Details for: CISH

Gene ID: 1154

Symbol: CISH

Ensembl ID: ENSG00000114737

Description: cytokine inducible SH2 containing protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.7961
    Cell Significance Index: -7.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.4902
    Cell Significance Index: -7.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.7028
    Cell Significance Index: -8.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.2105
    Cell Significance Index: 211.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.8210
    Cell Significance Index: -8.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1667
    Cell Significance Index: -8.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.7679
    Cell Significance Index: -5.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9197
    Cell Significance Index: 65.0500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.8976
    Cell Significance Index: 21.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8679
    Cell Significance Index: 11.1200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.6372
    Cell Significance Index: 2.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6358
    Cell Significance Index: 62.8900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.6086
    Cell Significance Index: 9.8200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5139
    Cell Significance Index: 4.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4829
    Cell Significance Index: 436.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4676
    Cell Significance Index: 50.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.4487
    Cell Significance Index: 7.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3582
    Cell Significance Index: 58.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3582
    Cell Significance Index: 10.3200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3557
    Cell Significance Index: 2.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3492
    Cell Significance Index: 7.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3329
    Cell Significance Index: 15.0900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.3257
    Cell Significance Index: 2.0200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.2927
    Cell Significance Index: 3.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2900
    Cell Significance Index: 33.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2526
    Cell Significance Index: 11.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2408
    Cell Significance Index: 16.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2188
    Cell Significance Index: 4.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2041
    Cell Significance Index: 15.2100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1689
    Cell Significance Index: 2.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1663
    Cell Significance Index: 73.5400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1654
    Cell Significance Index: 2.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1516
    Cell Significance Index: 3.9900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1478
    Cell Significance Index: 2.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1378
    Cell Significance Index: 26.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1190
    Cell Significance Index: 15.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0998
    Cell Significance Index: 13.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0920
    Cell Significance Index: 2.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0723
    Cell Significance Index: 3.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0675
    Cell Significance Index: 5.1800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0660
    Cell Significance Index: 0.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0621
    Cell Significance Index: 1.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0608
    Cell Significance Index: 46.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0587
    Cell Significance Index: 1.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0512
    Cell Significance Index: 1.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0472
    Cell Significance Index: 25.7600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0452
    Cell Significance Index: 0.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0403
    Cell Significance Index: 1.4000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.0271
    Cell Significance Index: 0.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0232
    Cell Significance Index: 4.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0219
    Cell Significance Index: 3.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0183
    Cell Significance Index: 13.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0083
    Cell Significance Index: 1.4100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0069
    Cell Significance Index: 0.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0060
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0055
    Cell Significance Index: 0.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0014
    Cell Significance Index: 0.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0014
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0074
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0110
    Cell Significance Index: -8.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0112
    Cell Significance Index: -0.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0133
    Cell Significance Index: -8.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0139
    Cell Significance Index: -1.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0140
    Cell Significance Index: -1.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0144
    Cell Significance Index: -8.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0150
    Cell Significance Index: -6.8200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0208
    Cell Significance Index: -0.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0217
    Cell Significance Index: -2.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0237
    Cell Significance Index: -8.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0286
    Cell Significance Index: -8.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0325
    Cell Significance Index: -0.8300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0365
    Cell Significance Index: -0.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0369
    Cell Significance Index: -0.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0379
    Cell Significance Index: -7.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0387
    Cell Significance Index: -1.9600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0408
    Cell Significance Index: -0.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0433
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0440
    Cell Significance Index: -9.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0452
    Cell Significance Index: -2.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0454
    Cell Significance Index: -0.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0475
    Cell Significance Index: -6.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0535
    Cell Significance Index: -2.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0592
    Cell Significance Index: -1.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0635
    Cell Significance Index: -3.9000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0690
    Cell Significance Index: -0.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0710
    Cell Significance Index: -1.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0729
    Cell Significance Index: -8.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0805
    Cell Significance Index: -8.3800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0829
    Cell Significance Index: -0.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0924
    Cell Significance Index: -5.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0953
    Cell Significance Index: -1.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0989
    Cell Significance Index: -1.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1045
    Cell Significance Index: -2.8000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1065
    Cell Significance Index: -0.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1317
    Cell Significance Index: -8.3000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1347
    Cell Significance Index: -2.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1358
    Cell Significance Index: -7.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** CISH is predominantly expressed in cells of the immune system, including CD4-positive T cells, mature T cells, and alpha-beta memory T cells. It is also found in non-immune cells, such as pulmonary interstitial fibroblasts, mural cells, and kidney proximal straight tubule epithelial cells. 2. **Protein structure:** CISH contains an SH2 domain, which enables it to interact with phosphotyrosine-containing proteins and phospholipids, facilitating signal transduction. 3. **Expression regulation:** CISH expression is induced by cytokine stimulation, suggesting a role in responding to immune signals. 4. **Protein modification:** CISH is subject to various post-translational modifications, including neddylation, ubiquitination, and phosphorylation, which regulate its activity and localization. **Pathways and Functions:** 1. **Cytokine signaling:** CISH is involved in the regulation of cytokine signaling, particularly in the context of interleukin-7 (IL-7) signaling. It modulates the activity of protein kinases and phosphatidylinositol 3-kinase complexes, influencing the downstream effects of cytokine stimulation. 2. **Immune system:** CISH plays a crucial role in regulating immune responses, including the activation and proliferation of T cells, and the production of cytokines. 3. **Cell growth and metabolism:** CISH is involved in the regulation of cell growth and protein metabolism, influencing the activity of protein kinases and phosphatidylinositol 3-kinase complexes. 4. **Growth hormone receptor signaling:** CISH interacts with the growth hormone receptor, modulating its activity and influencing cell growth and metabolism. **Clinical Significance:** 1. **Immune disorders:** Dysregulation of CISH expression has been implicated in various immune disorders, including autoimmune diseases and immunodeficiency syndromes. 2. **Cancer:** CISH expression has been found to be altered in certain types of cancer, suggesting a potential role in tumor development and progression. 3. **Inflammation:** CISH may play a role in regulating inflammation, particularly in the context of cytokine signaling. 4. **Therapeutic targeting:** Understanding the mechanisms of CISH regulation may provide novel therapeutic targets for the treatment of immune disorders and cancer. In conclusion, CISH is a critical regulator of immune response and cellular homeostasis, and its dysregulation has significant implications for various diseases. Further research is needed to elucidate the mechanisms of CISH regulation and to explore its potential as a therapeutic target.

