Details for: ADCYAP1

Gene ID: 116

Symbol: ADCYAP1

Ensembl ID: ENSG00000141433

Description: adenylate cyclase activating polypeptide 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 37.4168
    Cell Significance Index: -5.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.9456
    Cell Significance Index: -5.8200
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.3105
    Cell Significance Index: 3.3700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.2459
    Cell Significance Index: 2.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2379
    Cell Significance Index: 5.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2074
    Cell Significance Index: 129.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1655
    Cell Significance Index: 33.2000
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.0971
    Cell Significance Index: 0.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0678
    Cell Significance Index: 1.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0244
    Cell Significance Index: 2.7900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0221
    Cell Significance Index: 0.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0193
    Cell Significance Index: 10.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0116
    Cell Significance Index: 8.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0070
    Cell Significance Index: 0.1200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.0041
    Cell Significance Index: 0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0007
    Cell Significance Index: 0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0002
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0052
    Cell Significance Index: -1.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0069
    Cell Significance Index: -3.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0099
    Cell Significance Index: -5.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0103
    Cell Significance Index: -2.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0118
    Cell Significance Index: -4.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0124
    Cell Significance Index: -1.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0129
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0143
    Cell Significance Index: -1.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0145
    Cell Significance Index: -1.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0160
    Cell Significance Index: -2.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0230
    Cell Significance Index: -0.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0288
    Cell Significance Index: -5.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0301
    Cell Significance Index: -5.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0312
    Cell Significance Index: -4.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0389
    Cell Significance Index: -5.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0401
    Cell Significance Index: -5.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0412
    Cell Significance Index: -5.0600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0497
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0563
    Cell Significance Index: -0.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0569
    Cell Significance Index: -5.9200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0584
    Cell Significance Index: -0.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0704
    Cell Significance Index: -5.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0813
    Cell Significance Index: -5.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0845
    Cell Significance Index: -5.6800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0957
    Cell Significance Index: -2.3900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0959
    Cell Significance Index: -0.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1018
    Cell Significance Index: -7.8100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1023
    Cell Significance Index: -0.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1029
    Cell Significance Index: -3.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1062
    Cell Significance Index: -3.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1064
    Cell Significance Index: -5.0000
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.1145
    Cell Significance Index: -0.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1153
    Cell Significance Index: -6.4700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1175
    Cell Significance Index: -0.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1258
    Cell Significance Index: -3.5900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1346
    Cell Significance Index: -1.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1406
    Cell Significance Index: -7.3800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1478
    Cell Significance Index: -2.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1495
    Cell Significance Index: -5.6600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1588
    Cell Significance Index: -1.7300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1616
    Cell Significance Index: -0.9900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1767
    Cell Significance Index: -2.2300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1803
    Cell Significance Index: -2.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1807
    Cell Significance Index: -5.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1833
    Cell Significance Index: -5.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1836
    Cell Significance Index: -4.9100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1860
    Cell Significance Index: -2.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1888
    Cell Significance Index: -5.5600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1933
    Cell Significance Index: -2.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1961
    Cell Significance Index: -7.2000
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2002
    Cell Significance Index: -1.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2019
    Cell Significance Index: -5.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2075
    Cell Significance Index: -5.5600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2094
    Cell Significance Index: -4.2600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2273
    Cell Significance Index: -5.6700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2335
    Cell Significance Index: -2.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2343
    Cell Significance Index: -5.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2346
    Cell Significance Index: -2.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2389
    Cell Significance Index: -6.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2403
    Cell Significance Index: -5.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2417
    Cell Significance Index: -11.2700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2451
    Cell Significance Index: -5.1200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2479
    Cell Significance Index: -2.2400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2498
    Cell Significance Index: -4.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2498
    Cell Significance Index: -5.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2502
    Cell Significance Index: -5.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2512
    Cell Significance Index: -6.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2554
    Cell Significance Index: -5.4600
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: -0.2572
    Cell Significance Index: -2.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2573
    Cell Significance Index: -5.5600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2581
    Cell Significance Index: -5.0800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2582
    Cell Significance Index: -2.9400
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.2630
    Cell Significance Index: -2.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2632
    Cell Significance Index: -4.4100
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.2656
    Cell Significance Index: -2.6100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2668
    Cell Significance Index: -3.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2704
    Cell Significance Index: -7.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2744
    Cell Significance Index: -5.4300
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.2753
    Cell Significance Index: -2.8300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2764
    Cell Significance Index: -3.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ADCYAP1 is a 36-amino acid peptide that belongs to the adenylate cyclase-activating polypeptide family. It is primarily expressed in the pituitary gland, where it regulates adenylate cyclase activity, a key enzyme involved in signal transduction pathways. ADCYAP1 is also expressed in other tissues, including the brain, heart, and immune cells, where it modulates various cellular processes. **Pathways and Functions** ADCYAP1 exerts its effects through activation of adenylate cyclase activity, which leads to an increase in cyclic AMP (cAMP) levels. This increase in cAMP triggers a cascade of downstream signaling events, including the activation of protein kinase A (PKA) and the regulation of various transcription factors. ADCYAP1 also interacts with G-protein coupled receptors (GPCRs), including trka receptors, to modulate immune responses and inflammation. In the context of immune responses, ADCYAP1 has been shown to: * Regulate the production of chemokine (C-C motif) ligand 5 (CCL5) and cold-induced thermogenesis * Modulate the activity of immune cells, including T cells and dendritic cells * Influence the production of cytokines and growth factors involved in immune responses **Clinical Significance** ADCYAP1 has been implicated in various diseases, including: * **Thyroid disorders**: ADCYAP1 has been shown to regulate thyroid hormone production and is involved in the pathogenesis of thyroid disorders, such as hyperthyroidism and hypothyroidism. * **Immune-mediated disorders**: ADCYAP1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it regulates immune cell function and cytokine production. * **Cancer**: ADCYAP1 has been shown to promote tumor growth and metastasis in certain cancer types, including breast and lung cancer. * **Neurological disorders**: ADCYAP1 has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease, where it regulates neurotransmitter release and synaptic plasticity. In conclusion, ADCYAP1 is a crucial regulator of various physiological processes, including cell signaling, hormone regulation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying ADCYAP1 function and its potential therapeutic applications.

