Details for: Alpl

Gene ID: 11647

Symbol: Alpl

Ensembl ID: ENSMUSG00000028766

Description: alkaline phosphatase, liver/bone/kidney

Associated with

Other Information

Genular Protein ID: 1026578668

Symbol: PPBT_MOUSE

Name: Alkaline phosphatase 2

UniProtKB Accession Codes:

P09242 Q6P1B0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 51 ChEMBL 1 ChiTaRS 1 DNASU 1 EC 2 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneTree 1 Genevisible 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 16 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 3478679

Title: Cloning and characterization of a cDNA coding for mouse placental alkaline phosphatase.

PubMed ID: 3478679

DOI: 10.1073/pnas.84.20.7051

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2165496

Title: Induction of alkaline phosphatase in mouse L cells by overexpression of the catalytic subunit of cAMP-dependent protein kinase.

PubMed ID: 2165496

DOI: 10.1016/s0021-9258(19)38283-3

PubMed ID: 7789278

Title: Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells.

PubMed ID: 7789278

DOI: 10.1242/dev.121.5.1487

PubMed ID: 7550313

Title: Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6.

PubMed ID: 7550313

DOI: 10.1038/ng0995-45

PubMed ID: 9056646

Title: Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.

PubMed ID: 9056646

DOI: 10.1002/(sici)1097-0177(199703)208:3<432::aid-aja13>3.0.co;2-1

PubMed ID: 10620060

Title: Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia.

PubMed ID: 10620060

DOI: 10.1359/jbmr.1999.14.12.2015

PubMed ID: 11004006

Title: Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1.

PubMed ID: 11004006

DOI: 10.1152/ajpregu.2000.279.4.r1365

PubMed ID: 11028439

Title: Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice.

PubMed ID: 11028439

DOI: 10.1359/jbmr.2000.15.10.1879

PubMed ID: 11169525

Title: Abnormal vitamin B6 metabolism in alkaline phosphatase knock-out mice causes multiple abnormalities, but not the impaired bone mineralization.

PubMed ID: 11169525

DOI: 10.1002/1096-9896(2000)9999:9999<::aid-path722>3.0.co;2-y

PubMed ID: 12082181

Title: Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization.

PubMed ID: 12082181

DOI: 10.1073/pnas.142063399

PubMed ID: 14982838

Title: Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice.

PubMed ID: 14982838

DOI: 10.1016/s0002-9440(10)63172-0

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19874193

Title: Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles.

PubMed ID: 19874193

DOI: 10.1359/jbmr.091023

PubMed ID: 20684022

Title: Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification.

PubMed ID: 20684022

DOI: 10.1002/jbmr.195

PubMed ID: 23942722

Title: Effects of pH on the production of phosphate and pyrophosphate by matrix vesicles' biomimetics.

PubMed ID: 23942722

DOI: 10.1007/s00223-013-9745-3

PubMed ID: 24028588

Title: Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture.

PubMed ID: 24028588

DOI: 10.1111/eos.12078

PubMed ID: 23427088

Title: In vivo overexpression of tissue-nonspecific alkaline phosphatase increases skeletal mineralization and affects the phosphorylation status of osteopontin.

PubMed ID: 23427088

DOI: 10.1002/jbmr.1901

PubMed ID: 23825434

Title: Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord.

PubMed ID: 23825434

DOI: 10.1523/jneurosci.0133-13.2013

PubMed ID: 26457330

Title: The functional co-operativity of Tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 during initiation of skeletal mineralization.

PubMed ID: 26457330

DOI: 10.1016/j.bbrep.2015.09.013

PubMed ID: 29174347

Title: Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.

PubMed ID: 29174347

DOI: 10.1016/j.bmcl.2017.11.024

PubMed ID: 29148101

Title: Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage.

PubMed ID: 29148101

DOI: 10.1111/eos.12390

PubMed ID: 32035618

Title: Tissue-nonspecific alkaline phosphatase promotes the osteogenic differentiation of osteoprogenitor cells.

PubMed ID: 32035618

DOI: 10.1016/j.bbrc.2020.01.136

PubMed ID: 32028019

Title: Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase.

PubMed ID: 32028019

DOI: 10.1016/j.bone.2020.115262

PubMed ID: 33981039

Title: Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.

PubMed ID: 33981039

DOI: 10.1038/s41586-021-03533-z

Sequence Information:

  • Length: 524
  • Mass: 57514
  • Checksum: 59D99110C60FA050
  • Sequence:
    • MISPFLVLAI GTCLTNSFVP EKERDPSYWR QQAQETLKNA LKLQKLNTNV AKNVIMFLGD 
GMGVSTVTAA RILKGQLHHN TGEETRLEMD KFPFVALSKT YNTNAQVPDS AGTATAYLCG 
VKANEGTVGV SAATERTRCN TTQGNEVTSI LRWAKDAGKS VGIVTTTRVN HATPSAAYAH 
SADRDWYSDN EMPPEALSQG CKDIAYQLMH NIKDIDVIMG GGRKYMYPKN RTDVEYELDE 
KARGTRLDGL DLISIWKSFK PRHKHSHYVW NRTELLALDP SRVDYLLGLF EPGDMQYELN 
RNNLTDPSLS EMVEVALRIL TKNLKGFFLL VEGGRIDHGH HEGKAKQALH EAVEMDQAIG 
KAGAMTSQKD TLTVVTADHS HVFTFGGYTP RGNSIFGLAP MVSDTDKKPF TAILYGNGPG 
YKVVDGEREN VSMVDYAHNN YQAQSAVPLR HETHGGEDVA VFAKGPMAHL LHGVHEQNYI 
PHVMAYASCI GANLDHCAWA GSGSAPSPGA LLLPLAVLSL RTLF

Genular Protein ID: 2882894878

Symbol: Q3TQ02_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TQ02

Database IDs:

AGR 1 ARBA 25 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 47 ChiTaRS 1 DNASU 1 EC 2 EMBL 2 GO 4 Gene3D 1 Genevisible 1 InterPro 3 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 16 RuleBase 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 524
  • Mass: 57501
  • Checksum: 30C0FF789A313DA7
  • Sequence:
    • MISPFLVLAI GTCLTNSFVP EKERDPSYWR QQAQETLKNA LKLQKLSTNV AKNVIMFLGD 
GMGVSTVTAA RILKGQLHHN TGEETRLEMD KFPFVALSKT YNTNAQVPDS AGTATAYLCG 
VKANEGTVGV SAATERTRCN TTQGNEVTSI LRWAKDAGKS VGIVTTTRVN HATPSAAYAH 
SADRDWYSDN EMPPEALSQG CKDIAYQLMH NIKDIDVIMG GGRKYMYPKN RTDVEYELDE 
KARGTRLDGL DLISIWKSFK PRHKHSHYVW NRTELLALDP TRVDYLLGLF EPGDMQYELN 
RNNLTDPSLS EMVEVALRIL TKNLKGFFLL VEGGRIDHGH HEGKAKQALH EAVEMDQAIG 
KAGAMTSQKD TLTVVTADHS HVFTFGGYTP RGNSIFGLAP MVSDTDKKPF TAILYGNGPG 
YKVVDGEREN VSMVDYAHNN YQAQSAVPLR HETHGGEDVA VFAKGPMAHL LHGVHEQNYI 
PHVMAYASCI GANLDHCAWA GSGSAPSPGA LLLPLAVLSL RTLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.