Details for: CKB

Gene ID: 1152

Symbol: CKB

Ensembl ID: ENSG00000166165

Description: creatine kinase B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 738.9169
    Cell Significance Index: -114.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 453.6684
    Cell Significance Index: -115.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 244.4486
    Cell Significance Index: -100.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 233.7740
    Cell Significance Index: -110.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 208.3656
    Cell Significance Index: -84.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 194.2319
    Cell Significance Index: -99.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 93.7990
    Cell Significance Index: -115.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 88.6312
    Cell Significance Index: -84.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 39.1585
    Cell Significance Index: -104.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 29.3940
    Cell Significance Index: -115.9900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 19.3646
    Cell Significance Index: 149.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 16.0043
    Cell Significance Index: 840.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.9180
    Cell Significance Index: -23.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 8.8014
    Cell Significance Index: 398.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 6.6394
    Cell Significance Index: 418.4600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 5.7900
    Cell Significance Index: 71.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.7103
    Cell Significance Index: 320.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.4758
    Cell Significance Index: 126.5100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 3.7543
    Cell Significance Index: 19.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.3247
    Cell Significance Index: 87.4200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.1820
    Cell Significance Index: 28.0300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.8457
    Cell Significance Index: 42.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 2.5290
    Cell Significance Index: 200.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2914
    Cell Significance Index: 459.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2787
    Cell Significance Index: 225.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2506
    Cell Significance Index: 61.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6168
    Cell Significance Index: 222.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5943
    Cell Significance Index: 870.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.3496
    Cell Significance Index: 989.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1924
    Cell Significance Index: 427.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0459
    Cell Significance Index: 54.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0285
    Cell Significance Index: 167.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9788
    Cell Significance Index: 432.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8715
    Cell Significance Index: 111.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.6238
    Cell Significance Index: 10.6900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6072
    Cell Significance Index: 5.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3463
    Cell Significance Index: 65.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3194
    Cell Significance Index: 39.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3093
    Cell Significance Index: 6.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3059
    Cell Significance Index: 211.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2882
    Cell Significance Index: 260.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2674
    Cell Significance Index: 7.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1957
    Cell Significance Index: 368.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1798
    Cell Significance Index: 35.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1669
    Cell Significance Index: 75.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1057
    Cell Significance Index: 1.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0665
    Cell Significance Index: 2.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0636
    Cell Significance Index: 11.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0098
    Cell Significance Index: 6.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0462
    Cell Significance Index: -34.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0539
    Cell Significance Index: -3.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0555
    Cell Significance Index: -102.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0608
    Cell Significance Index: -93.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0795
    Cell Significance Index: -2.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0866
    Cell Significance Index: -117.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0898
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1472
    Cell Significance Index: -109.0500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1815
    Cell Significance Index: -2.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1864
    Cell Significance Index: -105.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1984
    Cell Significance Index: -20.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2157
    Cell Significance Index: -134.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3431
    Cell Significance Index: -98.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3606
    Cell Significance Index: -25.5000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3655
    Cell Significance Index: -2.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4339
    Cell Significance Index: -50.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4605
    Cell Significance Index: -59.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4809
    Cell Significance Index: -12.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4985
    Cell Significance Index: -72.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.6000
    Cell Significance Index: -102.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6245
    Cell Significance Index: -131.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6321
    Cell Significance Index: -18.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6772
    Cell Significance Index: -29.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7306
    Cell Significance Index: -23.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7310
    Cell Significance Index: -86.2100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.7816
    Cell Significance Index: -8.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7916
    Cell Significance Index: -59.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8249
    Cell Significance Index: -94.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8400
    Cell Significance Index: -87.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8477
    Cell Significance Index: -23.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8988
    Cell Significance Index: -68.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9360
    Cell Significance Index: -62.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.0617
    Cell Significance Index: -49.9000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -1.1347
    Cell Significance Index: -8.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2203
    Cell Significance Index: -46.2100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.3437
    Cell Significance Index: -18.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.4980
    Cell Significance Index: -96.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.5387
    Cell Significance Index: -32.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.5464
    Cell Significance Index: -95.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5839
    Cell Significance Index: -97.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.6058
    Cell Significance Index: -74.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.6255
    Cell Significance Index: -84.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.7606
    Cell Significance Index: -19.1400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.8724
    Cell Significance Index: -14.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.1314
    Cell Significance Index: -35.6700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -2.1805
    Cell Significance Index: -27.1900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.4037
    Cell Significance Index: -50.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.4378
    Cell Significance Index: -50.5700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -2.4460
    Cell Significance Index: -14.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.5285
    Cell Significance Index: -74.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -2.5671
    Cell Significance Index: -56.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CKB is a mitochondrial enzyme that belongs to the creatine kinase family, which consists of three isoforms: CKB, CKM, and CKB. CKB is distinct from CKM due to its unique tissue distribution and biochemical properties. Notably, CKB is highly expressed in glycinergic neurons, retinal rod cells, and kidney collecting duct intercalated cells, suggesting its involvement in specific cellular functions. The enzyme exhibits high affinity for creatine and phosphocreatine, allowing for efficient energy buffering and storage. **Pathways and Functions:** CKB is integral to several metabolic pathways, including: 1. **Creatine metabolism**: CKB plays a critical role in the regulation of creatine and phosphocreatine levels, which are essential for ATP production and storage. 2. **Mitochondrial function**: As a mitochondrial enzyme, CKB is involved in the regulation of mitochondrial ATP production and the maintenance of mitochondrial membrane potential. 3. **Signaling pathways**: CKB interacts with various signaling molecules, including Rho GTPases, to regulate cellular processes such as differentiation, proliferation, and survival. 4. **Extracellular space**: CKB is also expressed in extracellular spaces, where it may play a role in regulating the concentration of creatine and phosphocreatine in the extracellular environment. **Clinical Significance:** Dysregulation of CKB has been implicated in various human diseases, including: 1. **Muscular dystrophy**: Mutations in the CKB gene have been linked to certain forms of muscular dystrophy, highlighting the enzyme's role in muscle function and integrity. 2. **Neurodegenerative disorders**: Abnormal expression of CKB has been observed in neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, suggesting its potential involvement in neurodegenerative processes. 3. **Kidney disease**: CKB expression is altered in kidney disease, including diabetic nephropathy and chronic kidney disease, highlighting the enzyme's role in renal function and disease. In conclusion, CKB is a vital enzyme that plays a critical role in regulating cellular energy metabolism, signaling pathways, and extracellular processes. Further research into the functions and dysregulation of CKB is necessary to fully understand its significance in human health and disease.

