Details for: CKS2
Gene ID: 1164
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CKS2
Ensembl ID: ENSG00000123975
Description: CDC28 protein kinase regulatory subunit 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 45.23rCSI 40.84%PRS 36.82
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CSI 40.76rCSI 34.16%PRS 45.11
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CSI 34.36rCSI 40.36%PRS 43.86
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CSI 33.68rCSI 23.42%PRS 47.87
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CSI 31.74rCSI 25.67%PRS 40.51
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CSI 31.62rCSI 26.18%PRS 40.87
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CSI 29.75rCSI 50.96%PRS 49.12
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CSI 28rCSI 26.99%PRS 31.51
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CSI 26.28rCSI 30.35%PRS 35.07
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CSI 24.22rCSI 27.72%PRS 62.64
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CSI 24.06rCSI 68.68%PRS 54.73
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CSI 22.88rCSI 33.01%PRS 49.98
-
CSI 22.69rCSI 17.94%PRS 28.98
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CSI 21.12rCSI 68.49%PRS 43.45
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CSI 19.95rCSI 26.14%PRS 52.74
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CSI 18.92rCSI 37.49%PRS 64.96
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CSI 18.87rCSI 15.65%PRS 38.57
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CSI 18.46rCSI 25.65%PRS 39.74
-
CSI 18.04rCSI 37.43%PRS 38.32
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CSI 17.89rCSI 15.49%PRS 43.76
-
CSI 17.14rCSI 12.31%PRS 52.21
-
CSI 17.01rCSI 14.94%PRS 44.78
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CSI 16.58rCSI 11.02%PRS 44.07
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CSI 14.22rCSI 16.98%PRS 59.73
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CSI 13.78rCSI 23.57%PRS 60.65
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CSI 13.43rCSI 13.19%PRS 54.79
-
CSI 13.42rCSI 13.39%PRS 34.75
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CSI 13.07rCSI 12.06%PRS 41.11
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CSI 12.99rCSI 18%PRS 45.67
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CSI 12.65rCSI 26.11%PRS 47.27
-
CSI 11.91rCSI 12.47%PRS 37.62
-
CSI 11.42rCSI 61.64%PRS 55.13
-
CSI 11.24rCSI 8.32%PRS 34.4
-
CSI 11.22rCSI 14.08%PRS 49.18
-
CSI 10.97rCSI 8.71%PRS 61.36
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CSI 10.94rCSI 11.44%PRS 39.88
-
CSI 10.44rCSI 16.04%PRS 43.4
-
CSI 10.34rCSI 15.82%PRS 56.15
-
CSI 10.1rCSI 12.12%PRS 38.23
-
CSI 9.99rCSI 20.05%PRS 30.94
-
CSI 9.81rCSI 7.34%PRS 54.04
-
CSI 9.68rCSI 14.96%PRS 38.07
-
CSI 9.25rCSI 6.46%PRS 41.74
