Gene CISH - ENSG00000114737 | NCBI Gene ID: 1154

Details for: CISH

Gene ID: 1154

Symbol: CISH

Ensembl ID: ENSG00000114737

Description: cytokine inducible SH2 containing protein

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Growth hormone receptor signaling
(R-HSA-982772)
Immune system
(R-HSA-168256)
Interleukin-7 signaling
(R-HSA-1266695)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Post-translational protein modification
(R-HSA-597592)
Signaling by interleukins
(R-HSA-449147)
1-phosphatidylinositol-3-kinase regulator activity
(GO:0046935)
Cellular_component
(GO:0005575)
Cytosol
(GO:0005829)
Intracellular signal transduction
(GO:0035556)
Molecular_function
(GO:0003674)
Negative regulation of signal transduction
(GO:0009968)
Phosphatidylinositol 3-kinase complex
(GO:0005942)
Phosphatidylinositol phosphate biosynthetic process
(GO:0046854)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Protein ubiquitination
(GO:0016567)
Regulation of cell growth
(GO:0001558)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.72
Marker Score: 17367
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 2.01
Marker Score: 1609.5
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168982
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.23
Marker Score: 2906
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.23
Marker Score: 19303
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.22
Marker Score: 1955
Cell Name: mature T cell (CL0002419)
Fold Change: 1.12
Marker Score: 11050
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.09
Marker Score: 2065
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.07
Marker Score: 2103
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.02
Marker Score: 6666
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71783
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48010
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30404
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.98
Marker Score: 587
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 495
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 449
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2408
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.94
Marker Score: 4033
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.92
Marker Score: 3421.5
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.92
Marker Score: 2385
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2725
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.9
Marker Score: 608
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5040
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 315
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.87
Marker Score: 1770
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5272
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.87
Marker Score: 907
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.83
Marker Score: 44041
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.79
Marker Score: 1312
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1268
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 586
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.77
Marker Score: 1257
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 306
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.75
Marker Score: 553
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 384
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.73
Marker Score: 563
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.73
Marker Score: 346
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.72
Marker Score: 169
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 454
Cell Name: brush cell (CL0002204)
Fold Change: 0.7
Marker Score: 638
Cell Name: blood cell (CL0000081)
Fold Change: 0.7
Marker Score: 8126
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.7
Marker Score: 224
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.69
Marker Score: 4507
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2904
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.69
Marker Score: 731
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.66
Marker Score: 634
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.64
Marker Score: 979
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.63
Marker Score: 3844
Cell Name: thymocyte (CL0000893)
Fold Change: 0.63
Marker Score: 660.5
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.63
Marker Score: 1111
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.62
Marker Score: 1312.5
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.62
Marker Score: 15818
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.62
Marker Score: 982
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.62
Marker Score: 276
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.62
Marker Score: 657
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.61
Marker Score: 1668
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.61
Marker Score: 1641
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.6
Marker Score: 437
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.59
Marker Score: 312
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.59
Marker Score: 635
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.58
Marker Score: 519
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.58
Marker Score: 127
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.57
Marker Score: 653
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.55
Marker Score: 1356
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.54
Marker Score: 144
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.54
Marker Score: 766
Cell Name: kidney cell (CL1000497)
Fold Change: 0.54
Marker Score: 359
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.54
Marker Score: 168
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.53
Marker Score: 2811
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.53
Marker Score: 7035.5
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.53
Marker Score: 5356
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.53
Marker Score: 561
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.53
Marker Score: 264
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.52
Marker Score: 134
Cell Name: lactocyte (CL0002325)
Fold Change: 0.5
Marker Score: 8042
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.5
Marker Score: 854.5
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.49
Marker Score: 359
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.48
Marker Score: 1182
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.48
Marker Score: 862.5
Cell Name: erythroblast (CL0000765)
Fold Change: 0.47
Marker Score: 296
Cell Name: germ cell (CL0000586)
Fold Change: 0.47
Marker Score: 819
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.47
Marker Score: 1465.5
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.47
Marker Score: 472
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.46
Marker Score: 272
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.46
Marker Score: 513
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.45
Marker Score: 339
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.45
Marker Score: 164
Cell Name: ionocyte (CL0005006)
Fold Change: 0.44
Marker Score: 135
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.44
Marker Score: 214
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.44
Marker Score: 86
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 0.43
Marker Score: 195
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.43
Marker Score: 113
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.43
Marker Score: 1075
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.42
Marker Score: 421
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.42
Marker Score: 226
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.42
Marker Score: 110
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.42
Marker Score: 132
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.42
Marker Score: 1699

Hover over a box to see details here...

**Key characteristics:** - The protein is a cytokine-inducible SH2-containing protein (CISH). - It is a key regulator of the immune system. - It is highly expressed in cells of the immune system. - It is a key regulator of inflammation and cell growth. **Pathways and functions:** - CISH is a key regulator of the immune system. - It is involved in the regulation of inflammation and cell growth. - It is involved in the regulation of the immune response to cytokines. - It is involved in the regulation of the immune response to pathogens. **Clinical significance:** - Mutations in the CISH gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, lupus, and psoriasis. - CISH inhibitors are being investigated as a treatment for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cytokine-inducible SH2-containing protein

Genular Protein ID: 959203541

Symbol: CISH_HUMAN

Name: Cytokine-inducible SH2-containing protein

UniProtKB Accession Codes:

Q9NSE2 B2R9N1 G5E9R1 Q9NS38 Q9Y5R1

Database IDs:

Citations:

PubMed ID: 9465889

Title: Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues.

PubMed ID: 9465889

DOI: 10.1159/000134658

PubMed ID: 10902923

Title: Cloning and characterization of CIS 1b (cytokine inducible SH2-containing protein 1b), an alternative splicing form of CIS 1 gene.

PubMed ID: 10902923

DOI: 10.3109/10425170009033983

PubMed ID: 11032736

Title: cDNA representational difference analysis of human neutrophils stimulated by GM-CSF.

PubMed ID: 11032736

DOI: 10.1006/bbrc.2000.3678

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9774439

Title: Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated CIS protein.

PubMed ID: 9774439

DOI: 10.1074/jbc.273.43.28185

PubMed ID: 20484391

Title: CISH and susceptibility to infectious diseases.

PubMed ID: 20484391

DOI: 10.1056/nejmoa0905606

Sequence Information:

Length: 258
Mass: 28663
Checksum: 0BA97804E3B0F608
Sequence:

MVLCVQGPRP LLAVERTGQR PLWAPSLELP KPVMQPLPAG AFLEEVAEGT PAQTESEPKV 
LDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV 
KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCTAD TRSDSPDPAP 
TPALPMPKED APSDPALPAP PPATAVHLKL VQPFVRRSSA RSLQHLCRLV INRLVADVDC 
LPLPRRMADY LRQYPFQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CISH

Associated with

Cells (max top 100)

Other Information

Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues. PubMed ID: 9465889

Cloning and characterization of CIS 1b (cytokine inducible SH2-containing protein 1b), an alternative splicing form of CIS 1 gene. PubMed ID: 10902923

cDNA representational difference analysis of human neutrophils stimulated by GM-CSF. PubMed ID: 11032736

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated CIS protein. PubMed ID: 9774439

CISH and susceptibility to infectious diseases. PubMed ID: 20484391