Genular: Defining Cellular Identity and Function

Details for: Ahr

Gene ID: 11622

Symbol: Ahr

Ensembl ID: ENSMUSG00000019256

Description: aryl-hydrocarbon receptor

Associated with

Aryl hydrocarbon receptor signalling
(R-MMU-8937144)
Biological oxidations
(R-MMU-211859)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Endogenous sterols
(R-MMU-211976)
Metabolism
(R-MMU-1430728)
Phase i - functionalization of compounds
(R-MMU-211945)
Xenobiotics
(R-MMU-211981)
Arachidonic acid omega-hydroxylase activity
(GO:0052869)
Aryl hydrocarbon receptor binding
(GO:0017162)
B-1 b cell homeostasis
(GO:0001922)
B cell differentiation
(GO:0030183)
B cell homeostasis
(GO:0001782)
Blood circulation
(GO:0008015)
Blood vessel development
(GO:0001568)
Blood vessel morphogenesis
(GO:0048514)
Blood vessel remodeling
(GO:0001974)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Camera-type eye development
(GO:0043010)
Camp-mediated signaling
(GO:0019933)
Cardiac left ventricle morphogenesis
(GO:0003214)
Cell cycle
(GO:0007049)
Cell morphogenesis
(GO:0000902)
Cellular response to molecule of bacterial origin
(GO:0071219)
Circadian regulation of gene expression
(GO:0032922)
Circumferential growth involved in left ventricle morphogenesis
(GO:0003243)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Gland development
(GO:0048732)
Hsp90 protein binding
(GO:0051879)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Kidney morphogenesis
(GO:0060993)
Liver development
(GO:0001889)
Lymphocyte homeostasis
(GO:0002260)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of osteoblast proliferation
(GO:0033689)
Negative regulation of systemic arterial blood pressure
(GO:0003085)
Negative regulation of t cell mediated immune response to tumor cell
(GO:0002841)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of vasoconstriction
(GO:0045906)
Nuclear receptor activity
(GO:0004879)
Ovarian follicle development
(GO:0001541)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell size
(GO:0045793)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of growth rate
(GO:0040010)
Positive regulation of rna polymerase ii transcription preinitiation complex assembly
(GO:0045899)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Post-embryonic hemopoiesis
(GO:0035166)
Prostate gland development
(GO:0030850)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein localization to nucleus
(GO:0034504)
Regulation of adaptive immune response
(GO:0002819)
Regulation of b cell proliferation
(GO:0030888)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of heart growth
(GO:0060420)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Reproductive structure development
(GO:0048608)
Response to organic cyclic compound
(GO:0014070)
Response to toxic substance
(GO:0009636)
Response to xenobiotic stimulus
(GO:0009410)
Rhythmic process
(GO:0048511)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Spleen development
(GO:0048536)
Tbp-class protein binding
(GO:0017025)
T cell homeostasis
(GO:0043029)
Tfiid-class transcription factor complex binding
(GO:0001094)
Toxic substance binding
(GO:0015643)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Vasculature development
(GO:0001944)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Aryl hydrocarbon receptor
Q3U5D9_MOUSE

Genular Protein ID: 403849322

Symbol: AHR_MOUSE

Name: Aryl hydrocarbon receptor

UniProtKB Accession Codes:

P30561 Q8QZX6 Q8R4S3 Q99P79 Q9QVY1

Database IDs:

Citations:

PubMed ID: 1314586

Title: cDNA cloning and structure of mouse putative Ah receptor.

PubMed ID: 1314586

DOI: 10.1016/0006-291x(92)91185-s

PubMed ID: 1325649

Title: Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

PubMed ID: 1325649

DOI: 10.1073/pnas.89.17.8185

PubMed ID: 8148872

Title: Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice.

PubMed ID: 8148872

DOI: 10.1097/00008571-199312000-00005

PubMed ID: 8408082

Title: Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment.

PubMed ID: 8408082

DOI: 10.1016/s0021-9258(20)80668-1

PubMed ID: 7961644

Title: Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.

