Details for: CKM

Gene ID: 1158

Symbol: CKM

Ensembl ID: ENSG00000104879

Description: creatine kinase, M-type

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 33.3665
    Cell Significance Index: -5.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.5801
    Cell Significance Index: -5.2200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 10.0123
    Cell Significance Index: 161.5500
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 9.8437
    Cell Significance Index: 28.2100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 7.4481
    Cell Significance Index: 181.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 6.2925
    Cell Significance Index: 92.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.2094
    Cell Significance Index: -5.1900
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 2.9452
    Cell Significance Index: 21.6200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.3700
    Cell Significance Index: 37.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7966
    Cell Significance Index: 137.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.3279
    Cell Significance Index: -5.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7141
    Cell Significance Index: 10.2700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4607
    Cell Significance Index: 4.8100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3412
    Cell Significance Index: 4.9000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.3283
    Cell Significance Index: 4.3000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.2955
    Cell Significance Index: 4.4200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2672
    Cell Significance Index: 3.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1298
    Cell Significance Index: 2.2300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0710
    Cell Significance Index: 0.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0337
    Cell Significance Index: 6.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0291
    Cell Significance Index: 13.1900
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.0261
    Cell Significance Index: 0.2500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0200
    Cell Significance Index: 0.2800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0197
    Cell Significance Index: 0.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0192
    Cell Significance Index: 3.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0086
    Cell Significance Index: 0.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0075
    Cell Significance Index: 1.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0074
    Cell Significance Index: 5.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0060
    Cell Significance Index: 2.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0025
    Cell Significance Index: 3.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0022
    Cell Significance Index: 0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0014
    Cell Significance Index: 2.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: 0.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0014
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0026
    Cell Significance Index: -1.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0034
    Cell Significance Index: -1.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0038
    Cell Significance Index: -0.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0050
    Cell Significance Index: -0.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0059
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0102
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0119
    Cell Significance Index: -2.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0205
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0241
    Cell Significance Index: -5.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0399
    Cell Significance Index: -0.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0412
    Cell Significance Index: -4.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0416
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0426
    Cell Significance Index: -4.8800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0437
    Cell Significance Index: -0.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0455
    Cell Significance Index: -4.7400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0468
    Cell Significance Index: -0.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0480
    Cell Significance Index: -3.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0527
    Cell Significance Index: -3.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0534
    Cell Significance Index: -2.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0586
    Cell Significance Index: -3.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0649
    Cell Significance Index: -0.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0746
    Cell Significance Index: -4.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0755
    Cell Significance Index: -2.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0762
    Cell Significance Index: -3.9700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0804
    Cell Significance Index: -1.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0814
    Cell Significance Index: -4.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0816
    Cell Significance Index: -3.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0828
    Cell Significance Index: -3.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0889
    Cell Significance Index: -1.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0939
    Cell Significance Index: -2.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0939
    Cell Significance Index: -4.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0982
    Cell Significance Index: -3.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0988
    Cell Significance Index: -3.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1032
    Cell Significance Index: -1.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1067
    Cell Significance Index: -1.1600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1114
    Cell Significance Index: -1.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1152
    Cell Significance Index: -3.6700
  • Cell Name: parietal cell (CL0000162)
    Fold Change: -0.1173
    Cell Significance Index: -1.1100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1186
    Cell Significance Index: -1.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1189
    Cell Significance Index: -4.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1216
    Cell Significance Index: -3.9800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1327
    Cell Significance Index: -1.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1332
    Cell Significance Index: -3.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1347
    Cell Significance Index: -3.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1354
    Cell Significance Index: -3.6900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1357
    Cell Significance Index: -1.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1378
    Cell Significance Index: -4.0600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1388
    Cell Significance Index: -4.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1391
    Cell Significance Index: -7.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1413
    Cell Significance Index: -1.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1422
    Cell Significance Index: -5.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1491
    Cell Significance Index: -5.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1501
    Cell Significance Index: -2.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1502
    Cell Significance Index: -4.0100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1515
    Cell Significance Index: -3.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1527
    Cell Significance Index: -3.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1535
    Cell Significance Index: -4.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1538
    Cell Significance Index: -2.1900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1541
    Cell Significance Index: -2.1000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1566
    Cell Significance Index: -1.0600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1585
    Cell Significance Index: -1.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structural Homology**: CKM shares structural homology with other creatine kinases, including the M-type creatine kinase (CKM) and the brain-type creatine kinase (BCK). 2. **Subcellular Localization**: CKM is primarily localized to the cytosol, with some expression in the extracellular space. 3. **Tissue Distribution**: CKM is expressed in skeletal muscle, cardiac muscle cells, and various types of neurons, including bipolar cells in the retina. 4. **Isozyme Forms**: CKM exists in two isoform forms, CKM-B and CKM-A, which differ in their subunit composition and tissue distribution. **Pathways and Functions** 1. **Phosphocreatine Biosynthesis**: CKM catalyzes the conversion of phosphocreatine to creatine, a critical step in the phosphocreatine kinase reaction, which provides energy for muscle contraction and other high-energy processes. 2. **Creatine Metabolism**: CKM is involved in the regulation of creatine levels in the body, which is essential for maintaining proper muscle function and energy metabolism. 3. **ATP Binding**: CKM binds to ATP, facilitating the transfer of phosphate groups between creatine and high-energy phosphate compounds. 4. **Phosphorylation**: CKM undergoes phosphorylation, which regulates its activity and interaction with other proteins. **Clinical Significance** 1. **Myopathies**: Mutations in the CKM gene have been associated with various myopathies, including McArdle's disease and mitochondrial myopathies. 2. **Cardiac Arrhythmias**: Abnormalities in CKM expression have been linked to cardiac arrhythmias, including long QT syndrome. 3. **Neurological Disorders**: CKM has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 4. **Muscle Wasting**: CKM deficiency has been associated with muscle wasting and weakness, particularly in individuals with mitochondrial myopathies. In conclusion, CKM is a vital component of energy metabolism, with a broad range of functions and implications in various diseases. Further research is necessary to fully elucidate the mechanisms underlying CKM's functions and its role in disease pathology.

