Genular: Defining Cellular Identity and Function

Details for: Actn2

Gene ID: 11472

Symbol: Actn2

Ensembl ID: ENSMUSG00000052374

Description: actinin alpha 2

Associated with

Activation of nmda receptors and postsynaptic events
(R-MMU-442755)
Hemostasis
(R-MMU-109582)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Raf/map kinase cascade
(R-MMU-5673001)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Signal transduction
(R-MMU-162582)
Striated muscle contraction
(R-MMU-390522)
Transmission across chemical synapses
(R-MMU-112315)
Unblocking of nmda receptors, glutamate binding and activation
(R-MMU-438066)
Actin binding
(GO:0003779)
Actin cytoskeleton organization
(GO:0030036)
Actin filament binding
(GO:0051015)
Actin filament uncapping
(GO:0051695)
Calcium ion binding
(GO:0005509)
Cardiac muscle cell development
(GO:0055013)
Cell junction
(GO:0030054)
Cell projection
(GO:0042995)
Cortical actin cytoskeleton
(GO:0030864)
Cytoplasm
(GO:0005737)
Cytoskeletal protein binding
(GO:0008092)
Fatz binding
(GO:0051373)
Filopodium
(GO:0030175)
Focal adhesion
(GO:0005925)
Focal adhesion assembly
(GO:0048041)
Glutamatergic synapse
(GO:0098978)
Identical protein binding
(GO:0042802)
Lim domain binding
(GO:0030274)
Metal ion binding
(GO:0046872)
Microspike assembly
(GO:0030035)
Muscle cell development
(GO:0055001)
Muscle contraction
(GO:0006936)
Negative regulation of potassium ion transmembrane transporter activity
(GO:1901017)
Negative regulation of potassium ion transport
(GO:0043267)
Negative regulation of protein localization to cell surface
(GO:2000009)
Nuclear receptor coactivator activity
(GO:0030374)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Phospholipase c-activating angiotensin-activated signaling pathway
(GO:0086097)
Plasma membrane
(GO:0005886)
Positive regulation of cation channel activity
(GO:2001259)
Positive regulation of endocytic recycling
(GO:2001137)
Positive regulation of potassium ion transmembrane transporter activity
(GO:1901018)
Positive regulation of potassium ion transport
(GO:0043268)
Postsynaptic actin cytoskeleton
(GO:0098871)
Postsynaptic density, intracellular component
(GO:0099092)
Postsynaptic density membrane
(GO:0098839)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein localization to plasma membrane
(GO:0072659)
Regulation of membrane potential
(GO:0042391)
Sarcomere
(GO:0030017)
Sarcomere organization
(GO:0045214)
Striated muscle thin filament
(GO:0005865)
Titin binding
(GO:0031432)
Titin z domain binding
(GO:0070080)
Transmembrane transporter binding
(GO:0044325)
Z disc
(GO:0030018)

Other Information

Proteins

Alpha-actinin-2
Q5FW75_MOUSE

Genular Protein ID: 1236281897

Symbol: ACTN2_MOUSE

Name: Alpha-actinin-2

UniProtKB Accession Codes:

Q9JI91 G3UW84

Database IDs:

Citations:

PubMed ID: 11440986

Title: Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.

PubMed ID: 11440986

DOI: 10.1093/hmg/10.13.1335

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10788519

Title: Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha-actinin-2, is required for myoblast fusion.

PubMed ID: 10788519

DOI: 10.1074/jbc.275.18.13933

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19932097

Title: BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin.

PubMed ID: 19932097

DOI: 10.1016/j.yexcr.2009.11.010

Sequence Information:

Length: 894
Mass: 103834
Checksum: 79FCDC9C85B3949C
Sequence:

