Details for: Ager

Gene ID: 11596

Symbol: Ager

Ensembl ID: ENSMUSG00000015452

Description: advanced glycosylation end product-specific receptor

Associated with

  • Advanced glycosylation endproduct receptor signaling
    (R-MMU-879415)
  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Ddx58/ifih1-mediated induction of interferon-alpha/beta
    (R-MMU-168928)
  • Immune system
    (R-MMU-168256)
  • Innate immune system
    (R-MMU-168249)
  • Interleukin-1 family signaling
    (R-MMU-446652)
  • Interleukin-1 signaling
    (R-MMU-9020702)
  • Myd88 cascade initiated on plasma membrane
    (R-MMU-975871)
  • Myd88 dependent cascade initiated on endosome
    (R-MMU-975155)
  • Myd88-independent tlr4 cascade
    (R-MMU-166166)
  • Myd88:mal(tirap) cascade initiated on plasma membrane
    (R-MMU-166058)
  • Signaling by interleukins
    (R-MMU-449147)
  • Tak1-dependent ikk and nf-kappa-b activation
    (R-MMU-445989)
  • Toll-like receptor cascades
    (R-MMU-168898)
  • Toll like receptor 2 (tlr2) cascade
    (R-MMU-181438)
  • Toll like receptor 3 (tlr3) cascade
    (R-MMU-168164)
  • Toll like receptor 4 (tlr4) cascade
    (R-MMU-166016)
  • Toll like receptor 5 (tlr5) cascade
    (R-MMU-168176)
  • Toll like receptor 7/8 (tlr7/8) cascade
    (R-MMU-168181)
  • Toll like receptor 9 (tlr9) cascade
    (R-MMU-168138)
  • Toll like receptor 10 (tlr10) cascade
    (R-MMU-168142)
  • Toll like receptor tlr1:tlr2 cascade
    (R-MMU-168179)
  • Toll like receptor tlr6:tlr2 cascade
    (R-MMU-168188)
  • Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
    (R-MMU-975138)
  • Traf6 mediated nf-kb activation
    (R-MMU-933542)
  • Trif(ticam1)-mediated tlr4 signaling
    (R-MMU-937061)
  • Amyloid-beta binding
    (GO:0001540)
  • Astrocyte activation
    (GO:0048143)
  • Astrocyte development
    (GO:0014002)
  • Cellular response to amyloid-beta
    (GO:1904646)
  • Glucose mediated signaling pathway
    (GO:0010255)
  • High mobility group box 1 binding
    (GO:0070379)
  • Identical protein binding
    (GO:0042802)
  • Induction of positive chemotaxis
    (GO:0050930)
  • Inflammatory response
    (GO:0006954)
  • Laminin receptor activity
    (GO:0005055)
  • Learning or memory
    (GO:0007611)
  • Microglial cell activation
    (GO:0001774)
  • Molecular adaptor activity
    (GO:0060090)
  • Negative regulation of blood circulation
    (GO:1903523)
  • Negative regulation of cell adhesion
    (GO:0007162)
  • Negative regulation of collagen biosynthetic process
    (GO:0032966)
  • Negative regulation of endothelial cell migration
    (GO:0010596)
  • Negative regulation of endothelial cell proliferation
    (GO:0001937)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of long-term synaptic depression
    (GO:1900453)
  • Negative regulation of long-term synaptic potentiation
    (GO:1900272)
  • Negative regulation of protein phosphorylation
    (GO:0001933)
  • Neuron projection development
    (GO:0031175)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
    (GO:1902961)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of endothelial cell apoptotic process
    (GO:2000353)
  • Positive regulation of endothelin production
    (GO:1904472)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fibroblast migration
    (GO:0010763)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of heterotypic cell-cell adhesion
    (GO:0034116)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of jun kinase activity
    (GO:0043507)
  • Positive regulation of monocyte chemotactic protein-1 production
    (GO:0071639)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of p38mapk cascade
    (GO:1900745)
  • Positive regulation of phagocytosis, engulfment
    (GO:0060100)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Protein localization to membrane
    (GO:0072657)
  • Receptor signaling pathway via jak-stat
    (GO:0007259)
  • Regulation of dna binding
    (GO:0051101)
  • Regulation of inflammatory response
    (GO:0050727)
  • Regulation of long-term synaptic potentiation
    (GO:1900271)
  • Regulation of p38mapk cascade
    (GO:1900744)
  • Regulation of spontaneous synaptic transmission
    (GO:0150003)
  • Regulation of t cell mediated cytotoxicity
    (GO:0001914)
  • Response to amyloid-beta
    (GO:1904645)
  • Response to hypoxia
    (GO:0001666)
  • S100 protein binding
    (GO:0044548)
  • Signaling receptor activity
    (GO:0038023)
  • Transcytosis
    (GO:0045056)
  • Transport across blood-brain barrier
    (GO:0150104)

