Details for: CKB

Gene ID: 1152

Symbol: CKB

Ensembl ID: ENSG00000166165

Description: creatine kinase B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.64
    Marker Score: 5605.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 4.08
    Marker Score: 11648
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.95
    Marker Score: 3725
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.95
    Marker Score: 10573
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.73
    Marker Score: 11700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.59
    Marker Score: 7292
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.56
    Marker Score: 2345.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.53
    Marker Score: 5845
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.39
    Marker Score: 4416
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.33
    Marker Score: 19750
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3
    Marker Score: 26066
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.99
    Marker Score: 1563
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.99
    Marker Score: 1131
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.97
    Marker Score: 11508
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.94
    Marker Score: 932
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.89
    Marker Score: 7284
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.85
    Marker Score: 848
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.77
    Marker Score: 2932.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.74
    Marker Score: 3301
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.7
    Marker Score: 1697
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.69
    Marker Score: 3729
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.67
    Marker Score: 11125
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.62
    Marker Score: 5755.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.6
    Marker Score: 2255
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.56
    Marker Score: 2406
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.54
    Marker Score: 1481
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.53
    Marker Score: 54053
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.53
    Marker Score: 2705
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.43
    Marker Score: 5929.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.42
    Marker Score: 2714
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.39
    Marker Score: 4500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.39
    Marker Score: 3803
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.37
    Marker Score: 798
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.36
    Marker Score: 987
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.35
    Marker Score: 1109
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.29
    Marker Score: 5394
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.28
    Marker Score: 11974
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.26
    Marker Score: 25422
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.25
    Marker Score: 1535
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.23
    Marker Score: 3150
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.21
    Marker Score: 4196
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.21
    Marker Score: 22204
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.12
    Marker Score: 1808
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.09
    Marker Score: 855
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.06
    Marker Score: 1101
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.05
    Marker Score: 857
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.04
    Marker Score: 1538
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.04
    Marker Score: 4253.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.02
    Marker Score: 6961
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.02
    Marker Score: 2012
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2
    Marker Score: 1186.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.99
    Marker Score: 4764
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.97
    Marker Score: 1084
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.94
    Marker Score: 1968
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.92
    Marker Score: 879
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.92
    Marker Score: 1279
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.9
    Marker Score: 5179
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.9
    Marker Score: 624
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.88
    Marker Score: 65202
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.88
    Marker Score: 7859.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.87
    Marker Score: 933
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.86
    Marker Score: 587
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.85
    Marker Score: 7985
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.85
    Marker Score: 2722
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8
    Marker Score: 61377
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.79
    Marker Score: 1907
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.78
    Marker Score: 1174
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.78
    Marker Score: 487
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.77
    Marker Score: 912
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.76
    Marker Score: 836
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.75
    Marker Score: 1381
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.75
    Marker Score: 8088
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.75
    Marker Score: 2935
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.72
    Marker Score: 693
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.7
    Marker Score: 635
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.7
    Marker Score: 11084
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.69
    Marker Score: 758
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.68
    Marker Score: 3810
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.66
    Marker Score: 1594.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.66
    Marker Score: 389
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.65
    Marker Score: 2073
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.64
    Marker Score: 2783
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.64
    Marker Score: 16900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.62
    Marker Score: 1718
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.62
    Marker Score: 458
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.61
    Marker Score: 24112
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.59
    Marker Score: 664
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.58
    Marker Score: 5595
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.58
    Marker Score: 6091
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.56
    Marker Score: 1930
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.56
    Marker Score: 13377
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.56
    Marker Score: 6340
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.56
    Marker Score: 1617
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.55
    Marker Score: 58809
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.55
    Marker Score: 95138
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2370
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.54
    Marker Score: 14588
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.52
    Marker Score: 56252
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.52
    Marker Score: 516
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.48
    Marker Score: 6156

