Genular: Defining Cellular Identity and Function

Details for: Akap1

Gene ID: 11640

Symbol: Akap1

Ensembl ID: ENSMUSG00000018428

Description: A kinase anchor protein 1

Associated with

Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
Hemostasis
(R-MMU-109582)
Antiviral innate immune response
(GO:0140374)
Apoptotic process
(GO:0006915)
Beta-tubulin binding
(GO:0048487)
Endoplasmic reticulum
(GO:0005783)
Lipid droplet
(GO:0005811)
Membrane
(GO:0016020)
Microtubule binding
(GO:0008017)
Mitochondrial crista
(GO:0030061)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Molecular adaptor activity
(GO:0060090)
Negative regulation of cardiac muscle hypertrophy
(GO:0010614)
Negative regulation of protein dephosphorylation
(GO:0035308)
Negative regulation of protein import into nucleus
(GO:0042308)
Neuromuscular junction
(GO:0031594)
Nucleic acid binding
(GO:0003676)
Postsynaptic membrane
(GO:0045211)
Postsynaptic specialization, intracellular component
(GO:0099091)
Protein binding
(GO:0005515)
Protein kinase a regulatory subunit binding
(GO:0034237)
Protein kinase binding
(GO:0019901)
Protein phosphatase 2b binding
(GO:0030346)
Protein phosphatase binding
(GO:0019903)
Rna binding
(GO:0003723)

Other Information

Proteins

A-kinase anchor protein 1, mitochondrial
Q9CTT7_MOUSE

Genular Protein ID: 2720292464

Symbol: AKAP1_MOUSE

Name: A-kinase anchor protein 1, mitochondrial

UniProtKB Accession Codes:

O08715 B1AR25 O08714 P97488

Database IDs:

Citations:

PubMed ID: 9065479

Title: Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits.

PubMed ID: 9065479

DOI: 10.1074/jbc.272.12.8057

PubMed ID: 9182549

Title: Organelle-specific targeting of protein kinase AII (PKAII). Molecular and in situ characterization of murine A kinase anchor proteins that recruit regulatory subunits of PKAII to the cytoplasmic surface of mitochondria.

PubMed ID: 9182549

DOI: 10.1074/jbc.272.24.15247

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10352013

Title: NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum.

PubMed ID: 10352013

DOI: 10.1083/jcb.145.5.951

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18630941

Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

PubMed ID: 18630941

DOI: 10.1021/pr800223m

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24101730

Title: NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death.

PubMed ID: 24101730

DOI: 10.1242/jcs.129668

PubMed ID: 32072193

Title: Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis.

PubMed ID: 32072193

DOI: 10.1007/s00125-020-05103-w

Sequence Information:

Length: 857
Mass: 92195
Checksum: 455679FCF95C28E6
Sequence:

MAIQLRSLFP LALPGMLALL GWWWFFSRKK DRLSSSDKQV ETLKVGPAIK DRRLSEEACP 
GVLSVAPTVT QPPGREEQRC VDKPSTEPLA LPRTRQVRRR SESSGNLPSV ADTRSQPGPC 
RDEIAKVELS LMGDKAKSIP LGCPLLPKDA SFPYEAVERC KQESALGKTP GRGWPSPYAA 
SGEKARETGG TEGTGDAVLG ENVSEEGLLS QECVSEVEKS EFPILAPGGG EGEEVSHGPP 
QVAELLKKEE YIVGKLPSSF VEPVHSEPVK DEDALEPQVK GSSNTSDRDL AGELDKDETV 
PENDQIKQAA FQLISQVILE ATEEFRATTV GKTVAQVHPT SATQPKGKEE SCVPASQETS 
LGQDTSDPAS TRTGATASPS AEALPPKTYV SCLSSPLSGP TKDQKPKNSA HHISLAPCPP 
PVTPQRQSLE GASNPRGDDN FVACMANNSQ SVLSVSSLGQ CSDPVSTSGL EDSCTETISS 
SGDKAMTPPL PVSTQPFSNG VLKEELSDLG TEDGWTMDTE ADHSGGSDGN SMDSVDSCCG 
LTKPDSPQSV QAGSNPKKVD LIIWEIEVPK HLVGRLIGKQ GRYVSFLKQT SGAKIYISTL 
PYTQNIQICH IEGSQHHVDK ALNLIGKKFK ELNLTNIYAP PLPSLALPSL PMTSWLMLPD 
GITVEVIVVN QVNAGHLFVQ QHTHPTFHAL RSLDQQMYLC YSQPGIPTLP TPVEITVICA 
APGADGAWWR AQVVASYEET NEVEIRYVDY GGYKRVKVDV LRQIRSDFVT LPFQGAEVLL 
DSVVPLSDDD HFSPEADAAM SEMTGNTALL AQVTSYSATG LPLIQLWSVV GDEVVLINRS 
LVERGLAQWV DSYYASL

Genular Protein ID: 1869804332

Symbol: Q9CTT7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9CTT7

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 78
Mass: 8418
Checksum: 2BD6FA41CC6B1EE6
Sequence:

MDSVVPLSDD DHFSPEADAA MSEMTGNTAL LAQVTSYSAT GLPLIQLWSV VGDEVVLINR 
SLVERGLAQW VDSYYASL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Akap1

Associated with

Other Information

Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. PubMed ID: 9065479

Organelle-specific targeting of protein kinase AII (PKAII). Molecular and in situ characterization of murine A kinase anchor proteins that recruit regulatory subunits of PKAII to the cytoplasmic surface of mitochondria. PubMed ID: 9182549

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. PubMed ID: 10352013

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. PubMed ID: 18630941

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death. PubMed ID: 24101730

Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis. PubMed ID: 32072193

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073