Genular: Defining Cellular Identity and Function

Details for: Aicda

Gene ID: 11628

Symbol: Aicda

Ensembl ID: ENSMUSG00000040627

Description: activation-induced cytidine deaminase

Associated with

Catalytic activity
(GO:0003824)
Cellular response to lipopolysaccharide
(GO:0071222)
Cytidine deaminase activity
(GO:0004126)
Cytidine deamination
(GO:0009972)
Cytidine to uridine editing
(GO:0016554)
Cytoplasm
(GO:0005737)
Defense response to bacterium
(GO:0042742)
Defense response to virus
(GO:0051607)
Deoxycytidine deaminase activity
(GO:0047844)
Dna cytosine deamination
(GO:0070383)
Dna demethylation
(GO:0080111)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Isotype switching
(GO:0045190)
Metal ion binding
(GO:0046872)
Mrna processing
(GO:0006397)
Negative regulation of dna methylation-dependent heterochromatin formation
(GO:0090310)
Negative regulation of single stranded viral rna replication via double stranded dna intermediate
(GO:0045869)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of nuclear cell cycle dna replication
(GO:0033262)
Rna binding
(GO:0003723)
Somatic diversification of immunoglobulins
(GO:0016445)
Somatic hypermutation of immunoglobulin genes
(GO:0016446)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Single-stranded DNA cytosine deaminase

Genular Protein ID: 3428324387

Symbol: AICDA_MOUSE

Name: Single-stranded DNA cytosine deaminase

UniProtKB Accession Codes:

Q9WVE0

Database IDs:

Citations:

PubMed ID: 10373455

Title: Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.

PubMed ID: 10373455

DOI: 10.1074/jbc.274.26.18470

PubMed ID: 12692563

Title: Transcription-targeted DNA deamination by the AID antibody diversification enzyme.

PubMed ID: 12692563

DOI: 10.1038/nature01574

PubMed ID: 20507984

Title: GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.

PubMed ID: 20507984

DOI: 10.1074/jbc.m110.131441

PubMed ID: 21518874

Title: Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

PubMed ID: 21518874

DOI: 10.1073/pnas.1104423108

PubMed ID: 23803409

Title: A novel activation-induced cytidine deaminase (AID) mutation in Brazilian patients with hyper-IgM type 2 syndrome.

PubMed ID: 23803409

DOI: 10.1016/j.clim.2013.05.017

Sequence Information:

Length: 198
Mass: 24031
Checksum: 18A3BA10CA54BEB2
Sequence:

MDSLLMKQKK FLYHFKNVRW AKGRHETYLC YVVKRRDSAT SCSLDFGHLR NKSGCHVELL 
FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVAEFLRW NPNLSLRIFT ARLYFCEDRK 
AEPEGLRRLH RAGVQIGIMT FKDYFYCWNT FVENRERTFK AWEGLHENSV RLTRQLRRIL 
LPLYEVDDLR DAFRMLGF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Aicda

Associated with

Other Information

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. PubMed ID: 10373455

Transcription-targeted DNA deamination by the AID antibody diversification enzyme. PubMed ID: 12692563

GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA. PubMed ID: 20507984