Genular: Defining Cellular Identity and Function

Details for: Acvr1

Gene ID: 11477

Symbol: Acvr1

Ensembl ID: ENSMUSG00000026836

Description: activin A receptor, type 1

Associated with

Activin binding
(GO:0048185)
Activin receptor activity, type i
(GO:0016361)
Activin receptor complex
(GO:0048179)
Activin receptor signaling pathway
(GO:0032924)
Acute inflammatory response
(GO:0002526)
Apical part of cell
(GO:0045177)
Atp binding
(GO:0005524)
Atrial septum primum morphogenesis
(GO:0003289)
Atrioventricular valve morphogenesis
(GO:0003181)
Bmp receptor activity
(GO:0098821)
Bmp receptor complex
(GO:0070724)
Bmp signaling pathway
(GO:0030509)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Cadherin binding
(GO:0045296)
Cardiac muscle cell fate commitment
(GO:0060923)
Cellular response to bmp stimulus
(GO:0071773)
Cellular response to growth factor stimulus
(GO:0071363)
Determination of left/right symmetry
(GO:0007368)
Dorsal/ventral pattern formation
(GO:0009953)
Embryo development
(GO:0009790)
Embryonic heart tube morphogenesis
(GO:0003143)
Endocardial cushion cell fate commitment
(GO:0061445)
Endocardial cushion formation
(GO:0003272)
Endocardial cushion fusion
(GO:0003274)
Gastrulation
(GO:0007369)
Gastrulation with mouth forming second
(GO:0001702)
Germ cell development
(GO:0007281)
Growth factor binding
(GO:0019838)
Heart development
(GO:0007507)
In utero embryonic development
(GO:0001701)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Mesoderm development
(GO:0007498)
Mesoderm formation
(GO:0001707)
Metal ion binding
(GO:0046872)
Mitral valve morphogenesis
(GO:0003183)
Negative regulation of activin receptor signaling pathway
(GO:0032926)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Negative regulation of signal transduction
(GO:0009968)
Neural crest cell migration
(GO:0001755)
Nucleotide binding
(GO:0000166)
Outflow tract septum morphogenesis
(GO:0003148)
Pharyngeal system development
(GO:0060037)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of cardiac epithelial to mesenchymal transition
(GO:0062043)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of determination of dorsal identity
(GO:2000017)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of smad protein signal transduction
(GO:0060391)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of ossification
(GO:0030278)
Smad binding
(GO:0046332)
Smooth muscle cell differentiation
(GO:0051145)
Transferase activity
(GO:0016740)
Transforming growth factor beta binding
(GO:0050431)
Transforming growth factor beta receptor activity, type i
(GO:0005025)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Transmembrane receptor protein serine/threonine kinase activity
(GO:0004675)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)
Urogenital system development
(GO:0001655)
Ventricular septum morphogenesis
(GO:0060412)

Other Information

Proteins

Activin receptor type-1

Genular Protein ID: 2484659615

Symbol: ACVR1_MOUSE

Name: Activin receptor type-1

UniProtKB Accession Codes:

P37172 Q3UDH5 Q91VF1

Database IDs:

Citations:

PubMed ID: 8388127

Title: Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor.

PubMed ID: 8388127

DOI: 10.1126/science.8388127

PubMed ID: 11471062

Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.

PubMed ID: 11471062

DOI: 10.1007/s00335-001-1001-x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10479450

Title: Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis.

PubMed ID: 10479450

DOI: 10.1006/dbio.1999.9378

PubMed ID: 15531373

Title: BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo.

PubMed ID: 15531373

DOI: 10.1016/j.ydbio.2004.08.042

PubMed ID: 21945937

Title: Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1.

PubMed ID: 21945937

DOI: 10.1016/j.bbrc.2011.09.060

PubMed ID: 25413979

Title: The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development.

PubMed ID: 25413979

DOI: 10.1002/jbmr.2385

PubMed ID: 31800957

Title: Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.

PubMed ID: 31800957

DOI: 10.1182/blood.2019002620

Sequence Information:

Length: 509
Mass: 57226
Checksum: 05BCFC22C5740028
Sequence:

MVDGVMILPV LMMMAFPSPS VEDEKPKVNQ KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN 
DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF 
HLEVGLIILS VVFAVCLLAC ILGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 
AELLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 
DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 
DTVSCLRIVL SIASGLAHLH IEIFGTQGKS AIAHRDLKSK NILVKKNGQC CIADLGLAVM 
HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 
NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 
NPSARLTALR IKKTLTKIDN SLDKLKTDC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Acvr1

Associated with

Other Information

Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor. PubMed ID: 8388127

High-throughput sequence identification of gene coding variants within alcohol-related QTLs. PubMed ID: 11471062

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. PubMed ID: 10479450

BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo. PubMed ID: 15531373

Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1. PubMed ID: 21945937

The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development. PubMed ID: 25413979

Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3. PubMed ID: 31800957