Genular: Defining Cellular Identity and Function

Details for: Angpt2

Gene ID: 11601

Symbol: Angpt2

Ensembl ID: ENSMUSG00000031465

Description: angiopoietin 2

Associated with

Cell surface interactions at the vascular wall
(R-MMU-202733)
Hemostasis
(R-MMU-109582)
Tie2 signaling
(R-MMU-210993)
Angiogenesis
(GO:0001525)
Blood vessel morphogenesis
(GO:0048514)
Blood vessel remodeling
(GO:0001974)
Cell differentiation
(GO:0030154)
Cell projection
(GO:0042995)
Collagen-containing extracellular matrix
(GO:0062023)
Endoderm development
(GO:0007492)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Gene expression
(GO:0010467)
Glomerulus vasculature development
(GO:0072012)
Hemopoiesis
(GO:0030097)
Metal ion binding
(GO:0046872)
Multicellular organism development
(GO:0007275)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of blood vessel endothelial cell migration
(GO:0043537)
Negative regulation of cell-substrate adhesion
(GO:0010812)
Negative regulation of positive chemotaxis
(GO:0050928)
Positive regulation of angiogenesis
(GO:0045766)
Protein binding
(GO:0005515)
Receptor antagonist activity
(GO:0048019)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of angiogenesis
(GO:0045765)
Tie signaling pathway
(GO:0048014)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Vascular endothelial growth factor receptor binding
(GO:0005172)

Other Information

Proteins

Angiopoietin-2

Genular Protein ID: 1726189302

Symbol: ANGP2_MOUSE

Name: Angiopoietin-2

UniProtKB Accession Codes:

O35608 Q3U1A1 Q9D2D2

Database IDs:

Citations:

PubMed ID: 9204896

Title: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

PubMed ID: 9204896

DOI: 10.1126/science.277.5322.55

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28179430

Title: Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

PubMed ID: 28179430

DOI: 10.1161/circresaha.116.308825

PubMed ID: 32908006

Title: Characterization of ANGPT2 mutations associated with primary lymphedema.

PubMed ID: 32908006

DOI: 10.1126/scitranslmed.aax8013

Sequence Information:

Length: 496
Mass: 56576
Checksum: E7563B498A0EF331
Sequence:

MWQIIFLTFG WDLVLASAYS NFRKSVDSTG RRQYQVQNGP CSYTFLLPET DSCRSSSSPY 
MSNAVQRDAP LDYDDSVQRL QVLENILENN TQWLMKLENY IQDNMKKEMV EIQQNVVQNQ 
TAVMIEIGTS LLNQTAAQTR KLTDVEAQVL NQTTRLELQL LQHSISTNKL EKQILDQTSE 
INKLQNKNSF LEQKVLDMEG KHSEQLQSMK EQKDELQVLV SKQSSVIDEL EKKLVTATVN 
NSLLQKQQHD LMETVNSLLT MMSSPNSKSS VAIRKEEQTT FRDCAEIFKS GLTTSGIYTL 
TFPNSTEEIK AYCDMDVGGG GWTVIQHRED GSVDFQRTWK EYKEGFGSPL GEYWLGNEFV 
SQLTGQHRYV LKIQLKDWEG NEAHSLYDHF YLAGEESNYR IHLTGLTGTA GKISSISQPG 
SDFSTKDSDN DKCICKCSQM LSGGWWFDAC GPSNLNGQYY PQKQNTNKFN GIKWYYWKGS 
GYSLKATTMM IRPADF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Angpt2

Associated with

Other Information

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. PubMed ID: 9204896

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334