Genular: Defining Cellular Identity and Function

Details for: Abcd1

Gene ID: 11666

Symbol: Abcd1

Ensembl ID: ENSMUSG00000031378

Description: ATP-binding cassette, sub-family D member 1

Associated with

Abc-family proteins mediated transport
(R-MMU-382556)
Abc transporters in lipid homeostasis
(R-MMU-1369062)
Alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
(R-MMU-2046104)
Alpha-linolenic acid (ala) metabolism
(R-MMU-2046106)
Beta-oxidation of very long chain fatty acids
(R-MMU-390247)
Class i peroxisomal membrane protein import
(R-MMU-9603798)
Fatty acid metabolism
(R-MMU-8978868)
Linoleic acid (la) metabolism
(R-MMU-2046105)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Peroxisomal lipid metabolism
(R-MMU-390918)
Protein localization
(R-MMU-9609507)
Transport of small molecules
(R-MMU-382551)
Abc-type fatty-acyl-coa transporter activity
(GO:0015607)
Abc-type transporter activity
(GO:0140359)
Adp binding
(GO:0043531)
Atpase-coupled transmembrane transporter activity
(GO:0042626)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Fatty acid beta-oxidation
(GO:0006635)
Fatty acid elongation
(GO:0030497)
Fatty acid homeostasis
(GO:0055089)
Fatty acyl-coa hydrolase activity
(GO:0047617)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Long-chain fatty acid catabolic process
(GO:0042758)
Long-chain fatty acid import into peroxisome
(GO:0015910)
Long-chain fatty acid transporter activity
(GO:0005324)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Mitochondrial membrane
(GO:0031966)
Mitochondrion
(GO:0005739)
Myelin maintenance
(GO:0043217)
Negative regulation of cytokine production involved in inflammatory response
(GO:1900016)
Negative regulation of reactive oxygen species biosynthetic process
(GO:1903427)
Neuron projection maintenance
(GO:1990535)
Nucleotide binding
(GO:0000166)
Perinuclear region of cytoplasm
(GO:0048471)
Peroxisomal membrane
(GO:0005778)
Peroxisome
(GO:0005777)
Peroxisome organization
(GO:0007031)
Positive regulation of fatty acid beta-oxidation
(GO:0032000)
Positive regulation of unsaturated fatty acid biosynthetic process
(GO:2001280)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of cellular response to oxidative stress
(GO:1900407)
Regulation of fatty acid beta-oxidation
(GO:0031998)
Regulation of mitochondrial depolarization
(GO:0051900)
Regulation of oxidative phosphorylation
(GO:0002082)
Sterol homeostasis
(GO:0055092)
Transmembrane transport
(GO:0055085)
Very long-chain fatty-acyl-coa catabolic process
(GO:0036113)
Very long-chain fatty acid catabolic process
(GO:0042760)
Very long-chain fatty acid metabolic process
(GO:0000038)

Other Information

Proteins

ABCD1_MOUSE

Genular Protein ID: 747487270

Symbol: ABCD1_MOUSE

Name: N/A

UniProtKB Accession Codes:

P48410 Q9QY41 Q9QZ32

Database IDs:

Citations:

PubMed ID: 7894167

Title: cDNA sequence of Aldgh, the mouse homolog of the X-linked adrenoleukodystrophy gene.

PubMed ID: 7894167

DOI: 10.1007/bf00292021

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10504404

Title: The four murine peroxisomal ABC-transporter genes differ in constitutive, inducible and developmental expression.

PubMed ID: 10504404

DOI: 10.1046/j.1432-1327.1999.00772.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 9126326

Title: Adrenoleukodystrophy protein-deficient mice represent abnormality of very long chain fatty acid metabolism.

PubMed ID: 9126326

DOI: 10.1006/bbrc.1997.6340

PubMed ID: 9418970

Title: Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice.

PubMed ID: 9418970

DOI: 10.1002/(sici)1097-4547(19971201)50:5<829::aid-jnr19>3.0.co;2-w

PubMed ID: 9256488

Title: A mouse model for X-linked adrenoleukodystrophy.

PubMed ID: 9256488

DOI: 10.1073/pnas.94.17.9366

PubMed ID: 11875044

Title: Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy.

PubMed ID: 11875044

DOI: 10.1093/hmg/11.5.499

PubMed ID: 15276650

Title: Mouse liver PMP70 and ALDP: homomeric interactions prevail in vivo.

PubMed ID: 15276650

DOI: 10.1016/j.bbadis.2004.04.001

PubMed ID: 15489218

Title: Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy.

PubMed ID: 15489218

DOI: 10.1093/hmg/ddh323

PubMed ID: 18344354

Title: Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy.

PubMed ID: 18344354

DOI: 10.1093/hmg/ddn085

PubMed ID: 18723473

Title: Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy.

