Genular: Defining Cellular Identity and Function

Details for: Acvr2b

Gene ID: 11481

Symbol: Acvr2b

Ensembl ID: ENSMUSG00000061393

Description: activin receptor IIB

Associated with

Signaling by activin
(R-MMU-1502540)
Signaling by bmp
(R-MMU-201451)
Signaling by tgfb family members
(R-MMU-9006936)
Activin binding
(GO:0048185)
Activin receptor activity
(GO:0017002)
Activin receptor activity, type ii
(GO:0016362)
Activin receptor complex
(GO:0048179)
Activin receptor signaling pathway
(GO:0032924)
Anterior/posterior pattern specification
(GO:0009952)
Artery development
(GO:0060840)
Atp binding
(GO:0005524)
Blood vessel remodeling
(GO:0001974)
Bmp signaling pathway
(GO:0030509)
Cellular response to growth factor stimulus
(GO:0071363)
Cytoplasm
(GO:0005737)
Determination of left/right symmetry
(GO:0007368)
Embryonic foregut morphogenesis
(GO:0048617)
Gastrulation with mouth forming second
(GO:0001702)
Growth factor binding
(GO:0019838)
Heart development
(GO:0007507)
Inhibin binding
(GO:0034711)
Insulin secretion
(GO:0030073)
Kidney development
(GO:0001822)
Kinase activator activity
(GO:0019209)
Kinase activity
(GO:0016301)
Lung development
(GO:0030324)
Lymphangiogenesis
(GO:0001946)
Lymphatic endothelial cell differentiation
(GO:0060836)
Membrane
(GO:0016020)
Mesoderm development
(GO:0007498)
Metal ion binding
(GO:0046872)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleotide binding
(GO:0000166)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Organ growth
(GO:0035265)
Pancreas development
(GO:0031016)
Pattern specification process
(GO:0007389)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of activin receptor signaling pathway
(GO:0032927)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of osteoblast differentiation
(GO:0045669)
Post-embryonic development
(GO:0009791)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine/tyrosine kinase activity
(GO:0004712)
Protein serine/threonine kinase activity
(GO:0004674)
Receptor complex
(GO:0043235)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of signal transduction
(GO:0009966)
Response to glucose
(GO:0009749)
Retina vasculature development in camera-type eye
(GO:0061298)
Roof of mouth development
(GO:0060021)
Signal transduction
(GO:0007165)
Skeletal system development
(GO:0001501)
Skeletal system morphogenesis
(GO:0048705)
Transferase activity
(GO:0016740)
Transforming growth factor beta binding
(GO:0050431)
Transmembrane receptor protein serine/threonine kinase activity
(GO:0004675)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)
Venous blood vessel development
(GO:0060841)

Other Information

Proteins

Activin receptor type-2B

Genular Protein ID: 2449043564

Symbol: AVR2B_MOUSE

Name: Activin receptor type-2B

UniProtKB Accession Codes:

P27040 Q3KQI1

Database IDs:

Citations:

PubMed ID: 1310075

Title: Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors.

PubMed ID: 1310075

DOI: 10.1016/0092-8674(92)90209-u

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27502274

Title: Molecular basis for the protein recognition specificity of the dynein light chain DYNLT1/Tctex1: characterization of the interaction with activin receptor IIB.

PubMed ID: 27502274

DOI: 10.1074/jbc.m116.736884

PubMed ID: 22074949

Title: BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.

PubMed ID: 22074949

DOI: 10.1210/me.2011-1168

Sequence Information:

Length: 536
Mass: 60542
Checksum: BF1C8CAC974BF5E2
Sequence:

MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 
ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEPG 
GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEVRQCQR 
WAGRRDGCAD SFKPLPFQDP GPPPPSPLVG LKPLQLLEIK ARGRFGCVWK AQLMNDFVAV 
KIFPLQDKQS WQSEREIFST PGMKHENLLQ FIAAEKRGSN LEVELWLITA FHDKGSLTDY 
LKGNIITWNE LCHVAETMSR GLSYLHEDVP WCRGEGHKPS IAHRDFKSKN VLLKSDLTAV 
LADFGLAVRF EPGKPPGDTH GQVGTRRYMA PEVLEGAINF QRDAFLRIDM YAMGLVLWEL 
VSRCKAADGP VDEYMLPFEE EIGQHPSLEE LQEVVVHKKM RPTIKDHWLK HPGLAQLCVT 
IEECWDHDAE ARLSAGCVEE RVSLIRRSVN GTTSDCLVSL VTSVTNVDLL PKESSI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Acvr2b

Associated with

Other Information

Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. PubMed ID: 1310075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular basis for the protein recognition specificity of the dynein light chain DYNLT1/Tctex1: characterization of the interaction with activin receptor IIB. PubMed ID: 27502274

BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b. PubMed ID: 22074949

Database document:

PubMed ID: 1310075

PubMed ID: 15489334

PubMed ID: 27502274

PubMed ID: 22074949