaB signaling through synergizing the recruitment of IkappaB kinase (IKK) to TGF-beta-activated kinase 1 (TAK1). PubMed ID: 26334375

LRRC14 attenuates Toll-like receptor-mediated NF-kappa-B signaling through disruption of IKK complex. PubMed ID: 27426725

DDX3 directly facilitates IKKalpha activation and regulates downstream signalling pathways. PubMed ID: 30341167

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKalpha. PubMed ID: 30217973

Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2. PubMed ID: 32935379

TRIM56 positively regulates TNFalpha-induced NF-kappaB signaling by enhancing the ubiquitination of TAK1. PubMed ID: 35952808

Expanding the genetic and phenotypic spectrum of popliteal pterygium disorders. PubMed ID: 25691407

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site. PubMed ID: 18462684