-
CSI 8.75rCSI 7.66%PRS 49.46
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CSI 8.65rCSI 19.05%PRS 43.75
-
CSI 8.39rCSI 7.76%PRS 60.12
-
CSI 8.37rCSI 36.74%PRS 59.68
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CSI 8.29rCSI 7.99%PRS 40.63
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CSI 8.27rCSI 8.51%PRS 57.22
-
CSI 7.8rCSI 23.27%PRS 63.31
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CSI 7.73rCSI 6.08%PRS 46
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CSI 7.71rCSI 19.31%PRS 70.82
-
CSI 7.25rCSI 6.3%PRS 48.45
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CSI 7.01rCSI 6.89%PRS 68.39
-
CSI 6.9rCSI 6.12%PRS 39.26
-
CSI 6.84rCSI 10.45%PRS 48.65
-
CSI 6.72rCSI 5.66%PRS 56.88
-
CSI 6.56rCSI 71.83%PRS 57.01
-
CSI 6.55rCSI 8.76%PRS 41.76
-
CSI 6.42rCSI 33.17%PRS 63.9
-
CSI 6.4rCSI 20.55%PRS 48.18
-
CSI 6.04rCSI 4.91%PRS 41
-
CSI 6.02rCSI 10.67%PRS 25.45
-
CSI 5.97rCSI 9.25%PRS 50.19
-
CSI 5.91rCSI 4.44%PRS 43.03
-
CSI 5.76rCSI 21.94%PRS 34.65
-
CSI 5.69rCSI 36.58%PRS 62.84
-
CSI 5.48rCSI 12.43%PRS 45.76
-
CSI 5.29rCSI 5.09%PRS 63.79
-
CSI 5.21rCSI 17.61%PRS 50.53
-
CSI 5.13rCSI 7.02%PRS 42.65
-
CSI 5.1rCSI 29.25%PRS 50.96
-
CSI 4.97rCSI 4.7%PRS 41.2
-
CSI 4.81rCSI 3.57%PRS 52.51
-
CSI 4.71rCSI 9.67%PRS 62.53
-
CSI 4.71rCSI 7.1%PRS 41.64
-
CSI 4.61rCSI 13.23%PRS 56.75
-
CSI 4.45rCSI 5.66%PRS 44.95
-
CSI 4.31rCSI 9.63%PRS 46.04
-
CSI 4.28rCSI 6.13%PRS 47.56
-
CSI 4.15rCSI 4.3%PRS 45.54
-
CSI 4.13rCSI 20.65%PRS 82.65
-
CSI 4.11rCSI 7.76%PRS 63.94
-
CSI 4.01rCSI 8.49%PRS 61.22
-
CSI 4rCSI 10.34%PRS 71.11
-
CSI 3.97rCSI 4.79%PRS 47.1
-
CSI 3.85rCSI 6.66%PRS 31.65
-
CSI 3.7rCSI 3.4%PRS 46.91
-
CSI 3.66rCSI 4.7%PRS 38.22
-
CSI 3.65rCSI 9.69%PRS 53.41
-
CSI 3.62rCSI 12.87%PRS 76.82
-
CSI 3.52rCSI 5.62%PRS 34.56
-
CSI 3.5rCSI 2.72%PRS 40.21
-
CSI 3.48rCSI 8.83%PRS 36.82
-
CSI 3.36rCSI 2.9%PRS 49.33
-
CSI 3.24rCSI 4.69%PRS 55.59
-
CSI 3.22rCSI 7.65%PRS 52.47
-
CSI 3.07rCSI 3.13%PRS 52.28
-
CSI 3.02rCSI 4.62%PRS 44.38
-
CSI 2.9rCSI 15.47%PRS 79.16
-
CSI 0.2rCSI 4.8%PRS 68.4%
-
CSI 0.2rCSI 1.2%PRS 76.1%
-
CSI 0.4rCSI 3.5%PRS 68.7%
-
CSI 0.4rCSI 0.6%PRS 31.8%
-
CSI 0.6rCSI 4.0%PRS 59.0%
-
CSI 0.6rCSI 3.7%PRS 76.3%
-
CSI 0.7rCSI 1.4%PRS 69.6%
-
CSI 0.7rCSI 6.9%PRS 81.8%
-
CSI 0.8rCSI 1.2%PRS 57.4%
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CSI 0.9rCSI 1.5%PRS 34.0%
-
CSI 1.0rCSI 20.5%PRS 81.8%
-
CSI 1.0rCSI 1.2%PRS 58.6%
-
CSI 1.0rCSI 4.4%PRS 56.9%
-
CSI 1.1rCSI 8.1%PRS 60.4%
-
CSI 1.3rCSI 2.8%PRS 55.1%
-
CSI 1.3rCSI 2.4%PRS 60.2%
-
CSI 1.3rCSI 25.1%PRS 88.3%
-
CSI 1.3rCSI 3.2%PRS 83.7%
-
CSI 1.4rCSI 10.9%PRS 35.6%
-
CSI 1.4rCSI 3.0%PRS 49.8%
-
CSI 1.4rCSI 4.8%PRS 55.9%
-
CSI 1.4rCSI 2.5%PRS 67.2%
-
CSI 1.4rCSI 1.9%PRS 62.5%
-
CSI 1.5rCSI 37.7%PRS 82.0%
-
CSI 1.5rCSI 4.1%PRS 54.8%
-
CSI 1.5rCSI 2.2%PRS 57.1%
-
CSI 1.5rCSI 27.1%PRS 75.0%
-
CSI 1.5rCSI 2.4%PRS 38.9%