MNQIEPGVQY NYVYDEDEYM IQEEEWDRDL LLDPAWEKQQ RKTFTAWCNS HLRKAGTQIE 
NIEEDFRNGL KLMLLLEVIS GERLPKPDRG KMRFHKIANV NKALDYIASK GVKLVSIGAE 
EIVDGNVKMT LGMIWTIILR FAIQDISVEE TSAKEGLLLW CQRKTAPYRN VNIQNFHTSW 
KDGLGLCALI HRHRPDLIDY SKLNKDDPIG NINLAMEIAE KHLDIPKMLD AEDIVNTPKP 
DERAIMTYVS CFYHAFAGAE QAETAANRIC KVLAVNQENE RLMEEYERLA SELLEWIRRT 
IPWLENRTPE KTMQAMQKKL EDFRDYRRKH KPPKVQEKCQ LEINFNTLQT KLRISNRPAF 
MPSEGKMVSD IAGAWQRLEQ AEKGYEEWLL NEIRRLERLE HLAEKFRQKA STHETWAYGK 
EQILLQKDYE SASLTEVRAL LRKHEAFESD LAAHQDRVEQ IAAIAQELNE LDYHDAVNVN 
DRCQKICDQW DRLGTLTQKR REALERTEKL LETIDQLHLE FAKRAAPFNN WMEGAMEDLQ 
DMFIVHSIEE IQSLITAHEQ FKATLPEADG ERQSILAIQN EVEKVIQSYS IRISSSNPYS 
TVTMDELRNK WDKVKQLVPV RDQSLQEELA RQHANERLRR QFAAQANAIG PWIQNKMEEI 
ARSSIQITGA LEDQMNQLKQ YEHNIINYKN NIDKLEGDHQ LIQEALVFDN KHTNYTMEHI 
RVGWELLLTT IARTINEVET QILTRDAKGI TQEQMNEFRA SFNHFDRRKN GLMDHEDFRA 
CLISMGYDLG EAEFARIMTL VDPNGQGTVT FQSFIDFMTR ETADTDTAEQ VIASFRILAS 
DKPYILAEEL RRELPPDQAQ YCIKRMPPYS GPGSVPGALD YTAFSSALYG ESDL

Genular Protein ID: 164276227

Symbol: Q5FW75_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5FW75

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 894
Mass: 103919
Checksum: 40C9A3FF90B517AC
Sequence:

MNQIEPGVQY NYVYDEDEYM IQEEEWDRDL LLDPAWEKQQ RKTFTAWCNS HLRKAGTQIE 
NIEEDFRNGL KLMLLLEVIS GERLPKPDRG KMRFHKIANV NKALDYIASK GVKLVSIGAE 
EIVDGNVKMT LGMIWTIILR FAIQDISVEE TSAKEGLLLW CQRKTAPYRN VNIQNFHTSW 
KDGLGLCARI HRHRPDLIDY SKLNKDDPIG NINLAMEIAE KHLDIPKMLD AEDIVNTPKP 
DERAIMTYVS CFYHAFAGAE QAETAANRIC KVLAVNQENE RLMEEYERLA SELLEWIRRT 
IPWLENRTPE KTMQAMQKKL EDFRDYRRKH KPPKVQEKCQ LEINFNTLQT KLRISNRPAF 
MPSEGKMVSD IAGAWQRLEQ AEKGYEEWLL NEIRRLERLE HLAEKFRQKA STHETWAYGK 
EQILLQKDYE SATLTEVRAL LRRHEAFESD LAAHQDRVEQ IAAIAQELNE LDYHDAVNVN 
DRCQEICDQW DRLGTLTQKR REALERTEKL LETIDQLHLE FAKRAAPFNN WMEGAMEDLQ 
NMFIVHSIEE IQSLITAHEQ FKATLPEADG ERQSILAIQN EVEKVIQSYS IRISSSNPYS 
TVTMDELRNK WDKVKQLVPV RDQSLQEELA RQHANERLRR QFAAQANAIG PWIQNKMEEI 
ARSSIQITGA LEDQMNQLKQ YEHNIINYKN NIDKLEGDHQ LIQEALVFDN KHTNYTMEHI 
RVGWELLLTT IARTINEVET QILTRDAKGI TQEQMNEFRA SFNHFDRRKN GLMDHEDFRA 
CLISMGYDLG EAEFARIMTL VDPNGQGTVT FQSFIDFMTR ETADTDTAEQ VIASFRILAS 
DKPYILAEEL RRELPPDQAQ YCIKRMPPYS GPGSVPGALD YTAFSSALYG ESDL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Actn2

Associated with

Other Information

Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy. PubMed ID: 11440986

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha-actinin-2, is required for myoblast fusion. PubMed ID: 10788519

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin. PubMed ID: 19932097