Genular Protein ID: 959203541

Symbol: CISH_HUMAN

Name: Cytokine-inducible SH2-containing protein

UniProtKB Accession Codes:

Q9NSE2 B2R9N1 G5E9R1 Q9NS38 Q9Y5R1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9465889

Title: Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues.

PubMed ID: 9465889

DOI: 10.1159/000134658

PubMed ID: 10902923

Title: Cloning and characterization of CIS 1b (cytokine inducible SH2-containing protein 1b), an alternative splicing form of CIS 1 gene.

PubMed ID: 10902923

DOI: 10.3109/10425170009033983

PubMed ID: 11032736

Title: cDNA representational difference analysis of human neutrophils stimulated by GM-CSF.

PubMed ID: 11032736

DOI: 10.1006/bbrc.2000.3678

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9774439

Title: Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated CIS protein.

PubMed ID: 9774439

DOI: 10.1074/jbc.273.43.28185

PubMed ID: 20484391

Title: CISH and susceptibility to infectious diseases.

PubMed ID: 20484391

DOI: 10.1056/nejmoa0905606

Sequence Information:

  • Length: 258
  • Mass: 28663
  • Checksum: 0BA97804E3B0F608
  • Sequence:
    • MVLCVQGPRP LLAVERTGQR PLWAPSLELP KPVMQPLPAG AFLEEVAEGT PAQTESEPKV 
LDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV 
KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCTAD TRSDSPDPAP 
TPALPMPKED APSDPALPAP PPATAVHLKL VQPFVRRSSA RSLQHLCRLV INRLVADVDC 
LPLPRRMADY LRQYPFQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.