Genular: Defining Cellular Identity and Function

Details for: Adra2a

Gene ID: 11551

Symbol: Adra2a

Ensembl ID: ENSMUSG00000033717

Description: adrenergic receptor, alpha 2a

Associated with

Adrenaline,noradrenaline inhibits insulin secretion
(R-MMU-400042)
Adrenaline signalling through alpha-2 adrenergic receptor
(R-MMU-392023)
Adrenoceptors
(R-MMU-390696)
Amine ligand-binding receptors
(R-MMU-375280)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (z) signalling events
(R-MMU-418597)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Hemostasis
(R-MMU-109582)
Integration of energy metabolism
(R-MMU-163685)
Metabolism
(R-MMU-1430728)
Metabolism of proteins
(R-MMU-392499)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet aggregation (plug formation)
(R-MMU-76009)
Regulation of insulin secretion
(R-MMU-422356)
Signaling by gpcr
(R-MMU-372790)
Surfactant metabolism
(R-MMU-5683826)
Activation of protein kinase activity
(GO:0032147)
Activation of protein kinase b activity
(GO:0032148)
Adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071880)
Adenylate cyclase-inhibiting adrenergic receptor signaling pathway
(GO:0071881)
Adrenergic receptor activity
(GO:0004935)
Adrenergic receptor signaling pathway
(GO:0071875)
Alpha-2c adrenergic receptor binding
(GO:0031696)
Alpha2-adrenergic receptor activity
(GO:0004938)
Axon terminus
(GO:0043679)
Cellular response to hormone stimulus
(GO:0032870)
Cytoplasm
(GO:0005737)
Dna replication
(GO:0006260)
Dopaminergic synapse
(GO:0098691)
Epinephrine binding
(GO:0051379)
Fear response
(GO:0042596)
Female pregnancy
(GO:0007565)
Gaba-ergic synapse
(GO:0098982)
Glucose homeostasis
(GO:0042593)
Glutamatergic synapse
(GO:0098978)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heterotrimeric g-protein binding
(GO:0032795)
Membrane
(GO:0016020)
Negative regulation of calcium ion-dependent exocytosis
(GO:0045955)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0061179)
Negative regulation of lipid catabolic process
(GO:0050995)
Negative regulation of uterine smooth muscle contraction
(GO:0070473)
Neuronal cell body
(GO:0043025)
Norepinephrine binding
(GO:0051380)
Phospholipase c-activating adrenergic receptor signaling pathway
(GO:0071882)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of membrane protein ectodomain proteolysis
(GO:0051044)
Positive regulation of wound healing
(GO:0090303)
Postsynaptic density membrane
(GO:0098839)
Postsynaptic membrane
(GO:0045211)
Presynaptic active zone membrane
(GO:0048787)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Receptor complex
(GO:0043235)
Receptor transactivation
(GO:0035624)
Regulation of smooth muscle contraction
(GO:0006940)
Regulation of vasoconstriction
(GO:0019229)
Signal transduction
(GO:0007165)
Thermoception
(GO:0050955)
Thioesterase binding
(GO:0031996)
Vasodilation
(GO:0042311)

Other Information

Proteins

Alpha-2A adrenoreceptor

Genular Protein ID: 1385506197

Symbol: ADA2A_MOUSE

Name: Alpha-2A adrenoreceptor

UniProtKB Accession Codes:

Q01338 Q3URE6

Database IDs:

Citations:

PubMed ID: 1353249

Title: Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding.

PubMed ID: 1353249

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

Length: 465
Mass: 50555
Checksum: 0F23BA14F516F701
Sequence:

MFRQEQPLAE GSFAPMGSLQ PDAGNSSWNG TEAPGGGTRA TPYSLQVTLT LVCLAGLLML 
FTVFGNVLVI IAVFTSRALK APQNLFLVSL ASADILVATL VIPFSLANEV MGYWYFGKVW 
CEIYLALDVL FCTSSIVHLC AISLDRYWSI TQAIEYNLKR TPRRIKAIIV TVWVISAVIS 
FPPLISIEKK GAGGGQQPAE PSCKINDQKW YVISSSIGSF FAPCLIMILV YVRIYQIAKR 
RTRVPPSRRG PDACSAPPGG ADRRPNGLGP ERGAGPTGAE AEPLPTQLNG APGEPAPAGP 
RDGDALDLEE SSSSEHAERP PGPRRPDRGP RAKGKTRASQ VKPGDSLPRR GPGAAGPGAS 
GSGHGEERGG GAKASRWRGR QNREKRFTFV LAVVIGVFVV CWFPFFFTYT LIAVGCPVPS 
QLFNFFFWFG YCNSSLNPVI YTIFNHDFRR AFKKILCRGD RKRIV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Adra2a

Associated with

Other Information

Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding. PubMed ID: 1353249

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079