Genular: Defining Cellular Identity and Function

Details for: Akt2

Gene ID: 11652

Symbol: Akt2

Ensembl ID: ENSMUSG00000004056

Description: thymoma viral proto-oncogene 2

Associated with

Activation of akt2
(R-MMU-165158)
Adaptive immune system
(R-MMU-1280218)
Akt-mediated inactivation of foxo1a
(R-MMU-211163)
Akt phosphorylates targets in the cytosol
(R-MMU-198323)
Akt phosphorylates targets in the nucleus
(R-MMU-198693)
Cd28 co-stimulation
(R-MMU-389356)
Cd28 dependent pi3k/akt signaling
(R-MMU-389357)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Costimulation by the cd28 family
(R-MMU-388841)
Ctla4 inhibitory signaling
(R-MMU-389513)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Cytokine signaling in immune system
(R-MMU-1280215)
Deactivation of the beta-catenin transactivating complex
(R-MMU-3769402)
Developmental biology
(R-MMU-1266738)
Downregulation of erbb2 signaling
(R-MMU-8863795)
Downregulation of erbb2:erbb3 signaling
(R-MMU-1358803)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-MMU-9634638)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Flt3 signaling
(R-MMU-9607240)
Foxo-mediated transcription
(R-MMU-9614085)
G-protein beta:gamma signalling
(R-MMU-397795)
G1/s transition
(R-MMU-69206)
G beta:gamma signalling through pi3kgamma
(R-MMU-392451)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gpcr downstream signalling
(R-MMU-388396)
Igf1r signaling cascade
(R-MMU-2428924)
Immune system
(R-MMU-168256)
Inhibition of tsc complex formation by pkb
(R-MMU-165181)
Insulin receptor signalling cascade
(R-MMU-74751)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Membrane trafficking
(R-MMU-199991)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mtor signalling
(R-MMU-165159)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi3k cascade
(R-MMU-109704)
Pip3 activates akt signaling
(R-MMU-1257604)
Pten regulation
(R-MMU-6807070)
Rab gefs exchange gtp for gdp on rabs
(R-MMU-8876198)
Rab regulation of trafficking
(R-MMU-9007101)
Regulation of beta-cell development
(R-MMU-186712)
Regulation of gene expression in beta cells
(R-MMU-210745)
Regulation of localization of foxo transcription factors
(R-MMU-9614399)
Regulation of pten stability and activity
(R-MMU-8948751)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through acetylation
(R-MMU-6804758)
Regulation of tp53 activity through association with co-factors
(R-MMU-6804759)
Regulation of tp53 degradation
(R-MMU-6804757)
Regulation of tp53 expression and degradation
(R-MMU-6806003)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by erbb2
(R-MMU-1227986)
Signaling by gpcr
(R-MMU-372790)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Signaling by vegf
(R-MMU-194138)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Tp53 regulates metabolic genes
(R-MMU-5628897)
Transcriptional regulation by tp53
(R-MMU-3700989)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated vascular permeability
(R-MMU-5218920)
Vesicle-mediated transport
(R-MMU-5653656)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Carbohydrate metabolic process
(GO:0005975)
Carbohydrate transport
(GO:0008643)
Glucose metabolic process
(GO:0006006)
Glycogen biosynthetic process
(GO:0005978)
Glycogen metabolic process
(GO:0005977)
Insulin receptor signaling pathway
(GO:0008286)
Kinase activity
(GO:0016301)
Metal ion binding
(GO:0046872)
Molecular function activator activity
(GO:0140677)
Multicellular organism development
(GO:0007275)
Nucleotide binding
(GO:0000166)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of signal transduction
(GO:0009967)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase c binding
(GO:0005080)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of translation
(GO:0006417)
Transferase activity
(GO:0016740)

Other Information

Proteins

RAC-beta serine/threonine-protein kinase
Q8CE74_MOUSE

Genular Protein ID: 1825406829

Symbol: AKT2_MOUSE

Name: RAC-beta serine/threonine-protein kinase

UniProtKB Accession Codes:

Q60823

Database IDs:

Citations:

PubMed ID: 7566964

Title: Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene.

PubMed ID: 7566964

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16792529

Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

PubMed ID: 16792529

DOI: 10.1042/bj20060511

PubMed ID: 18160256

Title: A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.

PubMed ID: 18160256

DOI: 10.1016/j.cellsig.2007.11.004

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20019746

Title: Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation.

PubMed ID: 20019746

DOI: 10.1038/cdd.2009.194

PubMed ID: 20189988

Title: Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2.

PubMed ID: 20189988

DOI: 10.1074/jbc.m110.110536

PubMed ID: 21907143

Title: C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.

PubMed ID: 21907143

DOI: 10.1016/j.cmet.2011.06.015

PubMed ID: 21620960

Title: Akt signalling in health and disease.

PubMed ID: 21620960

DOI: 10.1016/j.cellsig.2011.05.004

PubMed ID: 21432781

Title: Akt1 and Akt2: differentiating the aktion.

PubMed ID: 21432781

DOI: 10.14670/hh-26.651

PubMed ID: 24156551

Title: KCTD20, a relative of BTBD10, is a positive regulator of Akt.

PubMed ID: 24156551

DOI: 10.1186/1471-2091-14-27

Sequence Information:

Length: 481
Mass: 55742
Checksum: 4AB4A9C4FB9CFA7D
Sequence:

MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC 
QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRGPGEDAM 
DYKCGSPSDS STSEMMEVAV NKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM 
KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH 
LSRERVFTED RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG 
ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE 
LILMEEIRFP RTLGPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK 
KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLD PLELDQRTHF PQFSYSASIR 
E

Genular Protein ID: 3315258106

Symbol: Q8CE74_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CE74

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 353
Mass: 40766
Checksum: 325D23F43975FFD7
Sequence:

DSSTSEMMEV AVNKARAKVT MNDFDYLKLL GKGTFGKVIL VREKATGRYY AMKILRKEVI 
IAKDEVAHTV TESRVLQNTR HPFLTALKYA FQTHDRLCFV MEYANGGELF FHLSRERVFT 
EDRARFYGAE IVSALEYLHS RDVVYRDIKL ENLMLDKDGH IKITDFGLCK EGISDGATMK 
TFCGTPEYLA PEVLEDNDYG RAVDWWGLGV VMYEMMCGRL PFYNQDHERL FELILMEEIR 
FPRTLGPEAK SLLAGLLKKD PKQRLGGGPS DAKEVMEHRF FLSINWQDVV QKKLLPPFKP 
QVTSEVDTRY FDDEFTAQSI TITPPDRYDS LDPLELDQRT HFPQFSYSAS IRE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Akt2

Associated with

Other Information

Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene. PubMed ID: 7566964

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. PubMed ID: 16792529

A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. PubMed ID: 18160256

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation. PubMed ID: 20019746

Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2. PubMed ID: 20189988

C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. PubMed ID: 21907143

Akt signalling in health and disease. PubMed ID: 21620960

Akt1 and Akt2: differentiating the aktion. PubMed ID: 21432781

KCTD20, a relative of BTBD10, is a positive regulator of Akt. PubMed ID: 24156551

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073