PubMed ID: 7961644

DOI: 10.1016/s0021-9258(18)46990-6

PubMed ID: 7969080

Title: Analysis of the four alleles of the murine aryl hydrocarbon receptor.

PubMed ID: 7969080

PubMed ID: 11875369

Title: Sequence variation and phylogenetic history of the mouse Ahr gene.

PubMed ID: 11875369

DOI: 10.1097/00008571-200203000-00009

PubMed ID: 1846217

Title: Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse.

PubMed ID: 1846217

PubMed ID: 8806768

Title: Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins.

PubMed ID: 8806768

DOI: 10.1006/abbi.1996.0378

PubMed ID: 8806883

Title: Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity.

PubMed ID: 8806883

DOI: 10.1006/taap.1996.0210

PubMed ID: 9427285

Title: Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor.

PubMed ID: 9427285

DOI: 10.1046/j.1365-2443.1997.1490345.x

PubMed ID: 10973493

Title: Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice.

PubMed ID: 10973493

DOI: 10.1073/pnas.190256997

PubMed ID: 10639156

Title: Benzoapyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor.

PubMed ID: 10639156

DOI: 10.1073/pnas.97.2.779

PubMed ID: 11956195

Title: Myb-binding protein 1a augments AhR-dependent gene expression.

PubMed ID: 11956195

DOI: 10.1074/jbc.m200740200

PubMed ID: 12213388

Title: Role of the aryl hydrocarbon receptor in cell cycle regulation.

PubMed ID: 12213388

DOI: 10.1016/s0009-2797(02)00069-8

PubMed ID: 12215427

Title: Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor.

PubMed ID: 12215427

DOI: 10.1074/jbc.m202413200

PubMed ID: 15581363

Title: Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex.

PubMed ID: 15581363

DOI: 10.1021/bi048736m

PubMed ID: 20106950

Title: Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene.

PubMed ID: 20106950

DOI: 10.1093/toxsci/kfq022

PubMed ID: 29726989

Title: A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa.

PubMed ID: 29726989

DOI: 10.1093/hmg/ddy165

PubMed ID: 33436590

Title: Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis.

PubMed ID: 33436590

DOI: 10.1038/s41467-020-20461-0

PubMed ID: 24001774

Title: Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain.

PubMed ID: 24001774

DOI: 10.1128/mcb.00698-13

PubMed ID: 28396409

Title: Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex.

PubMed ID: 28396409

DOI: 10.1073/pnas.1617035114

Sequence Information:

Length: 848
Mass: 95017
Checksum: AA1560FA83DDD03C
Sequence:

MSSGANITYA SRKRRKPVQK TVKPIPAEGI KSNPSKRHRD RLNTELDRLA SLLPFPQDVI 
NKLDKLSVLR LSVSYLRAKS FFDVALKSTP ADRNGGQDQC RAQIRDWQDL QEGEFLLQAL 
NGFVLVVTAD ALVFYASSTI QDYLGFQQSD VIHQSVYELI HTEDRAEFQR QLHWALNPDS 
AQGVDEAHGP PQAAVYYTPD QLPPENASFM ERCFRCRLRC LLDNSSGFLA MNFQGRLKYL 
HGQNKKGKDG ALLPPQLALF AIATPLQPPS ILEIRTKNFI FRTKHKLDFT PIGCDAKGQL 
ILGYTEVELC TRGSGYQFIH AADMLHCAES HIRMIKTGES GMTVFRLFAK HSRWRWVQSN 
ARLIYRNGRP DYIIATQRPL TDEEGREHLQ KRSTSLPFMF ATGEAVLYEI SSPFSPIMDP 
LPIRTKSNTS RKDWAPQSTP SKDSFHPSSL MSALIQQDES IYLCPPSSPA PLDSHFLMGS 
VSKCGSWQDS FAAAGSEAAL KHEQIGHAQD VNLALSGGPS ELFPDNKNND LYNIMRNLGI 
DFEDIRSMQN EEFFRTDSTA AGEVDFKDID ITDEILTYVQ DSLNNSTLMN SACQQQPVTQ 
HLSCMLQERL QLEQQQQLQQ PPPQALEPQQ QLCQMVCPQQ DLGPKHTQIN GTFASWNPTP 
PVSFNCPQQE LKHYQLFSSL QGTAQEFPYK PEVDSVPYTQ NFAPCNQPLL PEHSKSVQLD 
FPGRDFEPSL HPTTSNLDFV SCLQVPENQS HGINSQSTMV SPQAYYAGAM SMYQCQPGPQ 
RTPVDQTQYS SEIPGSQAFL SKVQSRGIFN ETYSSDLSSI GHAAQTTGHL HHLAEARPLP 
DITPGGFL

