Genular: Defining Cellular Identity and Function

Details for: Agtr1a

Gene ID: 11607

Symbol: Agtr1a

Ensembl ID: ENSMUSG00000049115

Description: angiotensin II receptor, type 1a

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
Clathrin-mediated endocytosis
(R-MMU-8856828)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Membrane trafficking
(R-MMU-199991)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Vesicle-mediated transport
(R-MMU-5653656)
Angiotensin-activated signaling pathway
(GO:0038166)
Angiotensin type ii receptor activity
(GO:0004945)
Angiotensin type i receptor activity
(GO:0001596)
Basolateral plasma membrane
(GO:0016323)
Blood vessel development
(GO:0001568)
Bradykinin receptor binding
(GO:0031711)
Brain renin-angiotensin system
(GO:0002035)
Calcium-mediated signaling
(GO:0019722)
Cell chemotaxis
(GO:0060326)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
D1 dopamine receptor binding
(GO:0031748)
Dendrite
(GO:0030425)
Dopamine biosynthetic process
(GO:0042416)
Drinking behavior
(GO:0042756)
Endosome
(GO:0005768)
Gene expression
(GO:0010467)
Golgi apparatus
(GO:0005794)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heart development
(GO:0007507)
Inflammatory response
(GO:0006954)
Kidney development
(GO:0001822)
Maintenance of blood vessel diameter homeostasis by renin-angiotensin
(GO:0002034)
Membrane
(GO:0016020)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of smooth muscle cell apoptotic process
(GO:0034392)
Neuron apoptotic process
(GO:0051402)
Organelle outer membrane
(GO:0031968)
Phospholipase c-activating angiotensin-activated signaling pathway
(GO:0086097)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood pressure
(GO:0045777)
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:1903589)
Positive regulation of branching involved in ureteric bud morphogenesis
(GO:0090190)
Positive regulation of calcium ion import across plasma membrane
(GO:1905665)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of coa-transferase activity
(GO:1905920)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of phospholipase a2 activity
(GO:0032430)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of receptor recycling
(GO:0001921)
Positive regulation of superoxide anion generation
(GO:0032930)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein kinase binding
(GO:0019901)
Recycling endosome
(GO:0055037)
Regulation of blood pressure
(GO:0008217)
Regulation of ph
(GO:0006885)
Regulation of renal output by angiotensin
(GO:0002019)
Regulation of systemic arterial blood pressure by circulatory renin-angiotensin
(GO:0001991)
Regulation of vascular associated smooth muscle cell apoptotic process
(GO:1905459)
Regulation of vasoconstriction
(GO:0019229)
Renin-angiotensin regulation of aldosterone production
(GO:0002018)
Renin secretion into blood stream
(GO:0002001)
Response to estrogen
(GO:0043627)
Rho protein signal transduction
(GO:0007266)
Signal transduction
(GO:0007165)
Symbiont entry into host cell
(GO:0046718)
Vascular associated smooth muscle cell proliferation
(GO:1990874)
Vasoconstriction
(GO:0042310)

Other Information

Proteins

AGTRA_MOUSE

Genular Protein ID: 902655686

Symbol: AGTRA_MOUSE

Name: N/A

UniProtKB Accession Codes:

P29754

Database IDs:

Citations:

PubMed ID: 1599461

Title: Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome.

PubMed ID: 1599461

DOI: 10.1016/s0006-291x(05)80983-0

PubMed ID: 1497638

Title: Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human).

PubMed ID: 1497638

DOI: 10.1016/0006-291x(92)90852-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 359
Mass: 40856
Checksum: 966958A738D8F53E
Sequence:

MALNSSTEDG IKRIQDDCPR AGRHSYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL CKIASASVSF NLYASVFLLT 
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLMAGLAS LPAVIHRNVY FIENTNITVC 
AFHYESRNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFR 
IIMAIVLFFF FSWVPHQIFT FLDVLIQLGV IHDCKIADIV DTAMPITICI AYFNNCLNPL 
FYGFLGKKFK KYFLQLLKYI PPKAKSHSSL STKMSTLSYR PSDNMSSAAK KPASCSEVE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.