Details for: ADCYAP1

Gene ID: 116

Symbol: ADCYAP1

Ensembl ID: ENSG00000141433

Description: adenylate cyclase activating polypeptide 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.44
    Marker Score: 2722
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7681
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.99
    Marker Score: 2011
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.96
    Marker Score: 1083
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.93
    Marker Score: 311
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 624.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.82
    Marker Score: 366
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12197
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.76
    Marker Score: 746
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.68
    Marker Score: 402.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 382
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.56
    Marker Score: 1871
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.52
    Marker Score: 4436
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 480
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.5
    Marker Score: 527
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.47
    Marker Score: 105
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 444
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 187
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 282
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.4
    Marker Score: 1084
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.37
    Marker Score: 1526
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 177
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.35
    Marker Score: 203
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.34
    Marker Score: 1775
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 84
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.32
    Marker Score: 653.5
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.27
    Marker Score: 131
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 119
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 84
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.24
    Marker Score: 129
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.23
    Marker Score: 79.5
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.21
    Marker Score: 111
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.2
    Marker Score: 85
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.2
    Marker Score: 61
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 114
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.19
    Marker Score: 51
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.18
    Marker Score: 86
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.17
    Marker Score: 260
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.16
    Marker Score: 182
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.16
    Marker Score: 52
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.14
    Marker Score: 43
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.14
    Marker Score: 1416
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.14
    Marker Score: 77
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.13
    Marker Score: 55
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.13
    Marker Score: 79
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.12
    Marker Score: 94
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1
    Marker Score: 6393
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 128.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.1
    Marker Score: 102
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 81
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.09
    Marker Score: 188.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 197
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 144
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.08
    Marker Score: 71
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 77
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.08
    Marker Score: 335.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.08
    Marker Score: 82
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.08
    Marker Score: 775
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 90
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.07
    Marker Score: 2443
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.07
    Marker Score: 149
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.07
    Marker Score: 72
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 202
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.06
    Marker Score: 489
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.06
    Marker Score: 113
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.06
    Marker Score: 329
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.06
    Marker Score: 84

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Other Information

**Key characteristics:** * The ADCYAP1 gene is located on chromosome 17q21.1. * It is a large gene that encodes a protein of 1,215 amino acids. * The protein is expressed in a variety of cell types, including cardiac endothelial cells, granulocyte monocyte progenitor cells, goblet cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, immature innate lymphoid cells, inhibitory motor neurons, and absorptive cells. **Pathways and functions:** * The ADCYAP1 gene is a key regulator of the trka receptor family of cell surface receptors. * Trka receptors are expressed on a variety of cell types, including endothelial cells, immune cells, and neurons. * Activation of trka receptors by their ligand, PACA, is involved in a variety of cellular processes, including cell growth, differentiation, and survival. * Dysregulation of trka receptors and the ADCYAP1 gene has been linked to a number of human diseases, including cancer and cardiovascular disease. **Clinical significance:** * Mutations in the ADCYAP1 gene have been linked to a number of human diseases, including cancer and cardiovascular disease. * Inhibition of ADCYAP1 has been shown to suppress the growth of cancer cells. * Therefore, ADCYAP1 is a promising target for the treatment of cancer.

Genular Protein ID: 429442188

Symbol: PACA_HUMAN

Name: Pituitary adenylate cyclase-activating polypeptide

UniProtKB Accession Codes:

P18509 B2R7N4 Q52LQ0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 EMDB 6 Ensembl 2 EvolutionaryTrace 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 11 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SABIO-RK 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1739432

Title: Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide.

PubMed ID: 1739432

DOI: 10.1089/dna.1992.11.21

PubMed ID: 1730060

Title: Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene.

PubMed ID: 1730060

DOI: 10.1016/0167-4781(92)90488-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2302217

Title: A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs.

PubMed ID: 2302217

DOI: 10.1016/0006-291x(90)91914-e

PubMed ID: 23800469

Title: Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells.

PubMed ID: 23800469

DOI: 10.1126/scisignal.2003993

PubMed ID: 8504103

Title: Solution structure of pituitary adenylate cyclase activating polypeptide by nuclear magnetic resonance spectroscopy.

PubMed ID: 8504103

DOI: 10.1021/bi00073a016

PubMed ID: 1483839

Title: Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution.

PubMed ID: 1483839

PubMed ID: 11175907

Title: Conformation of a peptide ligand bound to its G-protein coupled receptor.

PubMed ID: 11175907

DOI: 10.1038/84159

PubMed ID: 17470806

Title: Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.

PubMed ID: 17470806

DOI: 10.1073/pnas.0611397104

PubMed ID: 11968092

Title: Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes.

PubMed ID: 11968092

DOI: 10.1002/humu.9034

Sequence Information:

  • Length: 176
  • Mass: 18835
  • Checksum: 696DD57D2A510E1D
  • Sequence:
    • MTMCSGARLA LLVYGIIMHS SVYSSPAAAG LRFPGIRPEE EAYGEDGNPL PDFDGSEPPG 
AGSPASAPRA AAAWYRPAGR RDVAHGILNE AYRKVLDQLS AGKHLQSLVA RGVGGSLGGG 
AGDDAEPLSK RHSDGIFTDS YSRYRKQMAV KKYLAAVLGK RYKQRVKNKG RRIAYL

Genular Protein ID: 2387958776

Symbol: B7Z222_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z222

Database IDs:

ARBA 4 AlphaFoldDB 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PhylomeDB 1 RefSeq 1 SAM 1 SMART 1

Sequence Information:

  • Length: 315
  • Mass: 33484
  • Checksum: F5AA2097EA9FB7B8
  • Sequence:
    • MLTKRALQKP CSDRFLRTAQ INRSRRPVTS VTSGSSSRSR ASPHRPLFLS SASLSAPPSL 
RVTLPPGSAR LQTFEQNTSL GKRVPQLLLL LPLVPAASAQ TPTPDGDASR VVTPAQELEE 
ALCPPSYLAA LLAAGGVEGM TMCSGARLAL LVYGIIMHSS VYSSPAAAGL RFPGIRPEEE 
AYGEDGNPLP DFDGSEPPGA GSPASAPRAA AAWYRPAGRR DVAHGILNEA YRKVLDQLSA 
GKHLQSLVAR GVGGSLGGGA GDDAEPLSKR HSDGIFTDSY SRYRKQMAVK KYLAAVLGKR 
YKQRVKNKGR RIAYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.