Genular Protein ID: 3865624514

Symbol: Q3U5D9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U5D9

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 805
Mass: 90338
Checksum: CC36B58C6BE780C1
Sequence:

MSSGANITYA SRKRRKPVQK TVKPIPAEGI KSNPSKRHRD RLNTELDRLA SLLPFPQDVI 
NKLDKLSVLR LSVSYLRAKS FFDVALKSTP ADRNGGQDQC RAQIRDWQDL QEGEFLLQAL 
NGFVLVVTAD ALVFYASSTI QDYLGFQQSD VIHQSVYELI HTEDRAEFQR QLHWALNPDS 
AQGVDEAHGP PQAAVYYTPD QLPPENASFM ERCFRCRLRC LLDNSSGFLA MNFQGRLKYL 
HGQNKKGKDG ALLPPQLALF AIATPLQPPS ILEIRTKNFI FRTKHKLDFT PIGCDAKGQL 
ILGYTEVELC TRGSGYQFIH AADILHCAES HIRMIKTGES GMTVFRLLAK HSRWRWVQSN 
ARLIYRNGRP DYIIATQRPL TDEEGREHLQ KRSTSLPFMF ATGEAVLYEI SSPFSPIMDP 
LPIRTKSNTS RKDWAPQSTP SKDSFHPSSL MSALIQQDES IYLCPPSSPA LLDSHFLMGS 
VSKCGSWQDS FAAAGSEAAL KHEQIGHAQD VNLALSGGPS ELFPDNKNND LYSIMRNLGI 
DFEDIRSMQN EEFFRTDSTA AGEVDFKDID ITDEILTYVQ DSLNNSTLLN SACQQQPVTQ 
HLSCMLQERL QLEQQQQLQQ PPPQALEPQQ QLCQMVCPQQ DLGPKHTQIN GTFASWNPTP 
PVSFNCPQQE LKHYQLFSSL QGTAQEFPYK PEVDSVPYTQ NFAPCNQPLL PEHSKSVQLD 
FPGRDFEPSL HPTTSNLDFV SCLQVPENQS HGINSQSAMV SPQAYYAGAM SMYQCQPGPQ 
RTPVDQTQYS SEIPGSQAFL SKVQS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ahr

Associated with

Other Information

cDNA cloning and structure of mouse putative Ah receptor. PubMed ID: 1314586

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. PubMed ID: 1325649

Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. PubMed ID: 8148872

Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. PubMed ID: 8408082

Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. PubMed ID: 7961644

Analysis of the four alleles of the murine aryl hydrocarbon receptor. PubMed ID: 7969080

Sequence variation and phylogenetic history of the mouse Ahr gene. PubMed ID: 11875369

Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse. PubMed ID: 1846217

Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins. PubMed ID: 8806768

Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. PubMed ID: 8806883

Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. PubMed ID: 9427285

Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. PubMed ID: 10973493

Benzoapyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. PubMed ID: 10639156

Myb-binding protein 1a augments AhR-dependent gene expression. PubMed ID: 11956195

Role of the aryl hydrocarbon receptor in cell cycle regulation. PubMed ID: 12213388

Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor. PubMed ID: 12215427

Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex. PubMed ID: 15581363

Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene. PubMed ID: 20106950

A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa. PubMed ID: 29726989

Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. PubMed ID: 33436590

Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain. PubMed ID: 24001774

Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex. PubMed ID: 28396409

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303