Genular: Defining Cellular Identity and Function

Details for: Acvr1b

Gene ID: 11479

Symbol: Acvr1b

Ensembl ID: ENSMUSG00000000532

Description: activin A receptor, type 1B

Associated with

Signaling by activin
(R-MMU-1502540)
Signaling by tgfb family members
(R-MMU-9006936)
Activin binding
(GO:0048185)
Activin receptor activity
(GO:0017002)
Activin receptor activity, type i
(GO:0016361)
Activin receptor complex
(GO:0048179)
Activin receptor signaling pathway
(GO:0032924)
Atp binding
(GO:0005524)
Cardiac fibroblast cell development
(GO:0060936)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to growth factor stimulus
(GO:0071363)
Cytosol
(GO:0005829)
Embryo development
(GO:0009790)
Extrinsic apoptotic signaling pathway
(GO:0097191)
G1/s transition of mitotic cell cycle
(GO:0000082)
Growth factor binding
(GO:0019838)
Hair follicle development
(GO:0001942)
I-smad binding
(GO:0070411)
Inhibin binding
(GO:0034711)
In utero embryonic development
(GO:0001701)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Mesoderm development
(GO:0007498)
Metal ion binding
(GO:0046872)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of gene expression
(GO:0010629)
Nervous system development
(GO:0007399)
Nodal signaling pathway
(GO:0038092)
Nucleotide binding
(GO:0000166)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of activin receptor signaling pathway
(GO:0032927)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of trophoblast cell migration
(GO:1901165)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Receptor complex
(GO:0043235)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of signal transduction
(GO:0009966)
Signal transduction
(GO:0007165)
Smad binding
(GO:0046332)
Transferase activity
(GO:0016740)
Transmembrane receptor protein serine/threonine kinase activity
(GO:0004675)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Activin receptor type-1B

Genular Protein ID: 502091816

Symbol: ACV1B_MOUSE

Name: Activin receptor type-1B

UniProtKB Accession Codes:

Q61271

Database IDs:

Citations:

PubMed ID: 7577669

Title: Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogensis.

PubMed ID: 7577669

DOI: 10.1016/0925-4773(95)00395-h

PubMed ID: 10681527

Title: Identification and characterization of a PDZ protein that interacts with activin types II receptors.

PubMed ID: 10681527

DOI: 10.1074/jbc.275.8.5485

PubMed ID: 16885157

Title: Transgenic mice expressing dominant-negative activin receptor IB in forebrain neurons reveal novel functions of activin at glutamatergic synapses.

PubMed ID: 16885157

DOI: 10.1074/jbc.m604959200

PubMed ID: 18039968

Title: Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.

PubMed ID: 18039968

DOI: 10.1242/dev.000026

PubMed ID: 21191412

Title: Conditional activin receptor type 1B (Acvr1b) knockout mice reveal hair loss abnormality.

PubMed ID: 21191412

DOI: 10.1038/jid.2010.400

Sequence Information:

Length: 505
Mass: 56700
Checksum: 56E9EEF1607A2517
Sequence:

MAESAGASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QTNYTCETDG ACMVSIFNLD 
GVEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYIDF CNKIDLRVPS GHLKEPAHPS 
MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 
DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 
ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 
IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 
DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 
GVHEDYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNVPNWW QSYEALRVMG KMMRECWYAN 
GAARLTALRI KKTLSQLSVQ EDVKI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Acvr1b

Associated with

Other Information

Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogensis. PubMed ID: 7577669

Identification and characterization of a PDZ protein that interacts with activin types II receptors. PubMed ID: 10681527

Transgenic mice expressing dominant-negative activin receptor IB in forebrain neurons reveal novel functions of activin at glutamatergic synapses. PubMed ID: 16885157