Genular: Defining Cellular Identity and Function

Details for: Adam17

Gene ID: 11491

Symbol: Adam17

Ensembl ID: ENSMUSG00000052593

Description: a disintegrin and metallopeptidase domain 17

Associated with

Death receptor signaling
(R-MMU-73887)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
Regulated proteolysis of p75ntr
(R-MMU-193692)
Signal transduction
(R-MMU-162582)
Tnf signaling
(R-MMU-75893)
Actin cytoskeleton
(GO:0015629)
Amyloid precursor protein catabolic process
(GO:0042987)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
B cell differentiation
(GO:0030183)
Cell-cell junction
(GO:0005911)
Cell adhesion
(GO:0007155)
Cell adhesion mediated by integrin
(GO:0033627)
Cell motility
(GO:0048870)
Cell surface
(GO:0009986)
Cellular response to high density lipoprotein particle stimulus
(GO:0071403)
Commissural neuron axon guidance
(GO:0071679)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to gram-positive bacterium
(GO:0050830)
Endopeptidase activity
(GO:0004175)
Extracellular region
(GO:0005576)
Focal adhesion
(GO:0005925)
Germinal center formation
(GO:0002467)
Hydrolase activity
(GO:0016787)
Integrin binding
(GO:0005178)
Interleukin-6 receptor binding
(GO:0005138)
Membrane
(GO:0016020)
Membrane protein ectodomain proteolysis
(GO:0006509)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Metallodipeptidase activity
(GO:0070573)
Metalloendopeptidase activity
(GO:0004222)
Metalloendopeptidase activity involved in amyloid precursor protein catabolic process
(GO:1902945)
Metallopeptidase activity
(GO:0008237)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Notch binding
(GO:0005112)
Notch receptor processing
(GO:0007220)
Notch signaling pathway
(GO:0007219)
Pdz domain binding
(GO:0030165)
Peptidase activity
(GO:0008233)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045737)
Positive regulation of epidermal growth factor-activated receptor activity
(GO:0045741)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of t cell chemotaxis
(GO:0010820)
Positive regulation of tumor necrosis factor-mediated signaling pathway
(GO:1903265)
Positive regulation of vascular endothelial cell proliferation
(GO:1905564)
Production of molecular mediator involved in inflammatory response
(GO:0002532)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Regulation of axon regeneration
(GO:0048679)
Regulation of mast cell apoptotic process
(GO:0033025)
Regulation of neuron migration
(GO:2001222)
Response to hypoxia
(GO:0001666)
Response to lipopolysaccharide
(GO:0032496)
Response to xenobiotic stimulus
(GO:0009410)
Ruffle membrane
(GO:0032587)
Serine-type endopeptidase activity
(GO:0004252)
Sh3 domain binding
(GO:0017124)
Signaling receptor ligand precursor processing
(GO:0140448)
Spleen development
(GO:0048536)
T cell differentiation in thymus
(GO:0033077)
Tumor necrosis factor binding
(GO:0043120)

Other Information

Proteins

Disintegrin and metalloproteinase domain-containing protein 17
E9PXU2_MOUSE

Genular Protein ID: 2063777905

Symbol: ADA17_MOUSE

Name: Disintegrin and metalloproteinase domain-containing protein 17

UniProtKB Accession Codes:

Q9Z0F8 O88726 Q505A7 Q9R1U4 Q9Z0K3

Database IDs:

Citations:

PubMed ID: 10433800

Title: Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25.

PubMed ID: 10433800

DOI: 10.1006/cyto.1998.0466

PubMed ID: 9755855

Title: TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3.

PubMed ID: 9755855

DOI: 10.1016/s0014-5793(98)01031-x

PubMed ID: 10375622

Title: cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter.

PubMed ID: 10375622

DOI: 10.1016/s0378-1119(99)00155-9

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11108241

Title: Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation.

PubMed ID: 11108241

DOI: 10.1210/endo.141.12.7858

PubMed ID: 10799547

Title: Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme.

PubMed ID: 10799547

DOI: 10.1074/jbc.275.19.14608

PubMed ID: 10882063

Title: A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.

PubMed ID: 10882063

DOI: 10.1016/s1097-2765(00)80417-7

PubMed ID: 12907434

Title: Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets.

PubMed ID: 12907434

DOI: 10.1182/blood-2003-04-1305

PubMed ID: 17245433

Title: Metalloproteases regulate T-cell proliferation and effector function via LAG-3.

