Details for: CKMT1B

Gene ID: 1159

Symbol: CKMT1B

Ensembl ID: ENSG00000237289

Description: creatine kinase, mitochondrial 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.0528
    Cell Significance Index: -20.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.2722
    Cell Significance Index: -22.1600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 5.5572
    Cell Significance Index: 42.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.6917
    Cell Significance Index: 169.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8903
    Cell Significance Index: 85.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5367
    Cell Significance Index: 44.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5001
    Cell Significance Index: 90.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1824
    Cell Significance Index: 28.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1073
    Cell Significance Index: 23.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0687
    Cell Significance Index: 22.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0444
    Cell Significance Index: 15.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9693
    Cell Significance Index: 278.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9412
    Cell Significance Index: 48.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9015
    Cell Significance Index: 12.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8188
    Cell Significance Index: 26.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7545
    Cell Significance Index: 151.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6326
    Cell Significance Index: 43.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6280
    Cell Significance Index: 73.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4448
    Cell Significance Index: 12.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4444
    Cell Significance Index: 196.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3637
    Cell Significance Index: 25.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3421
    Cell Significance Index: 65.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2950
    Cell Significance Index: 105.8200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2318
    Cell Significance Index: 3.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2247
    Cell Significance Index: 7.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2194
    Cell Significance Index: 10.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2019
    Cell Significance Index: 19.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1984
    Cell Significance Index: 4.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0961
    Cell Significance Index: 86.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0858
    Cell Significance Index: 1.4700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0684
    Cell Significance Index: 1.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0650
    Cell Significance Index: 11.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0625
    Cell Significance Index: 1.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0503
    Cell Significance Index: 1.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0427
    Cell Significance Index: 2.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0366
    Cell Significance Index: 4.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0361
    Cell Significance Index: 1.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0161
    Cell Significance Index: 8.7700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0133
    Cell Significance Index: 0.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0053
    Cell Significance Index: 0.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0044
    Cell Significance Index: -2.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0092
    Cell Significance Index: -14.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0093
    Cell Significance Index: -17.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0105
    Cell Significance Index: -19.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0136
    Cell Significance Index: -0.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0165
    Cell Significance Index: -22.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0180
    Cell Significance Index: -10.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0253
    Cell Significance Index: -18.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0257
    Cell Significance Index: -19.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0288
    Cell Significance Index: -4.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0344
    Cell Significance Index: -21.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0357
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0389
    Cell Significance Index: -8.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0487
    Cell Significance Index: -6.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0494
    Cell Significance Index: -5.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0516
    Cell Significance Index: -23.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1061
    Cell Significance Index: -21.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1497
    Cell Significance Index: -17.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1513
    Cell Significance Index: -21.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1515
    Cell Significance Index: -20.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1525
    Cell Significance Index: -17.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1962
    Cell Significance Index: -12.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2015
    Cell Significance Index: -20.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2276
    Cell Significance Index: -4.8300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2313
    Cell Significance Index: -2.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2440
    Cell Significance Index: -15.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2526
    Cell Significance Index: -5.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2560
    Cell Significance Index: -2.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2584
    Cell Significance Index: -19.2600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2701
    Cell Significance Index: -2.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2741
    Cell Significance Index: -21.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2810
    Cell Significance Index: -8.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3040
    Cell Significance Index: -23.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3091
    Cell Significance Index: -10.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3479
    Cell Significance Index: -16.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3506
    Cell Significance Index: -7.5800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3543
    Cell Significance Index: -2.3100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3673
    Cell Significance Index: -4.5800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3675
    Cell Significance Index: -2.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3768
    Cell Significance Index: -21.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3828
    Cell Significance Index: -19.9400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.4149
    Cell Significance Index: -3.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4282
    Cell Significance Index: -14.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4333
    Cell Significance Index: -8.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4395
    Cell Significance Index: -10.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4476
    Cell Significance Index: -8.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4695
    Cell Significance Index: -17.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4705
    Cell Significance Index: -9.8200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4706
    Cell Significance Index: -5.9400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.4738
    Cell Significance Index: -4.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4877
    Cell Significance Index: -12.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4891
    Cell Significance Index: -7.3700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.4986
    Cell Significance Index: -3.3100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.5022
    Cell Significance Index: -3.6500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5029
    Cell Significance Index: -12.5400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5341
    Cell Significance Index: -13.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6435
    Cell Significance Index: -16.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6623
    Cell Significance Index: -23.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: CKMT1B is a mitochondrial enzyme, indicating its critical role in energy metabolism within the mitochondria. 2. **High expression levels**: CKMT1B is significantly expressed in numerous cell types, including enterocytes, placental trophoblasts, and neurons, highlighting its importance in various cellular processes. 3. **Specific substrate specificity**: CKMT1B has a high affinity for creatine, allowing it to efficiently catalyze the conversion to phosphocreatine. 4. **Regulatory mechanisms**: CKMT1B is subject to various regulatory mechanisms, including phosphorylation and protein binding, which modulate its activity in response to cellular demands. **Pathways and Functions:** 1. **Creatine metabolism**: CKMT1B plays a central role in the creatine metabolism pathway, facilitating the conversion of creatine to phosphocreatine, which serves as a rapid energy reservoir. 2. **Mitochondrial energy metabolism**: CKMT1B contributes to the regulation of mitochondrial energy metabolism by replenishing ATP stores during high-intensity, short-duration activities. 3. **Neurotransmission and synaptic plasticity**: CKMT1B is highly expressed in neurons, where it may play a role in regulating neurotransmitter release and synaptic plasticity. 4. **Cell growth and differentiation**: CKMT1B may also contribute to cell growth and differentiation by regulating energy metabolism and signaling pathways. **Clinical Significance:** 1. **Muscle disorders**: Mutations in the CKMT1B gene have been associated with muscle disorders, such as hypertrophic cardiomyopathy and malignant hyperthermia. 2. **Neurological disorders**: Dysregulation of CKMT1B has been implicated in various neurological disorders, including epilepsy and autism spectrum disorder. 3. **Cancer**: CKMT1B may play a role in cancer development and progression, particularly in the context of energy metabolism and mitochondrial function. 4. **Pregnancy complications**: CKMT1B is highly expressed in placental trophoblasts, and dysregulation of this gene may contribute to pregnancy complications, such as preeclampsia. In conclusion, the CKMT1B gene is a crucial regulator of energy metabolism and cellular development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying CKMT1B function and its potential therapeutic applications.

