Details for: CKMT2

Gene ID: 1160

Symbol: CKMT2

Ensembl ID: ENSG00000131730

Description: creatine kinase, mitochondrial 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 5.1530
    Cell Significance Index: 125.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.1439
    Cell Significance Index: 318.0000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.5547
    Cell Significance Index: 41.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.8844
    Cell Significance Index: 27.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.5381
    Cell Significance Index: 12.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.3994
    Cell Significance Index: 85.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9053
    Cell Significance Index: 179.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7971
    Cell Significance Index: 11.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6700
    Cell Significance Index: 127.5000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.6573
    Cell Significance Index: 7.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5574
    Cell Significance Index: 14.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4001
    Cell Significance Index: 39.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3935
    Cell Significance Index: 78.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3809
    Cell Significance Index: 22.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2961
    Cell Significance Index: 32.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2203
    Cell Significance Index: 35.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2164
    Cell Significance Index: 195.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1718
    Cell Significance Index: 10.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1378
    Cell Significance Index: 62.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1333
    Cell Significance Index: 92.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1094
    Cell Significance Index: 206.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0748
    Cell Significance Index: 1.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0723
    Cell Significance Index: 3.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0664
    Cell Significance Index: 4.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0557
    Cell Significance Index: 8.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0535
    Cell Significance Index: 1.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0500
    Cell Significance Index: 31.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0438
    Cell Significance Index: 1.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0407
    Cell Significance Index: 5.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0385
    Cell Significance Index: 0.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0366
    Cell Significance Index: 13.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0327
    Cell Significance Index: 1.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0320
    Cell Significance Index: 0.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0119
    Cell Significance Index: 18.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0113
    Cell Significance Index: 15.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0101
    Cell Significance Index: 18.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0057
    Cell Significance Index: 0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0021
    Cell Significance Index: 1.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0013
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0052
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0077
    Cell Significance Index: -4.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0104
    Cell Significance Index: -0.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0113
    Cell Significance Index: -5.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0157
    Cell Significance Index: -8.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0164
    Cell Significance Index: -1.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0184
    Cell Significance Index: -13.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0237
    Cell Significance Index: -4.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0267
    Cell Significance Index: -5.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0311
    Cell Significance Index: -5.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0342
    Cell Significance Index: -9.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0403
    Cell Significance Index: -0.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0429
    Cell Significance Index: -4.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0470
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0573
    Cell Significance Index: -6.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0579
    Cell Significance Index: -6.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0585
    Cell Significance Index: -3.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0613
    Cell Significance Index: -1.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0648
    Cell Significance Index: -1.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0677
    Cell Significance Index: -0.9700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0701
    Cell Significance Index: -0.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0713
    Cell Significance Index: -9.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0744
    Cell Significance Index: -9.1500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0836
    Cell Significance Index: -1.2000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0862
    Cell Significance Index: -1.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0894
    Cell Significance Index: -4.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1012
    Cell Significance Index: -11.7900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1029
    Cell Significance Index: -1.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1475
    Cell Significance Index: -11.6800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.1476
    Cell Significance Index: -0.5700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1501
    Cell Significance Index: -1.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1502
    Cell Significance Index: -4.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1543
    Cell Significance Index: -4.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1564
    Cell Significance Index: -8.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1818
    Cell Significance Index: -4.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1846
    Cell Significance Index: -13.7600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1936
    Cell Significance Index: -2.7900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2069
    Cell Significance Index: -2.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2166
    Cell Significance Index: -11.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2235
    Cell Significance Index: -14.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2334
    Cell Significance Index: -10.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2361
    Cell Significance Index: -6.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2387
    Cell Significance Index: -6.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2418
    Cell Significance Index: -4.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2457
    Cell Significance Index: -12.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2514
    Cell Significance Index: -8.2300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2529
    Cell Significance Index: -5.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2582
    Cell Significance Index: -8.2200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2587
    Cell Significance Index: -11.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2615
    Cell Significance Index: -5.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2646
    Cell Significance Index: -9.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2809
    Cell Significance Index: -5.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3143
    Cell Significance Index: -8.9700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3168
    Cell Significance Index: -4.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3192
    Cell Significance Index: -4.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3253
    Cell Significance Index: -11.9400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3282
    Cell Significance Index: -6.8500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3312
    Cell Significance Index: -4.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3448
    Cell Significance Index: -7.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: CKMT2 is exclusively localized to the mitochondrial inner membrane, where it is involved in the regulation of phosphocreatine synthesis. 2. **Creatine kinase activity**: CKMT2 exhibits creatine kinase activity, which is essential for the conversion of creatine to phosphocreatine. 3. **High expression levels**: CKMT2 is highly expressed in various cell types, including cardiac myocytes, skeletal muscle fibers, and endothelial cells. **Pathways and Functions:** 1. **Phosphocreatine biosynthetic process**: CKMT2 plays a central role in the phosphocreatine biosynthetic process, which involves the conversion of creatine to phosphocreatine. This process is essential for maintaining ATP levels in the cell. 2. **Mitochondrial energy metabolism**: CKMT2 is involved in the regulation of mitochondrial energy metabolism, which is critical for maintaining cellular homeostasis. 3. **Muscle contraction**: CKMT2 is also involved in muscle contraction, as phosphocreatine is a key energy source for muscle contraction. 4. **Cellular protection**: CKMT2 may also play a role in protecting cells against oxidative stress and apoptosis. **Clinical Significance:** 1. **Cardiac diseases**: CKMT2 has been implicated in various cardiac diseases, including heart failure, arrhythmias, and cardiac arrest. Altered CKMT2 expression levels have been observed in these conditions. 2. **Muscular dystrophy**: CKMT2 has also been linked to muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 3. **Neurological disorders**: CKMT2 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction and energy metabolism are key pathophysiological mechanisms. 4. **Cancer**: CKMT2 has also been linked to cancer, where altered expression levels have been observed in various cancer types, including breast cancer and lung cancer. In conclusion, CKMT2 is a crucial enzyme involved in the regulation of cellular energy homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying CKMT2's functions and its role in human disease.