Genular Protein ID: 429442188

Symbol: PACA_HUMAN

Name: Pituitary adenylate cyclase-activating polypeptide

UniProtKB Accession Codes:

P18509 B2R7N4 Q52LQ0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 EMDB 8 Ensembl 2 EvolutionaryTrace 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1739432

Title: Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide.

PubMed ID: 1739432

DOI: 10.1089/dna.1992.11.21

PubMed ID: 1730060

Title: Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene.

PubMed ID: 1730060

DOI: 10.1016/0167-4781(92)90488-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2302217

Title: A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs.

PubMed ID: 2302217

DOI: 10.1016/0006-291x(90)91914-e

PubMed ID: 23800469

Title: Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells.

PubMed ID: 23800469

DOI: 10.1126/scisignal.2003993

PubMed ID: 8504103

Title: Solution structure of pituitary adenylate cyclase activating polypeptide by nuclear magnetic resonance spectroscopy.

PubMed ID: 8504103

DOI: 10.1021/bi00073a016

PubMed ID: 1483839

Title: Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution.

PubMed ID: 1483839

PubMed ID: 11175907

Title: Conformation of a peptide ligand bound to its G-protein coupled receptor.

PubMed ID: 11175907

DOI: 10.1038/84159

PubMed ID: 17470806

Title: Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.

PubMed ID: 17470806

DOI: 10.1073/pnas.0611397104

PubMed ID: 11968092

Title: Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes.

PubMed ID: 11968092

DOI: 10.1002/humu.9034

Sequence Information:

  • Length: 176
  • Mass: 18835
  • Checksum: 696DD57D2A510E1D
  • Sequence:
    • MTMCSGARLA LLVYGIIMHS SVYSSPAAAG LRFPGIRPEE EAYGEDGNPL PDFDGSEPPG 
AGSPASAPRA AAAWYRPAGR RDVAHGILNE AYRKVLDQLS AGKHLQSLVA RGVGGSLGGG 
AGDDAEPLSK RHSDGIFTDS YSRYRKQMAV KKYLAAVLGK RYKQRVKNKG RRIAYL

Genular Protein ID: 2387958776

Symbol: B7Z222_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z222

Database IDs:

ARBA 4 AlphaFoldDB 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PhylomeDB 1 RefSeq 1 SAM 1 SMART 1

Sequence Information:

  • Length: 315
  • Mass: 33484
  • Checksum: F5AA2097EA9FB7B8
  • Sequence:
    • MLTKRALQKP CSDRFLRTAQ INRSRRPVTS VTSGSSSRSR ASPHRPLFLS SASLSAPPSL 
RVTLPPGSAR LQTFEQNTSL GKRVPQLLLL LPLVPAASAQ TPTPDGDASR VVTPAQELEE 
ALCPPSYLAA LLAAGGVEGM TMCSGARLAL LVYGIIMHSS VYSSPAAAGL RFPGIRPEEE 
AYGEDGNPLP DFDGSEPPGA GSPASAPRAA AAWYRPAGRR DVAHGILNEA YRKVLDQLSA 
GKHLQSLVAR GVGGSLGGGA GDDAEPLSKR HSDGIFTDSY SRYRKQMAVK KYLAAVLGKR 
YKQRVKNKGR RIAYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.