Genular Protein ID: 124065685

Symbol: KCRB_HUMAN

Name: Creatine phosphokinase B-type

UniProtKB Accession Codes:

P12277 A8K236 B2R5R4 Q2LE07 Q6FG40 Q9UC66

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 CarbonylDB 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 24 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3034271

Title: Human creatine kinase: isolation and sequence analysis of cDNA clones for the B subunit, development of subunit specific probes and determination of gene copy number.

PubMed ID: 3034271

DOI: 10.1016/0006-291x(87)91427-6

PubMed ID: 3692484

Title: Structure and expression of the human creatine kinase B gene.

PubMed ID: 3692484

DOI: 10.1016/0888-7543(87)90004-8

PubMed ID: 2883200

Title: Human creatine kinase-B complementary DNA. Nucleotide sequence, gene expression in lung cancer, and chromosomal assignment to two distinct loci.

PubMed ID: 2883200

DOI: 10.1172/jci112969

PubMed ID: 2771648

Title: Complete nucleotide sequence of the human creatine kinase B gene.

PubMed ID: 2771648

DOI: 10.1093/nar/17.15.6385

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2828370

Title: Isolation of a functional human gene for brain creatine kinase.

PubMed ID: 2828370

DOI: 10.1016/s0021-9258(18)69226-9

PubMed ID: 7637327

Title: Protein analysis of human maculae in relation to age-related maculopathy.

PubMed ID: 7637327

PubMed ID: 8186255

Title: Determination of the catalytic site of creatine kinase by site-directed mutagenesis.

PubMed ID: 8186255

DOI: 10.1016/0167-4838(94)90077-9

PubMed ID: 18566107

Title: HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3.

PubMed ID: 18566107

DOI: 10.1093/hmg/ddn172

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 33268465

Title: The mechanism of NEDD8 activation of CUL5 Ubiquitin E3 ligases.

PubMed ID: 33268465

DOI: 10.1074/mcp.ra120.002414

PubMed ID: 18977227

Title: Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex.

PubMed ID: 18977227

DOI: 10.1016/j.febslet.2008.10.039

PubMed ID: 32513959

Title: Structure and dynamics of the ASB9 CUL-RING E3 ligase.

PubMed ID: 32513959

DOI: 10.1038/s41467-020-16499-9

Sequence Information:

  • Length: 381
  • Mass: 42644
  • Checksum: 637AA67A86AE3059
  • Sequence:
    • MPFSNSHNAL KLRFPAEDEF PDLSAHNNHM AKVLTPELYA ELRAKSTPSG FTLDDVIQTG 
VDNPGHPYIM TVGCVAGDEE SYEVFKDLFD PIIEDRHGGY KPSDEHKTDL NPDNLQGGDD 
LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE RRAIEKLAVE ALSSLDGDLA GRYYALKSMT 
EAEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKTFLVWVN EEDHLRVISM 
QKGGNMKEVF TRFCTGLTQI ETLFKSKDYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP 
NLGKHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV QMVVDGVKLL 
IEMEQRLEQG QAIDDLMPAQ K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.