Genular: Defining Cellular Identity and Function

Details for: Parp2

Gene ID: 11546

Symbol: Parp2

Ensembl ID: ENSMUSG00000036023

Description: poly (ADP-ribose) polymerase family, member 2

Associated with

Base excision repair
(R-MMU-73884)
Dna damage recognition in gg-ner
(R-MMU-5696394)
Dna double-strand break repair
(R-MMU-5693532)
Dual incision in gg-ner
(R-MMU-5696400)
Formation of incision complex in gg-ner
(R-MMU-5696395)
Global genome nucleotide excision repair (gg-ner)
(R-MMU-5696399)
Hdr through mmej (alt-nhej)
(R-MMU-5685939)
Homology directed repair
(R-MMU-5693538)
Nucleotide excision repair
(R-MMU-5696398)
Polb-dependent long patch base excision repair
(R-MMU-110362)
Resolution of abasic sites (ap sites)
(R-MMU-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-MMU-110373)
Base-excision repair
(GO:0006284)
Catalytic activity
(GO:0003824)
Chromatin binding
(GO:0003682)
Chromosome
(GO:0005694)
Damaged dna binding
(GO:0003684)
Decidualization
(GO:0046697)
Dna adp-ribosylation
(GO:0030592)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Dna repair-dependent chromatin remodeling
(GO:0140861)
Double-strand break repair
(GO:0006302)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Glycosyltransferase activity
(GO:0016757)
Hippocampal neuron apoptotic process
(GO:0110088)
Metabolic process
(GO:0008152)
Nad+- protein-aspartate adp-ribosyltransferase activity
(GO:0140806)
Nad+-protein-glutamate adp-ribosyltransferase activity
(GO:0140807)
Nad+-protein-serine adp-ribosyltransferase activity
(GO:0140805)
Nad+-protein adp-ribosyltransferase activity
(GO:1990404)
Nad+ adp-ribosyltransferase activity
(GO:0003950)
Nad dna adp-ribosyltransferase activity
(GO:0140294)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleosome binding
(GO:0031491)
Nucleotidyltransferase activity
(GO:0016779)
Nucleus
(GO:0005634)
Poly-adp-d-ribose binding
(GO:0072572)
Poly-adp-d-ribose modification-dependent protein binding
(GO:0160004)
Positive regulation of cell growth involved in cardiac muscle cell development
(GO:0061051)
Protein auto-adp-ribosylation
(GO:0070213)
Protein binding
(GO:0005515)
Protein poly-adp-ribosylation
(GO:0070212)
Response to oxygen-glucose deprivation
(GO:0090649)
Site of dna damage
(GO:0090734)
Transferase activity
(GO:0016740)

Other Information

Proteins

Poly [ADP-ribose] polymerase 2

Genular Protein ID: 502849561

Symbol: PARP2_MOUSE

Name: Poly [ADP-ribose] polymerase 2

UniProtKB Accession Codes:

O88554 Q99N29

Database IDs:

Citations:

PubMed ID: 10364231

Title: PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase.

PubMed ID: 10364231

DOI: 10.1074/jbc.274.25.17860

PubMed ID: 11133988

Title: A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. Structure and expression of the mouse PARP-2 gene.

PubMed ID: 11133988

DOI: 10.1074/jbc.m007870200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10338144

Title: pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans.

PubMed ID: 10338144

DOI: 10.1016/s0014-5793(99)00448-2

PubMed ID: 11948190

Title: Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.

PubMed ID: 11948190

DOI: 10.1074/jbc.m202390200

PubMed ID: 12065591

Title: Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2.

PubMed ID: 12065591

DOI: 10.1074/jbc.m203941200

PubMed ID: 12727891

Title: Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse.

PubMed ID: 12727891

DOI: 10.1093/emboj/cdg206

PubMed ID: 18436469

Title: Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation.

PubMed ID: 18436469

DOI: 10.1016/j.biocel.2008.03.008

PubMed ID: 34580230

Title: Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss.

PubMed ID: 34580230

DOI: 10.1073/pnas.2109252118

PubMed ID: 14739238

Title: Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.

PubMed ID: 14739238

DOI: 10.1093/nar/gkh215

Sequence Information:

Length: 559
Mass: 63397
Checksum: E0AEDAEE412C1445
Sequence:

MAPRRQRSGS GRRVLNEAKK VDNGNKATED DSPPGKKMRT CQRKGPMAGG KDADRTKDNR 
DSVKTLLLKG KAPVDPECAA KLGKAHVYCE GDDVYDVMLN QTNLQFNNNK YYLIQLLEDD 
AQRNFSVWMR WGRVGKTGQH SLVTCSGDLN KAKEIFQKKF LDKTKNNWED RENFEKVPGK 
YDMLQMDYAA STQDESKTKE EETLKPESQL DLRVQELLKL ICNVQTMEEM MIEMKYDTKR 
APLGKLTVAQ IKAGYQSLKK IEDCIRAGQH GRALVEACNE FYTRIPHDFG LSIPPVIRTE 
KELSDKVKLL EALGDIEIAL KLVKSERQGL EHPLDQHYRN LHCALRPLDH ESNEFKVISQ 
YLQSTHAPTH KDYTMTLLDV FEVEKEGEKE AFREDLPNRM LLWHGSRLSN WVGILSHGLR 
VAPPEAPITG YMFGKGIYFA DMSSKSANYC FASRLKNTGL LLLSEVALGQ CNELLEANPK 
AQGLLRGKHS TKGMGKMAPS PAHFITLNGS TVPLGPASDT GILNPEGYTL NYNEFIVYSP 
NQVRMRYLLK IQFNFLQLW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Parp2

Associated with

Other Information

PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. PubMed ID: 10364231

A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. Structure and expression of the mouse PARP-2 gene. PubMed ID: 11133988

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans. PubMed ID: 10338144

Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. PubMed ID: 11948190

Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2. PubMed ID: 12065591

Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. PubMed ID: 12727891

Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation. PubMed ID: 18436469

Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss. PubMed ID: 34580230

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. PubMed ID: 14739238