Details for: CKS2

Gene ID: 1164

Symbol: CKS2

Ensembl ID: ENSG00000123975

Description: CDC28 protein kinase regulatory subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 90.0964
    Cell Significance Index: -37.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.6177
    Cell Significance Index: -21.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.4118
    Cell Significance Index: -37.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 54.9311
    Cell Significance Index: -36.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.4842
    Cell Significance Index: -28.9600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 14.0095
    Cell Significance Index: 6.3800
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 12.9452
    Cell Significance Index: 9.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3061
    Cell Significance Index: -30.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1332
    Cell Significance Index: -36.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9974
    Cell Significance Index: -27.6400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 8.5390
    Cell Significance Index: 64.4800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 8.5371
    Cell Significance Index: 90.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.9682
    Cell Significance Index: 43.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.5448
    Cell Significance Index: 93.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.7653
    Cell Significance Index: 326.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.5166
    Cell Significance Index: 87.4500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.1974
    Cell Significance Index: 6.5400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1010
    Cell Significance Index: 16.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.9105
    Cell Significance Index: 39.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8583
    Cell Significance Index: 49.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7071
    Cell Significance Index: 277.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5882
    Cell Significance Index: 867.3400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.1961
    Cell Significance Index: 4.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9048
    Cell Significance Index: 24.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8107
    Cell Significance Index: 38.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7537
    Cell Significance Index: 96.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7258
    Cell Significance Index: 89.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7187
    Cell Significance Index: 46.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6999
    Cell Significance Index: 48.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6933
    Cell Significance Index: 15.0200
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.6756
    Cell Significance Index: 3.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6285
    Cell Significance Index: 113.2900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.5784
    Cell Significance Index: 4.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5523
    Cell Significance Index: 498.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5458
    Cell Significance Index: 15.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5124
    Cell Significance Index: 26.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5050
    Cell Significance Index: 22.8900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.5047
    Cell Significance Index: 2.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4769
    Cell Significance Index: 14.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4359
    Cell Significance Index: 56.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4339
    Cell Significance Index: 191.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3917
    Cell Significance Index: 77.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3738
    Cell Significance Index: 10.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3732
    Cell Significance Index: 4.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3494
    Cell Significance Index: 11.1900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3238
    Cell Significance Index: 0.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2746
    Cell Significance Index: 52.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2396
    Cell Significance Index: 32.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1922
    Cell Significance Index: 5.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1477
    Cell Significance Index: 111.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1363
    Cell Significance Index: 13.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1329
    Cell Significance Index: 9.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1183
    Cell Significance Index: 2.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0579
    Cell Significance Index: 0.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0455
    Cell Significance Index: 3.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0433
    Cell Significance Index: 0.7700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0390
    Cell Significance Index: 0.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0248
    Cell Significance Index: 0.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0242
    Cell Significance Index: 6.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0091
    Cell Significance Index: -0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0176
    Cell Significance Index: -33.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0236
    Cell Significance Index: -14.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0237
    Cell Significance Index: -43.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0269
    Cell Significance Index: -2.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0274
    Cell Significance Index: -42.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0311
    Cell Significance Index: -42.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0420
    Cell Significance Index: -15.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0448
    Cell Significance Index: -32.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0460
    Cell Significance Index: -25.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0518
    Cell Significance Index: -32.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0828
    Cell Significance Index: -37.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0838
    Cell Significance Index: -2.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0861
    Cell Significance Index: -10.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0904
    Cell Significance Index: -18.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1049
    Cell Significance Index: -17.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1147
    Cell Significance Index: -24.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1323
    Cell Significance Index: -4.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1379
    Cell Significance Index: -7.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1631
    Cell Significance Index: -10.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1645
    Cell Significance Index: -1.5200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1974
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2089
    Cell Significance Index: -23.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2095
    Cell Significance Index: -23.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2236
    Cell Significance Index: -3.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2298
    Cell Significance Index: -33.4100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2389
    Cell Significance Index: -1.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2420
    Cell Significance Index: -6.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2433
    Cell Significance Index: -1.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2819
    Cell Significance Index: -14.8000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2941
    Cell Significance Index: -1.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3462
    Cell Significance Index: -36.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4328
    Cell Significance Index: -26.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4415
    Cell Significance Index: -34.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4636
    Cell Significance Index: -28.4200
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: -0.4822
    Cell Significance Index: 0.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5047
    Cell Significance Index: -38.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5129
    Cell Significance Index: -34.4900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.5440
    Cell Significance Index: -4.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5786
    Cell Significance Index: -5.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CKS2 is a regulatory subunit of CDKs, which are essential for the progression of the cell cycle. The CKS2 protein interacts with CDKs to form a holoenzyme complex, facilitating the phosphorylation and activation of downstream targets. CKS2 is characterized by its ability to bind to CDKs, histones, and other proteins, modulating the activity of CDKs and the cell cycle. The protein exhibits high sequence similarity to other regulatory subunits of CDKs, such as CKS1B, and shares functional similarities with these proteins. **Pathways and Functions** CKS2 is involved in several key cellular pathways, including: 1. **Cell Division**: CKS2 plays a crucial role in the regulation of the cell cycle, particularly during the G2/M phase transition. The CKS2-CDK complex is required for the phosphorylation and activation of downstream targets, such as cyclin B and Cdc25A, which drive the cell cycle forward. 2. **Cyclin-Dependent Kinase Holoenzyme Complex**: CKS2 is a regulatory subunit of CDKs, which are essential for the phosphorylation and activation of downstream targets. The CKS2-CDK complex is required for the regulation of the cell cycle and the response to DNA damage. 3. **Fibroblast Proliferation**: CKS2 is highly expressed in fibroblasts, where it plays a crucial role in regulating the cell cycle and promoting proliferation. 4. **Histone Binding**: CKS2 interacts with histones, modulating the activity of CDKs and the cell cycle. This interaction is essential for the regulation of gene expression and the maintenance of chromatin structure. **Clinical Significance** Dysregulation of CKS2 has been implicated in several diseases, including: 1. **Cancer**: CKS2 is often overexpressed in cancer cells, where it promotes cell proliferation and survival. The loss of CKS2 function has been associated with poor prognosis in several types of cancer. 2. **Autoimmune Disorders**: CKS2 has been implicated in the regulation of immune responses, and its dysregulation has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurological Disorders**: CKS2 has been implicated in the regulation of neuronal development and function, and its dysregulation has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CKS2 is a critical gene involved in various cellular processes, including cell division, proliferation, and transcription regulation. Its dysregulation has been implicated in several diseases, highlighting the importance of understanding the function and regulation of this gene in maintaining cellular homeostasis.

Genular Protein ID: 743374517

Symbol: CKS2_HUMAN

Name: Cyclin-dependent kinases regulatory subunit 2

UniProtKB Accession Codes:

P33552 Q6FGI9 Q6LET5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 Ensembl 1 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2227411

Title: Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.

PubMed ID: 2227411

DOI: 10.1101/gad.4.8.1332

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 8211159

Title: Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control.

PubMed ID: 8211159

DOI: 10.1126/science.8211159

Sequence Information:

  • Length: 79
  • Mass: 9860
  • Checksum: 811B5927691EEC5C
  • Sequence:
    • MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ SLGWVHYMIH 
EPEPHILLFR RPLPKDQQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.