Details for: ADCY9

Gene ID: 115

Symbol: ADCY9

Ensembl ID: ENSG00000162104

Description: adenylate cyclase 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 244.4305
    Cell Significance Index: -38.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 149.9743
    Cell Significance Index: -38.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.1735
    Cell Significance Index: -36.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.8695
    Cell Significance Index: -30.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.4744
    Cell Significance Index: -30.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.8365
    Cell Significance Index: -38.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.4498
    Cell Significance Index: -36.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.7147
    Cell Significance Index: -23.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6856
    Cell Significance Index: -38.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 3.0734
    Cell Significance Index: 446.7600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.0419
    Cell Significance Index: 74.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.7856
    Cell Significance Index: 123.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.7517
    Cell Significance Index: 104.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.3144
    Cell Significance Index: 59.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2196
    Cell Significance Index: 445.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1558
    Cell Significance Index: 165.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.0599
    Cell Significance Index: 138.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7406
    Cell Significance Index: 345.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.7234
    Cell Significance Index: 49.1800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.6709
    Cell Significance Index: 26.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2984
    Cell Significance Index: 465.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0442
    Cell Significance Index: 20.3800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.0195
    Cell Significance Index: 13.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9973
    Cell Significance Index: 689.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8624
    Cell Significance Index: 24.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6552
    Cell Significance Index: 64.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6146
    Cell Significance Index: 554.9000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4867
    Cell Significance Index: 7.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4383
    Cell Significance Index: 19.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4342
    Cell Significance Index: 26.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3359
    Cell Significance Index: 54.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3296
    Cell Significance Index: 620.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3013
    Cell Significance Index: 16.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2797
    Cell Significance Index: 8.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2125
    Cell Significance Index: 23.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1998
    Cell Significance Index: 4.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1976
    Cell Significance Index: 4.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1942
    Cell Significance Index: 123.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1762
    Cell Significance Index: 3.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1384
    Cell Significance Index: 3.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1377
    Cell Significance Index: 211.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1052
    Cell Significance Index: 142.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0978
    Cell Significance Index: 180.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0924
    Cell Significance Index: 17.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0900
    Cell Significance Index: 40.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0534
    Cell Significance Index: 1.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0521
    Cell Significance Index: 3.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0464
    Cell Significance Index: 8.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0391
    Cell Significance Index: 6.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0336
    Cell Significance Index: 2.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0232
    Cell Significance Index: 1.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0182
    Cell Significance Index: 9.9500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0135
    Cell Significance Index: 0.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0087
    Cell Significance Index: 3.8600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0181
    Cell Significance Index: -0.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0291
    Cell Significance Index: -4.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0390
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0394
    Cell Significance Index: -29.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0423
    Cell Significance Index: -32.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0429
    Cell Significance Index: -31.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0616
    Cell Significance Index: -34.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0633
    Cell Significance Index: -2.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0677
    Cell Significance Index: -42.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1101
    Cell Significance Index: -31.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1639
    Cell Significance Index: -18.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1655
    Cell Significance Index: -19.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1861
    Cell Significance Index: -6.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1906
    Cell Significance Index: -40.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2172
    Cell Significance Index: -4.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2223
    Cell Significance Index: -23.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2278
    Cell Significance Index: -29.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2390
    Cell Significance Index: -24.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2675
    Cell Significance Index: -34.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2676
    Cell Significance Index: -5.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2933
    Cell Significance Index: -15.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3114
    Cell Significance Index: -36.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3369
    Cell Significance Index: -17.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3477
    Cell Significance Index: -5.8600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3779
    Cell Significance Index: -5.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3957
    Cell Significance Index: -24.9400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4194
    Cell Significance Index: -5.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4208
    Cell Significance Index: -33.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4443
    Cell Significance Index: -14.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4494
    Cell Significance Index: -33.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4510
    Cell Significance Index: -21.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4520
    Cell Significance Index: -27.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4560
    Cell Significance Index: -32.2500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4883
    Cell Significance Index: -5.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5098
    Cell Significance Index: -16.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5129
    Cell Significance Index: -7.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5248
    Cell Significance Index: -7.5200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5491
    Cell Significance Index: -6.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5526
    Cell Significance Index: -11.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5588
    Cell Significance Index: -11.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5887
    Cell Significance Index: -30.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6027
    Cell Significance Index: -12.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6055
    Cell Significance Index: -7.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6592
    Cell Significance Index: -14.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6855
    Cell Significance Index: -21.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6865
    Cell Significance Index: -24.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Enzyme function**: ADCY9 is a G-protein coupled receptor (GPCR) that activates adenylate cyclase, an enzyme responsible for converting ATP into cAMP. 2. **Cellular localization**: ADCY9 is expressed in various cell types, including neurons, astrocytes, and skeletal muscle fibers. 3. **Signaling pathways**: ADCY9 is involved in multiple signaling pathways, including the activation of GABA receptors, adrenergic receptor signaling, and hedgehog signaling. 4. **Regulation**: ADCY9 is regulated by various mechanisms, including phosphorylation, ubiquitination, and proteasomal degradation. **Pathways and Functions** 1. **Neurotransmission**: ADCY9 plays a crucial role in neurotransmission, particularly in the regulation of GABAergic signaling in the cerebral cortex. 2. **Immune response**: ADCY9 is involved in the regulation of immune responses, including the production of anti-inflammatory cytokines and the modulation of inflammatory responses. 3. **Energy metabolism**: ADCY9 is involved in the regulation of energy metabolism, particularly in the regulation of glucagon signaling and glucose homeostasis. 4. **Infectious disease**: ADCY9 has been implicated in the regulation of Leishmania parasite growth and survival, highlighting its importance in the immune response to parasitic infections. **Clinical Significance** 1. **Neurological disorders**: Alterations in ADCY9 expression and function have been implicated in various neurological disorders, including epilepsy, schizophrenia, and Alzheimer's disease. 2. **Immune system dysregulation**: Dysregulation of ADCY9 has been linked to immune system dysregulation, including autoimmune diseases and cancer. 3. **Metabolic disorders**: ADCY9 has been implicated in the regulation of glucose homeostasis, highlighting its potential role in the treatment of metabolic disorders, such as type 2 diabetes. 4. **Infectious disease**: Understanding the role of ADCY9 in the regulation of Leishmania parasite growth and survival may provide new insights into the development of treatments for this disease. In conclusion, the ADCY9 gene plays a crucial role in regulating various cellular signaling pathways, including neurotransmission, immune response, and energy metabolism. Its dysregulation has been implicated in various neurological and metabolic disorders, highlighting the importance of further research into the mechanisms of ADCY9 function and its potential therapeutic applications.

