Details for: CKMT1B

Gene ID: 1159

Symbol: CKMT1B

Ensembl ID: ENSG00000237289

Description: creatine kinase, mitochondrial 1B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.73
    Marker Score: 8302.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.61
    Marker Score: 6329
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.35
    Marker Score: 2087
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.3
    Marker Score: 11241.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.28
    Marker Score: 3043
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.19
    Marker Score: 1062
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.16
    Marker Score: 42974
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.13
    Marker Score: 8419.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.04
    Marker Score: 63680.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1
    Marker Score: 9520
  • Cell Name: neuron (CL0000540)
    Fold Change: 1
    Marker Score: 4067
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71809
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.98
    Marker Score: 1509
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.98
    Marker Score: 368
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.96
    Marker Score: 234
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.96
    Marker Score: 6134.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5314
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.93
    Marker Score: 415
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9
    Marker Score: 9324
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.9
    Marker Score: 863
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.86
    Marker Score: 8103.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.84
    Marker Score: 841
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1355
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 330
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.79
    Marker Score: 2472
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.78
    Marker Score: 15440
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3196.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 692
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.76
    Marker Score: 353
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.73
    Marker Score: 27854
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.73
    Marker Score: 5725
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.73
    Marker Score: 764
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.71
    Marker Score: 2956
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.71
    Marker Score: 212
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.69
    Marker Score: 2665.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.68
    Marker Score: 278
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.68
    Marker Score: 5844.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.66
    Marker Score: 551
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.65
    Marker Score: 734
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.61
    Marker Score: 1389
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.61
    Marker Score: 1019
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.57
    Marker Score: 451
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.54
    Marker Score: 4120
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.53
    Marker Score: 1520
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.53
    Marker Score: 7873.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.52
    Marker Score: 208
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.49
    Marker Score: 240
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.47
    Marker Score: 197
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.47
    Marker Score: 952
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.45
    Marker Score: 577
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.44
    Marker Score: 654
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.43
    Marker Score: 488
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.43
    Marker Score: 474
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.43
    Marker Score: 197
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 422
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.42
    Marker Score: 372
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.41
    Marker Score: 406
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.41
    Marker Score: 200
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.39
    Marker Score: 241
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.39
    Marker Score: 96
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.39
    Marker Score: 1103
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.38
    Marker Score: 697
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.38
    Marker Score: 110
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.38
    Marker Score: 165
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.38
    Marker Score: 356
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.37
    Marker Score: 1563
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.37
    Marker Score: 107.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.37
    Marker Score: 4953
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.36
    Marker Score: 426
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.36
    Marker Score: 366
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.35
    Marker Score: 861
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.35
    Marker Score: 236
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.34
    Marker Score: 248
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.34
    Marker Score: 1165
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.34
    Marker Score: 560
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.34
    Marker Score: 951
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.33
    Marker Score: 2196
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.33
    Marker Score: 111
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.33
    Marker Score: 742
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.32
    Marker Score: 323
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.31
    Marker Score: 200
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.31
    Marker Score: 105
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.3
    Marker Score: 83
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.29
    Marker Score: 356
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.29
    Marker Score: 164
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.29
    Marker Score: 148
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.29
    Marker Score: 764
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.28
    Marker Score: 68
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.28
    Marker Score: 76

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Other Information

**Key characteristics:** * **Function:** Creatine kinase 1B is a key enzyme in the citric acid cycle, which is responsible for the production of ATP (adenosine triphosphate), the energy currency of cells. * **Location:** The protein is found in the mitochondria of cells. * **Tissue expression:** CKMT1B is highly expressed in the enterocyte, placental villous trophoblast, and L5 extratelencephalic projecting glutamatergic cortical neuron. It is also expressed in epithelial cells of the esophagus, stem cells, extravillous trophoblast, pvalb GABAergic cortical interneuron, basal cell of epithelium of trachea, L2/3-6 intratelencephalic projecting glutamatergic neuron, and corticothalamic-projecting glutamatergic cortical neuron. **Pathways and functions:** * **ATP production:** CKMT1B is responsible for the phosphorylation of phosphocreatine, a molecule that acts as a temporary store of energy. When phosphocreatine is phosphorylated, it is converted into ATP. * **Citric acid cycle:** CKMT1B is a key enzyme in the citric acid cycle, where it catalyzes the transfer of a phosphate group from phosphocreatine to oxaloacetate. This reaction is essential for the production of ATP. * **Other functions:** CKMT1B has also been shown to be involved in other cellular processes, including protein synthesis, apoptosis, and inflammation. **Clinical significance:** Mutations in the CKMT1B gene have been linked to several human genetic disorders, including hypertrophic cardiomyopathy, lactic acidosis, and mitochondrial myopathy. These disorders are caused by mutations in genes that are involved in the function of CKMT1B.

Genular Protein ID: 399656352

Symbol: KCRU_HUMAN

Name: Creatine kinase U-type, mitochondrial

UniProtKB Accession Codes:

P12532 B4DIT8 B7ZA09 Q0VAM3 Q32NF6 Q53FC4

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CDD 1 CTD 2 ChEBI 11 ChiTaRS 2 DMDM 1 DNASU 1 DisGeNET 2 DrugBank 4 EC 2 EMBL 11 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 2 GeneTree 1 GeneWiki 1 Genevisible 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 6 KEGG 2 MANE-Select 2 MIM 2 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 11 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 4 VEuPathDB 2 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2914937

Title: Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase.

PubMed ID: 2914937

DOI: 10.1016/s0021-9258(19)81696-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 10737943

Title: Crystal structure of human ubiquitous mitochondrial creatine kinase.

PubMed ID: 10737943

DOI: 10.1002/(sici)1097-0134(20000515)39:3<216::aid-prot40>3.0.co;2-#

Sequence Information:

  • Length: 417
  • Mass: 47037
  • Checksum: 274DAC2E9A8AD882
  • Sequence:
    • MAGPFSRLLS ARPGLRLLAL AGAGSLAAGF LLRPEPVRAA SERRRLYPPS AEYPDLRKHN 
NCMASHLTPA VYARLCDKTT PTGWTLDQCI QTGVDNPGHP FIKTVGMVAG DEETYEVFAD 
LFDPVIQERH NGYDPRTMKH TTDLDASKIR SGYFDERYVL SSRVRTGRSI RGLSLPPACT 
RAERREVERV VVDALSGLKG DLAGRYYRLS EMTEAEQQQL IDDHFLFDKP VSPLLTAAGM 
ARDWPDARGI WHNNEKSFLI WVNEEDHTRV ISMEKGGNMK RVFERFCRGL KEVERLIQER 
GWEFMWNERL GYILTCPSNL GTGLRAGVHI KLPLLSKDSR FPKILENLRL QKRGTGGVDT 
AATGGVFDIS NLDRLGKSEV ELVQLVIDGV NYLIDCERRL ERGQDIRIPT PVIHTKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.