Genular: Defining Cellular Identity and Function

Details for: Aldh1a1

Gene ID: 11668

Symbol: Aldh1a1

Ensembl ID: ENSMUSG00000053279

Description: aldehyde dehydrogenase family 1, subfamily A1

Associated with

Biological oxidations
(R-MMU-211859)
Ethanol oxidation
(R-MMU-71384)
Fructose catabolism
(R-MMU-70350)
Fructose metabolism
(R-MMU-5652084)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Phase i - functionalization of compounds
(R-MMU-211945)
Ra biosynthesis pathway
(R-MMU-5365859)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by retinoic acid
(R-MMU-5362517)
Signal transduction
(R-MMU-162582)
1-pyrroline dehydrogenase activity
(GO:0033737)
3-chloroallyl aldehyde dehydrogenase activity
(GO:0004028)
3-deoxyglucosone dehydrogenase activity
(GO:0106373)
9-cis-retinoic acid biosynthetic process
(GO:0042904)
9-cis-retinoic acid metabolic process
(GO:0042905)
Aldehyde dehydrogenase (nad+) activity
(GO:0004029)
Aminobutyraldehyde dehydrogenase activity
(GO:0019145)
Apoptotic process
(GO:0006915)
Axon
(GO:0030424)
Benzaldehyde dehydrogenase (nad+) activity
(GO:0018479)
Cell projection
(GO:0042995)
Cellular detoxification of aldehyde
(GO:0110095)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Embryonic eye morphogenesis
(GO:0048048)
Fructosamine catabolic process
(GO:0030392)
Fructose catabolic process
(GO:0006001)
Gamma-aminobutyric acid biosynthetic process
(GO:0009449)
Glyceraldehyde-3-phosphate dehydrogenase (nad+) (non-phosphorylating) activity
(GO:0043878)
Identical protein binding
(GO:0042802)
Lipid metabolic process
(GO:0006629)
Maintenance of lens transparency
(GO:0036438)
Nad binding
(GO:0051287)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Optic cup morphogenesis involved in camera-type eye development
(GO:0002072)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, nad or nadp as acceptor
(GO:0016620)
Positive regulation of apoptotic process
(GO:0043065)
Response to ethanol
(GO:0045471)
Response to oxidative stress
(GO:0006979)
Response to xenobiotic stimulus
(GO:0009410)
Retinal dehydrogenase activity
(GO:0001758)
Retinoic acid biosynthetic process
(GO:0002138)
Retinoic acid metabolic process
(GO:0042573)
Retinoid metabolic process
(GO:0001523)
Retinol metabolic process
(GO:0042572)
Synapse
(GO:0045202)

Other Information

Proteins

ALDH-E1

Genular Protein ID: 3398273623

Symbol: AL1A1_MOUSE

Name: ALDH-E1

UniProtKB Accession Codes:

P24549 Q7TQJ0 Q811J0

Database IDs:

Citations:

PubMed ID: 2055490

Title: Isolation and characterization of a cytosolic aldehyde dehydrogenase-encoding cDNA from mouse liver.

PubMed ID: 2055490

DOI: 10.1016/0378-1119(91)90421-7

PubMed ID: 7993664

Title: DNA sequence analysis of the cytosolic acetaldehyde dehydrogenase gene (Ahd-2) in mouse strains with variable ethanol preferences.

PubMed ID: 7993664

DOI: 10.1006/bmmb.1994.1048

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1935685

Title: Aldehyde dehydrogenase is a positional marker in the retina.

PubMed ID: 1935685

DOI: 10.1242/dev.112.3.693

PubMed ID: 12851412

Title: Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid.

PubMed ID: 12851412

DOI: 10.1074/jbc.m303709200

PubMed ID: 17567582

Title: Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice.

PubMed ID: 17567582

DOI: 10.1074/jbc.m702076200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26430123

Title: Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons.

PubMed ID: 26430123

DOI: 10.1126/science.aac4690

Sequence Information:

Length: 501
Mass: 54468
Checksum: 0E428151B799BD1D
Sequence:

MSSPAQPAVP APLADLKIQH TKIFINNEWH NSVSGKKFPV LNPATEEVIC HVEEGDKADV 
DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR LLLATMEALN GGKVFANAYL 
SDLGGCIKAL KYCAGWADKI HGQTIPSDGD IFTYTRREPI GVCGQIIPWN FPMLMFIWKI 
GPALSCGNTV VVKPAEQTPL TALHLASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDVD 
KVAFTGSTQV GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDIAVEF AHHGVFYHQG 
QCCVAASRIF VEESVYDEFV KRSVERAKKY VLGNPLTPGI NQGPQIDKEQ HDKILDLIES 
GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSVDDVIKR 
ANNTTYGLAA GLFTKDLDKA ITVSSALQAG VVWVNCYMML SAQCPFGGFK MSGNGRELGE 
HGLYEYTELK TVAMKISQKN S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Aldh1a1

Associated with

Other Information

Isolation and characterization of a cytosolic aldehyde dehydrogenase-encoding cDNA from mouse liver. PubMed ID: 2055490

DNA sequence analysis of the cytosolic acetaldehyde dehydrogenase gene (Ahd-2) in mouse strains with variable ethanol preferences. PubMed ID: 7993664

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Aldehyde dehydrogenase is a positional marker in the retina. PubMed ID: 1935685

Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid. PubMed ID: 12851412

Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice. PubMed ID: 17567582

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons. PubMed ID: 26430123