PubMed ID: 17245433

DOI: 10.1038/sj.emboj.7601520

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 827
Mass: 93056
Checksum: 6B434F80878197F5
Sequence:

MRRRLLILTT LVPFVLAPRP PEEAGSGSHP RLEKLDSLLS DYDILSLANI QQHSIRKRDL 
QSATHLETLL TFSALKRHFK LYLTSSTERF SQNLRVVVVD GKEESEYSVK WQNFFSGHVV 
GEPDSRVLAH IGDDDVTVRI NTDGAEYNVE PLWRFVNDTK DKRMLVYKSE DIKDFSRLQS 
PKVCGYLNAD SEELLPKGLI DREPSEEFVR RVKRRAEPNP LKNTCKLLVV ADHRFYKYMG 
RGEESTTTNY LIELIDRVDD IYRNTSWDNA GFKGYGVQIE QIRILKSPQE VKPGERHFNM 
AKSFPNEEKD AWDVKMLLEQ FSFDIAEEAS KVCLAHLFTY QDFDMGTLGL AYVGSPRANS 
HGGVCPKAYY NPTVKKNIYL NSGLTSTKNY GKTILTKEAD LVTTHELGHN FGAEHDPDGL 
AECAPNEDQG GKYVMYPIAV SGDHENNKMF SNCSKQSIYK TIESKAQECF QERSNKVCGN 
SRVDEGEECD PGIMYLNNDT CCNSDCTLKP GVQCSDRNSP CCKNCQFETA QKKCQEAINA 
TCKGVSYCTG NSSECPPPGD AEDDTVCLDL GKCKAGKCIP FCKREQELES CACVDTDNSC 
KVCCRNLSGP CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE RFWDFIDQLS 
INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCVDKKLDK QYESLSLFHH SNIEMLSSMD 
SASVRIIKPF PAPQTPGRLQ ALQPAAMMPP VPAAPKLDHQ RMDTIQEDPS TDSHADDDGF 
EKDPFPNSST AAKSFEDLTD HPVTRSEKAA SFKLQRQSRV DSKETEC

Genular Protein ID: 1449071154

Symbol: E9PXU2_MOUSE

Name: N/A

UniProtKB Accession Codes:

E9PXU2

Database IDs:

Citations:

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 846
Mass: 95232
Checksum: C01A02A09F36EB80
Sequence:

MRRRLLILTT LVPFVLAPRP PEEAGSGSHP RLEKLDSLLS DYDILSLANI QQHSIRKRDL 
QSATHLETLL TFSALKRHFK LYLTSSTERF SQNLRVVVVD GKEESEYSVK WQNFFSGHVV 
GEPDSRVLAH IGDDDVTVRI NTDGAEYNVE PLWRFVNDTK DKRMLVYKSE DIKDFSRLQS 
PKVCGYLNAD SEELLPKGLI DREPSEEFVR RVKRRAEPNP LKNTCKLLVV ADHRFYKYMG 
RGEESTTTNY LGYISGTRDR VTTDCFLEFL IELIDRVDDI YRNTSWDNAG FKGYGVQIEQ 
IRILKSPQEV KPGERHFNMA KSFPNEEKDA WDVKMLLEQF SFDIAEEASK VCLAHLFTYQ 
DFDMGTLGLA YVGSPRANSH GGVCPKAYYN PTVKKNIYLN SGLTSTKNYG KTILTKEADL 
VTTHELGHNF GAEHDPDGLA ECAPNEDQGG KYVMYPIAVS GDHENNKMFS NCSKQSIYKT 
IESKAQECFQ ERSNKVCGNS RVDEGEECDP GIMYLNNDTC CNSDCTLKPG VQCSDRNSPC 
CKNCQFETAQ KKCQEAINAT CKGVSYCTGN SSECPPPGDA EDDTVCLDLG KCKAGKCIPF 
CKREQELESC ACVDTDNSCK VCCRNLSGPC VPYVDAEQKN LFLRKGKPCT VGFCDMNGKC 
EKRVQDVIER FWDFIDQLSI NTFGKFLADN IVGSVLVFSL IFWIPFSILV HCVDKKLDKQ 
YESLSLFHHS NIEMLSSMDS ASVRIIKPFP APQTPGRLQA LQPAAMMPPV PAAPKLDHQR 
MDTIQEDPST DSHADDDGFE KDPFPNSSTA AKSFEDLTDH PVTRSEKAAS FKLQRQSRVD 
SKETEC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Adam17

Associated with

Other Information

Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25. PubMed ID: 10433800

TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3. PubMed ID: 9755855

cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter. PubMed ID: 10375622

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation. PubMed ID: 11108241

Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme. PubMed ID: 10799547

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. PubMed ID: 10882063

Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. PubMed ID: 12907434

Metalloproteases regulate T-cell proliferation and effector function via LAG-3. PubMed ID: 17245433

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 10433800

PubMed ID: 9755855

PubMed ID: 10375622

PubMed ID: 16141072

PubMed ID: 15489334

PubMed ID: 11108241

PubMed ID: 10799547

PubMed ID: 10882063

PubMed ID: 12907434

PubMed ID: 17245433

PubMed ID: 19144319

PubMed ID: 21183079

PubMed ID: 19144319

PubMed ID: 19468303

PubMed ID: 21183079