Genular Protein ID: 2220972989

Symbol: KCRM_HUMAN

Name: Creatine kinase M-type

UniProtKB Accession Codes:

P06732 Q96QL9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EC 1 EMBL 13 Ensembl 1 EvolutionaryTrace 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3778496

Title: Isolation and sequence analysis of a full-length cDNA for human M creatine kinase.

PubMed ID: 3778496

DOI: 10.1016/0006-291x(86)90732-1

PubMed ID: 2903158

Title: Developmental regulation and tissue-specific expression of the human muscle creatine kinase gene.

PubMed ID: 2903158

DOI: 10.1016/s0021-9258(18)37510-0

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1690725

Title: Muscle creatine kinase isoenzyme expression in adult human brain.

PubMed ID: 1690725

DOI: 10.1016/s0021-9258(19)39340-8

PubMed ID: 3031982

Title: cDNA cloning and mapping of the human creatine kinase M gene to 19q13.

PubMed ID: 3031982

PubMed ID: 10089465

Title: Crystallization and preliminary X-ray analysis of human muscle creatine kinase.

PubMed ID: 10089465

DOI: 10.1107/s0907444998011044

Sequence Information:

  • Length: 381
  • Mass: 43101
  • Checksum: 418FEAD0C2E138C8
  • Sequence:
    • MPFGNTHNKF KLNYKPEEEY PDLSKHNNHM AKVLTLELYK KLRDKETPSG FTVDDVIQTG 
VDNPGHPFIM TVGCVAGDEE SYEVFKELFD PIISDRHGGY KPTDKHKTDL NHENLKGGDD 
LDPNYVLSSR VRTGRSIKGY TLPPHCSRGE RRAVEKLSVE ALNSLTGEFK GKYYPLKSMT 
EKEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKSFLVWVN EEDHLRVISM 
EKGGNMKEVF RRFCVGLQKI EEIFKKAGHP FMWNQHLGYV LTCPSNLGTG LRGGVHVKLA 
HLSKHPKFEE ILTRLRLQKR GTGGVDTAAV GSVFDVSNAD RLGSSEVEQV QLVVDGVKLM 
VEMEKKLEKG QSIDDMIPAQ K

Genular Protein ID: 2999375223

Symbol: B2R892_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R892

Database IDs:

ARBA 12 AlphaFoldDB 1 BRENDA 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 10 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 2 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 1 RuleBase 1 SUPFAM 2

Sequence Information:

  • Length: 381
  • Mass: 43029
  • Checksum: 17BABEE597FA7E52
  • Sequence:
    • MPFGNTHNKF KLNYKPGEEY PDLSKHNNHM AKVLTLELYK KLRDKETPSG FTVDDVIQTG 
VDNPGHPFIM TVGCVAGDEE SYEVFKELFD PIISDRHGGY KPTDKHKTDL NHENLKGGDD 
LDPNYVLSSR VRTGRSIKGY TLPPHCSRGE RRAVEKLSVE ALNSLTGEFK GKYYPLKSMT 
EKEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKSFLVWVN EEDHLRVISM 
EKGGNMKEVF RRFCVGLQKI EEIFKKAGHP FMWNQHLGYV LTCPSNLGTG LRGGVHVKLA 
HLSKHPKFEE ILTRLRLQKR GTGGVDTAAV GSVFDVSNAD RLGSSEVEQV QLVVDGVKLM 
VEMEKKLEKG QSIDDMIPAQ K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.