Details for: CIRBP

Gene ID: 1153

Symbol: CIRBP

Ensembl ID: ENSG00000099622

Description: cold inducible RNA binding protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.45
    Marker Score: 5369.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.33
    Marker Score: 57167
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.28
    Marker Score: 3064
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.22
    Marker Score: 8854
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.17
    Marker Score: 5427
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.1
    Marker Score: 3869
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.08
    Marker Score: 1504
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.95
    Marker Score: 12473
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.93
    Marker Score: 207898
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.89
    Marker Score: 3475
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.87
    Marker Score: 131805
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.81
    Marker Score: 3753
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.78
    Marker Score: 904
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.75
    Marker Score: 3192
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.73
    Marker Score: 36910
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.72
    Marker Score: 10864
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.65
    Marker Score: 23772
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.65
    Marker Score: 15653
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.63
    Marker Score: 6825
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.59
    Marker Score: 9623
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.5
    Marker Score: 2985
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.5
    Marker Score: 14599
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.5
    Marker Score: 8822
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.48
    Marker Score: 5711.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.48
    Marker Score: 3711
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.45
    Marker Score: 5918
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.45
    Marker Score: 9521
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.42
    Marker Score: 2082
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.42
    Marker Score: 9758
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.4
    Marker Score: 780
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.35
    Marker Score: 38888
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.33
    Marker Score: 4116
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.32
    Marker Score: 8105
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 3.31
    Marker Score: 1155
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.3
    Marker Score: 2345
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.3
    Marker Score: 6700.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 3.28
    Marker Score: 1339
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.28
    Marker Score: 1925
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.28
    Marker Score: 9207
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.25
    Marker Score: 3142
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.24
    Marker Score: 2880
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.24
    Marker Score: 3434
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.24
    Marker Score: 3044
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.24
    Marker Score: 7890
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.22
    Marker Score: 1530
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 3.22
    Marker Score: 649
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.21
    Marker Score: 4950
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.2
    Marker Score: 2418
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.17
    Marker Score: 2664
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.16
    Marker Score: 23542
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.16
    Marker Score: 20607.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.16
    Marker Score: 4653
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.16
    Marker Score: 1849
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.16
    Marker Score: 1088
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 3.15
    Marker Score: 1981
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.15
    Marker Score: 2581
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.15
    Marker Score: 3045
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.15
    Marker Score: 1148
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.14
    Marker Score: 12090
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.13
    Marker Score: 2456.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.12
    Marker Score: 2738
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.11
    Marker Score: 3383
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.11
    Marker Score: 2045
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 3.1
    Marker Score: 1840
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.1
    Marker Score: 883.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.09
    Marker Score: 7866
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.09
    Marker Score: 2944
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.09
    Marker Score: 2416
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.08
    Marker Score: 1399
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.07
    Marker Score: 715
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.07
    Marker Score: 1590
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.06
    Marker Score: 2545
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.06
    Marker Score: 7326
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 3.05
    Marker Score: 1057
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.05
    Marker Score: 2853
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.04
    Marker Score: 2146
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 3.03
    Marker Score: 2622
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.02
    Marker Score: 4169
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.02
    Marker Score: 6034
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 3.02
    Marker Score: 893
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.01
    Marker Score: 2701
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.01
    Marker Score: 104345
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.01
    Marker Score: 1994
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.01
    Marker Score: 1349
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.01
    Marker Score: 4986
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3
    Marker Score: 790.5
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3
    Marker Score: 795
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 2.99
    Marker Score: 842
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 2.99
    Marker Score: 879
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.97
    Marker Score: 1731
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.97
    Marker Score: 2864
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 2.96
    Marker Score: 736
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.96
    Marker Score: 17537.5
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 2.96
    Marker Score: 834
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.95
    Marker Score: 1780
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.95
    Marker Score: 1270
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.95
    Marker Score: 731.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.95
    Marker Score: 1983
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 2.95
    Marker Score: 1365
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.95
    Marker Score: 3452.5

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Other Information

**Key characteristics:** * CIRBP is a protein of the immunoglobulin superfamily. * It is a highly conserved protein with sequences found in mammals, birds, and fish. * CIRBP is a nuclear protein that is found in the cytoplasm of cells. * It is a key regulator of gene expression, and its expression is controlled by a variety of factors, including temperature, ultraviolet (UV) light, and stress. **Pathways and functions:** * CIRBP binds to the 3'-untranslated region (UTR) of mRNA and stabilizes it. * This prevents the initiation translation of mRNA and leads to the regulation of gene expression. * CIRBP is also involved in the regulation of stress response. It is induced by a variety of stress factors, including heat, cold, and UV radiation. * CIRBP also plays a role in the regulation of apoptosis. It is induced by a variety of factors, including heat, cold, and DNA damage. **Clinical significance:** * CIRBP is a potential therapeutic target for a variety of diseases. For example, CIRBP is overexpressed in cancer cells, where it promotes tumor growth and metastasis. Inhibition of CIRBP has been shown to inhibit cancer cell growth and metastasis. **Additional notes:** * CIRBP is a highly important protein in mammalian cells. * It is involved in a wide range of cellular processes, including translation, stress response, and apoptosis. * CIRBP is a potential therapeutic target for a variety of diseases.

Genular Protein ID: 851846490

Symbol: CIRBP_HUMAN

Name: Cold-inducible RNA-binding protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9434172

Title: Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene.

PubMed ID: 9434172

DOI: 10.1016/s0378-1119(97)00530-1

PubMed ID: 9334257

Title: Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein.

PubMed ID: 9334257

DOI: 10.1074/jbc.272.42.26720

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11574538

Title: The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response.

PubMed ID: 11574538

DOI: 10.1074/jbc.m105396200

PubMed ID: 15075239

Title: Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism.

PubMed ID: 15075239

DOI: 10.1242/jcs.01026

PubMed ID: 16513844

Title: Post-transcriptional regulation of thioredoxin by the stress inducible heterogeneous ribonucleoprotein A18.

PubMed ID: 16513844

DOI: 10.1093/nar/gkj519

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 172
  • Mass: 18648
  • Checksum: 003FABF28F5405D0
  • Sequence:
  • MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA 
    KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD 
    RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYATH NE

Genular Protein ID: 2592939311

Symbol: D6W5Y5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 297
  • Mass: 31918
  • Checksum: AE3FD69D003AF404
  • Sequence:
  • MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA 
    KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD 
    RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYGKS HSEGATLLWP 
    AVGARFTLVP SPSTLGWTLR PCHCACPEEA HLSSQSHFYR RTQKPNETDQ KGKGERGPAG 
    QSARCMCGRR PASLGCGGWL LPGRRPRPGL ASGVKLPLVA SVPLHCACFL SSATHNE

Genular Protein ID: 1218888311

Symbol: K7EPM4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 168
  • Mass: 18152
  • Checksum: 2AF405D045616002
  • Sequence:
  • MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA 
    KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD 
    RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYG

Genular Protein ID: 2425003918

Symbol: K7EQR7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 202
  • Mass: 21658
  • Checksum: 3751FCD137D76EBA
  • Sequence:
  • MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA 
    KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD 
    RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYEAG QRAEARGIPG 
    RPQTASRLAS SAVASRVLSI LC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.