Genular: Defining Cellular Identity and Function

Details for: Acvrl1

Gene ID: 11482

Symbol: Acvrl1

Ensembl ID: ENSMUSG00000000530

Description: activin A receptor, type II-like 1

Associated with

Signaling by bmp
(R-MMU-201451)
Signaling by tgfb family members
(R-MMU-9006936)
Activin binding
(GO:0048185)
Activin receptor activity, type i
(GO:0016361)
Angiogenesis
(GO:0001525)
Artery development
(GO:0060840)
Atp binding
(GO:0005524)
Blood circulation
(GO:0008015)
Blood vessel morphogenesis
(GO:0048514)
Blood vessel remodeling
(GO:0001974)
Bmp receptor activity
(GO:0098821)
Bmp receptor complex
(GO:0070724)
Bmp signaling pathway
(GO:0030509)
Cell surface
(GO:0009986)
Cellular response to bmp stimulus
(GO:0071773)
Cellular response to growth factor stimulus
(GO:0071363)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Dendrite
(GO:0030425)
Dorsal/ventral pattern formation
(GO:0009953)
Dorsal aorta morphogenesis
(GO:0035912)
Endocardial cushion morphogenesis
(GO:0003203)
Endocardial cushion to mesenchymal transition
(GO:0090500)
Endothelial cell activation
(GO:0042118)
Endothelial tube morphogenesis
(GO:0061154)
Heart development
(GO:0007507)
In utero embryonic development
(GO:0001701)
Kinase activity
(GO:0016301)
Lymphangiogenesis
(GO:0001946)
Lymphatic endothelial cell differentiation
(GO:0060836)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of blood vessel endothelial cell migration
(GO:0043537)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of endothelial cell differentiation
(GO:0045602)
Negative regulation of endothelial cell migration
(GO:0010596)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of focal adhesion assembly
(GO:0051895)
Negative regulation of gene expression
(GO:0010629)
Neuronal cell body
(GO:0043025)
Nucleotide binding
(GO:0000166)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of bicellular tight junction assembly
(GO:1903348)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of endothelial cell differentiation
(GO:0045603)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial cell differentiation
(GO:0030858)
Positive regulation of notch signaling pathway
(GO:0045747)
Positive regulation of smad protein signal transduction
(GO:0060391)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of blood pressure
(GO:0008217)
Regulation of dna-templated transcription
(GO:0006355)
Retina vasculature development in camera-type eye
(GO:0061298)
Signal transduction
(GO:0007165)
Smad binding
(GO:0046332)
Transferase activity
(GO:0016740)
Transforming growth factor beta binding
(GO:0050431)
Transforming growth factor beta receptor activity
(GO:0005024)
Transforming growth factor beta receptor activity, type i
(GO:0005025)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Transmembrane receptor protein serine/threonine kinase activity
(GO:0004675)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)
Venous blood vessel development
(GO:0060841)
Wound healing, spreading of epidermal cells
(GO:0035313)

Other Information

Proteins

Serine/threonine-protein kinase receptor R3

Genular Protein ID: 968125797

Symbol: ACVL1_MOUSE

Name: Serine/threonine-protein kinase receptor R3

UniProtKB Accession Codes:

Q61288 Q61289 Q91YR0

Database IDs:

Citations:

PubMed ID: 7488127

Title: Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog.

PubMed ID: 7488127

DOI: 10.1006/bbrc.1995.2594

PubMed ID: 7750489

Title: Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.

PubMed ID: 7750489

DOI: 10.1210/endo.136.6.7750489

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 502
Mass: 56519
Checksum: 439510D3CC740D65
Sequence:

MTLGSFRRGL LMLSVAFGLT RGDLAKPSKL VNCTCESPHC KRPFCQGSWC TVVLVREQGR 
HPQVYRGCGS LNQELCLGRP TEFLNHHCCY RSFCNHNVSL MLEATQTPSE EPEVDAHLPL 
ILGPVLALPV LVALGALGLW RVRRRQEKQR DLHSDLGESS LILKASEQAD SMLGDFLDSD 
CTTGSGSGLP FLVQRTVARQ VALVECVGKG RYGEVWRGSW HGESVAVKIF SSRDEQSWFR 
ETEIYNTVLL RHDNILGFIA SDMTSRNSST QLWLITHYHE HGSLYDFLQR QTLEPQLALR 
LAVSAACGLA HLHVEIFGTQ GKPAIAHRDL KSRNVLVKSN LQCCIADLGL AVMHSQSSDY 
LDIGNNPRVG TKRYMAPEVL DEHIRTDCFE SYKWTDIWAF GLVLWEIARR TIINGIVEDY 
RPPFYDMVPN DPSFEDMKKV VCVDQQTPTI PNRLAADPVL SGLAQMMREC WYPNPSARLT 
ALRIKKTLQK LSHNPEKPKV IH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Acvrl1

Associated with

Other Information

Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog. PubMed ID: 7488127

Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis. PubMed ID: 7750489

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319