Genular Protein ID: 399656352

Symbol: KCRU_HUMAN

Name: Creatine kinase U-type, mitochondrial

UniProtKB Accession Codes:

P12532 B4DIT8 B7ZA09 Q0VAM3 Q32NF6 Q53FC4

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CDD 1 CTD 2 ChEBI 11 ChiTaRS 2 DMDM 1 DNASU 1 DisGeNET 2 DrugBank 4 EC 2 EMBL 11 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 2 GeneTree 1 GeneWiki 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 6 KEGG 2 MANE-Select 2 MIM 2 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 11 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2914937

Title: Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase.

PubMed ID: 2914937

DOI: 10.1016/s0021-9258(19)81696-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 10737943

Title: Crystal structure of human ubiquitous mitochondrial creatine kinase.

PubMed ID: 10737943

DOI: 10.1002/(sici)1097-0134(20000515)39:3<216::aid-prot40>3.0.co;2-#

Sequence Information:

  • Length: 417
  • Mass: 47037
  • Checksum: 274DAC2E9A8AD882
  • Sequence:
    • MAGPFSRLLS ARPGLRLLAL AGAGSLAAGF LLRPEPVRAA SERRRLYPPS AEYPDLRKHN 
NCMASHLTPA VYARLCDKTT PTGWTLDQCI QTGVDNPGHP FIKTVGMVAG DEETYEVFAD 
LFDPVIQERH NGYDPRTMKH TTDLDASKIR SGYFDERYVL SSRVRTGRSI RGLSLPPACT 
RAERREVERV VVDALSGLKG DLAGRYYRLS EMTEAEQQQL IDDHFLFDKP VSPLLTAAGM 
ARDWPDARGI WHNNEKSFLI WVNEEDHTRV ISMEKGGNMK RVFERFCRGL KEVERLIQER 
GWEFMWNERL GYILTCPSNL GTGLRAGVHI KLPLLSKDSR FPKILENLRL QKRGTGGVDT 
AATGGVFDIS NLDRLGKSEV ELVQLVIDGV NYLIDCERRL ERGQDIRIPT PVIHTKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.