Details for: ERCC8

Gene ID: 1161

Symbol: ERCC8

Ensembl ID: ENSG00000049167

Description: ERCC excision repair 8, CSA ubiquitin ligase complex subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 146.6133
    Cell Significance Index: -22.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.4563
    Cell Significance Index: -22.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.4576
    Cell Significance Index: -19.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.3196
    Cell Significance Index: -19.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.0761
    Cell Significance Index: -23.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4738
    Cell Significance Index: -22.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0161
    Cell Significance Index: -23.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.9776
    Cell Significance Index: -18.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6468
    Cell Significance Index: -10.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3632
    Cell Significance Index: 273.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2269
    Cell Significance Index: 68.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1172
    Cell Significance Index: 221.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0708
    Cell Significance Index: 82.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0404
    Cell Significance Index: 22.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9650
    Cell Significance Index: 95.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8563
    Cell Significance Index: 139.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7904
    Cell Significance Index: 34.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7387
    Cell Significance Index: 27.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6701
    Cell Significance Index: 605.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6189
    Cell Significance Index: 222.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5054
    Cell Significance Index: 30.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4871
    Cell Significance Index: 29.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4710
    Cell Significance Index: 325.7700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4039
    Cell Significance Index: 11.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3811
    Cell Significance Index: 9.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3492
    Cell Significance Index: 9.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3122
    Cell Significance Index: 20.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3031
    Cell Significance Index: 57.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2690
    Cell Significance Index: 7.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2088
    Cell Significance Index: 14.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1976
    Cell Significance Index: 4.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1696
    Cell Significance Index: 4.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1312
    Cell Significance Index: 3.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1223
    Cell Significance Index: 22.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1220
    Cell Significance Index: 5.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0834
    Cell Significance Index: 1.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0590
    Cell Significance Index: 32.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0556
    Cell Significance Index: 24.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0515
    Cell Significance Index: 97.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0505
    Cell Significance Index: 6.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0451
    Cell Significance Index: 0.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0390
    Cell Significance Index: 2.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0381
    Cell Significance Index: 58.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0332
    Cell Significance Index: 0.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0307
    Cell Significance Index: 56.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0275
    Cell Significance Index: 17.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0183
    Cell Significance Index: 8.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0157
    Cell Significance Index: 21.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0086
    Cell Significance Index: -1.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0206
    Cell Significance Index: -3.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0219
    Cell Significance Index: -16.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0261
    Cell Significance Index: -19.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0306
    Cell Significance Index: -23.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0348
    Cell Significance Index: -0.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0361
    Cell Significance Index: -4.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0395
    Cell Significance Index: -22.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0420
    Cell Significance Index: -26.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0576
    Cell Significance Index: -0.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0669
    Cell Significance Index: -8.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0672
    Cell Significance Index: -11.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0682
    Cell Significance Index: -19.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0739
    Cell Significance Index: -3.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0809
    Cell Significance Index: -8.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0830
    Cell Significance Index: -3.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0975
    Cell Significance Index: -3.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1051
    Cell Significance Index: -12.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1067
    Cell Significance Index: -7.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1198
    Cell Significance Index: -15.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1207
    Cell Significance Index: -25.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1471
    Cell Significance Index: -4.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1494
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1716
    Cell Significance Index: -19.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1745
    Cell Significance Index: -3.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1758
    Cell Significance Index: -18.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1887
    Cell Significance Index: -2.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1967
    Cell Significance Index: -12.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2010
    Cell Significance Index: -9.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2010
    Cell Significance Index: -4.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2032
    Cell Significance Index: -5.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2399
    Cell Significance Index: -17.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2517
    Cell Significance Index: -15.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2581
    Cell Significance Index: -8.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2676
    Cell Significance Index: -21.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2690
    Cell Significance Index: -3.6700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2800
    Cell Significance Index: -3.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2894
    Cell Significance Index: -9.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2898
    Cell Significance Index: -3.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3168
    Cell Significance Index: -16.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3285
    Cell Significance Index: -17.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3341
    Cell Significance Index: -11.6100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3388
    Cell Significance Index: -6.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3424
    Cell Significance Index: -5.7300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3577
    Cell Significance Index: -4.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3631
    Cell Significance Index: -7.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3851
    Cell Significance Index: -8.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4252
    Cell Significance Index: -11.1800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4373
    Cell Significance Index: -6.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4425
    Cell Significance Index: -15.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4493
    Cell Significance Index: -12.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4617
    Cell Significance Index: -6.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ERCC8 is a small protein (~30 kDa) that belongs to the Cullin family of E3 ubiquitin ligases. It is highly expressed in neurons and other cells involved in the nervous system, highlighting its importance in neural function and development. ERCC8 is also found in various other cell types, including retinal bipolar neurons, mural cells, and cardiac myocytes. Its ubiquitin ligase activity enables it to recognize and mark specific proteins for degradation or modification, thereby regulating the DNA damage response and repair processes. **Pathways and Functions:** ERCC8 is involved in several critical DNA repair pathways, including: 1. **Transcription-Coupled Nucleotide-Excision Repair (TC-NER):** ERCC8 works in conjunction with other TC-NER proteins to facilitate the incision and repair of DNA damage caused by UV radiation and other mutagenic agents. This process involves the recognition and processing of DNA lesions, followed by the recruitment of repair enzymes to the damaged site. 2. **Double-Strand Break Repair via Classical Nonhomologous End Joining (NHEJ):** ERCC8 is also involved in the repair of double-strand breaks through the NHEJ pathway, which is a critical mechanism for maintaining genome stability in response to DNA damage. 3. **Dna Damage Response:** ERCC8 plays a role in the DNA damage response, regulating the expression of genes involved in DNA repair and cell cycle arrest. 4. **Protein Modification:** ERCC8's ubiquitin ligase activity enables it to modify specific proteins, influencing their activity and localization within the cell. **Clinical Significance:** Dysregulation of ERCC8 function has been implicated in various diseases, including: 1. **Cancer:** Mutations in ERCC8 have been associated with an increased risk of cancer, particularly in individuals with a history of UV radiation exposure. 2. **Neurodegenerative Disorders:** ERCC8 dysfunction has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, which may be influenced by DNA damage and oxidative stress. 3. **Genetic Disorders:** ERCC8 mutations have also been associated with genetic disorders, such as xeroderma pigmentosum, a rare genetic disorder characterized by increased sensitivity to UV radiation. In conclusion, ERCC8 plays a critical role in the regulation of DNA damage response and repair pathways, highlighting its importance in maintaining genome stability and preventing disease. Further research into ERCC8 function and its dysregulation may provide valuable insights into the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 2852058752

