Details for: Agtr2

Gene ID: 11609

Symbol: Agtr2

Ensembl ID: ENSMUSG00000068122

Description: angiotensin II receptor, type 2

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-MMU-373076)
  • G alpha (i) signalling events
    (R-MMU-418594)
  • Gpcr downstream signalling
    (R-MMU-388396)
  • Gpcr ligand binding
    (R-MMU-500792)
  • Peptide ligand-binding receptors
    (R-MMU-375276)
  • Signaling by gpcr
    (R-MMU-372790)
  • Angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
    (GO:0002033)
  • Angiotensin type ii receptor activity
    (GO:0004945)
  • Blood vessel diameter maintenance
    (GO:0097746)
  • Brain renin-angiotensin system
    (GO:0002035)
  • Cell growth involved in cardiac muscle cell development
    (GO:0061049)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to dexamethasone stimulus
    (GO:0071549)
  • Cerebellar cortex development
    (GO:0021695)
  • Dopamine biosynthetic process
    (GO:0042416)
  • Exploration behavior
    (GO:0035640)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • G protein-coupled receptor signaling pathway coupled to cgmp nucleotide second messenger
    (GO:0007199)
  • Inflammatory response
    (GO:0006954)
  • Intracellular signal transduction
    (GO:0035556)
  • Intracellular sodium ion homeostasis
    (GO:0006883)
  • Kidney morphogenesis
    (GO:0060993)
  • Membrane
    (GO:0016020)
  • Negative regulation of fibroblast proliferation
    (GO:0048147)
  • Negative regulation of heart rate
    (GO:0010459)
  • Negative regulation of icosanoid secretion
    (GO:0032304)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of neurotrophin trk receptor signaling pathway
    (GO:0051387)
  • Negative regulation of norepinephrine secretion
    (GO:0010700)
  • Neuron apoptotic process
    (GO:0051402)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of metanephric glomerulus development
    (GO:0072300)
  • Positive regulation of nitric-oxide synthase activity
    (GO:0051000)
  • Positive regulation of phosphoprotein phosphatase activity
    (GO:0032516)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of metanephros size
    (GO:0035566)
  • Regulation of protein import into nucleus
    (GO:0042306)
  • Regulation of systemic arterial blood pressure by circulatory renin-angiotensin
    (GO:0001991)
  • Renin-angiotensin regulation of aldosterone production
    (GO:0002018)
  • Signal transduction
    (GO:0007165)
  • Vasodilation
    (GO:0042311)

Other Information

Genular Protein ID: 2675770225

Symbol: AGTR2_MOUSE

Name: Type-2 angiotensin II receptor

UniProtKB Accession Codes:

P35374

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DNASU 1 EMBL 7 Ensembl 1 GO 35 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8267573

Title: Cloning of cDNA and analysis of the gene for mouse angiotensin II type 2 receptor.

PubMed ID: 8267573

DOI: 10.1006/bbrc.1993.2492

PubMed ID: 8292631

Title: Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor.

PubMed ID: 8292631

DOI: 10.1016/0005-2736(94)90072-8

PubMed ID: 8726696

Title: Molecular and functional characterization of angiotensin II AT2 receptor in neuroblastoma N1E-115 cells.

PubMed ID: 8726696

DOI: 10.1007/978-1-4899-1376-0_17

PubMed ID: 7650042

Title: The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2.

PubMed ID: 7650042

DOI: 10.1074/jbc.270.34.20225

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11444984

Title: Identification and function of disulfide bridges in the extracellular domains of the angiotensin II type 2 receptor.

PubMed ID: 11444984

DOI: 10.1021/bi002805p

PubMed ID: 15539617

Title: Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein.

PubMed ID: 15539617

DOI: 10.1161/01.atv.0000150662.51436.14

Sequence Information:

  • Length: 363
  • Mass: 41374
  • Checksum: 6C7D6E3B026D1E80
  • Sequence:
    • MKDNFSFAAT SRNITSSRPF DNLNATGTNE SAFNCSHKPS DKHLEAIPVL YYMIFVIGFA 
VNIVVVSLFC CQKGPKKVSS IYIFNLALAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF 
GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY 
FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK 
TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL 
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR KGSSLREMDT 
FVS

Genular Protein ID: 2530207743

Symbol: Q3US12_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3US12

Database IDs:

AGR 1 ARBA 12 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 5 Gene3D 1 InterPro 4 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 393
  • Mass: 45167
  • Checksum: 83AAE73EED10346C
  • Sequence:
    • MRELSKLIYD NCFKHWQLKR CKNLELLQFN MKDNFSFAAT SRNITSSRPF DNLNATGTNE 
SAFNCSHKPS DKHLEAIPVL YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLALAD 
LLLLATLPLW ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF 
LSQRRNPWQA SYVVPLVWCM ACLSSXPTFY FRDVRTIEYL GVNACIMAFP PEKYAQWSAG 
IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT RDQVLKMAAA VVLAFIICWL 
PFHVLTFLDA LTWMGIINSC EVIAVIDLAL PFAILLGFTN SCVNPFLYCF VGNRFQQKLR 
SVFRVPITWL QGKRETMSCR KGSSLREMDT FVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.