Other Information

Genular Protein ID: 3119371360

Symbol: RAGE_MOUSE

Name: Advanced glycosylation end product-specific receptor

UniProtKB Accession Codes:

Q62151 C5H3H4 C5H3H5 C5H3H7 C5H3I0 C5H7W3 C5H7W4 C5H7W5 C5H7W6 C5H7W7 C5H7W8 C5H7W9 O35444 Q2PGG1 V5R4Y0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 EMBL 34 Ensembl 4 GO 77 Gene3D 1 GeneTree 1 GlyCosmos 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 9 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 6 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9224812

Title: Recombinant advanced glycation end product receptor pharmacokinetics in normal and diabetic rats.

PubMed ID: 9224812

DOI: 10.1124/mol.52.1.54

PubMed ID: 16503878

Title: Identification of mouse orthologue of endogenous secretory receptor for advanced glycation end-products: structure, function and expression.

PubMed ID: 16503878

DOI: 10.1042/bj20051573

PubMed ID: 19164451

Title: Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene.

PubMed ID: 19164451

DOI: 10.1096/fj.08-117739

PubMed ID: 24260107

Title: Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function.

PubMed ID: 24260107

DOI: 10.1371/journal.pone.0078267

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10399917

Title: RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides.

PubMed ID: 10399917

DOI: 10.1016/s0092-8674(00)80801-6

PubMed ID: 18539754

Title: AGE/RAGE produces endothelial dysfunction in coronary arterioles in type 2 diabetic mice.

PubMed ID: 18539754

DOI: 10.1152/ajpheart.00464.2008

PubMed ID: 19901339

Title: RAGE-mediated signaling contributes to intraneuronal transport of amyloid-{beta} and neuronal dysfunction.

PubMed ID: 19901339

DOI: 10.1073/pnas.0905686106

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19906677

Title: RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.

PubMed ID: 19906677

DOI: 10.1096/fj.09-139634

PubMed ID: 21270403

Title: Septic shock is associated with receptor for advanced glycation end products ligation of LPS.

PubMed ID: 21270403

DOI: 10.4049/jimmunol.1002253

PubMed ID: 32670276

Title: The Receptor for Advanced Glycation Endproducts (RAGE) Contributes to Severe Inflammatory Liver Injury in Mice.

PubMed ID: 32670276

DOI: 10.3389/fimmu.2020.01157

PubMed ID: 23679870

Title: Stable RAGE-heparan sulfate complexes are essential for signal transduction.

PubMed ID: 23679870

DOI: 10.1021/cb4001553

Sequence Information:

  • Length: 402
  • Mass: 42654
  • Checksum: DBFDC50A6C8CB902
  • Sequence:
    • MPAGTAARAW VLVLALWGAV AGGQNITARI GEPLVLSCKG APKKPPQQLE WKLNTGRTEA 
WKVLSPQGGP WDSVARILPN GSLLLPATGI VDEGTFRCRA TNRRGKEVKS NYRVRVYQIP 
GKPEIVDPAS ELTASVPNKV GTCVSEGSYP AGTLSWHLDG KLLIPDGKET LVKEETRRHP 
ETGLFTLRSE LTVIPTQGGT HPTFSCSFSL GLPRRRPLNT APIQLRVREP GPPEGIQLLV 
EPEGGIVAPG GTVTLTCAIS AQPPPQVHWI KDGAPLPLAP SPVLLLPEVG HEDEGTYSCV 
ATHPSHGPQE SPPVSIRVTE TGDEGPAEGS VGESGLGTLA LALGILGGLG VVALLVGAIL 
WRKRQPRREE RKAPESQEDE EERAELNQSE EAEMPENGAG GP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.