Details for: Adrb1

Gene ID: 11554

Symbol: Adrb1

Ensembl ID: ENSMUSG00000035283

Description: adrenergic receptor, beta 1

Associated with

  • Adrenoceptors
    (R-MMU-390696)
  • Amine ligand-binding receptors
    (R-MMU-375280)
  • Class a/1 (rhodopsin-like receptors)
    (R-MMU-373076)
  • G alpha (s) signalling events
    (R-MMU-418555)
  • Gpcr downstream signalling
    (R-MMU-388396)
  • Gpcr ligand binding
    (R-MMU-500792)
  • Signaling by gpcr
    (R-MMU-372790)
  • Adenylate cyclase-activating adrenergic receptor signaling pathway
    (GO:0071880)
  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0007189)
  • Adrenergic receptor activity
    (GO:0004935)
  • Alpha-2a adrenergic receptor binding
    (GO:0031694)
  • Amine binding
    (GO:0043176)
  • Beta1-adrenergic receptor activity
    (GO:0004940)
  • Brown fat cell differentiation
    (GO:0050873)
  • Diet induced thermogenesis
    (GO:0002024)
  • Early endosome
    (GO:0005769)
  • Endosome
    (GO:0005768)
  • Fear response
    (GO:0042596)
  • Glycogen catabolic process
    (GO:0005980)
  • G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
    (GO:0099579)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Heat generation
    (GO:0031649)
  • Inhibitory postsynaptic potential
    (GO:0060080)
  • Lipid homeostasis
    (GO:0055088)
  • Membrane
    (GO:0016020)
  • Memory
    (GO:0007613)
  • Negative regulation of multicellular organism growth
    (GO:0040015)
  • Negative regulation of smooth muscle contraction
    (GO:0045986)
  • Negative regulation of urine volume
    (GO:0035811)
  • Neuronal dense core vesicle
    (GO:0098992)
  • Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
    (GO:0002025)
  • Pdz domain binding
    (GO:0030165)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0106071)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of calcium ion import across plasma membrane
    (GO:1905665)
  • Positive regulation of cell growth involved in cardiac muscle cell development
    (GO:0061051)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of gtpase activity
    (GO:0043547)
  • Positive regulation of heart contraction
    (GO:0045823)
  • Positive regulation of heart rate
    (GO:0010460)
  • Positive regulation of heart rate by epinephrine-norepinephrine
    (GO:0001996)
  • Positive regulation of long-term synaptic potentiation
    (GO:1900273)
  • Positive regulation of systemic arterial blood pressure
    (GO:0003084)
  • Positive regulation of the force of heart contraction by epinephrine-norepinephrine
    (GO:0001997)
  • Positive regulation of the force of heart contraction by norepinephrine
    (GO:0003061)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein localization to organelle
    (GO:0033365)
  • Regulation of calcium ion transport
    (GO:0051924)
  • Regulation of cardiac muscle cell contraction
    (GO:0086004)
  • Regulation of circadian sleep/wake cycle, sleep
    (GO:0045187)
  • Response to cold
    (GO:0009409)
  • Rho protein signal transduction
    (GO:0007266)
  • Schaffer collateral - ca1 synapse
    (GO:0098685)
  • Signal transduction
    (GO:0007165)

Other Information

Genular Protein ID: 2356191775

Symbol: ADRB1_MOUSE

Name: Beta-1 adrenergic receptor

UniProtKB Accession Codes:

P34971 B2RVY4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DNASU 1 EMBL 4 Ensembl 1 GO 45 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8395893

Title: Primary structure of the mouse beta 1-adrenergic receptor gene.

PubMed ID: 8395893

DOI: 10.1016/0167-4889(93)90209-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 31473062

Title: A rare mutation of beta1-adrenergic receptor affects sleep/wake behaviors.

PubMed ID: 31473062

DOI: 10.1016/j.neuron.2019.07.026

Sequence Information:

  • Length: 466
  • Mass: 50494
  • Checksum: E4861E250B62F735
  • Sequence:
    • MGAGALALGA SEPCNLSSAA PLPDGAATAA RLLVLASPPA SLLPPASEGS APLSQQWTAG 
MGLLLALIVL LIVVGNVLVI VAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVV 
WGRWEYGSFF CELWTSVDVL CVTASIETLC VIALDRYLAI TSPFRYQSLL TRARARALVC 
TVWAISALVS FLPILMHWWR AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM 
AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPSPEPSPS PGPPRPADSL ANGRSSKRRP 
SRLVALREQK ALKTLGIIMG VFTLCWLPFF LANVVKAFHR DLVPDRLFVF FNWLGYANSA 
FNPIIYCRSP DFRKAFQRLL CCARRAACRR RAAHGDRPRA SGCLARAGPP PSPGAPSDDD 
DDDAGTTPPA RLLEPWTGCN GGTTTVDSDS SLDEPGRQGF SSESKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.