Details for: Angpt1

Gene ID: 11600

Symbol: Angpt1

Ensembl ID: ENSMUSG00000022309

Description: angiopoietin 1

Associated with

  • Cell surface interactions at the vascular wall
    (R-MMU-202733)
  • Hemostasis
    (R-MMU-109582)
  • Mapk1/mapk3 signaling
    (R-MMU-5684996)
  • Mapk family signaling cascades
    (R-MMU-5683057)
  • Raf/map kinase cascade
    (R-MMU-5673001)
  • Signal transduction
    (R-MMU-162582)
  • Tie2 signaling
    (R-MMU-210993)
  • Activation of transmembrane receptor protein tyrosine kinase activity
    (GO:0007171)
  • Angiogenesis
    (GO:0001525)
  • Branching involved in blood vessel morphogenesis
    (GO:0001569)
  • Cardiac muscle tissue morphogenesis
    (GO:0055008)
  • Cell-substrate adhesion
    (GO:0031589)
  • Cell differentiation
    (GO:0030154)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Endocardium morphogenesis
    (GO:0003160)
  • Endoderm development
    (GO:0007492)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Glomerulus vasculature development
    (GO:0072012)
  • Hemopoiesis
    (GO:0030097)
  • Heparin biosynthetic process
    (GO:0030210)
  • Identical protein binding
    (GO:0042802)
  • In utero embryonic development
    (GO:0001701)
  • Membrane raft
    (GO:0045121)
  • Microvillus
    (GO:0005902)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cell adhesion
    (GO:0007162)
  • Negative regulation of cytokine production involved in immune response
    (GO:0002719)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of protein import into nucleus
    (GO:0042308)
  • Negative regulation of protein phosphorylation
    (GO:0001933)
  • Negative regulation of vascular permeability
    (GO:0043116)
  • Neuron apoptotic process
    (GO:0051402)
  • Ovarian follicle development
    (GO:0001541)
  • Plasma membrane
    (GO:0005886)
  • Positive chemotaxis
    (GO:0050918)
  • Positive regulation of blood-brain barrier permeability
    (GO:1905605)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of protein ubiquitination
    (GO:0031398)
  • Positive regulation of receptor internalization
    (GO:0002092)
  • Positive regulation of vascular endothelial growth factor receptor signaling pathway
    (GO:0030949)
  • Protein binding
    (GO:0005515)
  • Protein localization to cell surface
    (GO:0034394)
  • Receptor tyrosine kinase binding
    (GO:0030971)
  • Regulation of canonical nf-kappab signal transduction
    (GO:0043122)
  • Regulation of macrophage migration inhibitory factor signaling pathway
    (GO:2000446)
  • Regulation of protein binding
    (GO:0043393)
  • Regulation of skeletal muscle satellite cell proliferation
    (GO:0014842)
  • Regulation of tumor necrosis factor production
    (GO:0032680)
  • Signaling receptor binding
    (GO:0005102)
  • Sprouting angiogenesis
    (GO:0002040)
  • Tie signaling pathway
    (GO:0048014)
  • Transmembrane receptor protein tyrosine kinase signaling pathway
    (GO:0007169)
  • Vascular endothelial growth factor receptor binding
    (GO:0005172)
  • Vasculogenesis
    (GO:0001570)
  • Vasculogenesis involved in coronary vascular morphogenesis
    (GO:0060979)

Other Information

Genular Protein ID: 17644273

Symbol: ANGP1_MOUSE

Name: Angiopoietin-1

UniProtKB Accession Codes:

O08538 Q6NWV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 2 Ensembl 1 GO 53 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8980223

Title: Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.

PubMed ID: 8980223

DOI: 10.1016/s0092-8674(00)81812-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8980224

Title: Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.

PubMed ID: 8980224

DOI: 10.1016/s0092-8674(00)81813-9

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 28179430

Title: Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

PubMed ID: 28179430

DOI: 10.1161/circresaha.116.308825

Sequence Information:

  • Length: 498
  • Mass: 57519
  • Checksum: FC36F905A9E79074
  • Sequence:
    • MTVFLSFAFF AAILTHIGCS NQRRNPENGG RRYNRIQHGQ CAYTFILPEH DGNCRESATE 
QYNTNALQRD APHVEPDFSS QKLQHLEHVM ENYTQWLQKL ENYIVENMKS EMAQIQQNAV 
QNHTATMLEI GTSLLSQTAE QTRKLTDVET QVLNQTSRLE IQLLENSLST YKLEKQLLQQ 
TNEILKIHEK NSLLEHKILE MEGKHKEELD TLKEEKENLQ GLVSRQTFII QELEKQLSRA 
TNNNSILQKQ QLELMDTVHN LISLCTKEGV LLKGGKREEE KPFRDCADVY QAGFNKSGIY 
TIYFNNMPEP KKVFCNMDVN GGGWTVIQHR EDGSLDFQRG WKEYKMGFGN PSGEYWLGNE 
FIFAITSQRQ YMLRIELMDW EGNRAYSQYD RFHIGNEKQN YRLYLKGHTG TAGKQSSLIL 
HGADFSTKDA DNDNCMCKCA LMLTGGWWFD ACGPSNLNGM FYTAGQNHGK LNGIKWHYFK 
GPSYSLRSTT MMIRPLDF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.