Symbol: ERCC8_HUMAN

Name: DNA excision repair protein ERCC-8

UniProtKB Accession Codes:

Q13216 B2RB64 Q6FHX5 Q96GB9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7664335

Title: The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.

PubMed ID: 7664335

DOI: 10.1016/0092-8674(95)90028-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 16751180

Title: CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome.

PubMed ID: 16751180

DOI: 10.1101/gad.378206

PubMed ID: 16916636

Title: Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.

PubMed ID: 16916636

DOI: 10.1016/j.molcel.2006.06.029

PubMed ID: 16964240

Title: Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

PubMed ID: 16964240

DOI: 10.1038/nature05175

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22466612

Title: Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.

PubMed ID: 22466612

DOI: 10.1038/ng.2228

PubMed ID: 26620705

Title: The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair.

PubMed ID: 26620705

DOI: 10.1074/jbc.m115.683235

PubMed ID: 29545921

Title: CSA and CSB play a role in the response to DNA breaks.

PubMed ID: 29545921

DOI: 10.18632/oncotarget.24342

PubMed ID: 22118460

Title: The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

PubMed ID: 22118460

DOI: 10.1016/j.cell.2011.10.035

PubMed ID: 14661080

Title: CKN1 (MIM 216400): mutations in Cockayne syndrome type A and a new common polymorphism.

PubMed ID: 14661080

DOI: 10.1007/s10038-003-0107-2

PubMed ID: 15744458

Title: Characterisation of novel mutations in Cockayne syndrome type A and xeroderma pigmentosum group C subjects.