Genular Protein ID: 2299000100

Symbol: ADCY9_HUMAN

Name: ATP pyrophosphate-lyase 9

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9628827

Title: Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9).

PubMed ID: 9628827

DOI: 10.1006/geno.1998.5293

PubMed ID: 12972952

Title: An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation.

PubMed ID: 12972952

DOI: 10.1097/00008571-200309000-00002

PubMed ID: 15879435

Title: Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways.

PubMed ID: 15879435

DOI: 10.1093/hmg/ddi175

PubMed ID: 10987815

Title: Characterisation of human adenylyl cyclase IX reveals inhibition by Ca(2+)/Calcineurin and differential mRNA plyadenylation.

PubMed ID: 10987815

DOI: 10.1046/j.1471-4159.2000.0751358.x

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1353
  • Mass: 150701
  • Checksum: 4CBF051EA49B5B7B
  • Sequence:
  • MASPPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN SHPKHCKYSI SSSCSSSGDS 
    GGVPRRVGGG GRLRRQKKLP QLFERASSRW WDPKFDSVNL EEACLERCFP QTQRRFRYAL 
    FYIGFACLLW SIYFAVHMRS RLIVMVAPAL CFLLVCVGFF LFTFTKLYAR HYAWTSLALT 
    LLVFALTLAA QFQVLTPVSG RGDSSNLTAT ARPTDTCLSQ VGSFSMCIEV LFLLYTVMHL 
    PLYLSLCLGV AYSVLFETFG YHFRDEACFP SPGAGALHWE LLSRGLLHGC IHAIGVHLFV 
    MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG DEESENSVKR 
    HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI VGFTKMSANK SAHALVGLLN 
    DLFGRFDRLC EETKCEKIST LGDCYYCVAG CPEPRADHAY CCIEMGLGMI KAIEQFCQEK 
    KEMVNMRVGV HTGTVLCGIL GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD 
    DRYEMEDGKV IERLGQSVVA DQLKGLKTYL ISGQRAKESR CSCAEALLSG FEVIDGSQVS 
    SGPRGQGTAS SGNVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGAP QNGCQDEHKN 
    STKASGGPNP KTQNGLLSPP QEEKLTNSQT SLCEILQEKG RWAGVSLDQS ALLPLRFKNI 
    REKTDAHFVD VIKEDSLMKD YFFKPPINQF SLNFLDQELE RSYRTSYQEE VIKNSPVKTF 
    ASPTFSSLLD VFLSTTVFLT LSTTCFLKYE AATVPPPPAA LAVFSAALLL EVLSLAVSIR 
    MVFFLEDVMA CTKRLLEWIA GWLPRHCIGA ILVSLPALAV YSHVTSEYET NIHFPVFTGS 
    AALIAVVHYC NFCQLSSWMR SSLATVVGAG PLLLLYVSLC PDSSVLTSPL DAVQNFSSER 
    NPCNSSVPRD LRRPASLIGQ EVVLVFFLLL LLVWFLNREF EVSYRLHYHG DVEADLHRTK 
    IQSMRDQADW LLRNIIPYHV AEQLKVSQTY SKNHDSGGVI FASIVNFSEF YEENYEGGKE 
    CYRVLNELIG DFDELLSKPD YSSIEKIKTI GATYMAASGL NTAQAQDGSH PQEHLQILFE 
    FAKEMMRVVD DFNNNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT 
    GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCTDHRV IPQHQLSISP 
    DIRVQVDGSI GRSPTDEIAN LVPSVQYVDK TSLGSDSSTQ AKDAHLSPKR PWKEPVKAEE 
    RGRFGKAIEK DDCDETGIEE ANELTKLNVS KSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.