Details for: CIDEA

Gene ID: 1149

Symbol: CIDEA

Ensembl ID: ENSG00000176194

Description: cell death inducing DFFA like effector a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 22.5943
    Cell Significance Index: 97.1600
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 7.2808
    Cell Significance Index: 9.4200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 4.2812
    Cell Significance Index: 53.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9642
    Cell Significance Index: 68.1900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.6179
    Cell Significance Index: 2.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.5353
    Cell Significance Index: 19.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4247
    Cell Significance Index: 22.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2558
    Cell Significance Index: 6.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2423
    Cell Significance Index: 3.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2306
    Cell Significance Index: 4.5000
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.2046
    Cell Significance Index: 1.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1808
    Cell Significance Index: 79.9300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.1623
    Cell Significance Index: 2.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1064
    Cell Significance Index: 19.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0959
    Cell Significance Index: 19.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0749
    Cell Significance Index: 0.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0747
    Cell Significance Index: 51.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0594
    Cell Significance Index: 2.2500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0572
    Cell Significance Index: 0.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0568
    Cell Significance Index: 2.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0487
    Cell Significance Index: 3.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0463
    Cell Significance Index: 5.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0457
    Cell Significance Index: 2.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0392
    Cell Significance Index: 4.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0108
    Cell Significance Index: 3.8700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0031
    Cell Significance Index: -0.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0046
    Cell Significance Index: -0.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0049
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0051
    Cell Significance Index: -3.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0059
    Cell Significance Index: -2.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0069
    Cell Significance Index: -3.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0075
    Cell Significance Index: -0.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0132
    Cell Significance Index: -2.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0151
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0156
    Cell Significance Index: -2.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0170
    Cell Significance Index: -2.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0176
    Cell Significance Index: -2.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0194
    Cell Significance Index: -1.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0197
    Cell Significance Index: -2.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0248
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0257
    Cell Significance Index: -2.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0295
    Cell Significance Index: -3.0100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0302
    Cell Significance Index: -0.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0313
    Cell Significance Index: -2.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0366
    Cell Significance Index: -2.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0366
    Cell Significance Index: -1.6600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0379
    Cell Significance Index: -0.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0402
    Cell Significance Index: -2.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0415
    Cell Significance Index: -2.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0428
    Cell Significance Index: -1.5000
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.0436
    Cell Significance Index: -0.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0444
    Cell Significance Index: -1.1100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0478
    Cell Significance Index: -0.5300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0496
    Cell Significance Index: -0.4700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0529
    Cell Significance Index: -0.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0553
    Cell Significance Index: -1.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0571
    Cell Significance Index: -2.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0654
    Cell Significance Index: -1.7800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0696
    Cell Significance Index: -0.8200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0762
    Cell Significance Index: -0.8300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0790
    Cell Significance Index: -0.9100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0814
    Cell Significance Index: -0.9500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0865
    Cell Significance Index: -1.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0869
    Cell Significance Index: -2.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0872
    Cell Significance Index: -2.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0887
    Cell Significance Index: -2.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0903
    Cell Significance Index: -2.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0914
    Cell Significance Index: -1.8400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0926
    Cell Significance Index: -1.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0933
    Cell Significance Index: -2.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0952
    Cell Significance Index: -3.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0964
    Cell Significance Index: -2.1100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0968
    Cell Significance Index: -1.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0999
    Cell Significance Index: -2.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1011
    Cell Significance Index: -2.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1046
    Cell Significance Index: -2.2600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1082
    Cell Significance Index: -1.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1089
    Cell Significance Index: -2.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1090
    Cell Significance Index: -2.7800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1116
    Cell Significance Index: -2.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1126
    Cell Significance Index: -2.7000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1127
    Cell Significance Index: -2.4100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1138
    Cell Significance Index: -2.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1148
    Cell Significance Index: -2.2700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1163
    Cell Significance Index: -2.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1194
    Cell Significance Index: -3.1400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1223
    Cell Significance Index: -1.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1247
    Cell Significance Index: -3.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1250
    Cell Significance Index: -3.0500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1263
    Cell Significance Index: -1.6200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1264
    Cell Significance Index: -2.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CIDEA is a member of the DFFA-like effector family, which consists of proteins that regulate apoptosis and lipid metabolism. The gene is primarily expressed in cells with high lipid content, such as fat cells and cardiac myocytes. CIDEA contains a unique structure, consisting of two intracellular domains and one extracellular domain, which allows it to interact with various cellular components. The protein is also characterized by its ability to induce apoptosis, regulate lipid metabolism, and modulate thermogenesis. **Pathways and Functions:** CIDEA's functions can be categorized into several key pathways: 1. **Apoptotic Process:** CIDEA induces apoptosis by interacting with pro-apoptotic proteins and modulating the activity of caspases, a family of enzymes responsible for executing cell death. 2. **Lipid Metabolism:** CIDEA regulates lipid storage, transfer, and catabolism by interacting with lipid droplet proteins and modulating the activity of enzymes involved in lipid metabolism. 3. **Thermogenesis:** CIDEA modulates thermogenesis by regulating the expression of genes involved in heat production in response to cold stress. 4. **Cellular Response to Cold:** CIDEA is involved in regulating the cellular response to cold stress, including the expression of genes involved in thermogenesis and apoptosis. 5. **Intermembrane Lipid Transfer:** CIDEA participates in intermembrane lipid transfer by interacting with lipid transfer proteins and modulating the activity of enzymes involved in lipid metabolism. **Clinical Significance:** Dysregulation of CIDEA has been implicated in various diseases, including: 1. **Obesity and Metabolic Disorders:** Overexpression of CIDEA has been linked to obesity and metabolic disorders, such as insulin resistance and type 2 diabetes. 2. **Cardiovascular Disease:** CIDEA's role in regulating thermogenesis and apoptosis makes it a potential target for preventing cardiovascular disease. 3. **Cancer:** CIDEA's ability to induce apoptosis makes it a potential target for cancer therapy. 4. **Neurodegenerative Diseases:** CIDEA's involvement in lipid metabolism and thermogenesis makes it a potential target for preventing neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, CIDEA is a key regulator of apoptosis, lipid metabolism, and thermogenesis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms of CIDEA's functions and to explore its potential as a therapeutic target.

