Details for: CKS1B

Gene ID: 1163

Symbol: CKS1B

Ensembl ID: ENSG00000173207

Description: CDC28 protein kinase regulatory subunit 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.1319
    Cell Significance Index: -23.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.4714
    Cell Significance Index: -33.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.6291
    Cell Significance Index: -30.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.8275
    Cell Significance Index: -30.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 46.2578
    Cell Significance Index: -31.0400
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 23.9159
    Cell Significance Index: -3.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.1662
    Cell Significance Index: -27.3300
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 19.7781
    Cell Significance Index: 15.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1060
    Cell Significance Index: -27.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6558
    Cell Significance Index: -30.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2983
    Cell Significance Index: -19.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.1941
    Cell Significance Index: 45.6000
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 2.8985
    Cell Significance Index: 1.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9620
    Cell Significance Index: 68.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8943
    Cell Significance Index: 39.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.8270
    Cell Significance Index: 48.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.6598
    Cell Significance Index: 27.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6217
    Cell Significance Index: 1464.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5342
    Cell Significance Index: 72.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5253
    Cell Significance Index: 179.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4850
    Cell Significance Index: -3.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4354
    Cell Significance Index: 39.0700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.4209
    Cell Significance Index: 12.2100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3984
    Cell Significance Index: 11.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3568
    Cell Significance Index: 95.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2739
    Cell Significance Index: 36.5200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.2194
    Cell Significance Index: 8.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1305
    Cell Significance Index: 499.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9711
    Cell Significance Index: 25.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9606
    Cell Significance Index: 124.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8964
    Cell Significance Index: 12.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8632
    Cell Significance Index: 140.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8324
    Cell Significance Index: 102.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8149
    Cell Significance Index: 42.3300
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.6936
    Cell Significance Index: 3.0700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.6650
    Cell Significance Index: 3.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6548
    Cell Significance Index: 357.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5817
    Cell Significance Index: 18.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5317
    Cell Significance Index: 95.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5135
    Cell Significance Index: 101.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4929
    Cell Significance Index: 48.7600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4913
    Cell Significance Index: 3.7100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4909
    Cell Significance Index: 3.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3794
    Cell Significance Index: 48.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3229
    Cell Significance Index: 44.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3223
    Cell Significance Index: 24.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2782
    Cell Significance Index: 12.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1601
    Cell Significance Index: 2.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1284
    Cell Significance Index: 3.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0873
    Cell Significance Index: 1.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0819
    Cell Significance Index: 3.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0712
    Cell Significance Index: 1.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0689
    Cell Significance Index: 52.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0667
    Cell Significance Index: 4.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0636
    Cell Significance Index: 1.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0583
    Cell Significance Index: 9.9600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0577
    Cell Significance Index: 0.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0437
    Cell Significance Index: 1.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0262
    Cell Significance Index: 0.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0040
    Cell Significance Index: 0.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0058
    Cell Significance Index: -3.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0089
    Cell Significance Index: -6.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0112
    Cell Significance Index: -21.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0128
    Cell Significance Index: -4.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0137
    Cell Significance Index: -0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0186
    Cell Significance Index: -34.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0226
    Cell Significance Index: -34.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0259
    Cell Significance Index: -35.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0292
    Cell Significance Index: -3.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0300
    Cell Significance Index: -16.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0313
    Cell Significance Index: -3.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0315
    Cell Significance Index: -21.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0337
    Cell Significance Index: -0.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0378
    Cell Significance Index: -24.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0679
    Cell Significance Index: -30.8100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0696
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0755
    Cell Significance Index: -15.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0776
    Cell Significance Index: -15.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1092
    Cell Significance Index: -31.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1151
    Cell Significance Index: -13.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1170
    Cell Significance Index: -13.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1417
    Cell Significance Index: -3.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1531
    Cell Significance Index: -22.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1864
    Cell Significance Index: -1.9300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2207
    Cell Significance Index: -2.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2498
    Cell Significance Index: -14.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2870
    Cell Significance Index: -22.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2926
    Cell Significance Index: -30.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3163
    Cell Significance Index: -4.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3451
    Cell Significance Index: -10.1400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3673
    Cell Significance Index: -2.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3674
    Cell Significance Index: -22.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3931
    Cell Significance Index: -24.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4038
    Cell Significance Index: -30.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4485
    Cell Significance Index: -13.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4502
    Cell Significance Index: -30.2700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4574
    Cell Significance Index: -6.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4595
    Cell Significance Index: -28.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4731
    Cell Significance Index: -24.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CKS1B is a regulatory subunit of CDKs, specifically CDK1 and CDK2. It is a phosphoserine/threonine kinase activator, meaning it phosphorylates and activates CDKs, enabling them to bind to their cyclin partners and drive the cell cycle forward. CKS1B is also involved in the regulation of histone binding and protein binding, further emphasizing its role in the complex interplay of protein-protein interactions that govern cell cycle progression. **Pathways and Functions:** CKS1B is involved in several key pathways, including: 1. **Cell cycle:** CKS1B regulates the progression of cells through the cell cycle by activating CDK1 and CDK2, which drive the G1/S transition and mitosis. 2. **Mitotic cell cycle phase transition:** CKS1B plays a critical role in the transition from the G1 phase to the mitotic phase, ensuring that cells enter mitosis at the correct time. 3. **Fibroblast proliferation:** CKS1B is highly expressed in fibroblasts, where it regulates cell proliferation and differentiation. 4. **Scf(skp2)-mediated degradation of p27/p21:** CKS1B interacts with the SCF ubiquitin ligase complex, which degrades the cyclin-dependent inhibitors p27 and p21, promoting cell cycle progression. **Clinical Significance:** Dysregulation of CKS1B has been implicated in various diseases, including: 1. **Cancer:** Overexpression of CKS1B has been observed in several types of cancer, including breast, lung, and colon cancer, where it can contribute to tumor progression and metastasis. 2. **Neurological disorders:** CKS1B has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may contribute to neuronal dysfunction and degeneration. 3. **Reproductive disorders:** CKS1B plays a critical role in the regulation of cell cycle and mitosis in reproductive cells, and its dysregulation may contribute to infertility and miscarriage. In conclusion, CKS1B is a key regulator of the cell cycle and mitotic processes, and its dysregulation has significant implications for human health. Further research is needed to fully understand the role of CKS1B in disease and to develop novel therapeutic strategies targeting this gene.

Genular Protein ID: 2616986888

Symbol: CKS1_HUMAN

Name: Cyclin-dependent kinases regulatory subunit 1

UniProtKB Accession Codes:

P61024 P33551

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 8 EMDB 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2227411

Title: Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.

PubMed ID: 2227411

DOI: 10.1101/gad.4.8.1332

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 7791211

Title: Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain.

PubMed ID: 7791211

DOI: 10.1006/jmbi.1995.0341

PubMed ID: 8601310

Title: Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.

PubMed ID: 8601310

DOI: 10.1016/s0092-8674(00)81065-x

Sequence Information:

  • Length: 79
  • Mass: 9660
  • Checksum: E64207B140FA38D5
  • Sequence:
    • MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ SQGWVHYMIH 
EPEPHILLFR RPLPKKPKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.