Genular: Defining Cellular Identity and Function

Details for: Adora2a

Gene ID: 11540

Symbol: Adora2a

Ensembl ID: ENSMUSG00000020178

Description: adenosine A2a receptor

Associated with

Adenosine p1 receptors
(R-MMU-417973)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (s) signalling events
(R-MMU-418555)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Metabolism of proteins
(R-MMU-392499)
Nucleotide-like (purinergic) receptors
(R-MMU-418038)
Signaling by gpcr
(R-MMU-372790)
Surfactant metabolism
(R-MMU-5683826)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Alpha-actinin binding
(GO:0051393)
Apoptotic signaling pathway
(GO:0097190)
Astrocyte activation
(GO:0048143)
Asymmetric synapse
(GO:0032279)
Axolemma
(GO:0030673)
Axon
(GO:0030424)
Calmodulin binding
(GO:0005516)
Dendrite
(GO:0030425)
Eating behavior
(GO:0042755)
Enzyme binding
(GO:0019899)
Excitatory postsynaptic potential
(GO:0060079)
Glutamatergic synapse
(GO:0098978)
G protein-coupled adenosine receptor activity
(GO:0001609)
G protein-coupled adenosine receptor signaling pathway
(GO:0001973)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Inhibition of non-skeletal tissue mineralization
(GO:0140928)
Inhibitory postsynaptic potential
(GO:0060080)
Intermediate filament
(GO:0005882)
Lipid binding
(GO:0008289)
Locomotory behavior
(GO:0007626)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Negative regulation of alpha-beta t cell activation
(GO:0046636)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of vascular permeability
(GO:0043116)
Neuronal cell body
(GO:0043025)
Neuron projection morphogenesis
(GO:0048812)
Plasma membrane
(GO:0005886)
Positive regulation of acetylcholine secretion, neurotransmission
(GO:0014057)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of circadian sleep/wake cycle, sleep
(GO:0045938)
Positive regulation of glutamate secretion
(GO:0014049)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of protein secretion
(GO:0050714)
Positive regulation of synaptic transmission, gabaergic
(GO:0032230)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Positive regulation of urine volume
(GO:0035810)
Postsynaptic membrane
(GO:0045211)
Prepulse inhibition
(GO:0060134)
Presynaptic active zone
(GO:0048786)
Presynaptic membrane
(GO:0042734)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein-containing complex binding
(GO:0044877)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Regulation of calcium ion transport
(GO:0051924)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of mitochondrial membrane potential
(GO:0051881)
Regulation of norepinephrine secretion
(GO:0014061)
Response to alkaloid
(GO:0043279)
Response to amphetamine
(GO:0001975)
Response to caffeine
(GO:0031000)
Response to inorganic substance
(GO:0010035)
Response to purine-containing compound
(GO:0014074)
Signal transduction
(GO:0007165)
Synaptic transmission, cholinergic
(GO:0007271)
Synaptic transmission, dopaminergic
(GO:0001963)
Synaptic transmission, glutamatergic
(GO:0035249)
Type 5 metabotropic glutamate receptor binding
(GO:0031802)
Vasodilation
(GO:0042311)

Other Information

Proteins

Adenosine receptor A2a
Q8CAU3_MOUSE

Genular Protein ID: 3413554790

Symbol: AA2AR_MOUSE

Name: Adenosine receptor A2a

UniProtKB Accession Codes:

Q60613 Q2NLC1

Database IDs:

Citations:

PubMed ID: 9262401

Title: Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.

PubMed ID: 9262401

DOI: 10.1038/41771

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8157966

Title: Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells.

PubMed ID: 8157966

PubMed ID: 23994616

Title: A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.

PubMed ID: 23994616

DOI: 10.1016/j.bbamcr.2013.08.009

Sequence Information:

Length: 410
Mass: 44971
Checksum: E5670F442D243E71
Sequence:

MGSSVYIMVE LAIAVLAILG NVLVCWAVWI NSNLQNVTNF FVVSLAAADI AVGVLAIPFA 
ITISTGFCAA CHGCLFFACF VLVLTQSSIF SLLAIAIDRY IAIRIPLRYN GLVTGMRAKG 
IIAICWVLSF AIGLTPMLGW NNCSQKDENS TKTCGEGRVT CLFEDVVPMN YMVYYNFFAF 
VLLPLLLMLA IYLRIFLAAR RQLKQMESQP LPGERTRSTL QKEVHAAKSL AIIVGLFALC 
WLPLHIINCF TFFCSTCQHA PPWLMYLAII LSHSNSVVNP FIYAYRIREF RQTFRKIIRT 
HVLRRQEPFR AGGSSAWALA AHSTEGEQVS LRLNGHPLGV WANGSAPHSG RRPNGYTLGP 
GGGGSTQGSP GDVELLTQEH QEGQEHPGLG DHLAQGRVGT ASWSSEFAPS

Genular Protein ID: 937066233

Symbol: Q8CAU3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CAU3

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 322
Mass: 35701
Checksum: 9A3EF60C5A40C7E4
Sequence:

IFSLLAIAID RYIAIRIPLR YNGLVTGMRA KGIIAICWVL SFAIGLTPML GWNNCSQKDE 
NSTKTCGGGR VTCLFEDVVP MNYMVYYNFF AFVLLPLLLM LAIYLRIFLA ARRQLKQMES 
QPLPGERTRS TLQKEVHAAK SLAIIVGLFA LCWLPLHIIN CFTFFCSTCQ HAPPWLMYLA 
IILSHSNSVV NPFIYAYRIR EFRQTFRKII RTHVLRRQEP FRAGGSSAWA LAAHSTEGEQ 
VSLRLNGHPL GVWANGSAPH SGRRPNGYTL GPGGGGSTQG SPGDVELLTQ EHQEGQEHPG 
LGDHLAQGRV GTASWSSEFA PS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Adora2a

Associated with

Other Information

Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. PubMed ID: 9262401

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. PubMed ID: 8157966

A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor. PubMed ID: 23994616

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073