Genular Protein ID: 3730378971

Symbol: CIDEA_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60543 B0YIY7 Q6UPR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9564035

Title: CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor.

PubMed ID: 9564035

DOI: 10.1093/emboj/17.9.2526

PubMed ID: 18509062

Title: Cidea is associated with lipid droplets and insulin sensitivity in humans.

PubMed ID: 18509062

DOI: 10.1073/pnas.0802063105

PubMed ID: 19843876

Title: Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA.

PubMed ID: 19843876

DOI: 10.1152/ajpendo.00188.2009

PubMed ID: 26118629

Title: Cidea improves the metabolic profile through expansion of adipose tissue.

PubMed ID: 26118629

DOI: 10.1038/ncomms8433

Sequence Information:

  • Length: 219
  • Mass: 24687
  • Checksum: 05F704823CE71C0E
  • Sequence:
    • MEAARDYAGA LIRPLTFMGS QTKRVLFTPL MHPARPFRVS NHDRSSRRGV MASSLQELIS 
KTLDALVIAT GLVTLVLEED GTVVDTEEFF QTLGDNTHFM ILEKGQKWMP GSQHVPTCSP 
PKRSGIARVT FDLYRLNPKD FIGCLNVKAT MYEMYSVSYD IRCTGLKGLL RSLLRFLSYS 
AQVTGQFLIY LGTYMLRVLD DKEERPSLRS QAKGRFTCG

Genular Protein ID: 771186769

Symbol: B3KVA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVA2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 120
  • Mass: 13758
  • Checksum: 1F30DA19A66E3119
  • Sequence:
    • MILEKGQKWM PGSQHFPTCS PPKRSGIARV TFDLYRLNPK DFIGCLNVKA TMYEMYSVSY 
DIRCTGLKGL LRSLLRFLSY SAQVTGQFLI YLGTYMLRVL DDKEERPSLR SQAKGRFTCG

Genular Protein ID: 3873400873

Symbol: Q8N5P9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N5P9

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 GO 3 Gene3D 1 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 253
  • Mass: 28314
  • Checksum: 4ADFFB3DD7760A68
  • Sequence:
    • MRGDRASGGP GNHNGSWARE GPRLGPSWKR GLWSPRGGPN RPAEPSRPLT FMGSQTKRVL 
FTPLMHPARP FRVSNHDRSS RRGVMASSLQ ELISKTLDAL VIATGLVTLV LEEDGTVVDT 
EEFFQTLGDN THFMILEKGQ KWMPGSQHVP TCSPPKRSGI ARVTFDLYRL NPKDFIGCLN 
VKATMYEMYS VSYDIRCTGL KGLLRSLLRF LSYSAQVTGQ FLIYLGTYML RVLDDKEERP 
SLRSQAKGRF TCG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.