Genular Protein ID: 2129227609

Symbol: KCRS_HUMAN

Name: Creatine kinase S-type, mitochondrial

UniProtKB Accession Codes:

P17540 Q6ICS8 Q8N1E1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 2 EMBL 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2324105

Title: Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes.

PubMed ID: 2324105

DOI: 10.1016/s0021-9258(19)39237-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2914937

Title: Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase.

PubMed ID: 2914937

DOI: 10.1016/s0021-9258(19)81696-4

Sequence Information:

  • Length: 419
  • Mass: 47504
  • Checksum: 0CAF000074D99B6F
  • Sequence:
    • MASIFSKLLT GRNASLLFAT MGTSVLTTGY LLNRQKVCAE VREQPRLFPP SADYPDLRKH 
NNCMAECLTP AIYAKLRNKV TPNGYTLDQC IQTGVDNPGH PFIKTVGMVA GDEESYEVFA 
DLFDPVIKLR HNGYDPRVMK HTTDLDASKI TQGQFDEHYV LSSRVRTGRS IRGLSLPPAC 
TRAERREVEN VAITALEGLK GDLAGRYYKL SEMTEQDQQR LIDDHFLFDK PVSPLLTCAG 
MARDWPDARG IWHNYDKTFL IWINEEDHTR VISMEKGGNM KRVFERFCRG LKEVERLIQE 
RGWEFMWNER LGYILTCPSN LGTGLRAGVH VRIPKLSKDP RFSKILENLR LQKRGTGGVD 
TAAVADVYDI SNIDRIGRSE VELVQIVIDG VNYLVDCEKK LERGQDIKVP PPLPQFGKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.