Details for: ERCC8

Gene ID: 1161

Symbol: ERCC8

Ensembl ID: ENSG00000049167

Description: ERCC excision repair 8, CSA ubiquitin ligase complex subunit

Associated with

Other Information

Genular Protein ID: 2852058752

Symbol: ERCC8_HUMAN

Name: DNA excision repair protein ERCC-8

UniProtKB Accession Codes:

Q13216 B2RB64 Q6FHX5 Q96GB9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 5 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7664335

Title: The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.

PubMed ID: 7664335

DOI: 10.1016/0092-8674(95)90028-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 16751180

Title: CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome.

PubMed ID: 16751180

DOI: 10.1101/gad.378206

PubMed ID: 16916636

Title: Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.

PubMed ID: 16916636

DOI: 10.1016/j.molcel.2006.06.029

PubMed ID: 16964240

Title: Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

PubMed ID: 16964240

DOI: 10.1038/nature05175

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22466612

Title: Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.

PubMed ID: 22466612

DOI: 10.1038/ng.2228

PubMed ID: 26620705

Title: The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair.

PubMed ID: 26620705

DOI: 10.1074/jbc.m115.683235

PubMed ID: 29545921

Title: CSA and CSB play a role in the response to DNA breaks.

PubMed ID: 29545921

DOI: 10.18632/oncotarget.24342

PubMed ID: 22118460

Title: The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

PubMed ID: 22118460

DOI: 10.1016/j.cell.2011.10.035

PubMed ID: 14661080

Title: CKN1 (MIM 216400): mutations in Cockayne syndrome type A and a new common polymorphism.

PubMed ID: 14661080

DOI: 10.1007/s10038-003-0107-2

PubMed ID: 15744458

Title: Characterisation of novel mutations in Cockayne syndrome type A and xeroderma pigmentosum group C subjects.

PubMed ID: 15744458

DOI: 10.1007/s10038-004-0228-2

PubMed ID: 19329487

Title: A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage.

PubMed ID: 19329487

DOI: 10.1073/pnas.0902113106

PubMed ID: 19894250

Title: Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome.

PubMed ID: 19894250

DOI: 10.1002/humu.21154

Sequence Information:

  • Length: 396
  • Mass: 44055
  • Checksum: EC962D56226D717B
  • Sequence:
    • MLGFLSARQT GLEDPLRLRR AESTRRVLGL ELNKDRDVER IHGGGINTLD IEPVEGRYML 
SGGSDGVIVL YDLENSSRQS YYTCKAVCSI GRDHPDVHRY SVETVQWYPH DTGMFTSSSF 
DKTLKVWDTN TLQTADVFNF EETVYSHHMS PVSTKHCLVA VGTRGPKVQL CDLKSGSCSH 
ILQGHRQEIL AVSWSPRYDY ILATASADSR VKLWDVRRAS GCLITLDQHN GKKSQAVESA 
NTAHNGKVNG LCFTSDGLHL LTVGTDNRMR LWNSSNGENT LVNYGKVCNN SKKGLKFTVS 
CGCSSEFVFV PYGSTIAVYT VYSGEQITML KGHYKTVDCC VFQSNFQELY SGSRDCNILA 
WVPSLYEPVP DDDETTTKSQ LNPAFEDAWS SSDEEG

Genular Protein ID: 3296823351

Symbol: A0A0S2Z3L1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3L1

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 205
  • Mass: 23182
  • Checksum: 6553CE607A392576
  • Sequence:
    • MLGFLSARQT GLEDPLRLRR AESTRRVLGL ELNKDRDVER IHGGGINTLD IEPVEGRYML 
SGGSDGVIVL YDLENSSRQS YYTCKAVCSI GRDHPDVHRY SVETVQWYPH DTGMFTSSSF 
DKTLKVWDTN TLQTADVFNF EETVYSHHMS PVSTKHCLVA VGTRGPKVQL CDLKSGSCSH 
ILQGIFILFQ TATTLSKRFN KKKRY

Genular Protein ID: 1336775171

Symbol: B4DGZ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DGZ9

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 5 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 243
  • Mass: 26814
  • Checksum: E1912E405AC00B04
  • Sequence:
    • MGYKYITIGT RGPKVQLCDL KSGSCSHILQ GHRQEILAVS WSPRYDYILA TASADSRVKL 
WDVRRASGCL ITLDQHNGKK SQAVESANTA HNGKVNGLCF TSDGLHLLTV GTDNRMRLWN 
SSNGENTLVN YGKVCNNSKK GLKFTVSCGC SSEFVFVPYG STIAVYTVYS GEQITMLKGH 
YKTVDCCVFQ SNFQELYSGS RDCNILAWVP SLYEPVPDDD ETTTKSQLNP AFEDAWSSSD 
EEG

Genular Protein ID: 2617974291

Symbol: B3KPW7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KPW7

Database IDs:

ARBA 2 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 6 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 338
  • Mass: 37483
  • Checksum: A5EBA5A61EEB0430
  • Sequence:
    • MLSGGSDGVI VLYDLENSSR QSYYTCKAVC SIGRDHPDVH RYSVETVQWY PHDTGMFTSS 
SFDKTLKVWD TNTLQTADVF NFEETVYSHH MSPVSTKHCL VAVGTRGPKV QLCDLKSGSC 
SHILQGHRQE ILAVSWSPRY DYILATASAD SRVKLWDVRR ASGCLITLDQ HNGKKSQAVE 
SANTAHNGKV NGLCFTSDGL HLLTVGTDNR MRLWNSSNGE NTLVNYGKVC NNSKKGLKFT 
VSCGCSSEFV FVPYGSTIAV YTVYSGEQIT MLKGHYKTVD CCVFQSNFQE LYSGSRDCNI 
LAWVPSLYEP VPDDDETTTK SQLNPAFEDA WSSSDEEG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.