Details for: ADCY9

Gene ID: 115

Symbol: ADCY9

Ensembl ID: ENSG00000162104

Description: adenylate cyclase 9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.04
    Marker Score: 7620
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.31
    Marker Score: 34590
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.24
    Marker Score: 6378
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.06
    Marker Score: 8546
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2
    Marker Score: 73923
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.95
    Marker Score: 41556
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.94
    Marker Score: 119022
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.91
    Marker Score: 17963
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.91
    Marker Score: 42665
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.88
    Marker Score: 7659
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.86
    Marker Score: 70703
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.85
    Marker Score: 17621
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.85
    Marker Score: 2131
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.82
    Marker Score: 36129
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.75
    Marker Score: 13410
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.74
    Marker Score: 14974
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.72
    Marker Score: 17799
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.71
    Marker Score: 7177
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.7
    Marker Score: 994
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.7
    Marker Score: 1277
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.69
    Marker Score: 2840
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.69
    Marker Score: 6522
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.67
    Marker Score: 26804
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.66
    Marker Score: 694
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.62
    Marker Score: 2495
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.58
    Marker Score: 1509
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.58
    Marker Score: 3717.5
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.57
    Marker Score: 3608
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.57
    Marker Score: 7245
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.55
    Marker Score: 5185
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.54
    Marker Score: 451
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.52
    Marker Score: 3083
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.52
    Marker Score: 2915
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168317
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.46
    Marker Score: 1123
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.45
    Marker Score: 787
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.4
    Marker Score: 641
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.38
    Marker Score: 470
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.38
    Marker Score: 377
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.36
    Marker Score: 672
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.36
    Marker Score: 755
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.33
    Marker Score: 2929
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.33
    Marker Score: 1610
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20343
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.3
    Marker Score: 882.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.23
    Marker Score: 9294
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.23
    Marker Score: 355
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.21
    Marker Score: 4284
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.18
    Marker Score: 6329
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.16
    Marker Score: 444.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.14
    Marker Score: 358
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.14
    Marker Score: 3725
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.14
    Marker Score: 1414
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.13
    Marker Score: 1216
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.08
    Marker Score: 648
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.08
    Marker Score: 5656
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.07
    Marker Score: 1443
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.03
    Marker Score: 1171
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.02
    Marker Score: 325
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.02
    Marker Score: 3634
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.01
    Marker Score: 4228
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.01
    Marker Score: 588
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48004
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.99
    Marker Score: 5950
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.99
    Marker Score: 475
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.98
    Marker Score: 646
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.96
    Marker Score: 304.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.96
    Marker Score: 6169
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.95
    Marker Score: 822
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.94
    Marker Score: 304
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.94
    Marker Score: 562
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.91
    Marker Score: 808
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5097
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.87
    Marker Score: 215
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.87
    Marker Score: 324.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.87
    Marker Score: 315
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.87
    Marker Score: 3740
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.84
    Marker Score: 1044
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.84
    Marker Score: 444
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.81
    Marker Score: 27419
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.79
    Marker Score: 441
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.78
    Marker Score: 1096
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.76
    Marker Score: 286
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.76
    Marker Score: 1073
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3177
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.75
    Marker Score: 437
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.75
    Marker Score: 4027

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Other Information

**Key characteristics:** * ADCY9 is a transmembrane protein that is expressed in a variety of cell types. * It is a key regulator of water and electrolyte homeostasis, and its expression is regulated by a number of hormones and signaling pathways. * ADCY9 is a key regulator of the aquaporin-mediated transport of water across cell membranes. * It is also a key regulator of the Gpcr downstream signaling pathway, which is involved in the regulation of blood pressure. * ADCY9 is a key regulator of the Hedgehog 'off' state, which is a developmental process that is involved in the formation of the central nervous system. * It is also a key regulator of the signaling by gpcr, which is a G protein-coupled receptor that is involved in the regulation of blood pressure and water balance. **Pathways and functions:** * ADCY9 is a key regulator of the aquaporin-mediated transport of water across cell membranes. This is important for maintaining water and electrolyte homeostasis in the body. * It is also a key regulator of the Gpcr downstream signaling pathway, which is involved in the regulation of blood pressure. * ADCY9 is a key regulator of the Hedgehog 'off' state, which is a developmental process that is involved in the formation of the central nervous system. * It is also a key regulator of the signaling by gpcr, which is a G protein-coupled receptor that is involved in the regulation of blood pressure and water balance. **Clinical significance:** Mutations in the ADCY9 gene have been linked to a number of human diseases, including cerebral palsy, stroke, and heart failure. These diseases are all characterized by abnormal water and electrolyte homeostasis, which is partly due to defects in the function of ADCY9.