PubMed ID: 15744458

DOI: 10.1007/s10038-004-0228-2

PubMed ID: 19329487

Title: A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage.

PubMed ID: 19329487

DOI: 10.1073/pnas.0902113106

PubMed ID: 19894250

Title: Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome.

PubMed ID: 19894250

DOI: 10.1002/humu.21154

Sequence Information:

  • Length: 396
  • Mass: 44055
  • Checksum: EC962D56226D717B
  • Sequence:
    • MLGFLSARQT GLEDPLRLRR AESTRRVLGL ELNKDRDVER IHGGGINTLD IEPVEGRYML 
SGGSDGVIVL YDLENSSRQS YYTCKAVCSI GRDHPDVHRY SVETVQWYPH DTGMFTSSSF 
DKTLKVWDTN TLQTADVFNF EETVYSHHMS PVSTKHCLVA VGTRGPKVQL CDLKSGSCSH 
ILQGHRQEIL AVSWSPRYDY ILATASADSR VKLWDVRRAS GCLITLDQHN GKKSQAVESA 
NTAHNGKVNG LCFTSDGLHL LTVGTDNRMR LWNSSNGENT LVNYGKVCNN SKKGLKFTVS 
CGCSSEFVFV PYGSTIAVYT VYSGEQITML KGHYKTVDCC VFQSNFQELY SGSRDCNILA 
WVPSLYEPVP DDDETTTKSQ LNPAFEDAWS SSDEEG

Genular Protein ID: 1336775171

Symbol: B4DGZ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DGZ9

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 243
  • Mass: 26814
  • Checksum: E1912E405AC00B04
  • Sequence:
    • MGYKYITIGT RGPKVQLCDL KSGSCSHILQ GHRQEILAVS WSPRYDYILA TASADSRVKL 
WDVRRASGCL ITLDQHNGKK SQAVESANTA HNGKVNGLCF TSDGLHLLTV GTDNRMRLWN 
SSNGENTLVN YGKVCNNSKK GLKFTVSCGC SSEFVFVPYG STIAVYTVYS GEQITMLKGH 
YKTVDCCVFQ SNFQELYSGS RDCNILAWVP SLYEPVPDDD ETTTKSQLNP AFEDAWSSSD 
EEG

Genular Protein ID: 2617974291

Symbol: B3KPW7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KPW7

Database IDs:

ARBA 2 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 338
  • Mass: 37483
  • Checksum: A5EBA5A61EEB0430
  • Sequence:
    • MLSGGSDGVI VLYDLENSSR QSYYTCKAVC SIGRDHPDVH RYSVETVQWY PHDTGMFTSS 
SFDKTLKVWD TNTLQTADVF NFEETVYSHH MSPVSTKHCL VAVGTRGPKV QLCDLKSGSC 
SHILQGHRQE ILAVSWSPRY DYILATASAD SRVKLWDVRR ASGCLITLDQ HNGKKSQAVE 
SANTAHNGKV NGLCFTSDGL HLLTVGTDNR MRLWNSSNGE NTLVNYGKVC NNSKKGLKFT 
VSCGCSSEFV FVPYGSTIAV YTVYSGEQIT MLKGHYKTVD CCVFQSNFQE LYSGSRDCNI 
LAWVPSLYEP VPDDDETTTK SQLNPAFEDA WSSSDEEG

Genular Protein ID: 3296823351

Symbol: A0A0S2Z3L1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3L1

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 5 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 205
  • Mass: 23182
  • Checksum: 6553CE607A392576
  • Sequence:
    • MLGFLSARQT GLEDPLRLRR AESTRRVLGL ELNKDRDVER IHGGGINTLD IEPVEGRYML 
SGGSDGVIVL YDLENSSRQS YYTCKAVCSI GRDHPDVHRY SVETVQWYPH DTGMFTSSSF 
DKTLKVWDTN TLQTADVFNF EETVYSHHMS PVSTKHCLVA VGTRGPKVQL CDLKSGSCSH 
ILQGIFILFQ TATTLSKRFN KKKRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.