Details for: CKM

Gene ID: 1158

Symbol: CKM

Ensembl ID: ENSG00000104879

Description: creatine kinase, M-type

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 8.85
    Marker Score: 6737
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.79
    Marker Score: 16886.5
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.69
    Marker Score: 16873.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.84
    Marker Score: 32432
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.38
    Marker Score: 9699
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.13
    Marker Score: 1030
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.04
    Marker Score: 67977
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.8
    Marker Score: 7983
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.48
    Marker Score: 32968
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.13
    Marker Score: 7556
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.12
    Marker Score: 1068.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.96
    Marker Score: 11764
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.56
    Marker Score: 2957
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169424
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19288
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5340
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.9
    Marker Score: 1126
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1773
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.77
    Marker Score: 1699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.73
    Marker Score: 219
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.68
    Marker Score: 328
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 446
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.55
    Marker Score: 247
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 329
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.48
    Marker Score: 154
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.48
    Marker Score: 157
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 217
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 384
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 219
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.38
    Marker Score: 2225.5
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.34
    Marker Score: 110
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.33
    Marker Score: 184
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.32
    Marker Score: 90
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.29
    Marker Score: 130
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.29
    Marker Score: 193
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.28
    Marker Score: 178
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.25
    Marker Score: 262
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.24
    Marker Score: 177.5
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.24
    Marker Score: 100
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.21
    Marker Score: 85
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.2
    Marker Score: 214
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2
    Marker Score: 108
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.19
    Marker Score: 66
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.19
    Marker Score: 124
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.19
    Marker Score: 124
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.18
    Marker Score: 49
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.18
    Marker Score: 82
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 102
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.18
    Marker Score: 154
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.18
    Marker Score: 63
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.17
    Marker Score: 1162
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.17
    Marker Score: 86
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.17
    Marker Score: 203
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.16
    Marker Score: 248.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.16
    Marker Score: 136
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.16
    Marker Score: 156
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.15
    Marker Score: 454
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.14
    Marker Score: 294
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.14
    Marker Score: 368
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.14
    Marker Score: 140
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 124
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.13
    Marker Score: 211
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.13
    Marker Score: 30
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.13
    Marker Score: 100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.13
    Marker Score: 83
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.13
    Marker Score: 46
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.12
    Marker Score: 61
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.12
    Marker Score: 50
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.12
    Marker Score: 807
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.12
    Marker Score: 301
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.12
    Marker Score: 185
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.12
    Marker Score: 193
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.12
    Marker Score: 88
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.12
    Marker Score: 103
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.11
    Marker Score: 225
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.11
    Marker Score: 157
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 125

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Other Information

**Key characteristics:** - CKM is a key enzyme in the citric acid cycle, which is responsible for the production of ATP from glucose. - CKM is also involved in the regulation of calcium signaling and apoptosis. - CKM is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. **Pathways and functions:** - CKM is involved in a number of cellular processes, including: - Muscle contraction - Cell growth and differentiation - Apoptosis - Calcium signaling - CKM is a key regulator of muscle metabolism. It is expressed in skeletal muscle cells, where it is responsible for maintaining muscle contractility. - CKM is also expressed in cardiac muscle cells, where it helps to regulate cardiac output. - In addition to its role in muscle and cardiac function, CKM is also expressed in retinal cells. It is involved in the regulation of retinal function, including the production of neurotransmitters and the maintenance of retinal health. **Clinical significance:** - Mutations in the CKM gene have been linked to a number of human diseases, including: - Creatine kinase deficiency - Congenital heart disease - Retinal degenerative diseases - Skeletal muscle disorders - CKM is a potential therapeutic target for a number of diseases. For example, CKM inhibitors are being investigated as a treatment for heart disease and stroke.

Genular Protein ID: 2220972989

Symbol: KCRM_HUMAN

Name: Creatine kinase M-type

UniProtKB Accession Codes:

P06732 Q96QL9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EC 1 EMBL 13 Ensembl 1 EvolutionaryTrace 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3778496

Title: Isolation and sequence analysis of a full-length cDNA for human M creatine kinase.

PubMed ID: 3778496

DOI: 10.1016/0006-291x(86)90732-1

PubMed ID: 2903158

Title: Developmental regulation and tissue-specific expression of the human muscle creatine kinase gene.

PubMed ID: 2903158

DOI: 10.1016/s0021-9258(18)37510-0

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1690725

Title: Muscle creatine kinase isoenzyme expression in adult human brain.

PubMed ID: 1690725

DOI: 10.1016/s0021-9258(19)39340-8

PubMed ID: 3031982

Title: cDNA cloning and mapping of the human creatine kinase M gene to 19q13.

PubMed ID: 3031982

PubMed ID: 10089465

Title: Crystallization and preliminary X-ray analysis of human muscle creatine kinase.

PubMed ID: 10089465

DOI: 10.1107/s0907444998011044

Sequence Information:

  • Length: 381
  • Mass: 43101
  • Checksum: 418FEAD0C2E138C8
  • Sequence:
    • MPFGNTHNKF KLNYKPEEEY PDLSKHNNHM AKVLTLELYK KLRDKETPSG FTVDDVIQTG 
VDNPGHPFIM TVGCVAGDEE SYEVFKELFD PIISDRHGGY KPTDKHKTDL NHENLKGGDD 
LDPNYVLSSR VRTGRSIKGY TLPPHCSRGE RRAVEKLSVE ALNSLTGEFK GKYYPLKSMT 
EKEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKSFLVWVN EEDHLRVISM 
EKGGNMKEVF RRFCVGLQKI EEIFKKAGHP FMWNQHLGYV LTCPSNLGTG LRGGVHVKLA 
HLSKHPKFEE ILTRLRLQKR GTGGVDTAAV GSVFDVSNAD RLGSSEVEQV QLVVDGVKLM 
VEMEKKLEKG QSIDDMIPAQ K

Genular Protein ID: 2999375223

Symbol: B2R892_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R892

Database IDs:

ARBA 12 AlphaFoldDB 1 BRENDA 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 10 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 1 RuleBase 1 SUPFAM 2

Sequence Information:

  • Length: 381
  • Mass: 43029
  • Checksum: 17BABEE597FA7E52
  • Sequence:
    • MPFGNTHNKF KLNYKPGEEY PDLSKHNNHM AKVLTLELYK KLRDKETPSG FTVDDVIQTG 
VDNPGHPFIM TVGCVAGDEE SYEVFKELFD PIISDRHGGY KPTDKHKTDL NHENLKGGDD 
LDPNYVLSSR VRTGRSIKGY TLPPHCSRGE RRAVEKLSVE ALNSLTGEFK GKYYPLKSMT 
EKEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKSFLVWVN EEDHLRVISM 
EKGGNMKEVF RRFCVGLQKI EEIFKKAGHP FMWNQHLGYV LTCPSNLGTG LRGGVHVKLA 
HLSKHPKFEE ILTRLRLQKR GTGGVDTAAV GSVFDVSNAD RLGSSEVEQV QLVVDGVKLM 
VEMEKKLEKG QSIDDMIPAQ K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.