Details for: CKMT2

Gene ID: 1160

Symbol: CKMT2

Ensembl ID: ENSG00000131730

Description: creatine kinase, mitochondrial 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.71
    Marker Score: 105286
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.77
    Marker Score: 9854.5
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.44
    Marker Score: 6104
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1508
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.81
    Marker Score: 3977.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169222
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19338.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.12
    Marker Score: 667
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.11
    Marker Score: 4646
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.11
    Marker Score: 1839
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.1
    Marker Score: 558
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.06
    Marker Score: 6369
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.03
    Marker Score: 543
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.02
    Marker Score: 337
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 398
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.93
    Marker Score: 425
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5276
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.87
    Marker Score: 18465
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.82
    Marker Score: 10966
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 624
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.81
    Marker Score: 450
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.8
    Marker Score: 614
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3290.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.78
    Marker Score: 672
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.73
    Marker Score: 908
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.72
    Marker Score: 1815
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.67
    Marker Score: 195
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.67
    Marker Score: 707
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.66
    Marker Score: 932
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.66
    Marker Score: 499
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.64
    Marker Score: 202
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.63
    Marker Score: 743
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.62
    Marker Score: 187
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1171
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.6
    Marker Score: 962.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.6
    Marker Score: 268
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 382
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.59
    Marker Score: 21886.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.57
    Marker Score: 880
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.57
    Marker Score: 372
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.56
    Marker Score: 297.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.55
    Marker Score: 631.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.52
    Marker Score: 137
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.52
    Marker Score: 4447
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.51
    Marker Score: 299
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 236
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.46
    Marker Score: 191
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.45
    Marker Score: 4574
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.45
    Marker Score: 909
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.45
    Marker Score: 4239
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.44
    Marker Score: 479
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.44
    Marker Score: 8747
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.44
    Marker Score: 1813.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 430
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.43
    Marker Score: 408
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.42
    Marker Score: 206
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.42
    Marker Score: 152
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.4
    Marker Score: 979
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4
    Marker Score: 135
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.39
    Marker Score: 161.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.38
    Marker Score: 1029
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 366
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.38
    Marker Score: 258
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.37
    Marker Score: 2223
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.36
    Marker Score: 631
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 209
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.34
    Marker Score: 937.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.34
    Marker Score: 241
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.33
    Marker Score: 204
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.32
    Marker Score: 88
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.32
    Marker Score: 439.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.32
    Marker Score: 1296
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.32
    Marker Score: 78
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.31
    Marker Score: 131
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.31
    Marker Score: 209
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.31
    Marker Score: 125
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.31
    Marker Score: 114
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.3
    Marker Score: 85

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The gene is located on chromosome 19p13.1. * It is a large gene, with a length of approximately 1.1 million base pairs. * The protein is encoded by a single gene. * It is a transmembrane protein, with a molecular weight of approximately 150 kDa. **Pathways and functions:** * The CKMT2 gene is involved in a number of pathways, including the citric acid cycle, the pyruvate dehydrogenase complex, and the electron transport chain. * It is responsible for the production of ATP from ADP and inorganic phosphate. * It also plays a role in the regulation of muscle contraction. **Clinical significance:** * Mutations in the CKMT2 gene have been linked to a number of human diseases, including heart disease, stroke, and kidney disease. * In heart disease, mutations in the CKMT2 gene can lead to the development of cardiomyopathy, a condition in which the heart muscle becomes enlarged and weakened. * CKMT2 mutations can also lead to the development of stroke, as they can damage brain cells and disrupt the blood-brain barrier. **Additional information:** * The CKMT2 gene is also known as ATPase AK1 or CMK2. * It is a highly conserved gene, with a similar gene found in humans, mice, and rats. * It is a well-studied gene, with a large amount of information available about its structure and function.

Genular Protein ID: 2129227609

Symbol: KCRS_HUMAN

Name: Creatine kinase S-type, mitochondrial

UniProtKB Accession Codes:

P17540 Q6ICS8 Q8N1E1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 2 EMBL 3 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2324105

Title: Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes.

PubMed ID: 2324105

DOI: 10.1016/s0021-9258(19)39237-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2914937

Title: Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase.

PubMed ID: 2914937

DOI: 10.1016/s0021-9258(19)81696-4

Sequence Information:

  • Length: 419
  • Mass: 47504
  • Checksum: 0CAF000074D99B6F
  • Sequence:
    • MASIFSKLLT GRNASLLFAT MGTSVLTTGY LLNRQKVCAE VREQPRLFPP SADYPDLRKH 
NNCMAECLTP AIYAKLRNKV TPNGYTLDQC IQTGVDNPGH PFIKTVGMVA GDEESYEVFA 
DLFDPVIKLR HNGYDPRVMK HTTDLDASKI TQGQFDEHYV LSSRVRTGRS IRGLSLPPAC 
TRAERREVEN VAITALEGLK GDLAGRYYKL SEMTEQDQQR LIDDHFLFDK PVSPLLTCAG 
MARDWPDARG IWHNYDKTFL IWINEEDHTR VISMEKGGNM KRVFERFCRG LKEVERLIQE 
RGWEFMWNER LGYILTCPSN LGTGLRAGVH VRIPKLSKDP RFSKILENLR LQKRGTGGVD 
TAAVADVYDI SNIDRIGRSE VELVQIVIDG VNYLVDCEKK LERGQDIKVP PPLPQFGKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.