-
CSI 1.5rCSI 8.1%PRS 55.9%
-
CSI 1.5rCSI 3.7%PRS 36.7%
-
CSI 1.5rCSI 9.5%PRS 71.5%
-
CSI 1.5rCSI 2.9%PRS 74.3%
-
CSI 1.6rCSI 3.0%PRS 63.2%
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CSI 1.6rCSI 2.0%PRS 36.1%
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CSI 1.7rCSI 8.1%PRS 51.2%
-
CSI 1.7rCSI 2.2%PRS 44.6%
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CSI 1.7rCSI 4.5%PRS 63.0%
-
CSI 1.7rCSI 2.7%PRS 46.4%
-
CSI 1.8rCSI 6.4%PRS 53.5%
-
CSI 1.9rCSI 3.3%PRS 25.1%
-
CSI 1.9rCSI 1.9%PRS 58.5%
-
CSI 1.9rCSI 3.1%PRS 45.2%
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CSI 1.9rCSI 2.4%PRS 42.5%
-
CSI 1.9rCSI 4.6%PRS 57.2%
-
CSI 1.9rCSI 2.2%PRS 55.8%
-
CSI 2.0rCSI 4.9%PRS 38.2%
-
CSI 2.0rCSI 3.2%PRS 43.3%
-
CSI 2.0rCSI 8.8%PRS 34.7%
-
CSI 2.0rCSI 2.1%PRS 55.4%
-
CSI 2.0rCSI 22.0%PRS 61.0%
-
CSI 2.0rCSI 2.5%PRS 37.6%
-
CSI 2.0rCSI 3.6%PRS 55.9%
-
CSI 2.0rCSI 2.9%PRS 42.8%
-
CSI 2.0rCSI 2.8%PRS 34.4%
-
CSI 2.0rCSI 2.6%PRS 53.1%
-
CSI 2.1rCSI 1.4%PRS 49.4%
-
CSI 2.1rCSI 3.1%PRS 50.7%
-
CSI 2.1rCSI 8.0%PRS 35.4%
-
CSI 2.1rCSI 9.3%PRS 55.8%
-
CSI 2.2rCSI 3.1%PRS 53.7%
-
CSI 2.2rCSI 64.9%PRS 65.2%
-
CSI 2.2rCSI 5.9%PRS 48.8%
-
CSI 2.2rCSI 3.5%PRS 49.5%
-
CSI 2.2rCSI 3.8%PRS 66.0%
-
CSI 2.2rCSI 8.7%PRS 59.8%
-
CSI 2.3rCSI 3.3%PRS 42.7%
-
CSI 2.3rCSI 4.5%PRS 57.8%
-
CSI 2.4rCSI 15.6%PRS 74.1%
-
CSI 2.4rCSI 2.1%PRS 30.3%
-
CSI 2.4rCSI 7.0%PRS 59.0%
-
CSI 2.6rCSI 3.8%PRS 43.2%
-
CSI 2.7rCSI 35.1%PRS 73.9%
-
CSI 2.7rCSI 7.7%PRS 58.0%
-
CSI 2.7rCSI 3.1%PRS 31.1%
-
CSI 2.7rCSI 3.7%PRS 48.1%
-
CSI 2.8rCSI 7.9%PRS 40.2%
-
CSI 2.8rCSI 12.6%PRS 76.5%
-
CSI 2.8rCSI 3.5%PRS 65.5%
-
CSI 2.8rCSI 18.5%PRS 71.5%
-
CSI 2.9rCSI 4.2%PRS 40.3%
-
CSI 2.9rCSI 8.5%PRS 71.9%
-
CSI 2.9rCSI 15.5%PRS 79.2%
-
CSI 3.0rCSI 4.6%PRS 44.4%
-
CSI 3.1rCSI 3.1%PRS 52.3%
-
CSI 3.2rCSI 7.7%PRS 52.5%
-
CSI 3.2rCSI 4.7%PRS 55.6%
-
CSI 3.4rCSI 2.9%PRS 49.3%
-
CSI 3.5rCSI 8.8%PRS 36.8%
-
CSI 3.5rCSI 2.7%PRS 40.2%
-
CSI 3.5rCSI 5.6%PRS 34.6%
-
CSI 3.6rCSI 12.9%PRS 76.8%
-
CSI 3.7rCSI 9.7%PRS 53.4%
-
CSI 3.7rCSI 4.7%PRS 38.2%
-
CSI 3.7rCSI 3.4%PRS 46.9%
-
CSI 3.9rCSI 6.7%PRS 31.7%
-
CSI 4.0rCSI 4.8%PRS 47.1%
-
CSI 4.0rCSI 10.3%PRS 71.1%
-
CSI 4.0rCSI 8.5%PRS 61.2%
-
CSI 4.1rCSI 7.8%PRS 63.9%
-
CSI 4.1rCSI 20.7%PRS 82.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 743374517
Symbol: CKS2_HUMAN
Name: Cyclin-dependent kinases regulatory subunit 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2227411
Title: Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.
PubMed ID: 2227411
DOI: 10.1101/gad.4.8.1332
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 8211159
Title: Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control.
PubMed ID: 8211159
Sequence Information:
- Length: 79
- Mass: 9860
- Checksum: 811B5927691EEC5C
- Sequence:
MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ SLGWVHYMIH EPEPHILLFR RPLPKDQQK