Details for: CKS2

Gene ID: 1164

Symbol: CKS2

Ensembl ID: ENSG00000123975

Description: CDC28 protein kinase regulatory subunit 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.94
    Marker Score: 2354
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.82
    Marker Score: 4050
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.65
    Marker Score: 4077
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.26
    Marker Score: 2127
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.2
    Marker Score: 5397
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.07
    Marker Score: 6147
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.03
    Marker Score: 830
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.98
    Marker Score: 3460
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.97
    Marker Score: 1542
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.97
    Marker Score: 2104
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.91
    Marker Score: 5180.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.9
    Marker Score: 3060
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.87
    Marker Score: 463
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.87
    Marker Score: 539
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.86
    Marker Score: 3875.5
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.83
    Marker Score: 586
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.81
    Marker Score: 7120
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.81
    Marker Score: 5001
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.8
    Marker Score: 2260
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.8
    Marker Score: 10687
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.8
    Marker Score: 1903
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.79
    Marker Score: 1127
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.78
    Marker Score: 61687.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.77
    Marker Score: 599
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.69
    Marker Score: 2877.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.64
    Marker Score: 10678
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.64
    Marker Score: 3886.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.61
    Marker Score: 403
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.58
    Marker Score: 909
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.55
    Marker Score: 1037
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.55
    Marker Score: 1172
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.54
    Marker Score: 508
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.53
    Marker Score: 787
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.51
    Marker Score: 6183
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.5
    Marker Score: 4094
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.5
    Marker Score: 2117
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.49
    Marker Score: 795
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.47
    Marker Score: 811
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.46
    Marker Score: 1554
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.38
    Marker Score: 510
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.38
    Marker Score: 1486
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.35
    Marker Score: 844
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.34
    Marker Score: 2132
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.34
    Marker Score: 1004
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.33
    Marker Score: 372
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.33
    Marker Score: 4922
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.32
    Marker Score: 804.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.32
    Marker Score: 1109
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.31
    Marker Score: 3084
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.3
    Marker Score: 310
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.28
    Marker Score: 295
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.28
    Marker Score: 299
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.24
    Marker Score: 618
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.23
    Marker Score: 12153
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.23
    Marker Score: 654
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.21
    Marker Score: 598
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.2
    Marker Score: 1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2
    Marker Score: 12085
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.17
    Marker Score: 15465
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.15
    Marker Score: 837
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.15
    Marker Score: 401
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.14
    Marker Score: 7439
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2165
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.12
    Marker Score: 359
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.12
    Marker Score: 1165.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.11
    Marker Score: 1168
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.11
    Marker Score: 1181
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.1
    Marker Score: 738
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.1
    Marker Score: 494
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.09
    Marker Score: 6960
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.09
    Marker Score: 14634
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.08
    Marker Score: 677
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.08
    Marker Score: 6917
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.07
    Marker Score: 589
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.07
    Marker Score: 10816
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.06
    Marker Score: 5584
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.06
    Marker Score: 521
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.05
    Marker Score: 744
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.05
    Marker Score: 2709.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.05
    Marker Score: 406
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.04
    Marker Score: 4039
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.04
    Marker Score: 988
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.04
    Marker Score: 203
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.03
    Marker Score: 781
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.03
    Marker Score: 738
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.03
    Marker Score: 1516
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.02
    Marker Score: 539
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.02
    Marker Score: 353
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.02
    Marker Score: 3208
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.02
    Marker Score: 498
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.02
    Marker Score: 583
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.01
    Marker Score: 2284
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1
    Marker Score: 786
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15671
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71633
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47858
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.99
    Marker Score: 934
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.99
    Marker Score: 2422
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.99
    Marker Score: 484
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.99
    Marker Score: 530

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Other Information

**Key characteristics:** - CKS2 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in a variety of cell types, including early promyelocyte, oogonial cell, mesenchymal stem cell, migratory enteric neural crest cell, glandular epithelial cell, tonsil germinal center B cell, eurydendroid cell, B-1 B cell, thyroid follicular cell, and neural crest cell. - It is a key regulator of the cell cycle, and mutations in the CKS2 gene have been linked to a number of human cancers. **Pathways and functions:** - CKS2 is a key regulator of cell cycle progression. It is involved in the regulation of mitosis, meiosis, and cell cycle phase transition. - In mitosis, CKS2 is responsible for the phosphorylation of CDK inhibitors, which allows them to bind to and inhibit CDK. This prevents the activation of CDK and inhibits cell cycle progression. - In meiosis, CKS2 is responsible for the phosphorylation of cyclin-dependent kinase inhibitors (CDI), which prevents them from interacting with CDK and inhibiting cell cycle progression. - In cell cycle phase transition, CKS2 is responsible for the phosphorylation of a number of proteins that are involved in cell cycle control. These modifications allow CDK to be activated and cell cycle progression to proceed. **Clinical significance:** - Mutations in the CKS2 gene have been linked to a number of human cancers. - CKS2 inhibitors are being investigated as a treatment for cancer. - CKS2 is a promising target for cancer therapy because it is involved in the regulation of cell cycle progression and is frequently mutated in cancer cells.

Genular Protein ID: 743374517

Symbol: CKS2_HUMAN

Name: Cyclin-dependent kinases regulatory subunit 2

UniProtKB Accession Codes:

P33552 Q6FGI9 Q6LET5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2227411

Title: Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.

PubMed ID: 2227411

DOI: 10.1101/gad.4.8.1332

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 8211159

Title: Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control.

PubMed ID: 8211159

DOI: 10.1126/science.8211159

Sequence Information:

  • Length: 79
  • Mass: 9860
  • Checksum: 811B5927691EEC5C
  • Sequence:
    • MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ SLGWVHYMIH 
EPEPHILLFR RPLPKDQQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.