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Other Information

**Key characteristics:** - Gene name: CKB - Ensembl ID: ENSG00000166165 - Pathway/ontology: Atp binding, Creatine kinase activity, Creatine metabolism, Cytosol, Extracellular space, Futile creatine cycle, Metabolism, Metabolism of amino acids and derivatives, Mitochondrion, Phosphocreatine biosynthetic process, Phosphorylation, Plasma membrane, Protein binding, Rho gtpase cycle, Rnd3 gtpase cycle, Signaling by rho gtpases, Signaling by rho gtpases, miro gtpases and rhobtb3, Signal transduction **Functions:** - Regulates the rate of ATP production by phosphorylating and dephosphorylating the regulatory protein AMP-activated protein kinase (AMPK) - Plays a critical role in maintaining cellular energy homeostasis by ensuring that ATP is used efficiently and that there is enough ATP for all the cellular processes - Regulates the production of creatine, a molecule that can be used as an energy source during periods of stress or starvation - Interacts with other proteins to regulate energy metabolism **Clinical significance:** - Mutations in the CKB gene have been linked to several human diseases, including cerebral ischemia, stroke, and metabolic disorders - CKB inhibitors are being investigated as potential treatments for these diseases by blocking the activity of the enzyme and restoring the levels of ATP in the cells - Understanding the function of CKB is crucial for developing new strategies to treat energy-related diseases

Genular Protein ID: 124065685

Symbol: KCRB_HUMAN

Name: Creatine phosphokinase B-type

UniProtKB Accession Codes:

P12277 A8K236 B2R5R4 Q2LE07 Q6FG40 Q9UC66

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 CarbonylDB 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 24 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 6 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SABIO-RK 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3034271

Title: Human creatine kinase: isolation and sequence analysis of cDNA clones for the B subunit, development of subunit specific probes and determination of gene copy number.

PubMed ID: 3034271

DOI: 10.1016/0006-291x(87)91427-6

PubMed ID: 3692484

Title: Structure and expression of the human creatine kinase B gene.

PubMed ID: 3692484

DOI: 10.1016/0888-7543(87)90004-8

PubMed ID: 2883200

Title: Human creatine kinase-B complementary DNA. Nucleotide sequence, gene expression in lung cancer, and chromosomal assignment to two distinct loci.

PubMed ID: 2883200

DOI: 10.1172/jci112969

PubMed ID: 2771648

Title: Complete nucleotide sequence of the human creatine kinase B gene.

PubMed ID: 2771648

DOI: 10.1093/nar/17.15.6385

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2828370

Title: Isolation of a functional human gene for brain creatine kinase.

PubMed ID: 2828370

DOI: 10.1016/s0021-9258(18)69226-9

PubMed ID: 7637327

Title: Protein analysis of human maculae in relation to age-related maculopathy.

PubMed ID: 7637327

PubMed ID: 8186255

Title: Determination of the catalytic site of creatine kinase by site-directed mutagenesis.

PubMed ID: 8186255

DOI: 10.1016/0167-4838(94)90077-9

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18977227

Title: Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex.

PubMed ID: 18977227

DOI: 10.1016/j.febslet.2008.10.039

PubMed ID: 18566107

Title: HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3.

PubMed ID: 18566107

DOI: 10.1093/hmg/ddn172

Sequence Information:

  • Length: 381
  • Mass: 42644
  • Checksum: 637AA67A86AE3059
  • Sequence:
    • MPFSNSHNAL KLRFPAEDEF PDLSAHNNHM AKVLTPELYA ELRAKSTPSG FTLDDVIQTG 
VDNPGHPYIM TVGCVAGDEE SYEVFKDLFD PIIEDRHGGY KPSDEHKTDL NPDNLQGGDD 
LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE RRAIEKLAVE ALSSLDGDLA GRYYALKSMT 
EAEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKTFLVWVN EEDHLRVISM 
QKGGNMKEVF TRFCTGLTQI ETLFKSKDYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP 
NLGKHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV QMVVDGVKLL 
IEMEQRLEQG QAIDDLMPAQ K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.