ADCYAP1 | ENSG00000141433 | NCBI 116

Details for: ADCYAP1

Gene ID: 116

Symbol: ADCYAP1

Ensembl ID: ENSG00000141433

Description: adenylate cyclase activating polypeptide 1

Associated with

Activation of trka receptors
(R-HSA-187015)
Class b/2 (secretin family receptors)
(R-HSA-373080)
G alpha (s) signalling events
(R-HSA-418555)
Glucagon-type ligand receptors
(R-HSA-420092)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Ngf-independant trka activation
(R-HSA-187024)
Signaling by gpcr
(R-HSA-372790)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Activation of adenylate cyclase activity
(GO:0007190)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Camp-mediated signaling
(GO:0019933)
Cell-cell signaling
(GO:0007267)
Extracellular region
(GO:0005576)
Female pregnancy
(GO:0007565)
Insulin secretion
(GO:0030073)
Negative regulation of cell cycle
(GO:0045786)
Neuron projection
(GO:0043005)
Neuron projection development
(GO:0031175)
Neuropeptide hormone activity
(GO:0005184)
Neuropeptide signaling pathway
(GO:0007218)
Peptide hormone receptor binding
(GO:0051428)
Perikaryon
(GO:0043204)
Pituitary adenylate cyclase activating polypeptide activity
(GO:0016521)
Positive regulation of chemokine (c-c motif) ligand 5 production
(GO:0071651)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of growth hormone secretion
(GO:0060124)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Regulation of protein localization
(GO:0032880)
Signaling receptor binding
(GO:0005102)

Other Information

Proteins

Pituitary adenylate cyclase-activating polypeptide
B7Z222_HUMAN

Genular Protein ID: 429442188

Symbol: PACA_HUMAN

Name: Pituitary adenylate cyclase-activating polypeptide

UniProtKB Accession Codes:

P18509 B2R7N4 Q52LQ0

Database IDs:

Citations:

PubMed ID: 1739432

Title: Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide.

PubMed ID: 1739432

DOI: 10.1089/dna.1992.11.21

PubMed ID: 1730060

Title: Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene.

PubMed ID: 1730060

DOI: 10.1016/0167-4781(92)90488-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2302217

Title: A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs.

PubMed ID: 2302217

DOI: 10.1016/0006-291x(90)91914-e

PubMed ID: 23800469

Title: Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells.

PubMed ID: 23800469

DOI: 10.1126/scisignal.2003993

PubMed ID: 8504103

Title: Solution structure of pituitary adenylate cyclase activating polypeptide by nuclear magnetic resonance spectroscopy.

PubMed ID: 8504103

DOI: 10.1021/bi00073a016

PubMed ID: 1483839

Title: Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution.

PubMed ID: 1483839

PubMed ID: 11175907

Title: Conformation of a peptide ligand bound to its G-protein coupled receptor.

PubMed ID: 11175907

DOI: 10.1038/84159

PubMed ID: 17470806

Title: Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.

PubMed ID: 17470806

DOI: 10.1073/pnas.0611397104

PubMed ID: 11968092

Title: Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes.

PubMed ID: 11968092

DOI: 10.1002/humu.9034

Sequence Information:

Length: 176
Mass: 18835
Checksum: 696DD57D2A510E1D
Sequence:

MTMCSGARLA LLVYGIIMHS SVYSSPAAAG LRFPGIRPEE EAYGEDGNPL PDFDGSEPPG 
AGSPASAPRA AAAWYRPAGR RDVAHGILNE AYRKVLDQLS AGKHLQSLVA RGVGGSLGGG 
AGDDAEPLSK RHSDGIFTDS YSRYRKQMAV KKYLAAVLGK RYKQRVKNKG RRIAYL

Genular Protein ID: 2387958776

Symbol: B7Z222_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z222

Database IDs:

Sequence Information:

Length: 315
Mass: 33484
Checksum: F5AA2097EA9FB7B8
Sequence:

MLTKRALQKP CSDRFLRTAQ INRSRRPVTS VTSGSSSRSR ASPHRPLFLS SASLSAPPSL 
RVTLPPGSAR LQTFEQNTSL GKRVPQLLLL LPLVPAASAQ TPTPDGDASR VVTPAQELEE 
ALCPPSYLAA LLAAGGVEGM TMCSGARLAL LVYGIIMHSS VYSSPAAAGL RFPGIRPEEE 
AYGEDGNPLP DFDGSEPPGA GSPASAPRAA AAWYRPAGRR DVAHGILNEA YRKVLDQLSA 
GKHLQSLVAR GVGGSLGGGA GDDAEPLSKR HSDGIFTDSY SRYRKQMAVK KYLAAVLGKR 
YKQRVKNKGR RIAYL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADCYAP1

Associated with

Other Information

Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide. PubMed ID: 1739432

Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. PubMed ID: 1730060

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. PubMed ID: 2302217

Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells. PubMed ID: 23800469

Solution structure of pituitary adenylate cyclase activating polypeptide by nuclear magnetic resonance spectroscopy. PubMed ID: 8504103

Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution. PubMed ID: 1483839

Conformation of a peptide ligand bound to its G-protein coupled receptor. PubMed ID: 11175907

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. PubMed ID: 17470806

Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes. PubMed ID: 11968092