Genular: Defining Cellular Identity and Function

Details for: Acvr2a

Gene ID: 11480

Symbol: Acvr2a

Ensembl ID: ENSMUSG00000052155

Description: activin receptor IIA

Associated with

Signaling by activin
(R-MMU-1502540)
Signaling by bmp
(R-MMU-201451)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Activin binding
(GO:0048185)
Activin receptor activity
(GO:0017002)
Activin receptor complex
(GO:0048179)
Activin receptor signaling pathway
(GO:0032924)
Anterior/posterior pattern specification
(GO:0009952)
Atp binding
(GO:0005524)
Autophagy
(GO:0006914)
Bmp receptor activity
(GO:0098821)
Bmp signaling pathway
(GO:0030509)
Cell surface
(GO:0009986)
Cellular response to bmp stimulus
(GO:0071773)
Cellular response to growth factor stimulus
(GO:0071363)
Cellular response to oxygen-glucose deprivation
(GO:0090650)
Coreceptor activity
(GO:0015026)
Cytoplasm
(GO:0005737)
Determination of left/right symmetry
(GO:0007368)
Embryonic skeletal system development
(GO:0048706)
Gastrulation with mouth forming second
(GO:0001702)
Growth factor binding
(GO:0019838)
Inhibin-betaglycan-actrii complex
(GO:0034673)
Inhibin binding
(GO:0034711)
Kinase activity
(GO:0016301)
Male gonad development
(GO:0008584)
Membrane
(GO:0016020)
Mesoderm development
(GO:0007498)
Metal ion binding
(GO:0046872)
Nucleotide binding
(GO:0000166)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Pdz domain binding
(GO:0030165)
Penile erection
(GO:0043084)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of activin receptor signaling pathway
(GO:0032927)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of follicle-stimulating hormone secretion
(GO:0046881)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of smad protein signal transduction
(GO:0060391)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein self-association
(GO:0043621)
Protein serine/threonine kinase activity
(GO:0004674)
Receptor complex
(GO:0043235)
Regulation of nitric oxide biosynthetic process
(GO:0045428)
Regulation of signal transduction
(GO:0009966)
Sertoli cell proliferation
(GO:0060011)
Smad protein signal transduction
(GO:0060395)
Spermatogenesis
(GO:0007283)
Sperm ejaculation
(GO:0042713)
Transferase activity
(GO:0016740)
Transmembrane receptor protein serine/threonine kinase activity
(GO:0004675)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)

Other Information

Proteins

Activin receptor type IIA
Q8BRV4_MOUSE

Genular Protein ID: 801870623

Symbol: AVR2A_MOUSE

Name: Activin receptor type IIA

UniProtKB Accession Codes:

P27038

Database IDs:

Citations:

PubMed ID: 1646080

Title: Expression cloning of an activin receptor, a predicted transmembrane serine kinase.

PubMed ID: 1646080

DOI: 10.1016/0092-8674(91)90549-e

PubMed ID: 8395525

Title: Characterization of type II activin receptors. Binding, processing, and phosphorylation.

PubMed ID: 8395525

DOI: 10.1016/s0021-9258(17)46728-7

PubMed ID: 9886286

Title: Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase.

PubMed ID: 9886286

DOI: 10.1038/4887

PubMed ID: 10449041

Title: The disulfide bond arrangement in the extracellular domain of the activin type II receptor.

PubMed ID: 10449041

DOI: 10.1023/a:1020640725959

PubMed ID: 10681527

Title: Identification and characterization of a PDZ protein that interacts with activin types II receptors.

PubMed ID: 10681527

DOI: 10.1074/jbc.275.8.5485

PubMed ID: 23527555

Title: Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage.

PubMed ID: 23527555

DOI: 10.1111/febs.12256

Sequence Information:

Length: 513
Mass: 57890
Checksum: 475CD292506BAC61
Sequence:

MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC YGDKDKRRHC 
FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NEKFSYFPEM 
EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 
PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 
MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 
GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 
QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 
QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL

Genular Protein ID: 810291078

Symbol: Q8BRV4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BRV4

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 513
Mass: 57916
Checksum: FCD177F45819DF74
Sequence:

MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC YGDKDKRRHC 
FATWKNISGF IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NEKFSYFPEM 
EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 
PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 
MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 
GTRRYMAPEV LEGAINLQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 
QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 
QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Acvr2a

Associated with

Other Information

Expression cloning of an activin receptor, a predicted transmembrane serine kinase. PubMed ID: 1646080

Characterization of type II activin receptors. Binding, processing, and phosphorylation. PubMed ID: 8395525

Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase. PubMed ID: 9886286

The disulfide bond arrangement in the extracellular domain of the activin type II receptor. PubMed ID: 10449041

Identification and characterization of a PDZ protein that interacts with activin types II receptors. PubMed ID: 10681527

Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage. PubMed ID: 23527555

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073