Genular Protein ID: 2299000100

Symbol: ADCY9_HUMAN

Name: ATP pyrophosphate-lyase 9

UniProtKB Accession Codes:

O60503 A7E2V5 A7E2X2 D3DUD1 O60273 Q4ZHT9 Q4ZIR5 Q9BWT4 Q9UGP2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 21 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 Rhea 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9628827

Title: Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9).

PubMed ID: 9628827

DOI: 10.1006/geno.1998.5293

PubMed ID: 12972952

Title: An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation.

PubMed ID: 12972952

DOI: 10.1097/00008571-200309000-00002

PubMed ID: 15879435

Title: Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways.

PubMed ID: 15879435

DOI: 10.1093/hmg/ddi175

PubMed ID: 10987815

Title: Characterisation of human adenylyl cyclase IX reveals inhibition by Ca(2+)/Calcineurin and differential mRNA plyadenylation.

PubMed ID: 10987815

DOI: 10.1046/j.1471-4159.2000.0751358.x

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1353
  • Mass: 150701
  • Checksum: 4CBF051EA49B5B7B
  • Sequence:
    • MASPPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN SHPKHCKYSI SSSCSSSGDS 
GGVPRRVGGG GRLRRQKKLP QLFERASSRW WDPKFDSVNL EEACLERCFP QTQRRFRYAL 
FYIGFACLLW SIYFAVHMRS RLIVMVAPAL CFLLVCVGFF LFTFTKLYAR HYAWTSLALT 
LLVFALTLAA QFQVLTPVSG RGDSSNLTAT ARPTDTCLSQ VGSFSMCIEV LFLLYTVMHL 
PLYLSLCLGV AYSVLFETFG YHFRDEACFP SPGAGALHWE LLSRGLLHGC IHAIGVHLFV 
MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG DEESENSVKR 
HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI VGFTKMSANK SAHALVGLLN 
DLFGRFDRLC EETKCEKIST LGDCYYCVAG CPEPRADHAY CCIEMGLGMI KAIEQFCQEK 
KEMVNMRVGV HTGTVLCGIL GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD 
DRYEMEDGKV IERLGQSVVA DQLKGLKTYL ISGQRAKESR CSCAEALLSG FEVIDGSQVS 
SGPRGQGTAS SGNVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGAP QNGCQDEHKN 
STKASGGPNP KTQNGLLSPP QEEKLTNSQT SLCEILQEKG RWAGVSLDQS ALLPLRFKNI 
REKTDAHFVD VIKEDSLMKD YFFKPPINQF SLNFLDQELE RSYRTSYQEE VIKNSPVKTF 
ASPTFSSLLD VFLSTTVFLT LSTTCFLKYE AATVPPPPAA LAVFSAALLL EVLSLAVSIR 
MVFFLEDVMA CTKRLLEWIA GWLPRHCIGA ILVSLPALAV YSHVTSEYET NIHFPVFTGS 
AALIAVVHYC NFCQLSSWMR SSLATVVGAG PLLLLYVSLC PDSSVLTSPL DAVQNFSSER 
NPCNSSVPRD LRRPASLIGQ EVVLVFFLLL LLVWFLNREF EVSYRLHYHG DVEADLHRTK 
IQSMRDQADW LLRNIIPYHV AEQLKVSQTY SKNHDSGGVI FASIVNFSEF YEENYEGGKE 
CYRVLNELIG DFDELLSKPD YSSIEKIKTI GATYMAASGL NTAQAQDGSH PQEHLQILFE 
FAKEMMRVVD DFNNNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT 
GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCTDHRV IPQHQLSISP 
DIRVQVDGSI GRSPTDEIAN LVPSVQYVDK TSLGSDSSTQ AKDAHLSPKR PWKEPVKAEE 
RGRFGKAIEK DDCDETGIEE ANELTKLNVS KSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.