Genular: Defining Cellular Identity and Function

Details for: Parp1

Gene ID: 11545

Symbol: Parp1

Ensembl ID: ENSMUSG00000026496

Description: poly (ADP-ribose) polymerase family, member 1

Associated with

Base excision repair
(R-MMU-73884)
Dna damage recognition in gg-ner
(R-MMU-5696394)
Dna double-strand break repair
(R-MMU-5693532)
Downregulation of smad2/3:smad4 transcriptional activity
(R-MMU-2173795)
Dual incision in gg-ner
(R-MMU-5696400)
Formation of incision complex in gg-ner
(R-MMU-5696395)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Global genome nucleotide excision repair (gg-ner)
(R-MMU-5696399)
Hdr through mmej (alt-nhej)
(R-MMU-5685939)
Homology directed repair
(R-MMU-5693538)
Metabolism of proteins
(R-MMU-392499)
Nucleotide excision repair
(R-MMU-5696398)
Polb-dependent long patch base excision repair
(R-MMU-110362)
Post-translational protein modification
(R-MMU-597592)
Resolution of abasic sites (ap sites)
(R-MMU-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-MMU-110373)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of dna damage response and repair proteins
(R-MMU-3108214)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Apoptotic process
(GO:0006915)
Base-excision repair
(GO:0006284)
Carbohydrate biosynthetic process
(GO:0016051)
Catalytic activity
(GO:0003824)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to uv
(GO:0034644)
Chromatin binding
(GO:0003682)
Damaged dna binding
(GO:0003684)
Dna adp-ribosylation
(GO:0030592)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna metabolic process
(GO:0006259)
Dna repair
(GO:0006281)
Double-strand break repair
(GO:0006302)
Enzyme binding
(GO:0019899)
Glycosyltransferase activity
(GO:0016757)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Metabolic process
(GO:0008152)
Metal ion binding
(GO:0046872)
Mitochondrial dna metabolic process
(GO:0032042)
Mitochondrion organization
(GO:0007005)
Nad+-histone h2be35 glutamate adp-ribosyltransferase activity
(GO:0140822)
Nad+-histone h2bs6 serine adp-ribosyltransferase activity
(GO:0140816)
Nad+-histone h3s10 serine adp-ribosyltransferase activity
(GO:0140817)
Nad+- protein-aspartate adp-ribosyltransferase activity
(GO:0140806)
Nad+-protein-glutamate adp-ribosyltransferase activity
(GO:0140807)
Nad+-protein-histidine adp-ribosyltransferase activity
(GO:0140815)
Nad+-protein-serine adp-ribosyltransferase activity
(GO:0140805)
Nad+-protein-tyrosine adp-ribosyltransferase activity
(GO:0140808)
Nad+-protein adp-ribosyltransferase activity
(GO:1990404)
Nad+ adp-ribosyltransferase activity
(GO:0003950)
Nad binding
(GO:0051287)
Nad dna adp-ribosyltransferase activity
(GO:0140294)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transcription elongation by rna polymerase ii
(GO:0034244)
Nuclear estrogen receptor binding
(GO:0030331)
Nucleosome binding
(GO:0031491)
Nucleotidyltransferase activity
(GO:0016779)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of dna-templated transcription, elongation
(GO:0032786)
Positive regulation of intracellular estrogen receptor signaling pathway
(GO:0033148)
Protein autoprocessing
(GO:0016540)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein modification process
(GO:0036211)
R-smad binding
(GO:0070412)
Regulation of growth rate
(GO:0040009)
Regulation of protein localization
(GO:0032880)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Telomere maintenance
(GO:0000723)
Transcription regulator activator activity
(GO:0140537)
Transferase activity
(GO:0016740)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Q921K2_MOUSE

Genular Protein ID: 3262729645

Symbol: Q921K2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q921K2

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

Length: 1014
Mass: 112721
Checksum: 5DCE68E4CB3F46EB
Sequence:

MAEASERLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH WYHFSCFWKV 
GHSIRQPDVE VDGFSELRWD DQQKVKKTAE AGGVAGKGQD GSGGKAEKTL GDFLAEYAKS 
NRSMCKGCLE KIEKGQMRLS KKMVDPEKPQ LGMIDRWYHP TCFVKKRDEL GFRPEYSASQ 
LKGFSLLSAE DKEALKKQLP AIKNEGKRKG DEVDGTDEVA KKKSKKGKDK DSSKLEKALK 
AQNELIWNIK DELKKACSTN DLKELLIFNQ QQVPSGESAI LDRVADGMAF GALLPCKECS 
GQLVFKSDAY YCTGDVTAWT KCMVKTQNPS RKEWVTPKEF REISYLKKLK VKKQDRIFPP 
ESSAPAPLAL PLSVTSAPTA VNSSAPADKP LSNMKILTLG KLSQNKDEAK AVIEKLGGKL 
TGSANKASLC ISTKKEVEKM SKKMEEVKAA NVRVVCEDFL QDVSASTKSL QELLSAHSLS 
SWGAEVKAEP GEVVAPKGKS AAPSKKSKGA VKEEGVNKSE KRMKLTLKGG AAVDPDSGLE 
HSAHVLEKGG KVFSATLGLV DIVKGTNSYY KLQLLEDDKE SRYWIFRSWG RVGTVIGSNK 
LEQMPSKEDA VEHFMKLYEE KTGNAWHSKN FTKYPKKFYP LEIDYGQDEE AVKKLTVKPG 
TKSKLPKPVQ ELVGMIFDVE SMKKALVEYE IDLQKMPLGK LSRRQIQAAY SILSEVQQAV 
SQGSSESQIL DLSNRFYTLI PHDFGMKKPP LLNNADSVQA KVEMLDNLLD IEVAYSLLRG 
GSDDSSKDPI DVNYEKLKTD IKVVDRDSEE AEVIRKYVKN THATTHNAYD LEVIDIFKIE 
REGESQRYKP FRQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM 
VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG LGKTTPDPSA 
SITLEGVEVP LGTGIPSGVN DTCLLYNEYI VYDIAQVNLK YLLKLKFNFK TSLW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Parp1

Associated with

Other Information

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337