Details for: Akt1
Associated with
Other Information
Genular Protein ID: 484876160
Symbol: AKT1_MOUSE
Name: RAC-alpha serine/threonine-protein kinase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8437858
Title: Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.
PubMed ID: 8437858
PubMed ID: 12783884
Title: Protein kinase B alpha/Akt1 regulates placental development and fetal growth.
PubMed ID: 12783884
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9415393
Title: Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells.
PubMed ID: 9415393
PubMed ID: 10454575
Title: Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.
PubMed ID: 10454575
PubMed ID: 11090077
Title: Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.
PubMed ID: 11090077
PubMed ID: 10716693
Title: Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.
PubMed ID: 10716693
PubMed ID: 11282895
Title: Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1.
PubMed ID: 11282895
PubMed ID: 11579209
Title: Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor.
PubMed ID: 11579209
PubMed ID: 11598301
Title: Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.
PubMed ID: 11598301
PubMed ID: 11994271
Title: A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.
PubMed ID: 11994271
PubMed ID: 12124386
Title: The role of Asp-462 in regulating Akt activity.
PubMed ID: 12124386
PubMed ID: 15753085
Title: A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.
PubMed ID: 15753085
PubMed ID: 15722337
Title: Phosphorylation of grb10 regulates its interaction with 14-3-3.
PubMed ID: 15722337
PubMed ID: 16792529
Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.
PubMed ID: 16792529
DOI: 10.1042/bj20060511
PubMed ID: 17242355
Title: Large-scale phosphorylation analysis of mouse liver.
PubMed ID: 17242355
PubMed ID: 18160256
Title: A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.
PubMed ID: 18160256
PubMed ID: 18388859
Title: Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis.
PubMed ID: 18388859
PubMed ID: 18570920
Title: O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells.
PubMed ID: 18570920
PubMed ID: 18288188
Title: Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.
PubMed ID: 18288188
DOI: 10.1038/nature06668
PubMed ID: 19028694
Title: Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.
PubMed ID: 19028694
PubMed ID: 19778506
Title: DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.
PubMed ID: 19778506
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20074525
Title: Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis.
PubMed ID: 20074525
PubMed ID: 21045808
Title: mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.
PubMed ID: 21045808
PubMed ID: 20189988
Title: Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2.
PubMed ID: 20189988
PubMed ID: 20333297
Title: Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
PubMed ID: 20333297
PubMed ID: 21262971
Title: Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
PubMed ID: 21262971
PubMed ID: 22057101
Title: ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.
PubMed ID: 22057101
DOI: 10.1038/ncb2373
PubMed ID: 11882383
Title: The protein kinase B/Akt signalling pathway in human malignancy.
PubMed ID: 11882383
PubMed ID: 21620960
PubMed ID: 21432781
PubMed ID: 24156551
Title: KCTD20, a relative of BTBD10, is a positive regulator of Akt.
PubMed ID: 24156551
PubMed ID: 23300339
Title: BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
PubMed ID: 23300339
PubMed ID: 26095253
Title: Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer.
PubMed ID: 26095253
PubMed ID: 26440888
Title: Akt kinase-mediated checkpoint of cGAS DNA sensing pathway.
PubMed ID: 26440888
PubMed ID: 26359501
Title: Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.
PubMed ID: 26359501
PubMed ID: 26107252
Title: Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
PubMed ID: 26107252
DOI: 10.1038/nm.3908
PubMed ID: 32228865
Title: Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175.
PubMed ID: 32228865
DOI: 10.7554/elife.53430
PubMed ID: 32350463
Title: AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment.
PubMed ID: 32350463
Sequence Information:
- Length: 480
- Mass: 55707
- Checksum: 98DF28E5EFE03730
- Sequence:
MNDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQRES PLNNFSVAQC QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWA TAIQTVADGL KRQEEETMDF RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEEIRFPR TLGPEAKSLL SGLLKKDPTQ RLGGGSEDAK EIMQHRFFAN IVWQDVYEKK LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.