Details for: CIDEA

Gene ID: 1149

Symbol: CIDEA

Ensembl ID: ENSG00000176194

Description: cell death inducing DFFA like effector a

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.52
    Marker Score: 1409
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.06
    Marker Score: 1002
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2216
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.37
    Marker Score: 500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.29
    Marker Score: 2438.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18126
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7522
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.93
    Marker Score: 245
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.9
    Marker Score: 1867
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 488
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.76
    Marker Score: 7210
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.7
    Marker Score: 1115
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.69
    Marker Score: 1413
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.66
    Marker Score: 258
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.66
    Marker Score: 314
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.64
    Marker Score: 5482
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.62
    Marker Score: 325
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 482
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.53
    Marker Score: 589
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.47
    Marker Score: 149
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.38
    Marker Score: 386
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.37
    Marker Score: 310.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 210
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.3
    Marker Score: 2584.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.29
    Marker Score: 223
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 119
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.26
    Marker Score: 80
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.25
    Marker Score: 380
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.23
    Marker Score: 533
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.22
    Marker Score: 81.5
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.22
    Marker Score: 1388
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 125.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.2
    Marker Score: 1554
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.18
    Marker Score: 43
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.16
    Marker Score: 100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 48.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.14
    Marker Score: 52
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.14
    Marker Score: 562.5
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.1
    Marker Score: 142.5
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.09
    Marker Score: 468
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.08
    Marker Score: 187.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 131
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.08
    Marker Score: 4640.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 59
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.07
    Marker Score: 98
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.06
    Marker Score: 93.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 66
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 15

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Other Information

**Key characteristics:** - CIDEA is a protein of the TNF superfamily. - It is a transmembrane protein that is expressed in both the nucleus and cytoplasm. - It is a key regulator of apoptosis, and its expression is upregulated in many types of cancer. **Pathways and functions:** - CIDEA is a key regulator of the apoptotic process. It binds to phosphatidic acid receptors on the surface of apoptotic cells, which triggers the activation of caspase-9, a protein that initiates the apoptotic cascade. - CIDEA also regulates the lipid metabolic process. It is a key regulator of lipid storage in fat cells, and its expression is upregulated in obesity and metabolic syndrome. - CIDEA also plays a role in negative regulation of cytokine production. It binds to phosphatidic acid receptors on the surface of immune cells, which inhibits the production of pro-inflammatory cytokines. **Clinical significance:** - Mutations in the CIDEA gene have been linked to a number of human diseases, including cancer, heart disease, and obesity. - CIDEA inhibitors are being investigated as a treatment for cancer and other diseases that are characterized by excessive cell death. **Other important points:** - CIDEA is a highly conserved protein, with a similar protein found in mice and rats. - It is a member of the TNF superfamily of proteins, which are a large family of proteins that are involved in inflammation and cell death. - CIDEA is a relatively new protein, and its full function is still being elucidated.

Genular Protein ID: 3730378971

Symbol: CIDEA_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60543 B0YIY7 Q6UPR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9564035

Title: CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor.

PubMed ID: 9564035

DOI: 10.1093/emboj/17.9.2526

PubMed ID: 18509062

Title: Cidea is associated with lipid droplets and insulin sensitivity in humans.

PubMed ID: 18509062

DOI: 10.1073/pnas.0802063105

PubMed ID: 19843876

Title: Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA.

PubMed ID: 19843876

DOI: 10.1152/ajpendo.00188.2009

PubMed ID: 26118629

Title: Cidea improves the metabolic profile through expansion of adipose tissue.

PubMed ID: 26118629

DOI: 10.1038/ncomms8433

Sequence Information:

  • Length: 219
  • Mass: 24687
  • Checksum: 05F704823CE71C0E
  • Sequence:
    • MEAARDYAGA LIRPLTFMGS QTKRVLFTPL MHPARPFRVS NHDRSSRRGV MASSLQELIS 
KTLDALVIAT GLVTLVLEED GTVVDTEEFF QTLGDNTHFM ILEKGQKWMP GSQHVPTCSP 
PKRSGIARVT FDLYRLNPKD FIGCLNVKAT MYEMYSVSYD IRCTGLKGLL RSLLRFLSYS 
AQVTGQFLIY LGTYMLRVLD DKEERPSLRS QAKGRFTCG

Genular Protein ID: 771186769

Symbol: B3KVA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVA2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GenomeRNAi 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 120
  • Mass: 13758
  • Checksum: 1F30DA19A66E3119
  • Sequence:
    • MILEKGQKWM PGSQHFPTCS PPKRSGIARV TFDLYRLNPK DFIGCLNVKA TMYEMYSVSY 
DIRCTGLKGL LRSLLRFLSY SAQVTGQFLI YLGTYMLRVL DDKEERPSLR SQAKGRFTCG

Genular Protein ID: 3873400873

Symbol: Q8N5P9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N5P9

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 GO 3 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 253
  • Mass: 28314
  • Checksum: 4ADFFB3DD7760A68
  • Sequence:
    • MRGDRASGGP GNHNGSWARE GPRLGPSWKR GLWSPRGGPN RPAEPSRPLT FMGSQTKRVL 
FTPLMHPARP FRVSNHDRSS RRGVMASSLQ ELISKTLDAL VIATGLVTLV LEEDGTVVDT 
EEFFQTLGDN THFMILEKGQ KWMPGSQHVP TCSPPKRSGI ARVTFDLYRL NPKDFIGCLN 
VKATMYEMYS VSYDIRCTGL KGLLRSLLRF LSYSAQVTGQ FLIYLGTYML RVLDDKEERP 
SLRSQAKGRF TCG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.