PubMed ID: 18723473

DOI: 10.1194/jlr.m800321-jlr200

PubMed ID: 18854420

Title: A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.

PubMed ID: 18854420

DOI: 10.1152/ajpendo.90736.2008

PubMed ID: 23123468

Title: Very long chain fatty acid beta-oxidation in astrocytes: contribution of the ABCD1-dependent and -independent pathways.

PubMed ID: 23123468

DOI: 10.1248/bpb.b12-00411

PubMed ID: 22521832

Title: Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins.

PubMed ID: 22521832

DOI: 10.1016/j.neuroscience.2012.03.058

PubMed ID: 23604518

Title: Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy.

PubMed ID: 23604518

DOI: 10.1093/hmg/ddt186

PubMed ID: 25255441

Title: Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1-deficient mice.

PubMed ID: 25255441

DOI: 10.1371/journal.pone.0108655

PubMed ID: 25583114

Title: Astrocytes and mitochondria from adrenoleukodystrophy protein (ABCD1)-deficient mice reveal that the adrenoleukodystrophy-associated very long-chain fatty acids target several cellular energy-dependent functions.

PubMed ID: 25583114

DOI: 10.1016/j.bbadis.2015.01.005

PubMed ID: 26108493

Title: Brain microsomal fatty acid elongation is increased in abcd1-deficient mouse during active myelination phase.

PubMed ID: 26108493

DOI: 10.1007/s11011-015-9701-1

Sequence Information:

Length: 736
Mass: 81859
Checksum: 20B1B191DFC599E9
Sequence:

MPVLSTPRPS RVTTLKRTAV VLALTAYGVH KIYPLVRQCL TPARGPQVPA GEPTQEASGA 
TATKAGMNRV FLQRLLALLR LLFPRVLCRE TGLLALHSAA LVSRTFLSVY VARLDGRLAR 
CIVRKDPRAF SWQLLQWLLI ALPATFINSA IRYLEGQLAL SFRSRLVAHA YGLYFSQQTY 
YRVSNMDGRL RNPDQSLTED VVAFAASVAH LYSNLTKPLL DVAVTSYTLL RAARSRGAGT 
AWPSAIAGLV VFLTANVLRA FSPKFGELVA EEARRKGELR YMHSRVVANS EEIAFYGGHE 
VELALLQHSY QDLASQINLI LLERLWYVML EQFLMKYVWS ASGLLMVAVP IITATGYAES 
DSEAMKKAAL EMKEEELVSE RTEAFTIARN LLTAAADATE RIMSSYKEVT ELAGYTARVY 
EMFQVFEDVK HCRFKRTGDL EEAQAGPGVM VQSGVHVEGP LKIQGQVVDV EQGIICENIP 
IITPTGEVVV ASLNIRVEEG MHLLITGPNG CGKSSLFRIL GGLWPTYSGV LYKPPPQRMF 
YIPQRPYMSV GSLRDQVIYP DSAEDMRRKG CSEQQLEAIL GIVHLRHILQ REGGWEAVCD 
WKDVLSGGEK QRIGMARMFY HRPKYALLDE CTSAVSIDVE GKIFQAAKDA GIALLSITHR 
PSLWKYHTHL LQFDGEGGWK FEKLDSAARL SLTEEKQRLE QQLAGIPKMQ GRLQELRQIL 
GEAAAPVQPL VPGVPT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Abcd1

Associated with

Other Information

cDNA sequence of Aldgh, the mouse homolog of the X-linked adrenoleukodystrophy gene. PubMed ID: 7894167

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The four murine peroxisomal ABC-transporter genes differ in constitutive, inducible and developmental expression. PubMed ID: 10504404

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Adrenoleukodystrophy protein-deficient mice represent abnormality of very long chain fatty acid metabolism. PubMed ID: 9126326

Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice. PubMed ID: 9418970

A mouse model for X-linked adrenoleukodystrophy. PubMed ID: 9256488

Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy. PubMed ID: 11875044

Mouse liver PMP70 and ALDP: homomeric interactions prevail in vivo. PubMed ID: 15276650

Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy. PubMed ID: 15489218

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy. PubMed ID: 18344354

Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy. PubMed ID: 18723473

A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis. PubMed ID: 18854420

Very long chain fatty acid beta-oxidation in astrocytes: contribution of the ABCD1-dependent and -independent pathways. PubMed ID: 23123468

Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins. PubMed ID: 22521832

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy. PubMed ID: 23604518

Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1-deficient mice. PubMed ID: 25255441

Astrocytes and mitochondria from adrenoleukodystrophy protein (ABCD1)-deficient mice reveal that the adrenoleukodystrophy-associated very long-chain fatty acids target several cellular energy-dependent functions. PubMed ID: 25583114

Brain microsomal fatty acid elongation is increased in abcd1-deficient mouse during active myelination phase. PubMed ID: 26108493